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MAKGHNAGKRTRRRRATGIAAAVAIPLLALPVGGASASAATTYEYFPTEPTRVLTLSLLPGGNNDDLNGV MCESPRTCRNVVYSRASTPEAVGTLDAVLRDGTDGKQIVFAYSQGARVSAAWIREHGGTEGVPTAENLTF VLMGNPARKYSGSDKVRGPDVFPDLGYRIIDVSQEYDMASDFPDDPSNLLAMLNSTAGFFFTHQTYEPVD IYDEANYVWTEGHITYVFVPTRNLPLLQPLRWFGLGFVADALNAPLKEIVDRAYDRSYLPAQPGFPSTPD PEIEEPQEGSAISAATVQSAAARTTASGAASARAVEQAPVDVDVVDDAGDEIADDDLGADLGADLGDDIG NDGTDVEVDVDVEVDVEKEPASDSDDATDAADAQGDTESPGSGADSGEGDSDSGGGQARQSAKPGSSGSD E
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3374 | - | - | 100% (421) | hypothetical protein Mflv_3374 |
| M. gilvum PYR-GCK | Mflv_3250 | - | 6e-47 | 32.53% (415) | hypothetical protein Mflv_3250 |
| M. gilvum PYR-GCK | Mflv_3378 | - | 1e-40 | 39.85% (261) | hypothetical protein Mflv_3378 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 8e-18 | 29.44% (231) | PE family protein |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 8e-18 | 29.44% (231) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 2e-08 | 27.55% (196) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 2e-10 | 28.53% (368) | PE/PPE family protein |
| M. marinum M | MMAR_2235 | - | 1e-16 | 26.87% (294) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 3e-07 | 25.29% (261) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 4e-22 | 32.18% (317) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-17 | 29.54% (325) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 2e-14 | 31.58% (228) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_3106 | - | 2e-84 | 43.00% (414) | hypothetical protein Mvan_3106 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01232|M.leprae_Br4923 ---MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVRENSPA
MAV_1760|M.avium_104 ---MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTPGAPGD----
Mflv_3374|M.gilvum_PYR-GCK -----------MAKGHNAGKRTRRRRATGIAAAVAIPLLALPVGGASASA
Mvan_3106|M.vanbaalenii_PYR-1 -----------MATTTGYAG---KRHAKWLAAAAAVPIMTFPAQAPAQAA
Mb1465|M.bovis_AF2122/97 --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
Rv1430|M.tuberculosis_H37Rv --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu -----------VVAVGALTWGGXGVASPAGQPERAAALRLTATADAIIMP
MAB_4141|M.abscessus_ATCC_1997 --------MAGQYSVPGKRHSLRRYVATITAVAATCTVLAPLAMESRTIA
MSMEG_6144|M.smegmatis_MC2_155 --------------MIAAVAAVVTAALVTTVPALGATAFTISGTRILHDP
MLBr_01232|M.leprae_Br4923 KIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPARAPFR-----
MAV_1760|M.avium_104 QTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAGQVQG-----
Mflv_3374|M.gilvum_PYR-GCK ATTYEYFPTEPTRVLTLSLLPGGNNDDLNGVMCESP--------------
Mvan_3106|M.vanbaalenii_PYR-1 AAPISMLP-ENARVLTLSLLPGGNDDDLRGEVCSGG--------------
Mb1465|M.bovis_AF2122/97 AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
Rv1430|M.tuberculosis_H37Rv AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
MMAR_2235|M.marinum_M AGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu GTKIGYIPSQDEFTAYATAVIGATAGAPGAVDYLGVPG------------
MAB_4141|M.abscessus_ATCC_1997 STLASYVIGIGGNNDGASANIPRKLGGAYSVDYHPVSYPG----------
MSMEG_6144|M.smegmatis_MC2_155 PYPEQLVPGEFAGYDVEHIKYPASVFGMDRGIWEAAG-------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_3374|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3106|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1465|M.bovis_AF2122/97 D---------------------TAATGAS--------ELGSGG-----RT
Rv1430|M.tuberculosis_H37Rv D---------------------TAATGAS--------ELGSGG-----RT
MMAR_2235|M.marinum_M RNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGG-----RS
MUL_0967|M.ulcerans_Agy99 AGLTEPVAN---LFAPVLSGPESVAASAT--------ALLSGAPLKPVEA
TH_3724|M.thermoresistible__bu --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 ----------------------------YVPTFLVPGP-----------R
MAV_1760|M.avium_104 ----------------------------HVLERLFPGIGKLDESFPGLGM
Mflv_3374|M.gilvum_PYR-GCK -----------------------------------------------RTC
Mvan_3106|M.vanbaalenii_PYR-1 -----------------------------------------------RTC
Mb1465|M.bovis_AF2122/97 ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSGLYTPAQFQPWTGI
Rv1430|M.tuberculosis_H37Rv ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSGLYTPAQFQPWTGI
MMAR_2235|M.marinum_M VLVVGSTGTPRPSYRFMREVYDLFVAPHY-FGDSLFGVQTPAQFQPFTGI
MUL_0967|M.ulcerans_Agy99 ALILSESGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGI
TH_3724|M.thermoresistible__bu ------------------------------------------EFWPATGL
MAB_4141|M.abscessus_ATCC_1997 ------------------------------------------AIWPVSGL
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 DEVTIGEAIAVATKNLNQAIHRGTEP------AAVVGLSQGSLALDTEQE
MAV_1760|M.avium_104 DGPSVGESVAEGIDNLDAAIRTTGRP------GTAIGLSEGAFVVDGEQA
Mflv_3374|M.gilvum_PYR-GCK RNVVYSRASTPEAVGTLDAVLRDGTDG----KQIVFAYSQGARVSAAWIR
Mvan_3106|M.vanbaalenii_PYR-1 SSVPYPYLLRAEGVELLDQAIRQPLPTPEQPHQIVFGYSQGARVAADWIA
Mb1465|M.bovis_AF2122/97 PSLTYDQSVAEGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMR
Rv1430|M.tuberculosis_H37Rv PSLTYDQSVAEGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMR
MMAR_2235|M.marinum_M PNLTFDESAATGASYLHAAITQQLAD---GNRVVVAGFSQGASVATLEMR
MUL_0967|M.ulcerans_Agy99 KDLSLDISLARGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMP
TH_3724|M.thermoresistible__bu DSLTFDASVAXGQAMLTPMVDGAIES---DTPIVVFGHSQSAVIATKEKQ
MAB_4141|M.abscessus_ATCC_1997 TAPTFKTSVAQGRTNLNDEIVTAGNQ-----PITIVGYSLGAVVVSKSHS
MSMEG_6144|M.smegmatis_MC2_155 -------AVAAGVDRFVGVDDEGNPIT---EKIIVAGFSQGAIVIAYEKK
. * .:
MLBr_01232|M.leprae_Br4923 QLAT--DPTAPPPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDY
MAV_1760|M.avium_104 RLAN--DPTAPPPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDY
Mflv_3374|M.gilvum_PYR-GCK EHG--GTEGVPTAENLTFVLMGNPARKYSG----SDK-----------VR
Mvan_3106|M.vanbaalenii_PYR-1 QHA--GTEDAPSPEHLSFVLIGNPGRKYGG----AHV-----------GW
Mb1465|M.bovis_AF2122/97 HLASLPAGVAPSPDQLSFVLLGNPNNPNGG----ILARFPGLYLQSLGLT
Rv1430|M.tuberculosis_H37Rv HLASLPAGVAPSPDQLSFVLLGNPNNPNGG----ILARFPGLYLQSLGLT
MMAR_2235|M.marinum_M HLQSLPIDSRPSPEDLSFVLLGNPNNPNGG----ILARFPGLYIQSVGLT
MUL_0967|M.ulcerans_Agy99 KLLAEGVTSS----QVNFVLLGNPMNPNGG----VLARFPDLTLPSLGFT
TH_3724|M.thermoresistible__bu RLLAEYPDPDTAP-DVTFVMVANPNRPNGG----LLARFPGLYIPILGVT
MAB_4141|M.abscessus_ATCC_1997 DLLQRYPGGNP---NIQFVLMGSANTPNGG----IFARFPWLKIPLADIE
MSMEG_6144|M.smegmatis_MC2_155 RLMKLDEDERPTVDQLKFVTIGDPTGPNGI------LRWIPFRIPIIGLT
: * .... .
MLBr_01232|M.leprae_Br4923 TMPQRMD---SQYDSNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISHT
MAV_1760|M.avium_104 TMPPPYE---SQYDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGHT
Mflv_3374|M.gilvum_PYR-GCK GPDVFPD---LGYRIIDVSQEYDMASDFPDDPSNLLAMLNSTAGFFFTHQ
Mvan_3106|M.vanbaalenii_PYR-1 G-QTVPD---SDYQILDVARQYDMAADMPDR-FNLLALANVLAGFMFIHA
Mb1465|M.bovis_AF2122/97 FNGATPD---TDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHS
Rv1430|M.tuberculosis_H37Rv FNGATPD---TDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHS
MMAR_2235|M.marinum_M FNGATPV---TEYPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSHS
MUL_0967|M.ulcerans_Agy99 FYGATPD---NAFPTVSYTLEYDGFADFPRYPINLLADINAVMGIPFVHA
TH_3724|M.thermoresistible__bu FNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHG
MAB_4141|M.abscessus_ATCC_1997 SNGAWEP---DQFKTKVINTEYDTYGDFPAY-FNPLALANSIAAIQYAHP
MSMEG_6144|M.smegmatis_MC2_155 PVRPPDT----PYETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHG
: :* .::* * .* * . *
MLBr_01232|M.leprae_Br4923 PSGFFNP--EDVPP--QNIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG
MAV_1760|M.avium_104 AVAFTNP--SMVPP--QNIRTTINSRGAKDTTIMIPEKHLPLVMPLKYIG
Mflv_3374|M.gilvum_PYR-GCK TYEPVDI--YDEA---NYVWT-----EGHITYVFVPTRNLPLLQPLRWFG
Mvan_3106|M.vanbaalenii_PYR-1 DYEEVDL--YDPR---NYVWK-----EGNTTYVFIPTENLPLLEPLRWLG
Mb1465|M.bovis_AF2122/97 LYYGLTP--EQVA---SGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGI-
Rv1430|M.tuberculosis_H37Rv LYYGLTP--EQVA---SGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGI-
MMAR_2235|M.marinum_M LYYGLTP--DQVA---AGVVLPVSSPDVNTTYILIPNEHLPLLQPLRGI-
MUL_0967|M.ulcerans_Agy99 DYQDLTQ--AQLD---SAVQLPTEGP-TQSTYYMIPTEHLPLLAPLRFIP
TH_3724|M.thermoresistible__bu GYYELLT--ENPDIL-DDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG
MAB_4141|M.abscessus_ATCC_1997 DAYYDRI--DPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLT
MSMEG_6144|M.smegmatis_MC2_155 RYEDKVDGWDLSTVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRDLG
. * :: ..*** **: :
MLBr_01232|M.leprae_Br4923 ---WSDALVDQIDAVLQPKIDAAYAY------------------------
MAV_1760|M.avium_104 ---IDENTLNKLDAILTPRVNAGYSR------------------------
Mflv_3374|M.gilvum_PYR-GCK ----LGFVADALNAPLKEIVDRAYDRSYLPAQPGFPSTPDPEIE-EPQEG
Mvan_3106|M.vanbaalenii_PYR-1 ----LTGIADALNGPLKAIVEDAYDRSYLPAEPGLPSEPEPEPEPEPEPE
Mb1465|M.bovis_AF2122/97 ---VPEPLLDLIEPDLRAIIELGYDR------TGYADVPTPAALFPVHID
Rv1430|M.tuberculosis_H37Rv ---VPEPLLDLIEPDLRAIIELGYDR------TGYADVPTPAALFPVHID
MMAR_2235|M.marinum_M ---VPDSVLDGIEPGLRDVVELGYDR------TGYADVPTPASLFPANVN
MUL_0967|M.ulcerans_Agy99 Y--VGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFPP-VS
TH_3724|M.thermoresistible__bu ---VPEEFVDALEPYVRRIVDLGYDR------------------------
MAB_4141|M.abscessus_ATCC_1997 NPIGASFVLDAIEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFN
MSMEG_6144|M.smegmatis_MC2_155 ---FPESFVAALEAPLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEITQ
:: : :: .*
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_3374|M.gilvum_PYR-GCK S-------------------------------------------------
Mvan_3106|M.vanbaalenii_PYR-1 E-------------------------------------------------
Mb1465|M.bovis_AF2122/97 P-------------------------------------------------
Rv1430|M.tuberculosis_H37Rv P-------------------------------------------------
MMAR_2235|M.marinum_M PNVVAGAF---------VEGAVRGIDNGLAGMGLPPLPDLPAAPLLPEIW
MUL_0967|M.ulcerans_Agy99 P-------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 KLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTNPGSATTQ
MSMEG_6144|M.smegmatis_MC2_155 TAVTEIDETPSTDG------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_3374|M.gilvum_PYR-GCK -------------------AISAATVQSAAARTTASGAASARAVEQAPVD
Mvan_3106|M.vanbaalenii_PYR-1 -------------------PQTDPEPEGETAPLTSVQSLTIDEDDQGSVP
Mb1465|M.bovis_AF2122/97 ----------------IAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVV
Rv1430|M.tuberculosis_H37Rv ----------------IAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVV
MMAR_2235|M.marinum_M SNAPPIPGWPASVPSAIAVPPQLGGAIAGPLDHLYRTLDSVINGQINPAI
MUL_0967|M.ulcerans_Agy99 ----------------LTVAEHLAAGTQQGIVNSG----AALQAQGPPSI
TH_3724|M.thermoresistible__bu ---------------------NTPYGEPAPVRVLPPLTPAPGPATQHNAG
MAB_4141|M.abscessus_ATCC_1997 IPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQ
MSMEG_6144|M.smegmatis_MC2_155 --------DIDETAVQSTTQRRTVANTAADRTAETAEVAEVTEDVDELAE
MLBr_01232|M.leprae_Br4923 -----------NDNPLNKPISVDPVNGMDP----IAGIDAELR---DSIL
MAV_1760|M.avium_104 -----------NDDPATAPVQVDPVHGFDPAEVTAPANQATFGGGADPLS
Mflv_3374|M.gilvum_PYR-GCK VDVVDDAGDEIADDDLGADLGADLGDDIGNDGTDVEVDVD---VEVDVEK
Mvan_3106|M.vanbaalenii_PYR-1 EEATSDQ--QAAEDQQAAEETQEPEEAQEPEEAQEPEEAA---EEAEEAA
Mb1465|M.bovis_AF2122/97 TSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADT
Rv1430|M.tuberculosis_H37Rv TSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADT
MMAR_2235|M.marinum_M TSGIYQYGADLSAEAARHGASSELLNAIYVGRQVLPILIEGPGVILTADT
MUL_0967|M.ulcerans_Agy99 P--LSDIAHTLTANPPWAGTPA-LPPSTSPASSIEDFIL----AVQAANS
TH_3724|M.thermoresistible__bu QGITVASATSTPDKRTPVVEAPVEEPPVQTGRSTLKREKPVSARHLVRNS
MAB_4141|M.abscessus_ATCC_1997 PDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPK
MSMEG_6144|M.smegmatis_MC2_155 QEEPVKEEATKDDEVTKVADEADKATPVKESTSVEKTDQAVKPDDTDKTV
MLBr_01232|M.leprae_Br4923 NVFAQLRSILPPPPG-----------------------------------
MAV_1760|M.avium_104 QIMAGAMSVLSHGAGEADH-------------------------------
Mflv_3374|M.gilvum_PYR-GCK EPASDSDDATDAADAQGDTESPGSGADSGEGDSDSGGGQARQSAKPGSSG
Mvan_3106|M.vanbaalenii_PYR-1 EPEAEEAEAPEAEEAEEAQEDP-------EDSSGTDDTPAQDSSSGDSSG
Mb1465|M.bovis_AF2122/97 HYLVDAIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTG
Rv1430|M.tuberculosis_H37Rv HYLVDAIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTG
MMAR_2235|M.marinum_M YYSINAIKDLAAGNLSGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIG
MUL_0967|M.ulcerans_Agy99 SISRGFVKTLSTAYAT-LLPTTDIASELVFTLPSYNLNLFLDGVIQAING
TH_3724|M.thermoresistible__bu LRAVPGLRRGEPAATPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEA
MAB_4141|M.abscessus_ATCC_1997 FPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETG
MSMEG_6144|M.smegmatis_MC2_155 TTAEKVEKADEAEKVEKTKPNVRKVKRPQFNVFKPKKTRVTVPKAEPSTK
MLBr_01232|M.leprae_Br4923 ---------------------------
MAV_1760|M.avium_104 ---------------------------
Mflv_3374|M.gilvum_PYR-GCK SDE------------------------
Mvan_3106|M.vanbaalenii_PYR-1 GDE------------------------
Mb1465|M.bovis_AF2122/97 QDFPV----------------------
Rv1430|M.tuberculosis_H37Rv QDFPV----------------------
MMAR_2235|M.marinum_M RDFP-----------------------
MUL_0967|M.ulcerans_Agy99 QPIGD----------------------
TH_3724|M.thermoresistible__bu DDASE----------------------
MAB_4141|M.abscessus_ATCC_1997 RGAA-----------------------
MSMEG_6144|M.smegmatis_MC2_155 AKPATKPDNDNDDTSDTTDKTAEKDAA