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MAQHDKTSTTSPTDAPAAVQSVDRALQVLEIVAAHGQAGVTEIAAELGVHKSTVSRLVAVLEARGYVEQV SERGKYRLGFAIPRLAHVAGGQNDLVKLGQAACDMLSAGVGETANLAVLDADRIVNIVEAIGPSEITLRT WVGQSCPAYATSSGKVLLAGLDPAELPARIRPPLTEFTDSTLCGLAELQDELAAVRERGWACVREELEVG LNAVAAPVYDVHAQVIAALSVSGPSYRLAVDRFDEVAKQTVAAAEQISRRLGWTTRN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3087 | - | - | 100% (267) | transcriptional regulator, TrmB |
| M. gilvum PYR-GCK | Mflv_0686 | - | 1e-27 | 31.44% (264) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_0596 | - | 3e-24 | 32.58% (221) | regulatory protein, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 2e-24 | 34.22% (225) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1719 | - | 2e-24 | 34.22% (225) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3295 | - | 5e-19 | 32.08% (240) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 1e-86 | 62.89% (256) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 1e-31 | 34.69% (245) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_2507 | - | 4e-29 | 34.98% (243) | IclR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3647 | - | 7e-19 | 30.83% (240) | PUTATIVE putative transcriptional regulator, IclR family |
| M. ulcerans Agy99 | MUL_1967 | - | 1e-20 | 33.33% (240) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | 2e-24 | 31.05% (248) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3087|M.gilvum_PYR-GCK --------MAQHDKTSTTSPTDAPAAVQSVDRALQVLEIVAAH-GQAGVT
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADL-GKAGVT
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQ-PEIRLS
Mvan_0462|M.vanbaalenii_PYR-1 --MQKPPVAG---MEHDSTGKLPQYPIESVDNALRLILLLGDR-SEIRLT
TH_3647|M.thermoresistible__bu ---VRKRARG--------AIERPTYLLESVDNALRLLQMLRDG-GAVRLT
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
MAB_3295|M.abscessus_ATCC_1997 --------------------MRQHSGIGVLDKAVQVLTAIGDSPCGL--A
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKSPCGL--A
MSMEG_2507|M.smegmatis_MC2_155 ----------------------------MLDRFVSVLSCFSVHAPVATAA
: . :: :
Mflv_3087|M.gilvum_PYR-GCK EIAAELGVHKSTVSRLVAVLEARGYVEQVSERGKYRLGFAIPRLAHVAGG
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
MAV_3513|M.avium_104 EATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIFG
Mvan_0462|M.vanbaalenii_PYR-1 DASEYLHVASSTAHRLLSMLQYRGFVRQDPISRAYQPGPSLTNVAFAVHS
TH_3647|M.thermoresistible__bu EAAEELGVAPSTAHRLLAMLVYRGFAVQD-EKRTYLPGPALRAGPAERGW
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
MAB_3295|M.abscessus_ATCC_1997 ELCERTGLPRATAHRLAAGLEVHRLLS-RDGDGQWQLGAGLTELAAHVN-
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLG-RDEDGRWGLGPAITELAAHVD-
MSMEG_2507|M.smegmatis_MC2_155 DVRERTGLPPTTTNRLIRSLVERGILSQD--PRGYKLSLRFVGWAEVAKA
: : :*. *: * . : . . .
Mflv_3087|M.gilvum_PYR-GCK QNDLVKLGQAACDMLSAGVGETANLAVLDADRIVNIVEAIGPSEITLRTW
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
MAV_3513|M.avium_104 RLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVASR
Mvan_0462|M.vanbaalenii_PYR-1 RMDIPRTAAPILRRLADTLQETVHVGTLDGRLVRFIAALESPSAVRVISR
TH_3647|M.thermoresistible__bu TREFTDVCLPHLEALSTVCGETVNLVIRVGTGVRFLTSVESTAMLRVGDR
Mb1748|M.bovis_AF2122/97 -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
MAB_3295|M.abscessus_ATCC_1997 -DPLLSASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGLRDTVP
MUL_1967|M.ulcerans_Agy99 -DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
MSMEG_2507|M.smegmatis_MC2_155 GSDLVEASTPILAELRDRSGESTGLALLDNDCRYVINNCSSRRSIVFHTE
. * *:. : : :
Mflv_3087|M.gilvum_PYR-GCK VGQSCPAYATSSGKVLLAGLDPAELPARIRPP-LTEFTDSTLCGLAELQD
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVGAT-LDSFTENTIVTIDALEA
MAV_3513|M.avium_104 LGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALET
Mvan_0462|M.vanbaalenii_PYR-1 LGGTRPAHCTSTGKVLLAGLSDDELDQLYPDPHLEPLTEHSVRTLTELRT
TH_3647|M.thermoresistible__bu RGQVLPAERTAGGRALLAELDDEVVERLYADR--------SAGQRAELLT
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
MAB_3295|M.abscessus_ATCC_1997 VGSRLPMSAGSGAKVLLAHSDPGTQAAVLPG--------ATFTER-----
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDPATQQAVLPT--------AKFTDR-----
MSMEG_2507|M.smegmatis_MC2_155 IGQTLPLYAGSGGKVILAFTDHLPNLRRLTKL-----ASGTITSRAKLEK
* * : .:.:** .
Mflv_3087|M.gilvum_PYR-GCK ELAAVRERGWACVREELEVGLNAVAAPVYDVHAQVIA--ALSVSGPSYRL
MMAR_4423|M.marinum_M QLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAA--ALSVSGPAYRL
MAV_3513|M.avium_104 ELAAIRERGYATNREESEEGVASVAVPIPTRAPGLR--LALNAAAPQNRL
Mvan_0462|M.vanbaalenii_PYR-1 QLAEVRKSGFAISNQESEEGVASVAVAVPQGGSGIRLALALNASAPSYRF
TH_3647|M.thermoresistible__bu ELAAVREVGFGLNVEHTEEGVAAFGAVVRNRLGRAVG--AVTVAVPIVRY
Mb1748|M.bovis_AF2122/97 ELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELV--AVSVPVPAQRF
Rv1719|M.tuberculosis_H37Rv ELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELV--AVSVPVPAQRF
MAB_3295|M.abscessus_ATCC_1997 ALADVRKRGWAQSAAEREAGVASVSAPVRDRHGNVIA--AISVSGPIDRM
MUL_1967|M.ulcerans_Agy99 VLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVA--AISVSGPIDRI
MSMEG_2507|M.smegmatis_MC2_155 ELEVIRERGWAYAQSEREDGLNSVAAPVLDASGLIGS---MTIGGPAFRM
* * * . . *: :... : :. * *
Mflv_3087|M.gilvum_PYR-GCK AVDRFDEVAKQTVAAAEQISRRLGWTTRN-----------------
MMAR_4423|M.marinum_M PAADFEEVAQQTIAAADAVSRGLGWTDRIS----------------
MAV_3513|M.avium_104 DAARYPAVAAALVAAAKEIGDQLG----------------------
Mvan_0462|M.vanbaalenii_PYR-1 RPSDVRKACSALKDAAAELARNLG----------------------
TH_3647|M.thermoresistible__bu QRHARGDLVRQLFRTADEISVDLDGRFDSLEP--------------
Mb1748|M.bovis_AF2122/97 YGR-EAELAGALLAWVSKVDAWFNGTEDRK----------------
Rv1719|M.tuberculosis_H37Rv YGR-EAELAGALLAWVSKVDAWFNGTEDRK----------------
MAB_3295|M.abscessus_ATCC_1997 GRRPGARWAADLVAASEAITARL-----------------------
MUL_1967|M.ulcerans_Agy99 GRRPGARWAADLLAAADELARRL-----------------------
MSMEG_2507|M.smegmatis_MC2_155 GEDRAEELGLMVLDAARELSLAIGYQGKYPPVRDTGDTQNTTIRRR
: :