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MPTVTWSRLGADRRAAVVAAAETEFAAHGFSGGSLNVIARRAGVAKGSLFQYFADKRDLYAHITEVGSQR VRRHMEDQIRILDPGRPFFEFLTDLLDVWVAYFAEHPQDRALHAAASFEVDTDARVSVRAVVHRHYLQVL RPLVHAAGTRGDLRPDADTDTMLSLLLMILPHLALAPYVRGMDPVLGLDEIAPEQPALVVRRYVAVLAAA FADTPTPGPRQPQPKENSHE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3060 | - | - | 100% (230) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0142 | - | 4e-09 | 28.48% (158) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4672 | - | 2e-06 | 31.46% (89) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0237 | - | 4e-92 | 74.01% (227) | TetR/ACRR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0232 | - | 4e-92 | 74.01% (227) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 8e-07 | 28.57% (161) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0647 | - | 1e-10 | 31.87% (160) | transcriptional regulator TetR |
| M. marinum M | MMAR_0489 | - | 2e-90 | 75.00% (216) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4938 | - | 1e-90 | 74.42% (215) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_3807 | - | 4e-12 | 35.00% (160) | TetR-type regulator |
| M. thermoresistible (build 8) | TH_2602 | - | 2e-07 | 36.67% (120) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1152 | - | 3e-90 | 74.54% (216) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3467 | - | 1e-106 | 85.33% (225) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00316|M.leprae_Br4923 MSVPRSGLSVQMAQPARPLRADAARNRARILGVAYEAFATEGLS-VPIDE
MAB_0647|M.abscessus_ATCC_1997 -----------MDQPARPLRADAARNRARVLEVAYQTFAEEGLG-VPIDE
MSMEG_3807|M.smegmatis_MC2_155 -----------MTSSVKPARADATRNREALLAAAEEEFAERGLA-ASVAD
Mflv_3060|M.gilvum_PYR-GCK ------------MPTVTWSRLGADR-RAAVVAAAETEFAAHGFSGGSLNV
Mvan_3467|M.vanbaalenii_PYR-1 ------------MPTVTWSRLNEDR-RAAVVAAAEAEFAAHGFSQGSLNV
Mb0237|M.bovis_AF2122/97 ------------MPTVTWARVDPAR-RAAVVEAAEAEFGAHGFSRGSLNV
Rv0232|M.tuberculosis_H37Rv ------------MPTVTWARVDPAR-RAAVVEAAEAEFGAHGFSRGSLNV
MMAR_0489|M.marinum_M ------------MPTVTWARVDPAR-RAAIVEAAEAEFGAHGFSQGSLNV
MUL_1152|M.ulcerans_Agy99 ------------MPTVTWARVDPAR-RAAIVEAAEAEFGAHGFSQGSLNV
MAV_4938|M.avium_104 ------------MPTVTWARVDPAR-RAAIIEAAESEFGAHGFSRGSLNV
TH_2602|M.thermoresistible__bu ------------VPRNNQTVPKAER-EAAVLMRAVELFKAYGYRATSIAA
* . :: * * * .:
MLBr_00316|M.leprae_Br4923 IARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYVLLKSAGPGEA
MAB_0647|M.abscessus_ATCC_1997 IARRAGVGAGTVYRHFPAKEDLYRAIAEDRMGSVIDKGRELLAAVDPGEA
MSMEG_3807|M.smegmatis_MC2_155 IARRAGVAKGTVFRHFPTKEDLIAAIVTAHTATLSETARSLVDAPDPGAA
Mflv_3060|M.gilvum_PYR-GCK IARRAGVAKGSLFQYFADKRDLYAHITEVGSQRVRRHMEDQIRILDPGRP
Mvan_3467|M.vanbaalenii_PYR-1 IARRAGVAKGSLFQYFADKRDLYAHITDVGSQRVRCYMEDQIRVLDPTRP
Mb0237|M.bovis_AF2122/97 IARRAGVAKGSLFQYFADKRDLYAFIADIASQRVRSYMEDLIRELDPNRP
Rv0232|M.tuberculosis_H37Rv IARRAGVAKGSLFQYFADKRDLYAFIADIASQRVRSYMEDLIRELDPNRP
MMAR_0489|M.marinum_M IARRARVAKGSLFQYFADKRDLYAYIADIASQRVRTHIEGLIRELDSSRP
MUL_1152|M.ulcerans_Agy99 IARRARVAKGSLFQYFADKRDLYAYIADIANQRVRTHIEGLIRELDSSRP
MAV_4938|M.avium_104 IARKAGVAKGSLFQYFADKRDLYAFIADIGSQRVRGYIEQLIRELDPTRP
TH_2602|M.thermoresistible__bu VAKAAGLAPAAVHWYFPTKDDLFAAVLRHMIGETQRRIESDPDVAGDPYL
:*: * :. .::. :*. * * : .
MLBr_00316|M.leprae_Br4923 LFTYLRSLVLHWGA------TDRGLVDALAGAGGIDI-LGVAPDAEDAFL
MAB_0647|M.abscessus_ATCC_1997 LFEFLRS-MMDWGG------TDQGLVDALSGAG-IDV-QALIPHIEESFY
MSMEG_3807|M.smegmatis_MC2_155 LLEFLTEAADQRRQ------HDLTFLQAASADD------SSVTAARDELH
Mflv_3060|M.gilvum_PYR-GCK FFEFLTDLLDVWVAYFAEHPQDRALHAAASFEVDTDARVSVRAVVHRHYL
Mvan_3467|M.vanbaalenii_PYR-1 FFAFLTDLLDVWVAYFAEHPRERSLHAAASFEVDTDTRVSVRAVIHRHYL
Mb0237|M.bovis_AF2122/97 FFEFLTDLLDGWVAYFAEHPRERALHAAATLEVDTDARISVRSVLHRHYL
Rv0232|M.tuberculosis_H37Rv FFEFLTDLLDGWVAYFAEHPRERALHAAATLEVDTDARISVRSVLHRHYL
MMAR_0489|M.marinum_M FFEFLTDLLDGWVAYFAEHPRERALHAAATLEVDTDARISVRSVIHRHYL
MUL_1152|M.ulcerans_Agy99 FFEFLTDLLDGWVAYFAEHPRERALHAAATLEVDTDARISVRSVIHRHYL
MAV_4938|M.avium_104 FFEFLTDLLDGWVAYFADHPHERALHAAATLEVDTEARISVQNVIHRHYL
TH_2602|M.thermoresistible__bu ELTTFLDLLAPYRS-----LHREAYERMDDSAALHAVYTETHDWLQERLM
: : . .
MLBr_00316|M.leprae_Br4923 TILSDLLYAAQYAGTARTDVGVREVKSILVG----------------CQA
MAB_0647|M.abscessus_ATCC_1997 AVLGDLLRAAQQAGTVRSDVGVHEVKALLVG----------------CQA
MSMEG_3807|M.smegmatis_MC2_155 GYVEQLVAAAREAGAIRADVTGTDVFLLMCTPI------------HVVEN
Mflv_3060|M.gilvum_PYR-GCK QVLRPLVHAAGTRGDLRPDADTDTMLSLLLMILPHLALAPYVRGMDPVLG
Mvan_3467|M.vanbaalenii_PYR-1 EVLRPLVRDARGRGDLRPDADTDALLSLLLMILPHLALAPYVRGMDPVLG
Mb0237|M.bovis_AF2122/97 DVLRPLVRDAHARGDLRADSDTGALMSLLLLIFPHLALAPYMRGLDPILG
Rv0232|M.tuberculosis_H37Rv DVLRPLVRDAHARGDLRADSDTGALMSLLLLIFPHLALAPYMRGLDPILG
MMAR_0489|M.marinum_M EVLRPLVRDALARGDLRADSDTDALLSLLLMIFPHLALAPYMRGLDPILG
MUL_1152|M.ulcerans_Agy99 EVLRPLVRDALARGDLRADSDTDALLSLLLMIFPHLALAPYMRGLDPILG
MAV_4938|M.avium_104 EVLRPLVRDARLRGDLRADSDTDALLSLLLLIFPHLALAPYMRGLDPVLG
TH_2602|M.thermoresistible__bu AVVSPELPADVDPAHV-VDVANFFFEGLLVS----------------VRR
: : . * . ::
MLBr_00316|M.leprae_Br4923 MEAYNSA----LAERVTDVVVDGLRAAR---------------
MAB_0647|M.abscessus_ATCC_1997 MQSYNKD----VSRQVTDVVFDGLRPRP---------------
MSMEG_3807|M.smegmatis_MC2_155 LPDPSPD----LWQRYLGILFDGLRPEGAHPLPQPPPRLT---
Mflv_3060|M.gilvum_PYR-GCK LDEIAPEQPALVVRRYVAVLAAAFADTPTPGPRQPQPKENSHE
Mvan_3467|M.vanbaalenii_PYR-1 LDELSPDQPALVVRRYVAVLAAAFA--PQPLTTATPGGAQSHG
Mb0237|M.bovis_AF2122/97 LDEPTPEQPALAVRRLVAVLAAAFDAQHPATNSAQTRSEEIT-
Rv0232|M.tuberculosis_H37Rv LDEPTPEQPALAVRRLVAVLAAAFDAQHPATNSAQTRSEEIT-
MMAR_0489|M.marinum_M LDEPTPEQPALAVRRLVAVLTAAYSP----SLTVEVR--KVT-
MUL_1152|M.ulcerans_Agy99 LDEPTPEQPALAVRRLVAVLTAAYSP----SLTVEVR--KVT-
MAV_4938|M.avium_104 LDEPTPEQPALAVRRLVAVLAAAFSP--APAHFATPRSEEVT-
TH_2602|M.thermoresistible__bu VDKPAAHYIDLVTSAVVGAAAARPRSGQQHPA-----------
: