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LVIKNTPSAVVGLVRGRSLAGQFLASQLVVVAVVLVAVAAVSVAQSEGEFREVRGQRMIAVAENMASAPI VRERSEQDPADPFIARTLAPEVDRAVALSGADLAELLGPDGTVRASSDPSRIGARVDLGVSRADEGRAWF GDADIDGTHSLVGQVPILSTDGEVLAVASVSEGYPSTWALLTRAGEGLLVYLGLGAMLGLVASWLLSRRI KRHTRGLEVAEIASLADHREALLHSIREGVIAVNNDGGITLLNDSARTLLGVPDSAVGQGVDTVGIDPAV VSFLMSGEDDGGDGDTVIATRTRVLALSRRATTSGGRRIGTVTTMRDSTELAALQGQLSSHKSVTDTLRA QTHEFANQLHTISGLVQLGEYDAVRELVGTLTRRRAEISDAVTQHISDPAVAALLIAKTSLAAESGVSLL LDPRSHLNPLDPAMATDVITLLGNLIDNAVDVSVGAADARVTICIDDRDGLAISVLDTGPGVPEHLREAI FARGITSKPEVPGGRGIGLALVRLVTAQHGGTIEVSDGPGGGARFLVRLKAVSHHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3503 | - | - | 100% (546) | signal transduction histidine kinase regulating citrate/malate metabolism |
| M. vanbaalenii PYR-1 | Mvan_4697 | - | 2e-51 | 28.60% (521) | signal transduction histidine kinase regulating citrate/malate |
| M. vanbaalenii PYR-1 | Mvan_0192 | - | 2e-12 | 27.46% (244) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 1e-12 | 29.75% (242) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_3003 | - | 0.0 | 84.86% (502) | signal transduction histidine kinase regulating citrate/malate |
| M. tuberculosis H37Rv | Rv3764c | - | 1e-12 | 31.22% (221) | two component sensor kinase |
| M. leprae Br4923 | MLBr_02440 | - | 3e-12 | 32.00% (175) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 3e-13 | 29.44% (231) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_5316 | tcrY | 3e-11 | 27.83% (230) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_3405 | - | 4e-15 | 30.18% (222) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_4211 | - | 0.0 | 73.52% (540) | two component system histidine kinase |
| M. thermoresistible (build 8) | TH_0454 | - | 1e-11 | 27.97% (286) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_4559 | senX3 | 7e-11 | 30.68% (176) | two component sensor histidine kinase SenX3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 --------------------------------------------------
Rv3764c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5316|M.marinum_M ------------------------------------------------MS
MAB_0674|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3503|M.vanbaalenii_PYR-1 -----MVIKNTPSAVVGLVRG-----RSLAGQFLASQLVVVAVVLVAVAA
Mflv_3003|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4211|M.smegmatis_MC2_155 MSSSQNATQSSPRARLRILPGDRVHAASLAGRFLVFQLLVVAVVLGAVAA
MAV_3405|M.avium_104 --------------------------------------------------
TH_0454|M.thermoresistible__bu --------------------------------------------------
Mb3790c|M.bovis_AF2122/97 -----------------------------MGITAATEMALRRHLVAQLDN
Rv3764c|M.tuberculosis_H37Rv -----------------------------MGITAATEMALRRHLVAQLDN
MMAR_5316|M.marinum_M SNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAATELALHHHLVAQLDG
MAB_0674|M.abscessus_ATCC_1997 ----MAWDTYCASRDERLREEQLALLVAVPGVRRGVPLRVSLVVGTLVLV
MLBr_02440|M.leprae_Br4923 -----------------------------------------MFSALLLAG
MUL_4559|M.ulcerans_Agy99 -----------------------------------------MFSALLLAG
Mvan_3503|M.vanbaalenii_PYR-1 VSVAQSEGEFREVRGQRMIAVAENMASAPIVRERSEQDPADPFIARTLAP
Mflv_3003|M.gilvum_PYR-GCK --MAQSEGEFRDVRGQRMIAVAENMASTPIVRERTEQTRADPFLARTLAP
MSMEG_4211|M.smegmatis_MC2_155 ISVAQSTREFRDVRGQRMIAVAENVASTPIVRDR----YADPLAARTLAP
MAV_3405|M.avium_104 --MFSGGPRACRIEGVHLGISARSAAVAAIVVFCALTVAGAGLDAILYRS
TH_0454|M.thermoresistible__bu ----------------------MNLVTRLFRRTPSLRTRVAFATAIAAAI
Mb3790c|M.bovis_AF2122/97 QLGGTSYRSVLMYPEKMPRPPWRRETHNYIRSGPGPRF-LDAPGQPAGMV
Rv3764c|M.tuberculosis_H37Rv QLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRF-LDAPGQPAGMV
MMAR_5316|M.marinum_M QLGGTSHRSALMYPESSHR-FWRHQ-HRYWRPGPGPRF-LDAPGQPAGMV
MAB_0674|M.abscessus_ATCC_1997 ALG--LVASGIAVTTTMQRTMMNRADRELIDAANG--W-ANRPPPPPPAF
MLBr_02440|M.leprae_Br4923 VLSGLAFVVGIVAGIRLSPRLIERR-------------------------
MUL_4559|M.ulcerans_Agy99 VLSALALAAGVAVGARLSQRLVRRR-------------------------
Mvan_3503|M.vanbaalenii_PYR-1 EVDRAVALSGADLAELLGPDGTVRASSDPSRIGARVDLGVSRADEGRAWF
Mflv_3003|M.gilvum_PYR-GCK EVDRAVALSGASLAEILGPDGTVRASSDPSRVGARVDLGATRADEGRAWF
MSMEG_4211|M.smegmatis_MC2_155 EVDRAVALSGADLVEITDPTGVVRVSSQPDRIGQRIELDASRADEGRSWF
MAV_3405|M.avium_104 LLSGVDYAAAERVRDIAKALQSDSR---------------------EELD
TH_0454|M.thermoresistible__bu VVGIVGVVVWVGITNDRKERLDRRLD---------------------EAA
:.
Mb3790c|M.bovis_AF2122/97 AAVVSDGTTVAAGYLTGSGSRAALTSTGRS------QLERIAGSRTPLTL
Rv3764c|M.tuberculosis_H37Rv AAVVSDGTTVAAGYLTGSGSRAALTSTGRS------QLERIAGSRTPLTL
MMAR_5316|M.marinum_M GAVVRDGKAIVAGYLTNSGDRAEISPTAQA------QLAAVAGSQDPVTL
MAB_0674|M.abscessus_ATCC_1997 ETTRHRPPSLFFIRTTDDRGRVVIMLNDRARADPDLPFDNDVGGRPVTVR
MLBr_02440|M.leprae_Br4923 QRLANEWAGITVLQMLQR--IIALMP--LG--------AAVVDTYRDVVY
MUL_4559|M.ulcerans_Agy99 QQASTEWTGITVAQMLQR--IVALMP--MG--------VAVVDSHRDVVY
Mvan_3503|M.vanbaalenii_PYR-1 GDADIDGTHSLVGQVPILSTDGEVLAVASVSEGYPSTWALLTRAGEGLLV
Mflv_3003|M.gilvum_PYR-GCK GDTDIDGTHSLVGQVPILSTDGEVLAIASVSEAYPSVWGLLSGAGESLLV
MSMEG_4211|M.smegmatis_MC2_155 GDTDIDGQHSLVGQVPILAPSGEPLAIVSVSQRYPSVWELLSGSGERLLI
MAV_3405|M.avium_104 NALLTTDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPD
TH_0454|M.thermoresistible__bu GFALPFVPRGLEQIPPSPNDQDVVITVRRGDEVRSNSEVVLPELDADYAD
Mb3790c|M.bovis_AF2122/97 DLDGLGRYRVLAAPSRNGHDVIVTG--LSMGNVDATMLQMLIIFGIVTVI
Rv3764c|M.tuberculosis_H37Rv DLDGLGRYRVLAAPSRNGHDVIVTG--LSMGNVDATMLQMLIIFGIVTVI
MMAR_5316|M.marinum_M NLDGLGRYRVVSALSRRGDELIVTG--LSMSDVDATMIRMLIIFGIVTIV
MAB_0674|M.abscessus_ATCC_1997 SSDGGTEWRAVSRHDALG-GYTTVA--RDITDVRTTVRDLLWLQVAIGIA
MLBr_02440|M.leprae_Br4923 LNEQAKELGLVRDRQLDDQAWRAAQ--QALGGDD----------------
MUL_4559|M.ulcerans_Agy99 LNDRAKELGLVRDRQLDDQAWEAAQ--QALRGSD----------------
Mvan_3503|M.vanbaalenii_PYR-1 YLGLGAMLGLVASWLLSRRIKRHTRG-LEVAEIASLADHREALLHSIREG
Mflv_3003|M.gilvum_PYR-GCK YLGLGAALGLLASWLLSRRIKRQTGG-LEVAEIASLADHREALLHSIREG
MSMEG_4211|M.smegmatis_MC2_155 YLGIGAALGLLTSWLLSRRIKTHTRG-LDIAEIADLADHREALLHSIREG
MAV_3405|M.avium_104 DAVSGDDMRVSGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPV
TH_0454|M.thermoresistible__bu TYIDGVRYRVRTVQTPYPIRTTLAVG-ATYDDTIADTANLHRRVILICTL
.
Mb3790c|M.bovis_AF2122/97 ALVAATTAGIVIIKRALAPLR--RVAQTASEVVDLPLDRGEVKLPVRVPE
Rv3764c|M.tuberculosis_H37Rv ALVAATTAGIVIIKRALAPLR--RVAQTASEVVDLPLDRGEVKLPVRVPE
MMAR_5316|M.marinum_M ALVAATTAGAIIIRRALAPLR--RVAQTATEVVDLPLDRGEVELPVRVSE
MAB_0674|M.abscessus_ATCC_1997 VLTVLGVAGYWLVHRSLRPLA--EVEATAADIAAGHLDR-------RVPE
MLBr_02440|M.leprae_Br4923 ------------VEFDLLPGK--RPAAGRSGLSVHGHAR-----------
MUL_4559|M.ulcerans_Agy99 ------------VEFDLSPGK--RPG-GRSGLSVHGQAR-----------
Mvan_3503|M.vanbaalenii_PYR-1 VIAVNNDGGITLLNDSARTLLGVPDSAVGQGVDTVGIDPAVVSFLMSGED
Mflv_3003|M.gilvum_PYR-GCK VIAVNGSGEITLLNDGAQELLDVTGPAVGRPVDSVGIDPAVVSLLTPGQE
MSMEG_4211|M.smegmatis_MC2_155 VVAVNTDGSITVLNDSACELLGIGPDAVGRHVGAIGLEPAVVEFLLSGHD
MAV_3405|M.avium_104 IVAVAAGATYWLVRRSLKSVD--AIRARVADISASDLAER-----VPVPD
TH_0454|M.thermoresistible__bu AIGAATIAGWLLAAFAVRPFKQLAAQARSIDAGDEVPDVEIR--------
Mb3790c|M.bovis_AF2122/97 PDANPSTEVGQLGSALNRMLDHIAAALS-------ARQASETRVRQFVAD
Rv3764c|M.tuberculosis_H37Rv PDANPSTEVGQLGSALNRMLDHIAAALS-------ARQASETCVRQFVAD
MMAR_5316|M.marinum_M TDANPDTEVGQLGSALNRMLDHIAAALS-------TRQASETRVRQFVAD
MAB_0674|M.abscessus_ATCC_1997 --RDPRTEVGRLSLALNGMLAQIQRAVADSEKSAKAARTSEERMRRFITD
MLBr_02440|M.leprae_Br4923 ----------LLSEKDRRFAVVFVHDQS-------DYVRMEAARRDFVAN
MUL_4559|M.ulcerans_Agy99 ----------LLSEEDRRFTVVFAYDQS-------DYARMEATRRDFVAN
Mvan_3503|M.vanbaalenii_PYR-1 ----DGGDGDTVIATRTRVLALSRRATTS------GGRRIGTVTTMRDST
Mflv_3003|M.gilvum_PYR-GCK ----SESAMDTVIATRTRVLALSRRPATS------QGRRIGTVTTMRDST
MSMEG_4211|M.smegmatis_MC2_155 RTDETANESDVIIATRSRVLALNRRAASS------QGHRIGTVTTMRDST
MAV_3405|M.avium_104 ----GRDEIAALAVTMNEMLSRLEAGHR--------------AQQRFVGD
TH_0454|M.thermoresistible__bu ----GATEAVEIADAVKGMLQRIWKEQDR-------TKAALASARDFASA
: .
Mb3790c|M.bovis_AF2122/97 ASHELRTPLAAIRGYTELTQRIGDDPEAVAHAMSRVA--SETERITRLVE
Rv3764c|M.tuberculosis_H37Rv ASHELRTPLAAIRGYTELTQRIGDDPEAVAHAMSRVA--SETERITRLVE
MMAR_5316|M.marinum_M ASHELRTPLAAIRGYTELAQRMGDDRAAVAHAMSRVG--SETERITSLVE
MAB_0674|M.abscessus_ATCC_1997 ASHELRTPLTTIRGYAELYRQG--AATDTELVLGRIE--GESTRMGQLVE
MLBr_02440|M.leprae_Br4923 VSHELKTPVGAMALLAEALLASADDAETVSRFAEKVL--IEANRLGYMVA
MUL_4559|M.ulcerans_Agy99 VSHELKTPVGAMALLAEALLASADDSDTVRRFAEKVL--IEANRLGDMVA
Mvan_3503|M.vanbaalenii_PYR-1 ELAALQGQLSSHKSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVG
Mflv_3003|M.gilvum_PYR-GCK ELAALQGQLSSHKSVTDTLRAQAHEFANQLHTISGLVQLGEFDAVRDLVG
MSMEG_4211|M.smegmatis_MC2_155 ELAALQAQLSSHRSVTDTLRAQTHEFANQLHTISGLVQLGEYDAVRELVG
MAV_3405|M.avium_104 ASHELRSPLTTIISGLEVAEAHPELLDAELAVNTLLP---EAHRMRALID
TH_0454|M.thermoresistible__bu AAHELRTPLTAMRTNLEVLSTLDMPEEQRKEVLADVIR-----TQSRIEA
*: : : : : :
Mb3790c|M.bovis_AF2122/97 DLLLLARLD-SGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP
Rv3764c|M.tuberculosis_H37Rv DLLLLARLD-SGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP
MMAR_5316|M.marinum_M DLLLLARLD-SGRPLEREPVDMSRLAVDAVSDAHVAGPDQQWELDLPAEP
MAB_0674|M.abscessus_ATCC_1997 DLLLLARLD-AHRPMEQRLVDLLVLATDAVHDAKATAPERDVELEVFDGP
MLBr_02440|M.leprae_Br4923 ELIELSRLQGAERLPNVTDIDVDIIVSEAIARHKVAADTAAIEVRTDPPS
MUL_4559|M.ulcerans_Agy99 ELIELSRLQGAERLHNVTDVDVDTIVSEAISRHKVAADNAEIEVRTDSSS
Mvan_3503|M.vanbaalenii_PYR-1 TLTRRRAEISDAVTQHISDPAVAALLIAKTSLAAESGVSLLLDPRSHLNP
Mflv_3003|M.gilvum_PYR-GCK TLTRRRAEISDAVTQRISDPAVAALLIAKTSLAAESGVALDLDPASHLAA
MSMEG_4211|M.smegmatis_MC2_155 TLTRRRAEINDAVTQHVSDPAVAALLIAKTSLAAESGVALTLTDDSHLAA
MAV_3405|M.avium_104 DLLLLARADERNLLRRKE-----LVALDDLAEAEAARVRRDADCAVHTDI
TH_0454|M.thermoresistible__bu TLSALERLAQGELSTSDDHVPVDITELLDRAAHEAMRIYPDLEVSLVPAP
*
Mb3790c|M.bovis_AF2122/97 --VVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGP-THVVLQVI
Rv3764c|M.tuberculosis_H37Rv --VVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGP-THVVLQVI
MMAR_5316|M.marinum_M --VVVTGDAARLHQVVANLLANARIHTGPGAVVTTRLSSGP-THVVLEVI
MAB_0674|M.abscessus_ATCC_1997 GTPEVIGDELRLRQVLGNLVSNALGHT--TAAVRVRVGTEG-DDAVLEVI
MLBr_02440|M.leprae_Br4923 G-LRVLGDQTLLVTALANLVSNAIAYSPGGSLVSISRRRRG-DNIEIAVT
MUL_4559|M.ulcerans_Agy99 G-LHVLGDQTLLVTALANLVSNAIAYSSPGSPVSISRRKRG-DNVEIAVT
Mvan_3503|M.vanbaalenii_PYR-1 LDPAMATDVITLLGNLIDNAVDVSVG---AADARVTICIDDRDGLAISVL
Mflv_3003|M.gilvum_PYR-GCK LDPALATDVITLLGNLIDNAVDVSVG---STPARVTVGIDDRDGLSILVS
MSMEG_4211|M.smegmatis_MC2_155 LDPALATDVITLLGNLVDNAVEVSAGSVGSTAAHVSVRLDDSAGLLLEVS
MAV_3405|M.avium_104 RPARLLADPAAMTRMIRNLVDNAVRHAVSCVAIEVGSRDGT---AVLTVG
TH_0454|M.thermoresistible__bu T-VIIVGLPAGLRLAVDNAIANAVKHGGATRVQLSAVSSRE--GVEIAID
: : : : :. : :
Mb3790c|M.bovis_AF2122/97 DNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTI
Rv3764c|M.tuberculosis_H37Rv DNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTI
MMAR_5316|M.marinum_M DNGPGIPEAMQSEIFERFARGDTSRSRKGGSTGLGLAIVAAVVKAHNGTI
MAB_0674|M.abscessus_ATCC_1997 DRGPGMTKTDAERVFERFYRADSSRTRSSGGTGLGLSIVDALTAAHGGTV
MLBr_02440|M.leprae_Br4923 DRGIGIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSI
MUL_4559|M.ulcerans_Agy99 DRGIGIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSI
Mvan_3503|M.vanbaalenii_PYR-1 DTGPGVPEHLREAIFA---RGITSKPEVPGGRGIGLALVRLVTAQHGGTI
Mflv_3003|M.gilvum_PYR-GCK DTGPGVPEHLREAIFS---RGVTSKPDVPGGRGIGLALVRLVTAQHGGTV
MSMEG_4211|M.smegmatis_MC2_155 DSGPGVPEHLRETIFA---RGVTSKPDVPGGRGIGLALVRLVTAQHGGTV
MAV_3405|M.avium_104 DDGPGIPPAQRSRVFERFVRLDTDRARSGGGAGLGLAIVAEVVAAHGGTV
TH_0454|M.thermoresistible__bu DNGTGVPEEERERVFDRFTRGSTASHS---GSGLGLALVAQQAEIHGGTA
* * *:. . :* * . . *:**::* . *.*:
Mb3790c|M.bovis_AF2122/97 TVSSSPGY-TEFAVRLP--------LDGWQPLESSPR-------------
Rv3764c|M.tuberculosis_H37Rv TVSSSPGY-TEFAVRLP--------LDGWQPLESSPR-------------
MMAR_5316|M.marinum_M TVNSSPGR-TEFVVRLP--------LDAWQRSGVPPG-------------
MAB_0674|M.abscessus_ATCC_1997 TVHTAPGAGCRFEVRLPRADMTDDDADVDEPESATPDAAASEPKIVRASR
MLBr_02440|M.leprae_Br4923 GVWSKPGTGSTFTLSIPAAMPL--YQDNDEQSGQPRGCDMWLNRPQREEE
MUL_4559|M.ulcerans_Agy99 GVWSKPGTGSTFTLSIPTSS----APDDSDQPDQPRGRDARPNRSQREEE
Mvan_3503|M.vanbaalenii_PYR-1 EVSDGPGGGARFLVRLK---------AVSHHA------------------
Mflv_3003|M.gilvum_PYR-GCK EVADVPGGGARFEVRLK---------AATHA-------------------
MSMEG_4211|M.smegmatis_MC2_155 EVTDGPAGGASFVVRLP---------EVTVHA------------------
MAV_3405|M.avium_104 TIGDRPGGGTTLTVALP-----------QHPAQHSSR-------------
TH_0454|M.thermoresistible__bu SLEASPLGGARLVLRLP------------GPR------------------
: * : : :
Mb3790c|M.bovis_AF2122/97 -----------------------------------
Rv3764c|M.tuberculosis_H37Rv -----------------------------------
MMAR_5316|M.marinum_M -----------------------------------
MAB_0674|M.abscessus_ATCC_1997 SESAQP-----------------------------
MLBr_02440|M.leprae_Br4923 EFKSMTPAQAMMQSEVTRGNVNDKCPDCGGRGIAG
MUL_4559|M.ulcerans_Agy99 ---------------LSR-----------------
Mvan_3503|M.vanbaalenii_PYR-1 -----------------------------------
Mflv_3003|M.gilvum_PYR-GCK -----------------------------------
MSMEG_4211|M.smegmatis_MC2_155 -----------------------------------
MAV_3405|M.avium_104 -----------------------------------
TH_0454|M.thermoresistible__bu -----------------------------------