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FSGGPRACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRSLLSGVDYAAAERVRDIAKALQSD SREELDNALLTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVSGQK VATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVAVAAGATYWLVRRSLKSVDAIRARVADISASD LAERVPVPDGRDEIAALAVTMNEMLSRLEAGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLDAE LAVNTLLPEAHRMRALIDDLLLLARADERNLLRRKELVALDDLAEAEAARVRRDADCAVHTDIRPARLLA DPAAMTRMIRNLVDNAVRHAVSCVAIEVGSRDGTAVLTVGDDGPGIPPAQRSRVFERFVRLDTDRARSGG GAGLGLAIVAEVVAAHGGTVTIGDRPGGGTTLTVALPQHPAQHSSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3405 | - | - | 100% (467) | hypothetical protein MAV_3405 |
| M. avium 104 | MAV_0703 | - | 3e-49 | 32.04% (465) | sensor histidine kinase PhoR |
| M. avium 104 | MAV_1095 | - | 1e-36 | 31.89% (439) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 9e-47 | 31.47% (464) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_1582 | - | 1e-50 | 31.73% (479) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 4e-47 | 31.47% (464) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00175 | - | 6e-35 | 30.39% (431) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 3e-50 | 31.50% (473) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_4941 | phoR | 4e-51 | 32.24% (456) | two-component system response phosphate sensor kinase, PhoR |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 7e-46 | 30.84% (467) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_2428 | - | 7e-39 | 30.06% (469) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_0464 | phoR | 2e-51 | 32.07% (474) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 7e-51 | 31.28% (470) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4941|M.marinum_M -MAER-----------------------LPRAVPLRVGLVAATLALVLCG
MUL_0464|M.ulcerans_Agy99 -MAER-----------------------LPRAVQLRVGLVAATLALVLCG
Mb0781|M.bovis_AF2122/97 -MARH-----------------------LRGRLPLRVRLVAATLILVATG
Rv0758|M.tuberculosis_H37Rv -MARH-----------------------LRGRLPLRVRLVAATLILVATG
Mflv_1582|M.gilvum_PYR-GCK -MSSASPDE----RSNLNNGDVAGRRRYLRRGVPLRVALVAATLLLVACG
Mvan_5174|M.vanbaalenii_PYR-1 -MDGG---D----GPTLNNGGVPGR---IRRGVPLRVGLVAAMLLLVACG
MSMEG_5870|M.smegmatis_MC2_155 -MNRG------------------------RRGIPLRVGLVAAALVLVACG
MAB_0674|M.abscessus_ATCC_1997 -MAWDTYCASRDERLREEQLALLVAVPGVRRGVPLRVSLVVGTLVLVALG
MAV_3405|M.avium_104 -MFSGGPRACR----------------IEGVHLGISARSAAVAAIVVFCA
MLBr_00175|M.leprae_Br4923 MVRFAW---------------RRRASLRATSSLSLRWRVMLLAMSMVAMV
TH_2428|M.thermoresistible__bu -MTFAQPYPPS--------PPQRQATSQPASSLSLRWRVMLLAMSMVAMV
: : : :*
MMAR_4941|M.marinum_M LLASGVAVTSILRHSLVSRIDSTLLEASRTWAQASWRHSMPSVEGPDPAR
MUL_0464|M.ulcerans_Agy99 LLASGVAVTSILRHSLVSRIDSTLLEASRTWAQASWRHSMPSVEGPDPAR
Mb0781|M.bovis_AF2122/97 LVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPIHNPDR
Rv0758|M.tuberculosis_H37Rv LVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDR
Mflv_1582|M.gilvum_PYR-GCK LLASGIAVTTIMQHSLMNRVDDTLLDASRGWAQVPRRLPTITVDDPNPAR
Mvan_5174|M.vanbaalenii_PYR-1 LLASGIAVTTIMQHSLMNRVDDTLLDASRGWAQVPRRVLTVPMEGPNPAR
MSMEG_5870|M.smegmatis_MC2_155 LLASGIAVTSIMRHTEVSRIDQTLLDASRSWAQAPRRAPTTPLEGPNPAR
MAB_0674|M.abscessus_ATCC_1997 LVASGIAVTTTMQRTMMNRADRELIDAANGWANRPP--PPPPAFETTRHR
MAV_3405|M.avium_104 LTVAGAGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNALLTT
MLBr_00175|M.leprae_Br4923 VVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGK--AIEGT
TH_2428|M.thermoresistible__bu VVLMSIALYAVVSRALYNDIDNQLHSRARLLIESGSLAADPGR--AIEGT
: . .: : . * . .
MMAR_4941|M.marinum_M PPSKFYVRSISPDGRAMTAINDRN-AEPALPADNDVGSDP-TTLPSVNGS
MUL_0464|M.ulcerans_Agy99 PPSKFYVRSISPDGRAMTAINDRN-AEPALPADNDVGSDP-TTLPSVNGS
Mb0781|M.bovis_AF2122/97 PPSRFYVRVISPDGQSYTALNDNT-AIPAVPANNDVGRHP-TTLPSIGGS
Rv0758|M.tuberculosis_H37Rv PPSRFYVRVISPDGQSYTALNDNT-AIPAVPANNDVGRHP-TTLPSIGGS
Mflv_1582|M.gilvum_PYR-GCK PPSDFYVRGIDPDGHVWMLINDRE-AEPELPADNNVGPEP-RTVGSVDHS
Mvan_5174|M.vanbaalenii_PYR-1 PPSDFYVRAVDPDGHVWMEVNDRE-AEPALPEDNDVGSEP-VTVASVDHS
MSMEG_5870|M.smegmatis_MC2_155 PPSNFYVRGFDEDGRTWIAVNDRE-AEPALPENNDVGPVP-VTVGSIDKS
MAB_0674|M.abscessus_ATCC_1997 PPSLFFIRTTDDRGRVVIMLNDRARADPDLPFDNDVGGRP-VTVRSSDGG
MAV_3405|M.avium_104 DQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGD
MLBr_00175|M.leprae_Br4923 AYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQ
TH_2428|M.thermoresistible__bu AYSDVNAMLVNPGRSIYTANQQGEALPLGEPERQVLSGELVMSLRTADQQ
. . . . . : .
MMAR_4941|M.marinum_M NIEWRAVSVHGPQGGLTTVAIDLS-DVQHTVRSLVWLQIGIGAGVLVVVG
MUL_0464|M.ulcerans_Agy99 NIEWRAVSVHGPQGGLTTVAIDLS-DVQHTVRSLVWLQIGIGAGVLVVVG
Mb0781|M.bovis_AF2122/97 KTLWRAVSVRASDGYLTTVAIDLA-DVRSTVRSLVLLQVGIGSAVLVVLG
Rv0758|M.tuberculosis_H37Rv KTLWRAVSVRASDGYLTTVAIDLA-DVRSTVRSLVLLQVGIGSAVLVVPG
Mflv_1582|M.gilvum_PYR-GCK DVQWRAMTVRGLRGELTTVAIDLS-DVKSTMRSLVYTQVGIGAAVLLVLG
Mvan_5174|M.vanbaalenii_PYR-1 HVQWRAMTVRGLSGELTTVAIDLS-DVKSTVRSLVYTQAGFGVAVLVVLG
MSMEG_5870|M.smegmatis_MC2_155 NVEWRAMTVRGPNGELTTVAIDLS-EVQSSVRALVWSQVGIGAAVLLVLG
MAB_0674|M.abscessus_ATCC_1997 -TEWRAVSRHDALGGYTTVARDIT-DVRTTVRDLLWLQVAIGIAVLTVLG
MAV_3405|M.avium_104 DMRVSGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVAVAA
MLBr_00175|M.leprae_Br4923 ----RILAIHLPNDSSLLISKSLR-PTEAVMTKLRWVLLIVGSLGVAVAA
TH_2428|M.thermoresistible__bu ----RVLAIHLSNGSSLLISKSLA-PTMEVLRRLGTVLLIVGGIGVAVAA
. : . . * . : * .
MMAR_4941|M.marinum_M LAGFAVVQRSLRPLSEVEQTAAAIASGQLDRRVPERDPRTEVGQLSLAMN
MUL_0464|M.ulcerans_Agy99 LAGFAVVQRSLRPLSEVEQTAAAIASGQLDRRVPERDPRTEVGQLSLAMN
Mb0781|M.bovis_AF2122/97 VAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALN
Rv0758|M.tuberculosis_H37Rv VAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALN
Mflv_1582|M.gilvum_PYR-GCK IAGYAVVHRSLRPLSEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALN
Mvan_5174|M.vanbaalenii_PYR-1 IAGYAVVHRSLRPLSEVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALN
MSMEG_5870|M.smegmatis_MC2_155 VVGYVVVHRSLRPLVEVERTAAAIAAGQLDRRVPERDPRTEVGRLSSALN
MAB_0674|M.abscessus_ATCC_1997 VAGYWLVHRSLRPLAEVEATAADIAAGHLDRRVPERDPRTEVGRLSLALN
MAV_3405|M.avium_104 GATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDEIAALAVTMN
MLBr_00175|M.leprae_Br4923 VAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGS-DELARLTEAFN
TH_2428|M.thermoresistible__bu IAGGMVARAGLRPVSRLTEAAERVARTDDLRPIPVVGS-DELARLTEAFN
. :.: .*:.: . . :. . . :* *:. *: ::*
MMAR_4941|M.marinum_M GMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIR-GFA
MUL_0464|M.ulcerans_Agy99 GMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIR-GFA
Mb0781|M.bovis_AF2122/97 GMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIR-GFA
Rv0758|M.tuberculosis_H37Rv GMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIR-GFA
Mflv_1582|M.gilvum_PYR-GCK GMLAQIQHAMALSESSAEKARSSEDRMRRFITDASHELRTPLTTIR-GFA
Mvan_5174|M.vanbaalenii_PYR-1 GMLAQIQRAMASSEASAEQARTSEDRMRRFITDASHELRTPLTTIR-GFA
MSMEG_5870|M.smegmatis_MC2_155 GMLAQIQRAVAASEASAEQARSSEDRMRRFITDASHELRTPLTTIR-GFA
MAB_0674|M.abscessus_ATCC_1997 GMLAQIQRAVADSEKSAKAARTSEERMRRFITDASHELRTPLTTIR-GYA
MAV_3405|M.avium_104 EMLSRLEAGHR--------------AQQRFVGDASHELRSPLTTIISGLE
MLBr_00175|M.leprae_Br4923 LMLRALAESRE--------------RQARLVTDAGHELRTPLTSLRTNVE
TH_2428|M.thermoresistible__bu MMLRALAESRE--------------RQARLVADAGHELRTPLTSLRTNVE
** : . ::: **.****:***:: .
MMAR_4941|M.marinum_M ELYRQGAARDVAMLLSRIESEASRMGLLVDDLLTLAR--LDVQRPLERNR
MUL_0464|M.ulcerans_Agy99 ELYRQGAARDVAMLLSRIESEASRMGLLVDDLLTLAR--LDVQRPLERNR
Mb0781|M.bovis_AF2122/97 ELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLAR--LDAHRPLELCR
Rv0758|M.tuberculosis_H37Rv ELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLAR--LDAHRPLELCR
Mflv_1582|M.gilvum_PYR-GCK ELYRQGAARDVEMLMGRIKSESRRMGLLVEDLLLLAR--LDAQRPLEHRR
Mvan_5174|M.vanbaalenii_PYR-1 ELYRQGAARDVEMLMSRIESESRRMGLLVEDLLLLAR--LDAQRPLDRHR
MSMEG_5870|M.smegmatis_MC2_155 ELYRQGAARDIEMLMGRIESESRRMGLLVEDLLLLAR--LDAQRPLERRR
MAB_0674|M.abscessus_ATCC_1997 ELYRQGAATDTELVLGRIEGESTRMGQLVEDLLLLAR--LDAHRPMEQRL
MAV_3405|M.avium_104 VAEAHPELLDAELAVNTLLPEAHRMRALIDDLLLLAR--ADERNLLRRK-
MLBr_00175|M.leprae_Br4923 LLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAGQV
TH_2428|M.thermoresistible__bu LLMASQQPGAPGLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDDAGGV
: : : :::* *. * .
MMAR_4941|M.marinum_M VDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNL
MUL_0464|M.ulcerans_Agy99 VDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNL
Mb0781|M.bovis_AF2122/97 VDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNL
Rv0758|M.tuberculosis_H37Rv VDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNL
Mflv_1582|M.gilvum_PYR-GCK VDLLALASDTVHDAQSIAPKRRIRMEVFDGPGTPEVLGDEARLRQVLSNL
Mvan_5174|M.vanbaalenii_PYR-1 VDLLTLATDAVHDAQSIAPKRSIKMEVFDGPGTPEVLGDEPRLRQVLSNL
MSMEG_5870|M.smegmatis_MC2_155 VDLLALATDAVHDAQSIAPKRRVKMEVFDGPGTPEVLGDEARLRQVIGNL
MAB_0674|M.abscessus_ATCC_1997 VDLLVLATDAVHDAKATAPERDVELEVFDGPGTPEVIGDELRLRQVLGNL
MAV_3405|M.avium_104 ---ELVALDDLAEAEAARVRRDADCAVHTDIRPARLLADPAAMTRMIRNL
MLBr_00175|M.leprae_Br4923 VHEPIDMSEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAVLNL
TH_2428|M.thermoresistible__bu IHEPVDIADVVDRSLERVRRRRNDIDFDIEVVPWQVYGDAAGLSRAVMNL
: : .* . .: .* : : : **
MMAR_4941|M.marinum_M VGNALQHTPDSADVTVRVGTAG-QNAVLEVADKGPGMPAEDAARVFERFY
MUL_0464|M.ulcerans_Agy99 VGNALQHTPDSADVTVRVGTAG-ENAVLEVADKGPGMPAEDAARVFERFY
Mb0781|M.bovis_AF2122/97 VANAIQHTPESADVTVRVGTEG-DDAILEVADDGPGMSQEDALRVFERFY
Rv0758|M.tuberculosis_H37Rv VANAIQHTPESADVTVRVGTEG-DDAILEVADDGPGMSQEDALRVFERFY
Mflv_1582|M.gilvum_PYR-GCK VANALQHTPESAGVTVRVGTAD-DTAIVEVCDEGPGMTGEDAQRVFERFY
Mvan_5174|M.vanbaalenii_PYR-1 VANALQHTPETAAVTVRVGTDG-NDAVVEVCDEGPGMRPEDAQRVFERFY
MSMEG_5870|M.smegmatis_MC2_155 VANAVQHTPETAGITVRVGTDG-DNAVLEVCDEGPGMSQEDARRVFERFY
MAB_0674|M.abscessus_ATCC_1997 VSNALGHT--TAAVRVRVGTEG-DDAVLEVIDRGPGMTKTDAERVFERFY
MAV_3405|M.avium_104 VDNAVRHA--VSCVAIEVGSRD-GTAVLTVGDDGPGIPPAQRSRVFERFV
MLBr_00175|M.leprae_Br4923 MDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFY
TH_2428|M.thermoresistible__bu LDNAAKWSPSGGRVGVRLTQVDPVHAELVVSDHGPGIPPQERRLVFERFY
: ** : . : : : . . : * * ***: : *****
MMAR_4941|M.marinum_M RTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAPGE----GCCFRVT
MUL_0464|M.ulcerans_Agy99 RTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAPGE----GCCFRVT
Mb0781|M.bovis_AF2122/97 RADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGE----GCCFRVS
Rv0758|M.tuberculosis_H37Rv RADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGE----GCCFRVS
Mflv_1582|M.gilvum_PYR-GCK RADSSRARASGGTGLGLSIVDSLVYAHGGRVSVTTAPGC----GCRFTVR
Mvan_5174|M.vanbaalenii_PYR-1 RTDTSRARASGGTGLGLSIVDSLVYAHGGRVSVTTAPGQ----GSRFRVS
MSMEG_5870|M.smegmatis_MC2_155 RADTSRTRASGGTGLGLSIVDSLVYAHGGTVKVTTALGK----GSRFTVS
MAB_0674|M.abscessus_ATCC_1997 RADSSRTRSSGGTGLGLSIVDALTAAHGGTVTVHTAPGA----GCRFEVR
MAV_3405|M.avium_104 RLDTDRARSGGGAGLGLAIVAEVVAAHGGTVTIGDRPGG----GTTLTVA
MLBr_00175|M.leprae_Br4923 RSTTARSLP--GSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVL
TH_2428|M.thermoresistible__bu RSTTARSMP--GSGLGLAIVKQVVLKHGGTLRVEDTVPGGQPPGTSIHVV
* : *: . *:****:** :. *** : : * : *
MMAR_4941|M.marinum_M LPRVSEAAVEL----------------------------TEPVS------
MUL_0464|M.ulcerans_Agy99 LPRVSEAAVEL----------------------------TEPVS------
Mb0781|M.bovis_AF2122/97 LPRVSDVDQLS----------------------------LTPVVPGPP--
Rv0758|M.tuberculosis_H37Rv LPRVSDVDQLS----------------------------LTPVVPGPP--
Mflv_1582|M.gilvum_PYR-GCK LPRVTDERLREEQATDERLREEQMPAPEHAGEESRGEQTDVPVSATAPTP
Mvan_5174|M.vanbaalenii_PYR-1 LPRIADAGP------------------------DAGPDAEVPVSSAQLG-
MSMEG_5870|M.smegmatis_MC2_155 LPRIADLPARL---------------------------------------
MAB_0674|M.abscessus_ATCC_1997 LPRADMTDDDADVDEPE----------SATPDAAASEPKIVRASRSESAQ
MAV_3405|M.avium_104 LPQHPAQHSSR---------------------------------------
MLBr_00175|M.leprae_Br4923 LPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISV
TH_2428|M.thermoresistible__bu LPGRPLSGVPPASQEPQPP-----QHAPGADPHAPTQTGN-DAVQSVFTA
**
MMAR_4941|M.marinum_M --------
MUL_0464|M.ulcerans_Agy99 --------
Mb0781|M.bovis_AF2122/97 --------
Rv0758|M.tuberculosis_H37Rv --------
Mflv_1582|M.gilvum_PYR-GCK P-------
Mvan_5174|M.vanbaalenii_PYR-1 --------
MSMEG_5870|M.smegmatis_MC2_155 --------
MAB_0674|M.abscessus_ATCC_1997 P-------
MAV_3405|M.avium_104 --------
MLBr_00175|M.leprae_Br4923 DYQSARAR
TH_2428|M.thermoresistible__bu ENK-----