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LSSSQNATQSSPRARLRILPGDRVHAASLAGRFLVFQLLVVAVVLGAVAAISVAQSTREFRDVRGQRMIA VAENVASTPIVRDRYADPLAARTLAPEVDRAVALSGADLVEITDPTGVVRVSSQPDRIGQRIELDASRAD EGRSWFGDTDIDGQHSLVGQVPILAPSGEPLAIVSVSQRYPSVWELLSGSGERLLIYLGIGAALGLLTSW LLSRRIKTHTRGLDIAEIADLADHREALLHSIREGVVAVNTDGSITVLNDSACELLGIGPDAVGRHVGAI GLEPAVVEFLLSGHDRTDETANESDVIIATRSRVLALNRRAASSQGHRIGTVTTMRDSTELAALQAQLSS HRSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVGTLTRRRAEINDAVTQHVSDPAVAALLIAKTS LAAESGVALTLTDDSHLAALDPALATDVITLLGNLVDNAVEVSAGSVGSTAAHVSVRLDDSAGLLLEVSD SGPGVPEHLRETIFARGVTSKPDVPGGRGIGLALVRLVTAQHGGTVEVTDGPAGGASFVVRLPEVTVHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4211 | - | - | 100% (559) | two component system histidine kinase |
| M. smegmatis MC2 155 | MSMEG_5304 | - | 2e-56 | 30.49% (528) | two-component sensor kinase |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 2e-13 | 28.40% (243) | sensor histidine kinase PhoR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 6e-14 | 30.51% (236) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_3003 | - | 0.0 | 75.59% (508) | signal transduction histidine kinase regulating citrate/malate |
| M. tuberculosis H37Rv | Rv3764c | - | 6e-14 | 30.51% (236) | two component sensor kinase |
| M. leprae Br4923 | MLBr_02124 | - | 3e-11 | 37.11% (97) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 5e-14 | 29.51% (288) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_5316 | tcrY | 2e-15 | 31.17% (231) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 3e-16 | 32.77% (235) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_0454 | - | 4e-12 | 28.98% (245) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_0464 | phoR | 1e-12 | 29.10% (244) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_3503 | - | 0.0 | 73.52% (540) | signal transduction histidine kinase regulating citrate/malate |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 --------------------------------------------------
Rv3764c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0305|M.avium_104 ----------------------------------MADTRRVWSLRLRLLV
MMAR_5316|M.marinum_M -----------------------------MSSNRLVRRPGAWSLRLRLLV
MAB_0674|M.abscessus_ATCC_1997 -------------------------MAWDTYCASRDERLREEQLALLVAV
MUL_0464|M.ulcerans_Agy99 ----------------------------------MAERLP----------
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
TH_0454|M.thermoresistible__bu --------------------------------------------------
Mflv_3003|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3503|M.vanbaalenii_PYR-1 -----MVIKNTPSAVVGLVRG-----RSLAGQFLASQLVVVAVVLVAVAA
MSMEG_4211|M.smegmatis_MC2_155 MSSSQNATQSSPRARLRILPGDRVHAASLAGRFLVFQLLVVAVVLGAVAA
Mb3790c|M.bovis_AF2122/97 ----------MGITAATEMALRRHLVAQLDNQLGG---TSYRSVLMYPEK
Rv3764c|M.tuberculosis_H37Rv ----------MGITAATEMALRRHLVAQLDNQLGG---TSYRSVLMYPEK
MAV_0305|M.avium_104 GQIVVLALVCLGITAVTELALNHHLVKQLDGQLAG---TSFRSALMYPE-
MMAR_5316|M.marinum_M GQILVLAVVCVGITAATELALHHHLVAQLDGQLGG---TSHRSALMYPE-
MAB_0674|M.abscessus_ATCC_1997 PGVRRGVPLRVSLVVGTLVLVALGLVASGIAVTTT---MQRTMMNRADRE
MUL_0464|M.ulcerans_Agy99 ----RAVQLRVGLVAATLALVLCGLLASGVAVTSI---LRHSLVSRIDST
MLBr_02124|M.leprae_Br4923 -MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVG---TVVWVGITNDRK
TH_0454|M.thermoresistible__bu -MNLVTRLFRRTPSLRTRVAFATAIAAAIVVGIVG---VVVWVGITNDRK
Mflv_3003|M.gilvum_PYR-GCK --MAQSEGEFRDVRGQRMIAVAENMASTPIVRERTEQTRADPFLARTLAP
Mvan_3503|M.vanbaalenii_PYR-1 VSVAQSEGEFREVRGQRMIAVAENMASAPIVRERSEQDPADPFIARTLAP
MSMEG_4211|M.smegmatis_MC2_155 ISVAQSTREFRDVRGQRMIAVAENVASTPIVRDR----YADPLAARTLAP
. :
Mb3790c|M.bovis_AF2122/97 MPRPPWRRETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTG
Rv3764c|M.tuberculosis_H37Rv MPRPPWRHETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTG
MAV_0305|M.avium_104 -PNHP-RHEHSPYPRPGPGPRFLDAPGQPAGMVAAVVSHGKTVDAGYLTS
MMAR_5316|M.marinum_M -SSHRFWRHQHRYWRPGPGPRFLDAPGQPAGMVGAVVRDGKAIVAGYLTN
MAB_0674|M.abscessus_ATCC_1997 LIDAANGWANR--PPPPPPAFETTRHRPPSLFFIRTTDDRGRVVIMLNDR
MUL_0464|M.ulcerans_Agy99 LLEASRTWAQASWRHSMPSVEGPDPARPPSKFYVRSISPDGRAMTAINDR
MLBr_02124|M.leprae_Br4923 ERLDRKLDEAAGFAIPFVPRGLDEIPRSPNDQDAIITVRRGNLVKSNFDI
TH_0454|M.thermoresistible__bu ERLDRRLDEAAGFALPFVPRGLEQIPPSPNDQDVVITVRRGDEVRSNSEV
Mflv_3003|M.gilvum_PYR-GCK EVDRAVALSGASLAEILGPDGTVRASSDPSRVGARVDLGATRADEGRAWF
Mvan_3503|M.vanbaalenii_PYR-1 EVDRAVALSGADLAELLGPDGTVRASSDPSRIGARVDLGVSRADEGRAWF
MSMEG_4211|M.smegmatis_MC2_155 EVDRAVALSGADLVEITDPTGVVRVSSQPDRIGQRIELDASRADEGRSWF
*
Mb3790c|M.bovis_AF2122/97 SGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIV
Rv3764c|M.tuberculosis_H37Rv SGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIV
MAV_0305|M.avium_104 SGTRDALTSTAQTQLEQIAGSRAPVTVNLDGLGRYRVVAAPSRNGSDIIV
MMAR_5316|M.marinum_M SGDRAEISPTAQAQLAAVAGSQDPVTLNLDGLGRYRVVSALSRRGDELIV
MAB_0674|M.abscessus_ATCC_1997 ARADPDLPFDN-----DVGGRPVTVRSSDGG-TEWRAVSRHDALG-GYTT
MUL_0464|M.ulcerans_Agy99 N-AEPALPADN-----DVGSDPTTLPSVNGSNIEWRAVSVHGPQG-GLTT
MLBr_02124|M.leprae_Br4923 TLPKLTNDYAD--------------TYLRGVRYRVRTVEIPAPEP-TSIA
TH_0454|M.thermoresistible__bu VLPELDADYAD--------------TYIDGVRYRVRTVQTPYPIR-TTLA
Mflv_3003|M.gilvum_PYR-GCK GDTDIDGTHSLVGQVPILSTDGEVLAIASVSEAYPSVWGLLSGAGESLLV
Mvan_3503|M.vanbaalenii_PYR-1 GDADIDGTHSLVGQVPILSTDGEVLAVASVSEGYPSTWALLTRAGEGLLV
MSMEG_4211|M.smegmatis_MC2_155 GDTDIDGQHSLVGQVPILAPSGEPLAIVSVSQRYPSVWELLSGSGERLLI
.
Mb3790c|M.bovis_AF2122/97 TGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIKRALAP-LRRVA
Rv3764c|M.tuberculosis_H37Rv TGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIKRALAP-LRRVA
MAV_0305|M.avium_104 TGLSMANIDATLIRMLVIFGIVTVIALAAATIAGVVIIRRALAP-LRRVA
MMAR_5316|M.marinum_M TGLSMSDVDATMIRMLIIFGIVTIVALVAATTAGAIIIRRALAP-LRRVA
MAB_0674|M.abscessus_ATCC_1997 VARDITDVRTTVRDLLWLQVAIGIAVLTVLGVAGYWLVHRSLRP-LAEVE
MUL_0464|M.ulcerans_Agy99 VAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRP-LSEVE
MLBr_02124|M.leprae_Br4923 VGATYDATVAETNNLHRRVLLICGFAIAAAAVFAWLLAAFAVRP-FKQLA
TH_0454|M.thermoresistible__bu VGATYDDTIADTANLHRRVILICTLAIGAATIAGWLLAAFAVRP-FKQLA
Mflv_3003|M.gilvum_PYR-GCK YLGLGAALGLLASWLLSRRIKRQTGGLEVAEIASLADHREALLHSIREGV
Mvan_3503|M.vanbaalenii_PYR-1 YLGLGAMLGLVASWLLSRRIKRHTRGLEVAEIASLADHREALLHSIREGV
MSMEG_4211|M.smegmatis_MC2_155 YLGIGAALGLLTSWLLSRRIKTHTRGLDIAEIADLADHREALLHSIREGV
: : :: : .
Mb3790c|M.bovis_AF2122/97 QTASEVVDLPLDRGEVKLPVRVPEPDANPSTEVGQLGSALNRMLDHIAA-
Rv3764c|M.tuberculosis_H37Rv QTASEVVDLPLDRGEVKLPVRVPEPDANPSTEVGQLGSALNRMLDHIAA-
MAV_0305|M.avium_104 QTAREVADLPLARGEVELPVRVRESDANPSTEVGQLGAALNRMLDHIAD-
MMAR_5316|M.marinum_M QTATEVVDLPLDRGEVELPVRVSETDANPDTEVGQLGSALNRMLDHIAA-
MAB_0674|M.abscessus_ATCC_1997 ATAADIAAGHLDR---------RVPERDPRTEVGRLSLALNGMLAQIQR-
MUL_0464|M.ulcerans_Agy99 QTAAAIASGQLDR---------RVPERDPRTEVGQLSLAMNGMLSQIQV-
MLBr_02124|M.leprae_Br4923 QQTRSVDAGGEAP----------RVEVHGATEAVEIAEAMRGMLQRIWN-
TH_0454|M.thermoresistible__bu AQARSIDAGDEVP----------DVEIRGATEAVEIADAVKGMLQRIWK-
Mflv_3003|M.gilvum_PYR-GCK IAVNGSGEITLLNDGAQELLDVTGPAVGRPVDSVGIDPAVVSLLTPGQE-
Mvan_3503|M.vanbaalenii_PYR-1 IAVNNDGGITLLNDSARTLLGVPDSAVGQGVDTVGIDPAVVSFLMSGED-
MSMEG_4211|M.smegmatis_MC2_155 VAVNTDGSITVLNDSACELLGIGPDAVGRHVGAIGLEPAVVEFLLSGHDR
. . : *: :*
Mb3790c|M.bovis_AF2122/97 -----------ALSAR-------QASETRVRQFVADASHELRTPLAAIRG
Rv3764c|M.tuberculosis_H37Rv -----------ALSAR-------QASETCVRQFVADASHELRTPLAAIRG
MAV_0305|M.avium_104 -----------ALSAR-------QASETRVRQFVADASHELRTPLAAIRG
MMAR_5316|M.marinum_M -----------ALSTR-------QASETRVRQFVADASHELRTPLAAIRG
MAB_0674|M.abscessus_ATCC_1997 -----------AVADSEKSAKAARTSEERMRRFITDASHELRTPLTTIRG
MUL_0464|M.ulcerans_Agy99 -----------ALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIRG
MLBr_02124|M.leprae_Br4923 -----------EQNRT-------KEALASARDFAAVSSHELRTPLTAMRT
TH_0454|M.thermoresistible__bu -----------EQDRT-------KAALASARDFASAAAHELRTPLTAMRT
Mflv_3003|M.gilvum_PYR-GCK ---SESAMDTVIATRTRVLALSRRPATSQGRRIGTVTTMRDSTELAALQG
Mvan_3503|M.vanbaalenii_PYR-1 ---DGGDGDTVIATRTRVLALSRRATTSGGRRIGTVTTMRDSTELAALQG
MSMEG_4211|M.smegmatis_MC2_155 TDETANESDVIIATRSRVLALNRRAASSQGHRIGTVTTMRDSTELAALQA
: : : : : :: . * *::::
Mb3790c|M.bovis_AF2122/97 YTELTQRIGDDPEAVAHAMSRVASETERITRL--------VEDLLLLARL
Rv3764c|M.tuberculosis_H37Rv YTELTQRIGDDPEAVAHAMSRVASETERITRL--------VEDLLLLARL
MAV_0305|M.avium_104 YTELTQRMGDDREAVAQAMSRVASETERMTRL--------VEDLLLLARL
MMAR_5316|M.marinum_M YTELAQRMGDDRAAVAHAMSRVGSETERITSL--------VEDLLLLARL
MAB_0674|M.abscessus_ATCC_1997 YAELYRQG--AATDTELVLGRIEGESTRMGQL--------VEDLLLLARL
MUL_0464|M.ulcerans_Agy99 FAELYRQG--AARDVAMLLSRIESEASRMGLL--------VDDLLTLARL
MLBr_02124|M.leprae_Br4923 NLEVLATLDLADDQRKEVLGDVIRTQSRIEAT--------LSALERLAQG
TH_0454|M.thermoresistible__bu NLEVLSTLDMPEEQRKEVLADVIRTQSRIEAT--------LSALERLAQG
Mflv_3003|M.gilvum_PYR-GCK QLSSHKSVTDTLRAQAHEFANQLHTISGLVQLGEFDAVRDLVGTLTRRRA
Mvan_3503|M.vanbaalenii_PYR-1 QLSSHKSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVGTLTRRRA
MSMEG_4211|M.smegmatis_MC2_155 QLSSHRSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVGTLTRRRA
. :. : : :
Mb3790c|M.bovis_AF2122/97 DSGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP--VVIPGDA
Rv3764c|M.tuberculosis_H37Rv DSGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP--VVIPGDA
MAV_0305|M.avium_104 DSGRPLEREPVDLSRLAVDAVNDAHVAGPDHQWELDLPEEP--VVITGDA
MMAR_5316|M.marinum_M DSGRPLEREPVDMSRLAVDAVSDAHVAGPDQQWELDLPAEP--VVVTGDA
MAB_0674|M.abscessus_ATCC_1997 DAHRPMEQRLVDLLVLATDAVHDAKATAPERDVELEVFDGPGTPEVIGDE
MUL_0464|M.ulcerans_Agy99 DVQRPLERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDE
MLBr_02124|M.leprae_Br4923 ELSTSDDHVPVDITELLDRAAHDATRSYP--ELKVSLVPSP-TCIIVGLP
TH_0454|M.thermoresistible__bu ELSTSDDHVPVDITELLDRAAHEAMRIYP--DLEVSLVPAP-TVIIVGLP
Mflv_3003|M.gilvum_PYR-GCK EISDAVTQRISDPAVAALLIAKTSLAAESGVALDLDP-ASHLAALDPALA
Mvan_3503|M.vanbaalenii_PYR-1 EISDAVTQHISDPAVAALLIAKTSLAAESGVSLLLDP-RSHLNPLDPAMA
MSMEG_4211|M.smegmatis_MC2_155 EINDAVTQHVSDPAVAALLIAKTSLAAESGVALTLTD-DSHLAALDPALA
: . : * . : : .
Mb3790c|M.bovis_AF2122/97 ARLHQVVTNLLANARVHTGP----GTIVTTRLSTGPTHVVLQVIDNGPGI
Rv3764c|M.tuberculosis_H37Rv ARLHQVVTNLLANARVHTGP----GTIVTTRLSTGPTHVVLQVIDNGPGI
MAV_0305|M.avium_104 ARLHQVLTNLLANARVHTGA----GTVVTTRLSTEPAHTVLQVIDNGPGI
MMAR_5316|M.marinum_M ARLHQVVANLLANARIHTGP----GAVVTTRLSSGPTHVVLEVIDNGPGI
MAB_0674|M.abscessus_ATCC_1997 LRLRQVLGNLVSNALGHT------TAAVRVRVGTEGDDAVLEVIDRGPGM
MUL_0464|M.ulcerans_Agy99 PRLRQVLSNLVGNALQHTPD----SADVTVRVGTAGENAVLEVADKGPGM
MLBr_02124|M.leprae_Br4923 AGLRLAVDNAVANAVKHGGA----TRVQLSAVSSR-AGVEIAVDDNGSGV
TH_0454|M.thermoresistible__bu AGLRLAVDNAIANAVKHGGA----TRVQLSAVSSR-EGVEIAIDDNGTGV
Mflv_3003|M.gilvum_PYR-GCK TDVITLLGNLIDNAVDVSVG---STPARVTVGIDDRDGLSILVSDTGPGV
Mvan_3503|M.vanbaalenii_PYR-1 TDVITLLGNLIDNAVDVSVG---AADARVTICIDDRDGLAISVLDTGPGV
MSMEG_4211|M.smegmatis_MC2_155 TDVITLLGNLVDNAVEVSAGSVGSTAAHVSVRLDDSAGLLLEVSDSGPGV
: : * : ** : : * *.*:
Mb3790c|M.bovis_AF2122/97 PAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVSSSP
Rv3764c|M.tuberculosis_H37Rv PAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVSSSP
MAV_0305|M.avium_104 PAELQSEVFERFARGDSSRSRKGGSTGLGLAIVSAVVKAHNGTISVNSSP
MMAR_5316|M.marinum_M PEAMQSEIFERFARGDTSRSRKGGSTGLGLAIVAAVVKAHNGTITVNSSP
MAB_0674|M.abscessus_ATCC_1997 TKTDAERVFERFYRADSSRTRSSGGTGLGLSIVDALTAAHGGTVTVHTAP
MUL_0464|M.ulcerans_Agy99 PAEDAARVFERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAP
MLBr_02124|M.leprae_Br4923 PEDERQVVFERFSRGSTASHS---GSGLGLALVAQQAQLHGGTASLETSP
TH_0454|M.thermoresistible__bu PEEERERVFDRFTRGSTASHS---GSGLGLALVAQQAEIHGGTASLEASP
Mflv_3003|M.gilvum_PYR-GCK PEHLREAIFS---RGVTSKPDVPGGRGIGLALVRLVTAQHGGTVEVADVP
Mvan_3503|M.vanbaalenii_PYR-1 PEHLREAIFA---RGITSKPEVPGGRGIGLALVRLVTAQHGGTIEVSDGP
MSMEG_4211|M.smegmatis_MC2_155 PEHLRETIFA---RGVTSKPDVPGGRGIGLALVRLVTAQHGGTVEVTDGP
. :* * :: . *:**::* . *.* : *
Mb3790c|M.bovis_AF2122/97 GY-TEFAVRLPLDGWQPLESSPR---------------------------
Rv3764c|M.tuberculosis_H37Rv GY-TEFAVRLPLDGWQPLESSPR---------------------------
MAV_0305|M.avium_104 GH-TEFTVRLPPNGWQPHASA-----------------------------
MMAR_5316|M.marinum_M GR-TEFVVRLPLDAWQRSGVPPG---------------------------
MAB_0674|M.abscessus_ATCC_1997 GAGCRFEVRLPRADMTDDDADVDEPESATPDAAASEPKIVRASRSESAQP
MUL_0464|M.ulcerans_Agy99 GEGCCFRVTLPR--VSEAAVELTEPVS-----------------------
MLBr_02124|M.leprae_Br4923 LGGARLLLRISAPS------------------------------------
TH_0454|M.thermoresistible__bu LGGARLVLRLPGPR------------------------------------
Mflv_3003|M.gilvum_PYR-GCK GGGARFEVRLKAATHA----------------------------------
Mvan_3503|M.vanbaalenii_PYR-1 GGGARFLVRLKAVSHHA---------------------------------
MSMEG_4211|M.smegmatis_MC2_155 AGGASFVVRLPEVTVHA---------------------------------
: : :