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LDRFVSVLSCFSVHAPVATAADVRERTGLPPTTTNRLIRSLVERGILSQDPRGYKLSLRFVGWAEVAKAG SDLVEASTPILAELRDRSGESTGLALLDNDCRYVINNCSSRRSIVFHTEIGQTLPLYAGSGGKVILAFTD HLPNLRRLTKLASGTITSRAKLEKELEVIRERGWAYAQSEREDGLNSVAAPVLDASGLIGSMTIGGPAFR MGEDRAEELGLMVLDAARELSLAIGYQGKYPPVRDTGDTQNTTIRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2507 | - | - | 100% (258) | IclR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4090 | - | 2e-34 | 32.49% (237) | putative IclR family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2025 | - | 1e-32 | 29.58% (240) | putative IclR family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 5e-18 | 28.26% (230) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3087 | - | 3e-29 | 34.98% (243) | transcriptional regulator, TrmB |
| M. tuberculosis H37Rv | Rv1719 | - | 6e-18 | 28.26% (230) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3295 | - | 9e-22 | 36.11% (216) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 7e-25 | 33.63% (226) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 1e-20 | 30.56% (216) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_2042 | - | 7e-21 | 31.62% (234) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_1967 | - | 7e-18 | 31.60% (212) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2889 | - | 2e-18 | 28.64% (220) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3087|M.gilvum_PYR-GCK -------------------MAQHDKTSTTSPTDAPAAVQSVDRALQVLEI
MMAR_4423|M.marinum_M -----------MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLEL
TH_2042|M.thermoresistible__bu -------------------------------MRKDSGIGVLDKAVSVLHS
MUL_1967|M.ulcerans_Agy99 -------------------------------MRQDSGIGVIDKAVGLLRA
MAB_3295|M.abscessus_ATCC_1997 -------------------------------MRQHSGIGVLDKAVQVLTA
Mb1748|M.bovis_AF2122/97 -------------------------MSAEEQDTRSGGIQVIARAAELLRV
Rv1719|M.tuberculosis_H37Rv -------------------------MSAEEQDTRSGGIQVIARAAELLRV
MAV_3024|M.avium_104 -----------------------MPAP------AETPTAVIDRISLVLDA
Mvan_2889|M.vanbaalenii_PYR-1 MTNRHMPIRSMTFRRIPMTVTIESPAAPAAKVATETPSAVIDRVSLVLDA
MSMEG_2507|M.smegmatis_MC2_155 ---------------------------------------MLDRFVSVLSC
: : :*
Mflv_3087|M.gilvum_PYR-GCK VAAHG-QAGVTEIAAELGVHKSTVSRLVAVLEARGYVEQVSERGKYRLGF
MMAR_4423|M.marinum_M LADLG-KAGVTEVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGI
TH_2042|M.thermoresistible__bu VAES--PCGLAELCERTGLPRATAHRLAAGLEVHRLLARDGD-GRWCLGP
MUL_1967|M.ulcerans_Agy99 TAKS--PCGLAELCERTGLPRATAYRLAAALEVHRLLGRDED-GRWGLGP
MAB_3295|M.abscessus_ATCC_1997 IGDS--PCGLAELCERTGLPRATAHRLAAGLEVHRLLSRDGD-GQWQLGA
Mb1748|M.bovis_AF2122/97 LQAHPGGLSQAEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGP
Rv1719|M.tuberculosis_H37Rv LQAHPGGLSQAEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGP
MAV_3024|M.avium_104 FDGPG-RLTLAQIVRRTGLPRSSAHRMLERLVQLRWLRRSGR--DYELGM
Mvan_2889|M.vanbaalenii_PYR-1 FDGPG-RLTLAQIVRRTGLPRSSAHRMLERLVQLRWLRRSGR--DYELGM
MSMEG_2507|M.smegmatis_MC2_155 FSVHAPVATAADVRERTGLPPTTTNRLIRSLVERGILSQDPR--GYKLSL
::: . *: ::. *: * : : *.
Mflv_3087|M.gilvum_PYR-GCK AIPRLAHVAGGQNDLVKLGQAACDMLSAGVGETANLAVLDADRIVNIVEA
MMAR_4423|M.marinum_M GVSRLARARSGHSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEA
TH_2042|M.thermoresistible__bu AVTELAARVDDP--LLAAAAVVLPRLREITGESVQLYRREGTSRICVAAL
MUL_1967|M.ulcerans_Agy99 AITELAAHVDDP--LLTAGATVLPRLCETTGESVQLYRREGTSRVCVAAL
MAB_3295|M.abscessus_ATCC_1997 GLTELAAHVNDP--LLSASAQVLPKLREITGESVQLYRREGTVRICVAAL
Mb1748|M.bovis_AF2122/97 EITRMATTVRLG--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQV
Rv1719|M.tuberculosis_H37Rv EITRMATTVRLG--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQV
MAV_3024|M.avium_104 RLVELGSLAVHQDRLVRAATPLLVELHRATGLVVHLAVLDGPDVVYLEKV
Mvan_2889|M.vanbaalenii_PYR-1 RLVELGSLAVHQDRLHKAAIPMLHELHAATGLVVHLAVLDGSDVVYMEKV
MSMEG_2507|M.smegmatis_MC2_155 RFVGWAEVAKAGSDLVEASTPILAELRDRSGESTGLALLDNDCRYVINNC
. . : * . . * : :
Mflv_3087|M.gilvum_PYR-GCK IGPSEITLRTWVGQSCPAYATSSGKVLLAGLDPAELPARIRPPLTEFTDS
MMAR_4423|M.marinum_M VSTAEIALQTWVGQSCPVHATSSGKVLLAGLDADEVRQRVGATLDSFTEN
TH_2042|M.thermoresistible__bu EPPAGLRDTVPVGTRLPMTAGSGAKVLLAYADSTTQQAVLSN--AKFSER
MUL_1967|M.ulcerans_Agy99 EPPAGLRDTVPVGARLPMTAGSGAKVLLAHSDPATQQAVLPT--AKFTDR
MAB_3295|M.abscessus_ATCC_1997 EPPAGLRDTVPVGSRLPMSAGSGAKVLLAHSDPGTQAAVLPG--ATFTER
Mb1748|M.bovis_AF2122/97 VPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARALPSRLAPLTAN
Rv1719|M.tuberculosis_H37Rv VPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARALPSRLAPLTAN
MAV_3024|M.avium_104 GDRLNSVIPSRVGGRQPAHCTAVGKAILAYRD----EATDLDLGARPTKY
Mvan_2889|M.vanbaalenii_PYR-1 GNRMTAAIPTRVGGRQPAHCAAVGKAMLAFAAAEDIQAYDSAQLPRRTKY
MSMEG_2507|M.smegmatis_MC2_155 SSRRSIVFHTEIGQTLPLYAGSGGKVILAFTDHLPNLRRLTK----LASG
:* * . : .*.:** :
Mflv_3087|M.gilvum_PYR-GCK TLCGLAELQDELAAVRERGWACVREELEVGLNAVAAPVYDVHAQVIAALS
MMAR_4423|M.marinum_M TIVTIDALEAQLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAAALS
TH_2042|M.thermoresistible__bu ----------ALAEVHKRGWAQSVAEREPGVASVSAPVRDGRGTVVAAVS
MUL_1967|M.ulcerans_Agy99 ----------VLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVAAIS
MAB_3295|M.abscessus_ATCC_1997 ----------ALADVRKRGWAQSAAEREAGVASVSAPVRDRHGNVIAAIS
Mb1748|M.bovis_AF2122/97 TITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLRG-VSVELVAVS
Rv1719|M.tuberculosis_H37Rv TITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLRG-VSVELVAVS
MAV_3024|M.avium_104 SISSAPQLAAELAKVRAHGVAFEREESLLGFGCVAAPIGG-PGEAAAAVS
Mvan_2889|M.vanbaalenii_PYR-1 SISTHAQLRTELQKVRSHGIAFDREESVPGFGCVAAPIGD-PGEAAAAVS
MSMEG_2507|M.smegmatis_MC2_155 TITSRAKLEKELEVIRERGWAYAQSEREDGLNSVAAPVLD-ASGLIGSMT
* : * * * *. .*.* : . . :::
Mflv_3087|M.gilvum_PYR-GCK VSGPSYRLAVDRFDEVAKQTVAA-----AEQISRRLGWTTRN--------
MMAR_4423|M.marinum_M VSGPAYRLPAADFEEVAQQTIAA-----ADAVSRGLGWTDRIS-------
TH_2042|M.thermoresistible__bu VSGPIDRIGRRPGARWAADLLAA-----AEALTRRL--------------
MUL_1967|M.ulcerans_Agy99 VSGPIDRIGRRPGARWAADLLAA-----ADELARRL--------------
MAB_3295|M.abscessus_ATCC_1997 VSGPIDRMGRRPGARWAADLVAA-----SEAITARL--------------
Mb1748|M.bovis_AF2122/97 VPVPAQRFYGR-EAELAGALLAW-----VSKVDAWFNGTEDRK-------
Rv1719|M.tuberculosis_H37Rv VPVPAQRFYGR-EAELAGALLAW-----VSKVDAWFNGTEDRK-------
MAV_3024|M.avium_104 VCGPLQRMALDQRLAAPVRMTAMGVWRNVEGGPQRVAPTLQRLRPLPPMR
Mvan_2889|M.vanbaalenii_PYR-1 VCGPMNAMKFDQRLVAPVRMAAMRIWRAVEGGPMRVAPTLQQVRPL----
MSMEG_2507|M.smegmatis_MC2_155 IGGPAFRMGEDRAEELGLMVLDA-----ARELSLAIGYQGKYPPVRDTGD
: * : .
Mflv_3087|M.gilvum_PYR-GCK ---------------
MMAR_4423|M.marinum_M ---------------
TH_2042|M.thermoresistible__bu ---------------
MUL_1967|M.ulcerans_Agy99 ---------------
MAB_3295|M.abscessus_ATCC_1997 ---------------
Mb1748|M.bovis_AF2122/97 ---------------
Rv1719|M.tuberculosis_H37Rv ---------------
MAV_3024|M.avium_104 PQHPVPKPRPALQYA
Mvan_2889|M.vanbaalenii_PYR-1 --------RGGMQLA
MSMEG_2507|M.smegmatis_MC2_155 TQNTTIRRR------