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M. tuberculosis H37Rv Rv3855 (ethR)

annotation: TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR
coordinates: 4327549 - 4328199
length: 216

VTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEA
VLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWST
FMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTS
IYGENR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3855 ethR - 100% (216) TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR
M. tuberculosis H37Rv Rv3058c - 1e-16 29.28% (222) TetR family transcriptional regulator
M. tuberculosis H37Rv Rv2506 - 4e-07 38.67% (75) TetR family transcriptional regulator

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3885 ethR 1e-120 100.00% (216) transcriptional regulatory repressor protein (TETR-family)
M. gilvum PYR-GCK Mflv_0963 - 5e-64 62.02% (208) TetR family transcriptional regulator
M. leprae Br4923 MLBr_00064 - 1e-86 76.39% (216) putative transcriptional regulator
M. abscessus ATCC 19977 MAB_0984c - 7e-59 53.23% (201) TetR family transcriptional regulator
M. marinum M MMAR_5405 ethR 4e-92 78.24% (216) TetR family transcriptional regulator
M. avium 104 MAV_0173 - 3e-66 59.43% (212) transcriptional regulator, TetR family protein
M. smegmatis MC2 155 MSMEG_6441 - 1e-68 62.56% (211) transcriptional regulator, TetR family protein
M. thermoresistible (build 8) TH_1150 - 5e-73 66.18% (207) TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR
M. ulcerans Agy99 MUL_5027 ethR 3e-92 77.78% (216) TetR family transcriptional regulator
M. vanbaalenii PYR-1 Mvan_5684 - 1e-72 65.09% (212) TetR family transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Rv3855|M.tuberculosis_H37Rv         -MTTSAASQAS---------LPRGRRTARPSGDDRELAILATAENLLEDR
Mb3885|M.bovis_AF2122/97            -MTTSAASQAS---------LPRGRRTARPSGDDRELAILATAENLLEDR
MLBr_00064|M.leprae_Br4923          -MINSTAGQTS---------QSRSRRSTRPSGDDRELAILATAEQLLEDR
MMAR_5405|M.marinum_M               MVSTSTASQAS---------PSRGRRSARPSGDERELAILNTAEKLLEDR
MUL_5027|M.ulcerans_Agy99           -MSTSTASQAS---------LSRGRRSARPSGDERELAILNTAEKLLEDR
Mvan_5684|M.vanbaalenii_PYR-1       -MRSSTRCKVSPVTATSPTRPARGRRAARPSGDDRELAILETAERLLADR
Mflv_0963|M.gilvum_PYR-GCK          -MSSTTRTG-------------RGRRAARPSGDDRESAILTTAEQLLEQR
TH_1150|M.thermoresistible__bu      -MSTASPVRS------------RGRRSTRPSGDDRELAILTTAEKLLAER
MAV_0173|M.avium_104                -MTTAGQTRAL-----------RGRRAIRPTGDEREQAILATALRLLETR
MSMEG_6441|M.smegmatis_MC2_155      -MTTASQTRTP-----------RGRRSARPSGDDREAAILATAQRLLETK
MAB_0984c|M.abscessus_ATCC_199      -MTKPAT---------------RGRKTTRPSGDERIQAILATAEELLGKR
                                     : ..                 *.*:: **:**:*  *** ** .**  :

Rv3855|M.tuberculosis_H37Rv         PLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTL
Mb3885|M.bovis_AF2122/97            PLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTL
MLBr_00064|M.leprae_Br4923          PLTEISVDYLAKSAGISRPTFYFYFASKEAVLLTLLDRVFNKANAALETL
MMAR_5405|M.marinum_M               PMVDISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNEADAALDNL
MUL_5027|M.ulcerans_Agy99           PMVDISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNEADAALDNL
Mvan_5684|M.vanbaalenii_PYR-1       SLAEISVDDLAKGAGISRPTFYFYFASKDAVLLTLLERVIAEADAALAQL
Mflv_0963|M.gilvum_PYR-GCK          PLNDISVDDLARGAGISRPTFYFYFSSKDAVLLALLDRVIAEANARADAA
TH_1150|M.thermoresistible__bu      PLAEISVDDLAKGAGLSRPTFYFYFPSKDAVLLALVERVIAEADQRADAA
MAV_0173|M.avium_104                PFAGISVDDLAKGAGLSRPTFYFYFKSKEAVVLSLLEPVIARADAEFDGA
MSMEG_6441|M.smegmatis_MC2_155      KFAEISVDDLAKGAGISRPTFYFYFPSKEAVLLSLIDPLIKRADSGFDNA
MAB_0984c|M.abscessus_ATCC_199      PLADVSVDDLARGAGISRPTFYFYFSSKESVLLTLAERIIEEADANVASI
                                     :  :*** **:.**:********* **::*:*:* : :. .*:      

Rv3855|M.tuberculosis_H37Rv         AENP--ADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELW
Mb3885|M.bovis_AF2122/97            AENP--ADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELW
MLBr_00064|M.leprae_Br4923          IKN---RDNKRGNKWRTGINVFFETFGSHKAVTCAGQVTRDN-TEVRKLW
MMAR_5405|M.marinum_M               AQA---PDVDHVTMWRNGINVFFETFGSHRAVVQGGQGVRSISAEVRELW
MUL_5027|M.ulcerans_Agy99           AQA---PDVDHVTMWRNGINVFFETFGSHRAVVQGGQGVRSISTEVRELW
Mvan_5684|M.vanbaalenii_PYR-1       IAE---RSSDRRTIWRRGINVFFETFGAHRAVCATTVGVKSTNSEARELW
Mflv_0963|M.gilvum_PYR-GCK          LGGRDDRPLEPAGVWQ-AIKALFETFAAHRAVMLAGAAMRPNNPEVQRVW
TH_1150|M.thermoresistible__bu      LNGMDARAVDPAGVWR-AINALFETFGAHRAVTLAGAAARTTNTEVDALW
MAV_0173|M.avium_104                VQR---LPTDPRRVWRNGIKAFFTAFSSHRALARAATEALATSSELRSVW
MSMEG_6441|M.smegmatis_MC2_155      VES---MPADPQRAIRRGIEIFFNSFGSHPATARAGTEALKSSPEFKEFW
MAB_0984c|M.abscessus_ATCC_199      DPA---AMTSPAQYWRAVIKAYFDAFGSHRALTVALSSMQGTSPELDQRW
                                             .     :  *:  * :*.:* *             *    *

Rv3855|M.tuberculosis_H37Rv         STFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFA
Mb3885|M.bovis_AF2122/97            STFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFA
MLBr_00064|M.leprae_Br4923          STFMQKWISYTAAVIDAERKRGVAPDTLPATELATALNLMNERALFASFT
MMAR_5405|M.marinum_M               STFMQKWIAYTAKIIEAERERGAAPVTLPALELATALNLMNERTLSASFL
MUL_5027|M.ulcerans_Agy99           STFMQKWIAYTAKIIEAERERGAAPVTLPALELATALNLMNERTLSASFL
Mvan_5684|M.vanbaalenii_PYR-1       SRSMQRWIDHIAAVIEAERADGAAPVTVPARELSTALNLMNESVMTATFT
Mflv_0963|M.gilvum_PYR-GCK          SHFMQKWIDYTAASIRAERERGAAPDTLPAEDLAIALNLMNERIMLSAFA
TH_1150|M.thermoresistible__bu      SRFMKKWIDYTAESIRAERERGAAPDTIPAEDLAVSLNLMNERTMFAAFA
MAV_0173|M.avium_104                SGFMQKWIDQTAAMITAERERGAAPDTIPAADLATSLNQMNERTMMAALS
MSMEG_6441|M.smegmatis_MC2_155      SGLMQKWIAATAALITAERERGAAPDTIPALDLATSLNLMNERTMMAALA
MAB_0984c|M.abscessus_ATCC_199      SEVTENWVANTTVGIEAERARGAAPSVVPARDIAIALNLINQAMMRATFT
                                    *   :.*:   :  * ***  *.** .:** ::: :** :*:  : ::: 

Rv3855|M.tuberculosis_H37Rv         GEQPSVPEARVLDTLVHIWVTSIYGENR----
Mb3885|M.bovis_AF2122/97            GEQPSVPEARVLDTLVHIWVTSIYGENR----
MLBr_00064|M.leprae_Br4923          AEQPHVPESRVLDTLVHIWVSSIYNEIR----
MMAR_5405|M.marinum_M               AEEPSVPETHVVDTLVHIWVSSIYGEAR----
MUL_5027|M.ulcerans_Agy99           AEEPSVPETHVVDTLVHVWVSSIYGAAR----
Mvan_5684|M.vanbaalenii_PYR-1       GHQPAIPDDRVLDNLVHIWTTSIYGKTD----
Mflv_0963|M.gilvum_PYR-GCK          SEQAAVTADRLVGTLAHIWVSSIYGTPRA---
TH_1150|M.thermoresistible__bu      DEKPAVPEDRIVDTLAHIWLTSIYGTGR----
MAV_0173|M.avium_104                AETPAVAEDRVVDTLTHIWVSSIYGESG----
MSMEG_6441|M.smegmatis_MC2_155      DEQPGVAPEKVVATLTHIWLNSIYGTLPVGTA
MAB_0984c|M.abscessus_ATCC_199      GQQPAVDDGKVVDTLLHVWLNAIYGGVCANS-
                                     . . :   ::: .* *:* .:**.

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3855	ethR	-	100% (216)	TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR
M. tuberculosis H37Rv	Rv3058c	-	1e-16	29.28% (222)	TetR family transcriptional regulator
M. tuberculosis H37Rv	Rv2506	-	4e-07	38.67% (75)	TetR family transcriptional regulator