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VCLAGGMDVSGLAPIEQTALLTEYCRALDSRSARPILGDSHADATVRRIDHDFASLGATPSVVALVALRA KMLDECLSRFVAADPSAVVVDLGAGLSSAAFRVDPPPTVDWVNVDLPGVIGLRNAVVPAHERVRDVAANV LEPDWVTAVPPDRPTIVFADGLFAFLDEDAVVSLLRRITGHFPSGVVAFNDYGRVSKANQVIGRLTSSRN ANSPHRQWNFPGFKDARQPESWDPALRLLDESSAMHRPETAQFPTGLRIASRLSRRVPSIARKARVLQYR F
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3375 | - | - | 100% (281) | O-methyltransferase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3385 | - | 1e-34 | 33.45% (281) | O-methyltransferase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2136 | - | 2e-19 | 30.43% (184) | O-methyltransferase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 3e-21 | 32.42% (182) | O-methyltransferase |
| M. tuberculosis H37Rv | Rv1153c | omt | 5e-22 | 32.97% (182) | O-methyltransferase |
| M. leprae Br4923 | MLBr_02020 | - | 3e-05 | 26.74% (187) | hypothetical protein MLBr_02020 |
| M. abscessus ATCC 19977 | MAB_1517c | - | 2e-63 | 44.20% (276) | O-methyltransferase Omt |
| M. marinum M | MMAR_2317 | - | 2e-45 | 36.65% (281) | O-methyltransferase |
| M. avium 104 | MAV_4048 | - | 4e-63 | 44.20% (276) | Omt protein |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 6e-35 | 34.41% (279) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 3e-25 | 33.69% (187) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 7e-19 | 30.98% (184) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_3107 | - | 1e-110 | 69.04% (281) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1184c|M.bovis_AF2122/97 -------MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDTIIDDPM
Rv1153c|M.tuberculosis_H37Rv -------MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDAIIDDPM
TH_0783|M.thermoresistible__bu -------VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPM
MUL_4852|M.ulcerans_Agy99 -----------MP-VIDARHLDDISETALLTLHQRATEAARPDAIIDDPM
Mflv_3375|M.gilvum_PYR-GCK ---------MCLAGGMDVSGLAPIEQTALLTEYCRALDSRSARPILGDSH
Mvan_3107|M.vanbaalenii_PYR-1 ---------MCLAGNMDVSGLTPIEQTALLTEYCRALDSKAARPILGDRL
MAB_1517c|M.abscessus_ATCC_199 -------------MGIDVSGITPEEETAFLTLKARAVNDGWRRPILRDPG
MAV_4048|M.avium_104 -------------MGIDTSAITPEEETAFLTLQARAINNGWARPILPDPG
MMAR_2317|M.marinum_M -------------MSIAMPAFSPAQESLFLTLGGRALDSRLPHPFLGDTI
MSMEG_6473|M.smegmatis_MC2_155 ------------MTDKLKVDLSGAPQTMLATFYAKALDARLPTPILGDDM
MLBr_02020|M.leprae_Br4923 MMAATPEFGSLRSDDDHWDIVSSVGYTALLVAGWRALHAVGPQPLVRDEY
. : : . :* . .:: *
Mb1184c|M.bovis_AF2122/97 AVALVES-IDFGFAKFGPTG----------QGFALRARAFDMAAQHYLDQ
Rv1153c|M.tuberculosis_H37Rv AVALVES-IDFDFAKFGPTG----------QGFALRARAFDMAAQHYLDQ
TH_0783|M.thermoresistible__bu AVRLVDR-IDFDFTKFGRRG----------QEMALRSLAFDRAALRYLSD
MUL_4852|M.ulcerans_Agy99 AIALRND-IDYPYHHFGRTH----------QATALRALAFDNSTRDFLQT
Mflv_3375|M.gilvum_PYR-GCK ADATVRR-IDHDFASLGATP-------SVVALVALRAKMLDECLSRFVAA
Mvan_3107|M.vanbaalenii_PYR-1 AEKTVDQ-IDYDFTTLAATP-------SVVPLVALRAKMLDERLRAFTAR
MAB_1517c|M.abscessus_ATCC_199 ATAAVSK-IDYDFHALGVIT-------PVVCQSSLRAKLLDDRVRAFVTE
MAV_4048|M.avium_104 AADAVTK-IDYDFDGLGLVT-------PVVCQTSLRAKLLDDRVRAFIAQ
MMAR_2317|M.marinum_M ADEILGE-TGYDLGKFPSLTTKLIDARTKVFDIAVRAKRLDEVAGRFIER
MSMEG_6473|M.smegmatis_MC2_155 AAEIAER-IDYDWSRTAITP-------SRAPAVTTRSRHFDRWARQFLAV
MLBr_02020|M.leprae_Br4923 AKYFITASRDPYLMNLLANPGTSLNETAFPRLYGVQTRFFDDFFSSAGDT
* . :: :*
Mb1184c|M.bovis_AF2122/97 HPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSS
Rv1153c|M.tuberculosis_H37Rv HPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSS
TH_0783|M.thermoresistible__bu HPRATVVALAEGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAE
MUL_4852|M.ulcerans_Agy99 RPGATVVALAEGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPAC
Mflv_3375|M.gilvum_PYR-GCK DPSAVVVDLGAGLSSAAFRVD---PPPTVDWVNVDLPGVIGLRNAVVPAH
Mvan_3107|M.vanbaalenii_PYR-1 HPDAVVVDLGAGFSSAVFRVD---PPSTVDWYSVDLPAVIALREALLPVR
MAB_1517c|M.abscessus_ATCC_199 HPNAVVVDMGAGLDDGYRRIQ---PPATVDWYSVDLPGMATLRDEVMPPG
MAV_4048|M.avium_104 HADAVVVDLGAGLDDGYARVN---PPDTVDWYSVELPGLAALRDKVMPPG
MMAR_2317|M.marinum_M HPDAIGLDLGAGLDSRVLRIN---PPSTVGWYDVDFPQIVDLRRRLLPAQ
MSMEG_6473|M.smegmatis_MC2_155 HPEAVVLHLGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEH
MLBr_02020|M.leprae_Br4923 G-IRQAVIVAAGLDSRAYRLK---WPNGATVFEIDLPKVLEFKARVLAEQ
: :. *:. *: :: . : :: : .
Mb1184c|M.bovis_AF2122/97 PRVSVCAQS----ALDYSWMDSVDPA-----GGVFITAEGLLMYLQPEQA
Rv1153c|M.tuberculosis_H37Rv PRVSVCAQS----ALDYSWMDSVDPA-----GGVFITAEGLLMYLQPEQA
TH_0783|M.thermoresistible__bu PRIVTLAQS----ALDFSWMDRVDTD-----HGVLITAEGLLMYLQPDEA
MUL_4852|M.ulcerans_Agy99 DRLRYCAQS----AFDYSWMEQVDDT-----NGVLITAEGLFQYLRRDVV
Mflv_3375|M.gilvum_PYR-GCK ERVRDVAAN----VLEPDWVTAVPPD-----RPTIVFADGLFAFLDEDAV
Mvan_3107|M.vanbaalenii_PYR-1 DRDRSVPTS----LLEPGWADSIPAD-----RPTMLFADGLVAFLTEADV
MAB_1517c|M.abscessus_ATCC_199 PGEHTVGIS----ITDPNWLGGIPSD-----RPAMVIADGFFAFLTKEQI
MAV_4048|M.avium_104 PHEHTIGIS----VTDPEWISAIPAD-----RPAIVIADGLFPFLNKEQI
MMAR_2317|M.marinum_M VGAHNIGAD----LTDPNWLDEVPAD-----RPAVIIADGLVAFLRQHDF
MSMEG_6473|M.smegmatis_MC2_155 ARCHLVSAS----VTDPAWLDEVPTG-----RPALMLGEGLTMYLTETEG
MLBr_02020|M.leprae_Br4923 GAIPNAGRSEVAADLRADWPRALKAAGFDPQRSSAWSVEGLLPYLTNDAQ
. * : :*: :*
Mb1184c|M.bovis_AF2122/97 LGLIAQCAQTFPGG-QMLFDLPPRWFAGWSR-LGLRTSLRYKVP----RM
Rv1153c|M.tuberculosis_H37Rv LGLIAQCAQTFPGG-QMLFDLPPRWFAGWSR-LGLRTSLRYKVP----RM
TH_0783|M.thermoresistible__bu MTLIERCAARFPGG-QMLFDLPPVLLKKLAP-KGLRASRRYRVP----PM
MUL_4852|M.ulcerans_Agy99 FELIAACAKRVPHG-QLVFDSIPWLLSVYSRRRGFKLSEHYTAP----PM
Mflv_3375|M.gilvum_PYR-GCK VSLLRRITGHFPSG-VVAFNDYGRVSKANQVIGRLTSSRNANSPHRQWNF
Mvan_3107|M.vanbaalenii_PYR-1 VAILRRITGHFASG-VVAFNDYGPVSKLNRLLGRLATSSKTNSPHGQWNF
MAB_1517c|M.abscessus_ATCC_199 IATLRAITDHFSTG-QLAFNDYGRMVVG-VWISKLFPQKMFKKVNQLRGF
MAV_4048|M.avium_104 IAVMRAITDHFPAG-QLAFNDYGRMVIG-VWISKLFPQRMFKKVNQLRAF
MMAR_2317|M.marinum_M AALLSRLTNHFASG-EIAFNLY---TTQAIWATKHLASLAAISAGVVN--
MSMEG_6473|M.smegmatis_MC2_155 LALLRRVVDRFGTG-ELQFDAFNTFGIRTQWTNTVVRRSGATLR------
MLBr_02020|M.leprae_Br4923 SALFTRIGELCAPGSRIAVGALGSRLDRKQLAALEATHPGVNISG-----
: * : ..
Mb1184c|M.bovis_AF2122/97 PFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDP
Rv1153c|M.tuberculosis_H37Rv PFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDP
TH_0783|M.thermoresistible__bu PFSLSPAQLARLADTVPGVRAVHDLPMPEGRGFFFRAVFPRFWQARPTRQ
MUL_4852|M.ulcerans_Agy99 PFWFTADHYDELR-AIPGVRAVRELPAPAGRGRFLRWALPVAYRLPGLGR
Mflv_3375|M.gilvum_PYR-GCK PGFKDARQPESWDPALRLLDESSAMHRPETAQFPTGLRIASRLSRRVPSI
Mvan_3107|M.vanbaalenii_PYR-1 PGFKDAHRPEAWNRDLTLLEEASVMQRPEGALFPAGLRLAAKLSHRVPAI
MAB_1517c|M.abscessus_ATCC_199 EGYNDPRTPERWNPRLRFVEEFNLVDAPEIELFPTWLRISSQLARYSTSM
MAV_4048|M.avium_104 EGYNDPHTPERWSPKLTLVEETSLASVPEVDLFPTWLRIATRMAGWSKRT
MMAR_2317|M.marinum_M PGFNDPRQPERWVAGLELAEEILLTRAPEVAELPLVTRLTSRLVAPSAAV
MSMEG_6473|M.smegmatis_MC2_155 WAIDRPDDILDTVPGTRLLAWMSVFEDPVFDELAWHYRLLAKVMRPLSPL
MLBr_02020|M.leprae_Br4923 DVDFSALTYEPKTDSAQWLAAHGWAVEPVRNTLELQTSYGMTPPDVDVQM
*
Mb1184c|M.bovis_AF2122/97 LRPCLT-LLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv LRPCLT-LLEFSRPARG
TH_0783|M.thermoresistible__bu WRGAYT-LLEFG-----
MUL_4852|M.ulcerans_Agy99 LRAPVT-LVEFG-----
Mflv_3375|M.gilvum_PYR-GCK ARKAR--VLQYRF----
Mvan_3107|M.vanbaalenii_PYR-1 ARKAR--VLQYRF----
MAB_1517c|M.abscessus_ATCC_199 KRSAR--ILRFEF----
MAV_4048|M.avium_104 ARSAR--ILRFSF----
MMAR_2317|M.marinum_M SRMIGTTLVRYKF----
MSMEG_6473|M.smegmatis_MC2_155 RYMAQYHRYAF------
MLBr_02020|M.leprae_Br4923 DSFMHSQYITATR----