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AQSEGEFRDVRGQRMIAVAENMASTPIVRERTEQTRADPFLARTLAPEVDRAVALSGASLAEILGPDGTV RASSDPSRVGARVDLGATRADEGRAWFGDTDIDGTHSLVGQVPILSTDGEVLAIASVSEAYPSVWGLLSG AGESLLVYLGLGAALGLLASWLLSRRIKRQTGGLEVAEIASLADHREALLHSIREGVIAVNGSGEITLLN DGAQELLDVTGPAVGRPVDSVGIDPAVVSLLTPGQESESAMDTVIATRTRVLALSRRPATSQGRRIGTVT TMRDSTELAALQGQLSSHKSVTDTLRAQAHEFANQLHTISGLVQLGEFDAVRDLVGTLTRRRAEISDAVT QRISDPAVAALLIAKTSLAAESGVALDLDPASHLAALDPALATDVITLLGNLIDNAVDVSVGSTPARVTV GIDDRDGLSILVSDTGPGVPEHLREAIFSRGVTSKPDVPGGRGIGLALVRLVTAQHGGTVEVADVPGGGA RFEVRLKAATHA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3003 | - | - | 100% (503) | signal transduction histidine kinase regulating citrate/malate metabolism |
| M. gilvum PYR-GCK | Mflv_2837 | - | 1e-13 | 28.40% (243) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_0892 | - | 4e-13 | 29.55% (247) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 6e-12 | 27.52% (258) | two component system response sensor kinase membrane |
| M. tuberculosis H37Rv | Rv0758 | phoR | 6e-12 | 27.52% (258) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_02440 | - | 1e-12 | 34.03% (144) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 3e-15 | 28.47% (288) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_0815 | senX3 | 5e-15 | 26.32% (399) | two-component sensor histidine kinase SenX3 |
| M. avium 104 | MAV_3405 | - | 8e-19 | 28.83% (326) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_4211 | - | 0.0 | 75.59% (508) | two component system histidine kinase |
| M. thermoresistible (build 8) | TH_0454 | - | 2e-12 | 30.45% (220) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_4559 | senX3 | 1e-14 | 26.13% (398) | two component sensor histidine kinase SenX3 |
| M. vanbaalenii PYR-1 | Mvan_3503 | - | 0.0 | 84.86% (502) | signal transduction histidine kinase regulating citrate/malate |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0781|M.bovis_AF2122/97 ------------------------------------------------MA
Rv0758|M.tuberculosis_H37Rv ------------------------------------------------MA
MAB_0674|M.abscessus_ATCC_1997 -------------------------MAWDTYCASRDERLREEQLALLVAV
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
Mflv_3003|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3503|M.vanbaalenii_PYR-1 -----MVIKNTPSAVVGLVRG-----RSLAGQFLASQLVVVAVVLVAVAA
MSMEG_4211|M.smegmatis_MC2_155 MSSSQNATQSSPRARLRILPGDRVHAASLAGRFLVFQLLVVAVVLGAVAA
MAV_3405|M.avium_104 ---------------------------------------------MFSGG
TH_0454|M.thermoresistible__bu ---------------------------------------------MNLVT
Mb0781|M.bovis_AF2122/97 RHLRGRLPLRVRLVAATLILVATGLVASGIAVTS--------MLQHRLTS
Rv0758|M.tuberculosis_H37Rv RHLRGRLPLRVRLVAATLILVATGLVASGIAVTS--------MLQHRLTS
MAB_0674|M.abscessus_ATCC_1997 PGVRRGVPLRVSLVVGTLVLVALGLVASGIAVTT--------TMQRTMMN
MMAR_0815|M.marinum_M ------------MTVFSALLLAGVLSALALAAGV--------AVGARLSQ
MUL_4559|M.ulcerans_Agy99 --------------MFSALLLAGVLSALALAAGV--------AVGARLSQ
MLBr_02440|M.leprae_Br4923 --------------MFSALLLAGVLSGLAFVVGI--------VAGIRLSP
Mflv_3003|M.gilvum_PYR-GCK --MAQSEGEFRDVRGQRMIAVAENMASTPIVRERTEQTRADPFLARTLAP
Mvan_3503|M.vanbaalenii_PYR-1 VSVAQSEGEFREVRGQRMIAVAENMASAPIVRERSEQDPADPFIARTLAP
MSMEG_4211|M.smegmatis_MC2_155 ISVAQSTREFRDVRGQRMIAVAENVASTPIVRDR----YADPLAARTLAP
MAV_3405|M.avium_104 PRACRIEGVHLGISARSAAVAAIVVFCALTVAGAG----LDAILYRSLLS
TH_0454|M.thermoresistible__bu RLFRRTPSLRTRVAFATAIAAAIVVGIVGVVVWVG--------ITNDRKE
* : .
Mb0781|M.bovis_AF2122/97 RIDRVLLEEAQIWAQITLPLAPDPYPIHNPDRPPSRFYVRVISPDGQ---
Rv0758|M.tuberculosis_H37Rv RIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQ---
MAB_0674|M.abscessus_ATCC_1997 RADRELIDAANGWANR--PPPPPPAFETTRHRPPSLFFIRTTDDRGR---
MMAR_0815|M.marinum_M RLVRRRQQASTEWTGIT----------------VAQMLQRIVALMPM---
MUL_4559|M.ulcerans_Agy99 RLVRRRQQASTEWTGIT----------------VAQMLQRIVALMPM---
MLBr_02440|M.leprae_Br4923 RLIERRQRLANEWAGIT----------------VLQMLQRIIALMPL---
Mflv_3003|M.gilvum_PYR-GCK EVDRAVALSGASLAEILGPDGTVRASSDPSRVGARVDLGATRADEGRAWF
Mvan_3503|M.vanbaalenii_PYR-1 EVDRAVALSGADLAELLGPDGTVRASSDPSRIGARVDLGVSRADEGRAWF
MSMEG_4211|M.smegmatis_MC2_155 EVDRAVALSGADLVEITDPTGVVRVSSQPDRIGQRIELDASRADEGRSWF
MAV_3405|M.avium_104 GVDYAAAERVRDIAKALQSDSREELDNALLTTDQRVVATQLIGPDGS---
TH_0454|M.thermoresistible__bu RLDRRLDEAAGFALPFVPRG--------LEQIPPSPNDQDVVITVRR---
Mb0781|M.bovis_AF2122/97 SYTALNDNT-AIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYL
Rv0758|M.tuberculosis_H37Rv SYTALNDNT-AIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYL
MAB_0674|M.abscessus_ATCC_1997 VVIMLNDRARADPDLPFDNDVGGRPVTVRSSDGG-TEWRAVSRHDALGGY
MMAR_0815|M.marinum_M GVAVVDSHR----DVVYLNDRAKELGLVRDRQLDDQAWEAAQQALRG---
MUL_4559|M.ulcerans_Agy99 GVAVVDSHR----DVVYLNDRAKELGLVRDRQLDDQAWEAAQQALRG---
MLBr_02440|M.leprae_Br4923 GAAVVDTYR----DVVYLNEQAKELGLVRDRQLDDQAWRAAQQALGG---
Mflv_3003|M.gilvum_PYR-GCK GDTDIDGTHSLVGQVPILSTDGEVLAIASVSEAYPSVWGLLSGAGESLLV
Mvan_3503|M.vanbaalenii_PYR-1 GDADIDGTHSLVGQVPILSTDGEVLAVASVSEGYPSTWALLTRAGEGLLV
MSMEG_4211|M.smegmatis_MC2_155 GDTDIDGQHSLVGQVPILAPSGEPLAIVSVSQRYPSVWELLSGSGERLLI
MAV_3405|M.avium_104 -VVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVSGQKVATRSG
TH_0454|M.thermoresistible__bu GDEVRSNSEVVLPELDADYADTYIDGVRYRVRTVQTPYPIRTTLAVGATY
. :
Mb0781|M.bovis_AF2122/97 ---TTVAIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPL
Rv0758|M.tuberculosis_H37Rv ---TTVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPL
MAB_0674|M.abscessus_ATCC_1997 ---TTVARDITDVRTTVRDLLWLQVAIGIAVLTVLGVAGYWLVHRSLRPL
MMAR_0815|M.marinum_M ---SDVEFDLSPGK---------RPG-GRSGLSVHGQA---------RLL
MUL_4559|M.ulcerans_Agy99 ---SDVEFDLSPGK---------RPG-GRSGLSVHGQA---------RLL
MLBr_02440|M.leprae_Br4923 ---DDVEFDLLPGK---------RPAAGRSGLSVHGHA---------RLL
Mflv_3003|M.gilvum_PYR-GCK YLGLGAALGLLASWLLSRRIKRQTGGLEVAEIASLADHREALLHSIREGV
Mvan_3503|M.vanbaalenii_PYR-1 YLGLGAMLGLVASWLLSRRIKRHTRGLEVAEIASLADHREALLHSIREGV
MSMEG_4211|M.smegmatis_MC2_155 YLGIGAALGLLTSWLLSRRIKTHTRGLDIAEIADLADHREALLHSIREGV
MAV_3405|M.avium_104 VYTVLVGGGSEAVEATARTLAILLATTAPVIVAVAAGATYWLVRRSLKSV
TH_0454|M.thermoresistible__bu DDTIADTANLHRRVILICTLAIGAATIAGWLLAAFAVRPFKQLAAQARSI
. : . . :
Mb0781|M.bovis_AF2122/97 AEFEQTAAAIGAGQLDRRVPQWHPRTE-VGRLSLALNGMLAQIQRAVASA
Rv0758|M.tuberculosis_H37Rv AEFEQTAAAIGAGQLDRRVPQWHPRTE-VGRLSLALNGMLAQIQRAVASA
MAB_0674|M.abscessus_ATCC_1997 AEVEATAADIAAGHLDRRVPERDPRTE-VGRLSLALNGMLAQIQRAVADS
MMAR_0815|M.marinum_M SEEDR-------------------------RFTVVFAYDQSDYARMEATR
MUL_4559|M.ulcerans_Agy99 SEEDR-------------------------RFTVVFAYDQSDYARMEATR
MLBr_02440|M.leprae_Br4923 SEKDR-------------------------RFAVVFVHDQSDYVRMEAAR
Mflv_3003|M.gilvum_PYR-GCK IAVNGSGEITLLNDGAQELLDVTGPAVGRPVDSVGIDPAVVSLLTPGQE-
Mvan_3503|M.vanbaalenii_PYR-1 IAVNNDGGITLLNDSARTLLGVPDSAVGQGVDTVGIDPAVVSFLMSGED-
MSMEG_4211|M.smegmatis_MC2_155 VAVNTDGSITVLNDSACELLGIGPDAVGRHVGAIGLEPAVVEFLLSGHDR
MAV_3405|M.avium_104 DAIRARVADISASDLAERVPVPDGRDE-IAALAVTMNEMLSRLEAGHRAQ
TH_0454|M.thermoresistible__bu DAGDEVPDVEIRG------------ATEAVEIADAVKGMLQRIWKEQDRT
: .
Mb0781|M.bovis_AF2122/97 ESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQG------AA
Rv0758|M.tuberculosis_H37Rv ESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQG------AA
MAB_0674|M.abscessus_ATCC_1997 EKSAKAARTSEERMRRFITDASHELRTPLTTIRGYAELYRQG------AA
MMAR_0815|M.marinum_M --------------RDFVANVSHELKTPVGAMALLAEALLAS------AD
MUL_4559|M.ulcerans_Agy99 --------------RDFVANVSHELKTPVGAMALLAEALLAS------AD
MLBr_02440|M.leprae_Br4923 --------------RDFVANVSHELKTPVGAMALLAEALLAS------AD
Mflv_3003|M.gilvum_PYR-GCK ---SESAMDTVIATRTRVLALSRRPATSQGRRIGTVTTMRDSTELAALQG
Mvan_3503|M.vanbaalenii_PYR-1 ---DGGDGDTVIATRTRVLALSRRATTSGGRRIGTVTTMRDSTELAALQG
MSMEG_4211|M.smegmatis_MC2_155 TDETANESDVIIATRSRVLALNRRAASSQGHRIGTVTTMRDSTELAALQA
MAV_3405|M.avium_104 --------------QRFVGDASHELRSPLTTIISGLEVAEAH-------P
TH_0454|M.thermoresistible__bu -------KAALASARDFASAAAHELRTPLTAMRTNLEVLSTLD-----MP
: :. :.
Mb0781|M.bovis_AF2122/97 R--DVGMLLSRIESEASRMG---LLVDDLLLLARLD-AHRPL---ELCRV
Rv0758|M.tuberculosis_H37Rv R--DVGMLLSRIESEASRMG---LLVDDLLLLARLD-AHRPL---ELCRV
MAB_0674|M.abscessus_ATCC_1997 T--DTELVLGRIEGESTRMG---QLVEDLLLLARLD-AHRPM---EQRLV
MMAR_0815|M.marinum_M DSDTVRRFAEKVLIEANRLG---DMVAELIELSRLQGAERLH---NVTDV
MUL_4559|M.ulcerans_Agy99 DSDTVRRFAEKVLIEANRLG---DMVAELIELSRLQGAERLH---NVTDV
MLBr_02440|M.leprae_Br4923 DAETVSRFAEKVLIEANRLG---YMVAELIELSRLQGAERLP---NVTDI
Mflv_3003|M.gilvum_PYR-GCK QLSSHKSVTDTLRAQAHEFANQLHTISGLVQLGEFDAVRDLVGTLTRRRA
Mvan_3503|M.vanbaalenii_PYR-1 QLSSHKSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVGTLTRRRA
MSMEG_4211|M.smegmatis_MC2_155 QLSSHRSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVGTLTRRRA
MAV_3405|M.avium_104 ELLDAELAVNTLLPEAHRMR---ALIDDLLLLARADERNLLR--------
TH_0454|M.thermoresistible__bu EEQRKEVLADVIRTQS-------RIEATLSALERLAQGELST-----SDD
: :: * * . .
Mb0781|M.bovis_AF2122/97 DLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGD----------ES
Rv0758|M.tuberculosis_H37Rv DLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGD----------ES
MAB_0674|M.abscessus_ATCC_1997 DLLVLATDAVHDAKATAPERDVELEVFDGPGTPEVIGD----------EL
MMAR_0815|M.marinum_M DVDTIVSEAISRHKVAADNAEIEVRTDSSSG-LHVLGD----------QT
MUL_4559|M.ulcerans_Agy99 DVDTIVSEAISRHKVAADNAEIEVRTDSSSG-LHVLGD----------QT
MLBr_02440|M.leprae_Br4923 DVDIIVSEAIARHKVAADTAAIEVRTDPPSG-LRVLGD----------QT
Mflv_3003|M.gilvum_PYR-GCK EISDAVTQRISDPAVAALLIAKTSLAAESGVALDLDPASHLAALDPALAT
Mvan_3503|M.vanbaalenii_PYR-1 EISDAVTQHISDPAVAALLIAKTSLAAESGVSLLLDPRSHLNPLDPAMAT
MSMEG_4211|M.smegmatis_MC2_155 EINDAVTQHVSDPAVAALLIAKTSLAAESGVALTLTDDSHLAALDPALAT
MAV_3405|M.avium_104 RKELVALDDLAEAEAARVRRDADCAVHTDIRPARLLAD----------PA
TH_0454|M.thermoresistible__bu HVPVDITELLDRAAHEAMRIYPDLEVSLVPAPTVIIVG---------LPA
: . :
Mb0781|M.bovis_AF2122/97 RLRQVLRNLVANAIQHTPE---SADVTVRVGTEG-DDAILEVADDGPGMS
Rv0758|M.tuberculosis_H37Rv RLRQVLRNLVANAIQHTPE---SADVTVRVGTEG-DDAILEVADDGPGMS
MAB_0674|M.abscessus_ATCC_1997 RLRQVLGNLVSNALGHT-----TAAVRVRVGTEG-DDAVLEVIDRGPGMT
MMAR_0815|M.marinum_M LLVTALANLVSNAIAYSSP---GSPVSISRRKRG-DNVEIAVTDRGIGIA
MUL_4559|M.ulcerans_Agy99 LLVTALANLVSNAIAYSSP---GSPVSISRRKRG-DNVEIAVTDRGIGIA
MLBr_02440|M.leprae_Br4923 LLVTALANLVSNAIAYSPG---GSLVSISRRRRG-DNIEIAVTDRGIGIA
Mflv_3003|M.gilvum_PYR-GCK DVITLLGNLIDNAVDVSVG---STPARVTVGIDDRDGLSILVSDTGPGVP
Mvan_3503|M.vanbaalenii_PYR-1 DVITLLGNLIDNAVDVSVG---AADARVTICIDDRDGLAISVLDTGPGVP
MSMEG_4211|M.smegmatis_MC2_155 DVITLLGNLVDNAVEVSAGSVGSTAAHVSVRLDDSAGLLLEVSDSGPGVP
MAV_3405|M.avium_104 AMTRMIRNLVDNAVRHAVS-----CVAIEVGSRD-GTAVLTVGDDGPGIP
TH_0454|M.thermoresistible__bu GLRLAVDNAIANAVKHGGA----TRVQLSAVSSR-EGVEIAIDDNGTGVP
: : * : **: . : : : * * *:.
Mb0781|M.bovis_AF2122/97 QEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALG
Rv0758|M.tuberculosis_H37Rv QEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALG
MAB_0674|M.abscessus_ATCC_1997 KTDAERVFERFYRADSSRTRSSGGTGLGLSIVDALTAAHGGTVTVHTAPG
MMAR_0815|M.marinum_M LEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPG
MUL_4559|M.ulcerans_Agy99 LEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPG
MLBr_02440|M.leprae_Br4923 LEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPG
Mflv_3003|M.gilvum_PYR-GCK EHLREAIFS---RGVTSKPDVPGGRGIGLALVRLVTAQHGGTVEVADVPG
Mvan_3503|M.vanbaalenii_PYR-1 EHLREAIFA---RGITSKPEVPGGRGIGLALVRLVTAQHGGTIEVSDGPG
MSMEG_4211|M.smegmatis_MC2_155 EHLRETIFA---RGVTSKPDVPGGRGIGLALVRLVTAQHGGTVEVTDGPA
MAV_3405|M.avium_104 PAQRSRVFERFVRLDTDRARSGGGAGLGLAIVAEVVAAHGGTVTIGDRPG
TH_0454|M.thermoresistible__bu EEERERVFDRFTRGSTASHS---GSGLGLALVAQQAEIHGGTASLEASPL
:* * . * *:**::* . *.*: :
Mb0781|M.bovis_AF2122/97 EGCCFRVSLPRVS------DVDQ-LSLTPVVPGPP---------------
Rv0758|M.tuberculosis_H37Rv EGCCFRVSLPRVS------DVDQ-LSLTPVVPGPP---------------
MAB_0674|M.abscessus_ATCC_1997 AGCRFEVRLPRADMTDDDADVDEPESATPDAAASEPKIVRASRSESAQP-
MMAR_0815|M.marinum_M TGSTFTLSIPASS-----APDDSDQPDQPRARDARPNRSQREEE------
MUL_4559|M.ulcerans_Agy99 TGSTFTLSIPTSS-----APDDSDQPDQPRGRDARPNRSQREEE------
MLBr_02440|M.leprae_Br4923 TGSTFTLSIPAAMPL---YQDNDEQSGQPRGCDMWLNRPQREEEEFKSMT
Mflv_3003|M.gilvum_PYR-GCK GGARFEVRLKAATHA-----------------------------------
Mvan_3503|M.vanbaalenii_PYR-1 GGARFLVRLKAVSHHA----------------------------------
MSMEG_4211|M.smegmatis_MC2_155 GGASFVVRLPEVTVHA----------------------------------
MAV_3405|M.avium_104 GGTTLTVALPQHP---------AQHSSR----------------------
TH_0454|M.thermoresistible__bu GGARLVLRLPGPR-------------------------------------
* : : :
Mb0781|M.bovis_AF2122/97 -----------------------------
Rv0758|M.tuberculosis_H37Rv -----------------------------
MAB_0674|M.abscessus_ATCC_1997 -----------------------------
MMAR_0815|M.marinum_M ---------LSR-----------------
MUL_4559|M.ulcerans_Agy99 ---------LSR-----------------
MLBr_02440|M.leprae_Br4923 PAQAMMQSEVTRGNVNDKCPDCGGRGIAG
Mflv_3003|M.gilvum_PYR-GCK -----------------------------
Mvan_3503|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_4211|M.smegmatis_MC2_155 -----------------------------
MAV_3405|M.avium_104 -----------------------------
TH_0454|M.thermoresistible__bu -----------------------------