For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TPPPASTARRRRRRGRPGIGLRLLAAQAIVLAAGAVTTAVVAAVVGPPLFREHLHRAGVPMNSPEEVHAE EAYGYATVMSIGGALAVSALAALAVSFYVSRRLQRSVTEVASAATDVAQGNYDVRVSSPRLGDDFDALCT AFNQMASRLQTVDSTRQQLFGDLAHEIRTPVAVLEAYIEALEDGVRTLTPQTATMLRDQTRRLVRFSNDV AALAKAEESSVSMSYANIDVDRLTHRCVAAAQERYDNKGVALRVRLQKALPPLWADEQRLSQVLGNLLEN ALRHTPSGGSVEVNCVRDGDRLRIAVADTGEGIAAEHVNRVFERFYRADSARDREHGGAGLGLAIAKALV EAHGGAISVASAGPGGGATFTLAMPITPERTEQTPVTADSARI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2837 | - | - | 100% (394) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_0892 | - | 0.0 | 86.51% (393) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_3888 | - | e-159 | 77.81% (374) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 8e-35 | 31.35% (303) | two component system response sensor kinase membrane |
| M. tuberculosis H37Rv | Rv0758 | phoR | 9e-35 | 30.45% (312) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_02440 | - | 7e-31 | 34.58% (240) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 1e-107 | 54.84% (372) | sensor histidine kinase |
| M. marinum M | MMAR_4941 | phoR | 3e-35 | 32.15% (311) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0703 | - | 1e-39 | 32.48% (311) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 1e-36 | 31.53% (314) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_2452 | - | 3e-30 | 28.48% (323) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_0464 | phoR | 1e-35 | 32.15% (311) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_1833 | - | 1e-163 | 77.75% (373) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2837|M.gilvum_PYR-GCK -------------------------------------MTPPPASTARRRR
Mvan_1833|M.vanbaalenii_PYR-1 -------------------------------------MARTEEELRPRRR
MAB_3340|M.abscessus_ATCC_1997 -------------------------------------MTRP---------
MMAR_4941|M.marinum_M -----------MAERLPRAVPLRVGLVAATLALVLCGLLASGVAVTSILR
MUL_0464|M.ulcerans_Agy99 -----------MAERLPRAVQLRVGLVAATLALVLCGLLASGVAVTSILR
MAV_0703|M.avium_104 ----------MVVTRPRRGLPLRVGLVAATLALVACGLAVSGIAVTSILR
MSMEG_5870|M.smegmatis_MC2_155 ------------MNRGRRGIPLRVGLVAAALVLVACGLLASGIAVTSIMR
Mb0781|M.bovis_AF2122/97 -----------MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQ
Rv0758|M.tuberculosis_H37Rv -----------MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQ
TH_2452|M.thermoresistible__bu MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVTLTTWRLMV
MLBr_02440|M.leprae_Br4923 ---------------------------MFSALLLAGVLSGLAFVVGIVAG
:
Mflv_2837|M.gilvum_PYR-GCK RRGRPGIGLRLLAAQAIVLAAGAV-----------------TTAVVAAVV
Mvan_1833|M.vanbaalenii_PYR-1 MLRRPGIGLRLLAAQAIVLVAGAV-----------------TTSVVAAIV
MAB_3340|M.abscessus_ATCC_1997 ---RYGIGLRLLVVNSLVVLAGIA-----------------TTSVVAAIV
MMAR_4941|M.marinum_M HSLVSRIDSTLLEASRTWAQASWR-----------------HSMPSVEGP
MUL_0464|M.ulcerans_Agy99 HSLVSRIDSTLLEASRTWAQASWR-----------------HSMPSVEGP
MAV_0703|M.avium_104 HSLVSRIDSTLLDASRGWAQAPRR-----------------QSSSAYEGP
MSMEG_5870|M.smegmatis_MC2_155 HTEVSRIDQTLLDASRSWAQAPRR-----------------APTTPLEGP
Mb0781|M.bovis_AF2122/97 HRLTSRIDRVLLEEAQIWAQITLP-----------------LAPDPYPIH
Rv0758|M.tuberculosis_H37Rv HRLTSRIDRVLLEEAQIWAQITLP-----------------LAPDPYPGH
TH_2452|M.thermoresistible__bu SSIDARMDEALHIEVDEFEELTASGLNPRTGAPFTGVAEVIREAIAYNLA
MLBr_02440|M.leprae_Br4923 IRLSPRLIERRQRLANEWAGITVL-----------------QMLQRIIAL
:
Mflv_2837|M.gilvum_PYR-GCK GPP----------LFREHLHRAGVPMNSPEEVHAEEAYG--------YAT
Mvan_1833|M.vanbaalenii_PYR-1 GPP----------LFHDHLHQAGISAGSPEEMHAEEAYT--------YAT
MAB_3340|M.abscessus_ATCC_1997 GPP----------MFRRLMDQQ-VSPGAGNDHPYERAFR--------DAT
MMAR_4941|M.marinum_M DPAR-----PPSKFYVRSISPDGRAMTAINDRNAEPALPADNDVGSDPTT
MUL_0464|M.ulcerans_Agy99 DPAR-----PPSKFYVRSISPDGRAMTAINDRNAEPALPADNDVGSDPTT
MAV_0703|M.avium_104 DPGR-----PPSKFYVRGVSTDGTPFTAINDRNAEPALPADNDVGPNPTT
MSMEG_5870|M.smegmatis_MC2_155 NPAR-----PPSNFYVRGFDEDGRTWIAVNDREAEPALPENNDVGPVPVT
Mb0781|M.bovis_AF2122/97 NPDR-----PPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTT
Rv0758|M.tuberculosis_H37Rv NPDR-----PPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTT
TH_2452|M.thermoresistible__bu RPNEKFLGYVDGEYHTQSRQEPGFPEVLAGDDAFTERVATVTEPVEGSYD
MLBr_02440|M.leprae_Br4923 MPLG------------AAVVDTYRDVVYLNEQAKELGLVR----------
* :
Mflv_2837|M.gilvum_PYR-GCK VMSIGG----------------------------------------ALAV
Mvan_1833|M.vanbaalenii_PYR-1 VISIGG----------------------------------------ALAV
MAB_3340|M.abscessus_ATCC_1997 AMSIGF----------------------------------------AVAV
MMAR_4941|M.marinum_M LPSVNGSNIEWRAVSVHGPQGGLTTVAIDLSDVQ-HTVRSLVWLQIGIGA
MUL_0464|M.ulcerans_Agy99 LPSVNGSNIEWRAVSVHGPQGGLTTVAIDLSDVQ-HTVRSLVWLQIGIGA
MAV_0703|M.avium_104 LPSVNGSDIQWRAVSVRGPHG-LTTVAIDLSDVQ-HTVSSLVWLQIGIGV
MSMEG_5870|M.smegmatis_MC2_155 VGSIDKSNVEWRAMTVRGPNGELTTVAIDLSEVQ-SSVRALVWSQVGIGA
Mb0781|M.bovis_AF2122/97 LPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVR-STVRSLVLLQVGIGS
Rv0758|M.tuberculosis_H37Rv LPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVR-STVRSLVLLQVGIGS
TH_2452|M.thermoresistible__bu HPEVGEVRYLAIPVTMAGDPAQGVIVAAYLGDAERAAADDAARLMLLVGA
MLBr_02440|M.leprae_Br4923 ------------------------------------------------DR
Mflv_2837|M.gilvum_PYR-GCK SALAALAVS-FYVSRRLQRSVTEVASAATDVAQGNYDVRVSSPRLGDDFD
Mvan_1833|M.vanbaalenii_PYR-1 SALAALAVS-WYISRRLQRSVTEVAEAASSVAEGHYDVRVSSPQLGDDFD
MAB_3340|M.abscessus_ATCC_1997 SALAALTLS-WYLSHRVHRSATALSQAASAVADGNYDIRVPPPRLGKEFD
MMAR_4941|M.marinum_M GVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIASGQLDRRVPERDPRTEVG
MUL_0464|M.ulcerans_Agy99 GVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIASGQLDRRVPERDPRTEVG
MAV_0703|M.avium_104 AVLAVVGIASFAVVQRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVG
MSMEG_5870|M.smegmatis_MC2_155 AVLLVLGVVGYVVVHRSLRPLVEVERTAAAIAAGQLDRRVPERDPRTEVG
Mb0781|M.bovis_AF2122/97 AVLVVLGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVG
Rv0758|M.tuberculosis_H37Rv AVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVG
TH_2452|M.thermoresistible__bu ATLFGAIGAAWLVAGRILRPLRDVADTARTITDTDLSRRIPSRGEGDEMD
MLBr_02440|M.leprae_Br4923 QLDDQAWRAAQQALGGDDVEFDLLPGKRPAAGRSGLSVHGHARLLSEKDR
. . : .
Mflv_2837|M.gilvum_PYR-GCK ALCTAFNQMASRLQTVDSTR--------------QQLFGDLAHEIRTPVA
Mvan_1833|M.vanbaalenii_PYR-1 ALADAFNQMASRLQTVESTR--------------QRLFSDLAHEIRTPVA
MAB_3340|M.abscessus_ATCC_1997 AVAAAFNKMAQRLGAVDEAR--------------RQMLADLAHEIRTPVA
MMAR_4941|M.marinum_M QLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLT
MUL_0464|M.ulcerans_Agy99 QLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLT
MAV_0703|M.avium_104 RLSLALNGMLAQIQQALASSESSAEKARGSEDRMRRFITDASHELRTPLT
MSMEG_5870|M.smegmatis_MC2_155 RLSSALNGMLAQIQRAVAASEASAEQARSSEDRMRRFITDASHELRTPLT
Mb0781|M.bovis_AF2122/97 RLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLT
Rv0758|M.tuberculosis_H37Rv RLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLT
TH_2452|M.thermoresistible__bu SLVRTINGMLDRIEAGVSAQ--------------RRFIDDAGHELRTPIT
MLBr_02440|M.leprae_Br4923 RFAVVFVHDQSDYVRMEAAR--------------RDFVANVSHELKTPVG
. .: : : :. : .**::**:
Mflv_2837|M.gilvum_PYR-GCK VLEAYIEALED--GVRTLTPQTATMLRDQTRRLVRFSNDVAALAKAEESS
Mvan_1833|M.vanbaalenii_PYR-1 VLEAYIEALED--GVRTLTPQTAAMLRDQTRRLVRFSDDVAALAKAEESS
MAB_3340|M.abscessus_ATCC_1997 VLEAYMEAVED--GVQQLDQQTVATLRDQTRRLTRFSIDVNALSVAESRT
MMAR_4941|M.marinum_M TIRGFAELYRQ--GAARDVAMLLSRIESEASRMGLLVDDLLTLARLDVQR
MUL_0464|M.ulcerans_Agy99 TIRGFAELYRQ--GAARDVAMLLSRIESEASRMGLLVDDLLTLARLDVQR
MAV_0703|M.avium_104 TIRGFAELYRQ--GAARDVAMLLSRIESEASRMGLLVDDLLLLARLDVQR
MSMEG_5870|M.smegmatis_MC2_155 TIRGFAELYRQ--GAARDIEMLMGRIESESRRMGLLVEDLLLLARLDAQR
Mb0781|M.bovis_AF2122/97 TIRGFAELYRQ--GAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHR
Rv0758|M.tuberculosis_H37Rv TIRGFAELYRQ--GAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHR
TH_2452|M.thermoresistible__bu IVRGHLEVLDP--DDPDDVRSTVALVDDELVRMNRMVTDLLLLARSE-QP
MLBr_02440|M.leprae_Br4923 AMALLAEALLASADDAETVSRFAEKVLIEANRLGYMVAELIELSRLQGAE
: * . : : *: : :: *: :
Mflv_2837|M.gilvum_PYR-GCK VSMSYANIDVDRLTHRCVAAAQERYDNKGVALRVRLQKALPPLWADEQRL
Mvan_1833|M.vanbaalenii_PYR-1 ASMACSFVDVPRLAHHCAAAAQERFDSKNVTLAVRVAEGLPPLWADEQRL
MAB_3340|M.abscessus_ATCC_1997 TSIDARSVSPADLVTTAVAAFAPRYQTKGVILTSHADDGLPDVWADPERM
MMAR_4941|M.marinum_M P-LERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRL
MUL_0464|M.ulcerans_Agy99 P-LERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRL
MAV_0703|M.avium_104 P-LEHHRVDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDEPRI
MSMEG_5870|M.smegmatis_MC2_155 P-LERRRVDLLALATDAVHDAQSIAPKRRVKMEVFDGPGTPEVLGDEARL
Mb0781|M.bovis_AF2122/97 P-LELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRL
Rv0758|M.tuberculosis_H37Rv P-LELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRL
TH_2452|M.thermoresistible__bu TFLTPEPTDIGALTRAIFDKVVQLGDRD----YQLQSVAEVTAVLDAQRI
MLBr_02440|M.leprae_Br4923 RLPNVTDIDVDIIVSEAIARHKVAADTAAIEVRTDP-PSGLRVLGDQTLL
. :. . * :
Mflv_2837|M.gilvum_PYR-GCK SQVLGNLLENALRHTPSGGSVEVNCVRDGDRLRIAVADTGEGIAAEHVNR
Mvan_1833|M.vanbaalenii_PYR-1 AQVVGNLVDNALRHTPAGGRVEVSWEREGAELALRVADNGAGIAAEHLPR
MAB_3340|M.abscessus_ATCC_1997 GQVLSNLLDNALRHTGPGGQVTVTATATGTGATIAVADTGDGVPAEHLDR
MMAR_4941|M.marinum_M RQVLSNLVGNALQHTPDSADVTVRVGTAGQNAVLEVADKGPGMPAEDAAR
MUL_0464|M.ulcerans_Agy99 RQVLSNLVGNALQHTPDSADVTVRVGTAGENAVLEVADKGPGMPAEDAAR
MAV_0703|M.avium_104 RQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVADRGPGMNEQDASR
MSMEG_5870|M.smegmatis_MC2_155 RQVIGNLVANAVQHTPETAGITVRVGTDGDNAVLEVCDEGPGMSQEDARR
Mb0781|M.bovis_AF2122/97 RQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALR
Rv0758|M.tuberculosis_H37Rv RQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALR
TH_2452|M.thermoresistible__bu TQALIALADNACRYTRDGDWIAVGSGLYDGWLRFWVSDSGPGVSDADRDR
MLBr_02440|M.leprae_Br4923 VTALANLVSNAIAYSPGGSLVSISRRRRGDNIEIAVTDRGIGIALEDQER
.: * ** :: : : . : * * * *: . *
Mflv_2837|M.gilvum_PYR-GCK VFERFYRADSARDREHGGAGLGLAIAKALVEAHGGAISVASAGPGGGATF
Mvan_1833|M.vanbaalenii_PYR-1 LFERFYRADTARDREHGGAGIGLAITRALVEAHGGTISVASAGPGTGATF
MAB_3340|M.abscessus_ATCC_1997 LFDRFYRADAARDRQHGGAGIGLSIAKALVEAHEGRIEAHSAGHAAGTTF
MMAR_4941|M.marinum_M VFERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAP-GEGCCF
MUL_0464|M.ulcerans_Agy99 VFERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAP-GEGCCF
MAV_0703|M.avium_104 VFERFYRTDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTAP-GQGCCF
MSMEG_5870|M.smegmatis_MC2_155 VFERFYRADTSRTRASGGTGLGLSIVDSLVYAHGGTVKVTTAL-GKGSRF
Mb0781|M.bovis_AF2122/97 VFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTAL-GEGCCF
Rv0758|M.tuberculosis_H37Rv VFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTAL-GEGCCF
TH_2452|M.thermoresistible__bu IFERFARGSAGGQRSDG-AGLGLSIVRAIAGAHGGHVDLDTVV-GRGSTF
MLBr_02440|M.leprae_Br4923 VFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSKP-GTGSTF
:*:** * . . * * :*:**:*. :. * * : : . * *
Mflv_2837|M.gilvum_PYR-GCK TLAMPITPERTEQTPVTADSARI---------------------------
Mvan_1833|M.vanbaalenii_PYR-1 TVTLPLAPARDELVALGVARPAAQ--------------------------
MAB_3340|M.abscessus_ATCC_1997 TVSLPRPSDHPEKAPG--QRPG----------------------------
MMAR_4941|M.marinum_M RVTLPRVSEAAVELTEPVS-------------------------------
MUL_0464|M.ulcerans_Agy99 RVTLPRVSEAAVELTEPVS-------------------------------
MAV_0703|M.avium_104 RVTLPRISDVPAVQAS----------------------------------
MSMEG_5870|M.smegmatis_MC2_155 TVSLPRIADLPARL------------------------------------
Mb0781|M.bovis_AF2122/97 RVSLPRVSDVDQLSLTPVVPGPP---------------------------
Rv0758|M.tuberculosis_H37Rv RVSLPRVSDVDQLSLTPVVPGPP---------------------------
TH_2452|M.thermoresistible__bu TITIPAVLEAPWPAS-----------------------------------
MLBr_02440|M.leprae_Br4923 TLSIPAAMPLYQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPAQAMMQS
:::*
Mflv_2837|M.gilvum_PYR-GCK ---------------------
Mvan_1833|M.vanbaalenii_PYR-1 ---------------------
MAB_3340|M.abscessus_ATCC_1997 ---------------------
MMAR_4941|M.marinum_M ---------------------
MUL_0464|M.ulcerans_Agy99 ---------------------
MAV_0703|M.avium_104 ---------------------
MSMEG_5870|M.smegmatis_MC2_155 ---------------------
Mb0781|M.bovis_AF2122/97 ---------------------
Rv0758|M.tuberculosis_H37Rv ---------------------
TH_2452|M.thermoresistible__bu ---------------------
MLBr_02440|M.leprae_Br4923 EVTRGNVNDKCPDCGGRGIAG