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VPSLHSSADRPHSGQIRMPRPVQGVGCHTVPVTQSGETRGLRERKKAATRLAIRREAFRLFEDQGYANTT VEQIADAAEISPSTFYRYFAVKEAVLLSDDHTTPIVDAFVAAPSDMSPIAAYRHAVAEVFAGLSPEERDN AILGQRLLYTVPDARGLVYNEYVRLLGLIADGLAHRLPEPTDAMERRVIAGAVVGVLIAASHNNPLPGDV VDRALTFLDSRLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3877 | - | - | 100% (223) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_5173 | - | 8e-62 | 58.55% (193) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0350 | - | 6e-50 | 51.61% (186) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3885 | ethR | 9e-06 | 40.28% (72) | transcriptional regulatory repressor protein (TETR-family) |
| M. tuberculosis H37Rv | Rv3855 | ethR | 9e-06 | 40.28% (72) | transcriptional regulatory repressor protein (TETR-family) |
| M. leprae Br4923 | MLBr_00064 | - | 4e-06 | 40.30% (67) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0248c | - | 2e-08 | 38.46% (104) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0222 | - | 8e-13 | 34.81% (181) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4894 | - | 5e-42 | 46.96% (181) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5673 | - | 2e-12 | 46.43% (84) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_4253 | - | 4e-09 | 37.61% (109) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_4892 | - | 3e-12 | 34.25% (181) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1156 | - | 3e-66 | 65.76% (184) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3877|M.gilvum_PYR-GCK MPSLHSSADRPHSGQIRMPRPVQGVGCHTVPVTQSGETRGLRERKKAATR
Mvan_1156|M.vanbaalenii_PYR-1 ----MSGHDRPQS---------------------------LRERKKVRTR
MAV_4894|M.avium_104 ----MPASEAPPG---------------------------LRERKKIKTR
MMAR_0222|M.marinum_M ----MSPPPAATS---------------------------LAERKRTATR
MUL_4892|M.ulcerans_Agy99 ----MSPPPAATA---------------------------LAERKRTATR
MSMEG_5673|M.smegmatis_MC2_155 ----MAYQTQQPG---------------------------LRERKKQRTR
TH_4253|M.thermoresistible__bu --------------------------------------------------
Mb3885|M.bovis_AF2122/97 ----MTTSAASQASL-------------------------PRGRRTARPS
Rv3855|M.tuberculosis_H37Rv ----MTTSAASQASL-------------------------PRGRRTARPS
MLBr_00064|M.leprae_Br4923 ----MINSTAGQTSQ-------------------------SRSRRSTRPS
MAB_0248c|M.abscessus_ATCC_199 ----MRPASG------------------------------LREQKKSETK
Mflv_3877|M.gilvum_PYR-GCK -----LAIRREAFRLFEDQG-YANTTVEQIADAAEISPSTFYRYFAVKEA
Mvan_1156|M.vanbaalenii_PYR-1 -----LAIRREAFRLFAKQG-YANTTVEQIAEAADVSPRTFYRYFGVKER
MAV_4894|M.avium_104 -----QAIRREAFRLIEQNG-YAATTVEQIAEAADVSPSTFFRYFGSKES
MMAR_0222|M.marinum_M -----QRIATAAAQLVADLG-LAAATVERIADTADISRATFFRYFNSKED
MUL_4892|M.ulcerans_Agy99 -----QRIATAAAQLVADLG-LVAATVERIADTADISRATFFRYFNSKED
MSMEG_5673|M.smegmatis_MC2_155 -----ATLISAAIDLCVRQG-YEQTTVEQIAAAAEVSARTFSRYFATKDA
TH_4253|M.thermoresistible__bu ------MLTDAAVELFLRHG-YENTTVDQIAAVADVSPRTFSRYFATKDA
Mb3885|M.bovis_AF2122/97 GDDRELAILATAENLLEDRP-LADISVDDLAKGAGISRPTFYFYFPSKEA
Rv3855|M.tuberculosis_H37Rv GDDRELAILATAENLLEDRP-LADISVDDLAKGAGISRPTFYFYFPSKEA
MLBr_00064|M.leprae_Br4923 GDDRELAILATAEQLLEDRP-LTEISVDYLAKSAGISRPTFYFYFASKEA
MAB_0248c|M.abscessus_ATCC_199 -----LALSRAALELALDRGDLAAVTVDDIADAVRVSARTFRNYFTSKED
: * * :*: :* . :* ** ** *:
Mflv_3877|M.gilvum_PYR-GCK VLLS-----DDHTTPIVDAFVAAPSDMSPIAAYRHAVAEVFAGLSPEERD
Mvan_1156|M.vanbaalenii_PYR-1 LLIS-----DDKISPIVEAFIAAPKELPIVPAYRHAVGTVFDGLTQEERD
MAV_4894|M.avium_104 LLLA-----DDLDPLILDALKAQPRELSLPQAFRRAYATVLSQLPDDQLE
MMAR_0222|M.marinum_M AVAEGMT--AHWLDRIATALAAQPEHLSAVEAVVGAFGGLAVGFA-EMED
MUL_4892|M.ulcerans_Agy99 AVAEGMT--AHWLDRIATALAAQPEHQSAVEAVVGAFGGLAVGFA-EMED
MSMEG_5673|M.smegmatis_MC2_155 VMLA-FL--DDVVDLVAGELAQQPPELGELDAVFCAHITAFEKTRVAMPG
TH_4253|M.thermoresistible__bu VIVT-LL--DENLDQGARALREQPADMNHYDALFCAYRLFYARTKDAGPD
Mb3885|M.bovis_AF2122/97 VLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAV
Rv3855|M.tuberculosis_H37Rv VLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAV
MLBr_00064|M.leprae_Br4923 VLLTLLDRVFNKANAALETLIKN-RDNKRGNKWRTGINVFFETFGSHKAV
MAB_0248c|M.abscessus_ATCC_199 AVLFSLR---GIEDNAVALLRQRPQHEHVVDSLEAVMLDLATSEAFSTTV
: : .
Mflv_3877|M.gilvum_PYR-GCK NAILGQRLLYTVPDARGL-VYNEYVRLLG--LIADGLAHRLP--EPTDAM
Mvan_1156|M.vanbaalenii_PYR-1 DFVAGEQMMYAIPEARGL-VYTEYVRLID--LIADALTDRPD--GPTDEM
MAV_4894|M.avium_104 FESTRQRLMFSIPELKAA-MYDEYYRTVT--VAAEAIAHRIG--RAADDF
MMAR_0222|M.marinum_M QVRELATLTRSSETLEAW-TLHIYVRYES--AIADLIAPRIPNLVPQDPR
MUL_4892|M.ulcerans_Agy99 QVRELATLTRSSETLEAW-TLHIYVRYES--AIADLIAPRIPNLVPQDPR
MSMEG_5673|M.smegmatis_MC2_155 QLTDDRLLAAARIFTSSP-SLMQATMGFRPAPLFEVLAKRMG--VSADDR
TH_4253|M.thermoresistible__bu DLTSDRVVAMTRIIMCSP-TLRQAVGEFRPHAVNVALAERMA--VDLEDS
Mb3885|M.bovis_AF2122/97 TRAGQAARATSVEVAELW-STFMQKWIAYTAAVIDAERDRGAAPRTLPAH
Rv3855|M.tuberculosis_H37Rv TRAGQAARATSVEVAELW-STFMQKWIAYTAAVIDAERDRGAAPRTLPAH
MLBr_00064|M.leprae_Br4923 TCAGQVTRDN-TEVRKLW-STFMQKWISYTAAVIDAERKRGVAPDTLPAT
MAB_0248c|M.abscessus_ATCC_199 AVTRLSAQNPGLAAHDAARSEDVGTVVLTEVSRRAGLDPDVDLYPRLVCN
Mflv_3877|M.gilvum_PYR-GCK ERRVIAGAVVGVLIAASHNNPLPGDVVDRALTFLDSRLL-----------
Mvan_1156|M.vanbaalenii_PYR-1 ERRVVAGAIVGVLIAASHNNPFPEDVLLRSLEILGRRLT-----------
MAV_4894|M.avium_104 EVRVFAGALTGAMMAAFDSAPTTPETIYRALDFMDAGMPLD---------
MMAR_0222|M.marinum_M PRLVGALAMAVVRIALDDWLGQGGSLPDRVQQGLAAIVIA----------
MUL_4892|M.ulcerans_Agy99 PRLVGALAMAVVRIALDDWLGQGGSLPDRVQQGLAAIVIA----------
MSMEG_5673|M.smegmatis_MC2_155 KIALIASLWNAIMTTALVQLVPDVDWATVTVERIVNQMRTTYAEFLEVAG
TH_4253|M.thermoresistible__bu RLRLVSSVWDAIMWASQQDLGPHTDWDTVTVDNLIERMEHTYRQFVAQAS
Mb3885|M.bovis_AF2122/97 ELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR---
Rv3855|M.tuberculosis_H37Rv ELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR---
MLBr_00064|M.leprae_Br4923 ELATALNLMNERALFASFTAEQPHVPESRVLDTLVHIWVSSIYNEIR---
MAB_0248c|M.abscessus_ATCC_199 AAYAVLATVIQLAVSGSKLSKDPGALVAQGFQRLRDGLA-----------
:
Mflv_3877|M.gilvum_PYR-GCK ------
Mvan_1156|M.vanbaalenii_PYR-1 ------
MAV_4894|M.avium_104 ------
MMAR_0222|M.marinum_M ------
MUL_4892|M.ulcerans_Agy99 ------
MSMEG_5673|M.smegmatis_MC2_155 RRHEFA
TH_4253|M.thermoresistible__bu AIGRPV
Mb3885|M.bovis_AF2122/97 ------
Rv3855|M.tuberculosis_H37Rv ------
MLBr_00064|M.leprae_Br4923 ------
MAB_0248c|M.abscessus_ATCC_199 ------