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GIDVSGITPEEETAFLTLKARAVNDGWRRPILRDPGATAAVSKIDYDFHALGVITPVVCQSSLRAKLLDD RVRAFVTEHPNAVVVDMGAGLDDGYRRIQPPATVDWYSVDLPGMATLRDEVMPPGPGEHTVGISITDPNW LGGIPSDRPAMVIADGFFAFLTKEQIIATLRAITDHFSTGQLAFNDYGRMVVGVWISKLFPQKMFKKVNQ LRGFEGYNDPRTPERWNPRLRFVEEFNLVDAPEIELFPTWLRISSQLARYSTSMKRSARILRFEF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1517c | - | - | 100% (276) | O-methyltransferase Omt |
| M. abscessus ATCC 19977 | MAB_0963c | - | 4e-33 | 32.59% (270) | putative polyketide synthase protein |
| M. abscessus ATCC 19977 | MAB_2169c | - | 1e-30 | 28.47% (274) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 2e-19 | 30.77% (182) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3375 | - | 3e-63 | 44.20% (276) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 4e-20 | 31.32% (182) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2317 | - | 8e-49 | 36.14% (285) | O-methyltransferase |
| M. avium 104 | MAV_4048 | - | 1e-125 | 74.28% (276) | Omt protein |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 7e-29 | 34.74% (190) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 2e-20 | 27.39% (230) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 9e-17 | 28.80% (184) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_3107 | - | 8e-62 | 43.27% (275) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1517c|M.abscessus_ATCC_199 -----MG-IDVSGITPEEETAFLTLKARAVNDGWRRPILRDPGATAAVSK
MAV_4048|M.avium_104 -----MG-IDTSAITPEEETAFLTLQARAINNGWARPILPDPGAADAVTK
Mflv_3375|M.gilvum_PYR-GCK --MCLAGGMDVSGLAPIEQTALLTEYCRALDSRSARPILGDSHADATVRR
Mvan_3107|M.vanbaalenii_PYR-1 --MCLAGNMDVSGLTPIEQTALLTEYCRALDSKAARPILGDRLAEKTVDQ
MMAR_2317|M.marinum_M -----MS-IAMPAFSPAQESLFLTLGGRALDSRLPHPFLGDTIADEILGE
MSMEG_6473|M.smegmatis_MC2_155 -----MTDKLKVDLSGAPQTMLATFYAKALDARLPTPILGDDMAAEIAER
Mb1184c|M.bovis_AF2122/97 MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
TH_0783|M.thermoresistible__bu VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMAVRLVDR
MUL_4852|M.ulcerans_Agy99 ----MP-VIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALRND
: :: : * :* : .:: * *
MAB_1517c|M.abscessus_ATCC_199 IDYDFHALGVIT-------PVVCQSSLRAKLLDDRVRAFVTEHPNAVVVD
MAV_4048|M.avium_104 IDYDFDGLGLVT-------PVVCQTSLRAKLLDDRVRAFIAQHADAVVVD
Mflv_3375|M.gilvum_PYR-GCK IDHDFASLGATP-------SVVALVALRAKMLDECLSRFVAADPSAVVVD
Mvan_3107|M.vanbaalenii_PYR-1 IDYDFTTLAATP-------SVVPLVALRAKMLDERLRAFTARHPDAVVVD
MMAR_2317|M.marinum_M TGYDLGKFPSLTTKLIDARTKVFDIAVRAKRLDEVAGRFIERHPDAIGLD
MSMEG_6473|M.smegmatis_MC2_155 IDYDWSRTAITP-------SRAPAVTTRSRHFDRWARQFLAVHPEAVVLH
Mb1184c|M.bovis_AF2122/97 IDFGFAKFGPTG----------QGFALRARAFDMAAQHYLDQHPAATVVA
Rv1153c|M.tuberculosis_H37Rv IDFDFAKFGPTG----------QGFALRARAFDMAAQHYLDQHPAATVVA
TH_0783|M.thermoresistible__bu IDFDFTKFGRRG----------QEMALRSLAFDRAALRYLSDHPRATVVA
MUL_4852|M.ulcerans_Agy99 IDYPYHHFGRTH----------QATALRALAFDNSTRDFLQTRPGATVVA
.. : *: :* : . * :
MAB_1517c|M.abscessus_ATCC_199 MGAGLDDGYRRIQ---PPATVDWYSVDLPGMATLRDEVMPPGPGEHTVGI
MAV_4048|M.avium_104 LGAGLDDGYARVN---PPDTVDWYSVELPGLAALRDKVMPPGPHEHTIGI
Mflv_3375|M.gilvum_PYR-GCK LGAGLSSAAFRVD---PPPTVDWVNVDLPGVIGLRNAVVPAHERVRDVAA
Mvan_3107|M.vanbaalenii_PYR-1 LGAGFSSAVFRVD---PPSTVDWYSVDLPAVIALREALLPVRDRDRSVPT
MMAR_2317|M.marinum_M LGAGLDSRVLRIN---PPSTVGWYDVDFPQIVDLRRRLLPAQVGAHNIGA
MSMEG_6473|M.smegmatis_MC2_155 LGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSA
Mb1184c|M.bovis_AF2122/97 LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
Rv1153c|M.tuberculosis_H37Rv LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
TH_0783|M.thermoresistible__bu LAEGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAEPRIVTLAQ
MUL_4852|M.ulcerans_Agy99 LAEGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQ
:. *:. *: . * :: . : ** : *
MAB_1517c|M.abscessus_ATCC_199 SITDPNWLGGIPSDRPAMVIADGFFAFLTKEQIIATLRAITDHFSTGQLA
MAV_4048|M.avium_104 SVTDPEWISAIPADRPAIVIADGLFPFLNKEQIIAVMRAITDHFPAGQLA
Mflv_3375|M.gilvum_PYR-GCK NVLEPDWVTAVPPDRPTIVFADGLFAFLDEDAVVSLLRRITGHFPSGVVA
Mvan_3107|M.vanbaalenii_PYR-1 SLLEPGWADSIPADRPTMLFADGLVAFLTEADVVAILRRITGHFASGVVA
MMAR_2317|M.marinum_M DLTDPNWLDEVPADRPAVIIADGLVAFLRQHDFAALLSRLTNHFASGEIA
MSMEG_6473|M.smegmatis_MC2_155 SVTDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQ
Mb1184c|M.bovis_AF2122/97 SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
Rv1153c|M.tuberculosis_H37Rv SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
TH_0783|M.thermoresistible__bu SALDFSWMDRVDTDHGVLITAEGLLMYLQPDEAMTLIERCAARFPGGQML
MUL_4852|M.ulcerans_Agy99 SAFDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLV
. : * : ..: .:*: :* : . . * :
MAB_1517c|M.abscessus_ATCC_199 FNDYGRMVVG-VWISKLFPQKMFKKVNQLRGFEGYNDPRTPERWNPRLRF
MAV_4048|M.avium_104 FNDYGRMVIG-VWISKLFPQRMFKKVNQLRAFEGYNDPHTPERWSPKLTL
Mflv_3375|M.gilvum_PYR-GCK FNDYGRVSKANQVIGRLTSSRNANSPHRQWNFPGFKDARQPESWDPALRL
Mvan_3107|M.vanbaalenii_PYR-1 FNDYGPVSKLNRLLGRLATSSKTNSPHGQWNFPGFKDAHRPEAWNRDLTL
MMAR_2317|M.marinum_M FNLY---TTQAIWATKHLASLAAISAGVVN--PGFNDPRQPERWVAGLEL
MSMEG_6473|M.smegmatis_MC2_155 FDAFNTFGIRTQWTNTVVRRSGATLRWAIDRPDDILDT------VPGTRL
Mb1184c|M.bovis_AF2122/97 FDLPPRWFAGWSR-LGLRTSLRYKVP----RMPFSMSVAQAADLVNKVPG
Rv1153c|M.tuberculosis_H37Rv FDLPPRWFAGWSR-LGLRTSLRYKVP----RMPFSMSVAQAADLVNKVPG
TH_0783|M.thermoresistible__bu FDLPPVLLKKLAP-KGLRASRRYRVP----PMPFSLSPAQLARLADTVPG
MUL_4852|M.ulcerans_Agy99 FDSIPWLLSVYSRRRGFKLSEHYTAP----PMPFWFTADHYDELR-AIPG
*:
MAB_1517c|M.abscessus_ATCC_199 VEEFNLVDAPEIELFPTWLRISSQLARYSTSMKRSAR--ILRFEF----
MAV_4048|M.avium_104 VEETSLASVPEVDLFPTWLRIATRMAGWSKRTARSAR--ILRFSF----
Mflv_3375|M.gilvum_PYR-GCK LDESSAMHRPETAQFPTGLRIASRLSRRVPSIARKAR--VLQYRF----
Mvan_3107|M.vanbaalenii_PYR-1 LEEASVMQRPEGALFPAGLRLAAKLSHRVPAIARKAR--VLQYRF----
MMAR_2317|M.marinum_M AEEILLTRAPEVAELPLVTRLTSRLVAPSAAVSRMIGTTLVRYKF----
MSMEG_6473|M.smegmatis_MC2_155 LAWMSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQ--YHRYAF----
Mb1184c|M.bovis_AF2122/97 VVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLT-LLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv VVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLT-LLEFSRPARG
TH_0783|M.thermoresistible__bu VRAVHDLPMPEGRGFFFRAVFPRFWQARPTRQWRGAYT-LLEFG-----
MUL_4852|M.ulcerans_Agy99 VRAVRELPAPAGRGRFLRWALPVAYRLPGLGRLRAPVT-LVEFG-----
* : .: