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SGRHRKPASSAKSVAKIAFTGAVIGGGGIALAGHAGAATDGEWDRVASCESGGNWAINTGNGYHGGLQFS PSTWSGHGGGEFAPAAYLATKEEQIAVAERVLASQGKGAWPTCGKVLSAATPRNVVDEPPAPAPVDPLGL NGVLPPPPAPLDPFAPPPPPPAPAPFDALAAPAPAPLPPAPETLPPAPVEQLAAPVPLPAPAPEAVPVDA MAAPAPLPPAPEALPPAPLDAPAPAQTVAFDAVAAPAPLPAPEALPPAPLPAPAPEAVPFDALSAPAPVE PIVAPIPVDAPPSAVVTAVNWDTAPAPAPGDPQMWSLGLDAPLQPAPVTPPLPAPAPETVAAPAPVVGVP AGQAGPVPAAPAEVPHLVSPDNPPPGTTVTPQGPQQSPNVTYLKEIWHAIQTQEISGSDALLALTQRPLT ANGGGPAPMAPVGAPAPAPEAPVQGAAAPLPAPAVPAPAPVLPPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1703 | - | - | 100% (466) | transglycosylase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3289 | - | 2e-24 | 45.27% (148) | hypothetical protein Mflv_3289 |
| M. gilvum PYR-GCK | Mflv_2619 | - | 5e-24 | 60.92% (87) | transglycosylase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0891c | rpfA | 4e-78 | 45.69% (418) | resuscitation-promoting factor RpfA |
| M. tuberculosis H37Rv | Rv0867c | rpfA | 8e-91 | 46.84% (427) | resuscitation-promoting factor RpfA |
| M. leprae Br4923 | MLBr_02151 | - | 6e-50 | 53.96% (202) | hypothetical protein MLBr_02151 |
| M. abscessus ATCC 19977 | MAB_0869c | - | 2e-83 | 45.01% (431) | resuscitation-promoting factor RpfA |
| M. marinum M | MMAR_4665 | rpfA | 1e-105 | 53.72% (430) | resuscitation-promoting factor RpfA |
| M. avium 104 | MAV_0996 | - | 2e-63 | 57.32% (239) | resuscitation-promoting factor RpfA |
| M. smegmatis MC2 155 | MSMEG_5700 | - | 1e-151 | 62.93% (499) | secreted protein |
| M. thermoresistible (build 8) | TH_0357 | - | 3e-25 | 55.77% (104) | PROBABLE RESUSCITATION-PROMOTING FACTOR RPFE |
| M. ulcerans Agy99 | MUL_0283 | rpfA | 2e-85 | 55.09% (334) | resuscitation-promoting factor RpfA |
| M. vanbaalenii PYR-1 | Mvan_5049 | - | 1e-176 | 70.23% (487) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0891c|M.bovis_AF2122/97 MSGRHRKPTT--SNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEWDQVA
Rv0867c|M.tuberculosis_H37Rv MSGRHRKPTT--SNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEWDQVA
MMAR_4665|M.marinum_M MSGRHRKPTT--SNVSVAKIAFTGAVLGGGGIALAGHAAAATDGEWDQVA
MUL_0283|M.ulcerans_Agy99 MSGRHRKPTT--SNVSVAKIAFTGAVLGGGGIALAGHAAAATDGEWDQVA
MLBr_02151|M.leprae_Br4923 MSESYRKLTT--SSIIVAKITFTGAMLDG-SIALAGQASPATDSEWDQVA
Mflv_1703|M.gilvum_PYR-GCK MSGRHRKPAS--SAKSVAKIAFTGAVIGGGGIALAGHAGAATDGEWDRVA
Mvan_5049|M.vanbaalenii_PYR-1 MSGRHRKPAP--SAVNVAKIAFTGAVIGGGGLALAGQAGAATDGEWDQVA
MSMEG_5700|M.smegmatis_MC2_155 MSGRHRKPTSSSSAKNVAKIAFTGAVLGGGGLGMAGQAMAATDGEWDQVA
MAV_0996|M.avium_104 -------------------------MLGGGAIAMAGQAAAATDGEWDQVA
MAB_0869c|M.abscessus_ATCC_199 MSGRHSKPSK--ASAKAAKVAVAGAGLVGGGLMMAATANAATDGEWDQVA
TH_0357|M.thermoresistible__bu -LKHIRKTLG---------LATFAGALAVAPIALAGTASADS-VNWDAIA
: : :*. * . : :** :*
Mb0891c|M.bovis_AF2122/97 RCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIAV
Rv0867c|M.tuberculosis_H37Rv RCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIAV
MMAR_4665|M.marinum_M RCESGGNWAINTGNGYYGGVQFAQSTWASHGGGEYAPSAQLASREEQIAV
MUL_0283|M.ulcerans_Agy99 RCESGGNWAINTGNGYYGGVQFAQSTWASHGGGEYAPSAQLASREEQIAV
MLBr_02151|M.leprae_Br4923 RCESGGNWSINTGNGYLGGLQFSQGTWASHGGGEYAPSAQLATREQQIAV
Mflv_1703|M.gilvum_PYR-GCK SCESGGNWAINTGNGYHGGLQFSPSTWSGHGGGEFAPAAYLATKEEQIAV
Mvan_5049|M.vanbaalenii_PYR-1 RCESGGNWAINTGNGYHGGLQFSPGTWSGHGGGEYAPAAYLATKEEQIAV
MSMEG_5700|M.smegmatis_MC2_155 RCESGGNWAINTGNGYHGGLQFSPSTWRAHGGTEFAPAAYMATKEEQIAV
MAV_0996|M.avium_104 RCESGGNWGINTGNGYHGGVQFSASTWAAHGGGEYAPSAELATREQQIAV
MAB_0869c|M.abscessus_ATCC_199 RCESGGNWAINTGNGYQGGLQFSPSTWINSGGGQYAPSAHLATKEQQIAV
TH_0357|M.thermoresistible__bu ACESGGNWSINTGNGYYGGLQFSLSTWRANGG---TGMPHQASRAEQIRV
*******.******* **:**: .** ** : . *:: :** *
Mb0891c|M.bovis_AF2122/97 GERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPAP
Rv0867c|M.tuberculosis_H37Rv GERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPAP
MMAR_4665|M.marinum_M AERVLATQGRGAWPVCGHGLSAATPRDV-PAPAALDAPLDAPGINGEPAP
MUL_0283|M.ulcerans_Agy99 AERVLATQGRGAWPVCGHGLSAATPRDV-PPPAALDAPLDAPGINGEPAP
MLBr_02151|M.leprae_Br4923 AERVLATQGSGAWPACGHGLSGPSLQEVLPAGMG------APWINGAPAP
Mflv_1703|M.gilvum_PYR-GCK AERVLASQGKGAWPTCGKVLSAATPRNVVDEPPA-PAPVDPLGLNGVLPP
Mvan_5049|M.vanbaalenii_PYR-1 AERVLASQGKGAWPSCGGPLSAATPRNVVAEP---PAPVDPVGLNGLLPP
MSMEG_5700|M.smegmatis_MC2_155 AERVLASQGKGAWPTCGRGLSGATPRNVVAEP-E-PAPLDAPGVNGELPP
MAV_0996|M.avium_104 AERVLATQGRGAWPVCGGPLSGPTPR---DVP-A-PAGLDAPGVNGVPQA
MAB_0869c|M.abscessus_ATCC_199 AEKVLAGQGRGAWPVCGRGLSGSTPRTAPAANITPAAHHEEQAAAEPAPA
TH_0357|M.thermoresistible__bu AENTLRSQGIGAWPTCGK-------RG-----------------------
.*..* ** **** ** :
Mb0891c|M.bovis_AF2122/97 LAPP----------------------------------------------
Rv0867c|M.tuberculosis_H37Rv LAPPPADPAPPVELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVAP
MMAR_4665|M.marinum_M LAPPPGDDVPP---------------------------------------
MUL_0283|M.ulcerans_Agy99 LAPPPGDDVPP---------------------------------------
MLBr_02151|M.leprae_Br4923 LAPPP---------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK PPAPLD--------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 P--PVD--------------------------------------------
MSMEG_5700|M.smegmatis_MC2_155 P-APVD--------------------------------------------
MAV_0996|M.avium_104 P-------------------------------------------------
MAB_0869c|M.abscessus_ATCC_199 PEPPAEGDEQ----------------------------------------
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 ----------------------------------PADLAP----PAP-AD
Rv0867c|M.tuberculosis_H37Rv PVELAVNDLPAPLGEPLPAAPADPAPPADLAPPAPADLAP----PAP-AD
MMAR_4665|M.marinum_M ----------------------------------PADPAP----PVELAA
MUL_0283|M.ulcerans_Agy99 ----------------------------------PADPAP----PVELAA
MLBr_02151|M.leprae_Br4923 ----------------------------------PAEPAP----PQPPAD
Mflv_1703|M.gilvum_PYR-GCK ----------------------------------PFAPPPPPPAPAPFDA
Mvan_5049|M.vanbaalenii_PYR-1 ----------------------------------PFAPPP---APAPVDA
MSMEG_5700|M.smegmatis_MC2_155 ----------------------------------MLAAPM----PAPEG-
MAV_0996|M.avium_104 ----------------------------------PADAPP----------
MAB_0869c|M.abscessus_ATCC_199 ---------------------------------FVAEAPEAPAIDEAPAP
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 LAPPAPADLAPP---VELAVN-------DLPAPLGEPLPA----APAE-L
Rv0867c|M.tuberculosis_H37Rv LAPPAPADLAPP---VELAVN-------DLPAPLGEPLPA----APAE-L
MMAR_4665|M.marinum_M NDVPAPADLPPAPEDLPPAPE-------DLAPPAPADLPP----APED-L
MUL_0283|M.ulcerans_Agy99 NDVPAPADLPPAPEDLPPAPE-------DLAPPAPADLPP----APED-L
MLBr_02151|M.leprae_Br4923 NFPPTPGDVPSP-----------------LARP-----------------
Mflv_1703|M.gilvum_PYR-GCK LAAPAPAPLPPAPETLPPAPVEQLAAPVPLPAPAPEAVPVDAMAAPAP-L
Mvan_5049|M.vanbaalenii_PYR-1 LAAPAP--LPPAPEALP-------------PAPAP-AAPFDAMSAPAP-L
MSMEG_5700|M.smegmatis_MC2_155 -LPPAPEALPPAPEALPPAP--------EAPAPAPEALPP----APEA-L
MAV_0996|M.avium_104 ---PAPVQLASFDRPAPP------------DAPAPDAPPP----APAD-L
MAB_0869c|M.abscessus_ATCC_199 EEAPAPEAQDVDFQSGPAPEE---------PAPAPEPAPVDEAQAPAPEL
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 AP-PADLAPASADLAPPAPADLAP--------------------------
Rv0867c|M.tuberculosis_H37Rv AP-PADLAPASADLAPPAPADLAP--------------------------
MMAR_4665|M.marinum_M PPAPQDLPPAPEDVAAPAPADLPPAPEDVAPPVELVGNDVPAPVDLPPAP
MUL_0283|M.ulcerans_Agy99 PPAPQDLPPAPEDVAAPAPADLP---------------------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK PPAPEALPPAPLDAPAPAQTVAFDAVAAPA----------PLP-APEALP
Mvan_5049|M.vanbaalenii_PYR-1 PPAPEALP------PAPAPAAPFDAMSAPA----------PLPPAPEALP
MSMEG_5700|M.smegmatis_MC2_155 PPAPEALPPAP-EAPAPAPEALPPAPEAPAPVAE------ALPPAPEALP
MAV_0996|M.avium_104 PPAPADLP------------------------------------------
MAB_0869c|M.abscessus_ATCC_199 IAAPAPEAPVVDEAPAPEEAPAPEAPAADD---------QVLPYELQSGP
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 ----PAPAELAPPAPAD--------------LAPPAAVNEQTAPGDQPAT
Rv0867c|M.tuberculosis_H37Rv ----PAPAELAPPAPAD--------------LAPPAAVNEQTAPGDQPAT
MMAR_4665|M.marinum_M EDLPPAPEDLAPPAPADL-------PPAPEDLAPPAPADLPPAPEDLAPP
MUL_0283|M.ulcerans_Agy99 ----------------------------------PAPADLPPAPEDLAP-
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK PAPLPAPAPEAVP------FDALSAPAPVEPIVAPIPVDAPP--SAVVTA
Mvan_5049|M.vanbaalenii_PYR-1 ----PAPVVDAAN------IAPLDAPLP-----PPAPVDAPPAQSAIIAA
MSMEG_5700|M.smegmatis_MC2_155 PAPEAPPAPEALPPAPEAQIVDASLQVPADVPPAPPVEPAPPAPVDAVAA
MAV_0996|M.avium_104 ----PAPPADATPPAP------------------PADAPAP---------
MAB_0869c|M.abscessus_ATCC_199 APAEPAPAPEPAP--------------------APAAAPEIPLPAGVPDA
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 -----------------------------------------APGGPVGLA
Rv0867c|M.tuberculosis_H37Rv -----------------------------------------APGGPVGLA
MMAR_4665|M.marinum_M -----------------------------------------APADLPPAP
MUL_0283|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK ---VNWDTAPAPAPGDPQMWSLGLDAPLQPAPVTP-----PLPAPAP---
Mvan_5049|M.vanbaalenii_PYR-1 ---ANWDTAPVPG-EHPQLWSLGVDAPLQPAPVLPP---APAPAPAP---
MSMEG_5700|M.smegmatis_MC2_155 PENQNWDQAPAPA-DQPQTWALHVGGPLPLDPVLPAPAPAPAPAPAPGAP
MAV_0996|M.avium_104 --------------------------------------------------
MAB_0869c|M.abscessus_ATCC_199 ----------------------------------------ADIGFAAGKA
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 TDLELPEPD--------------------------PQPADAPPPGDVTEA
Rv0867c|M.tuberculosis_H37Rv TDLELPEPD--------------------------PQPADAPPPGDVTEA
MMAR_4665|M.marinum_M EDLAPPAPADLPPAPEDL----------------PPAPEDLPPPADADNP
MUL_0283|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK ETVAAPAPVVGVPAGQAG-PVPA-------------APAEVPHLVSPDNP
Mvan_5049|M.vanbaalenii_PYR-1 AAVAAPAPDPLAPLGAVEVPAPAYDIANQAISGELPVPSEVPHLASPDNL
MSMEG_5700|M.smegmatis_MC2_155 AAVAAPAPDPLAPAPNADVAPTP--------------PEGVPHLASPENL
MAV_0996|M.avium_104 --------------------------------------DGDFHGFVPAGM
MAB_0869c|M.abscessus_ATCC_199 AFDAGPVASNGIPTSPEA------------------VAGVVRHLPDPNNL
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 PAETPQVS--------NIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG-
Rv0867c|M.tuberculosis_H37Rv PAETPQVS--------NIAYTKKLWQAIRAQDVCGNDALDSLAQPYVIG-
MMAR_4665|M.marinum_M PVDVHEAS--------TVAYTKKLWQAIVGQNISGNDALDALAQPTVFA-
MUL_0283|M.ulcerans_Agy99 PVDVHEAS--------TVAYTKKLWQAIVGQNISGNDALDALAQPAVFA-
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK PPGTTVTP-QGPQQSPNVTYLKEIWHAIQTQEISGSDALLALTQRPLTAN
Mvan_5049|M.vanbaalenii_PYR-1 PPGTAMAP-QGPRQSPNVTYLKEIWHAIQTQEISGADALLALTQRPLTTP
MSMEG_5700|M.smegmatis_MC2_155 PPGTTETPDQIPGQGPNMTYLREIWHAIQTQDISGKDALLALTQRPLTTP
MAV_0996|M.avium_104 PDHVSEAG-----------YTQRLWEAIRAQDVQGNDALDALVQ------
MAB_0869c|M.abscessus_ATCC_199 PPGTTDVA---PGDSRGVSYLKDIVFAMQTQDVKASDAILALAQR-----
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 --------------------------------------------------
Rv0867c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4665|M.marinum_M --------------------------------------------------
MUL_0283|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02151|M.leprae_Br4923 --------------------------------------------------
Mflv_1703|M.gilvum_PYR-GCK G--GGPAP---MAPV---GAPAPAPEAPVQGAAAPLPAPA-------VPA
Mvan_5049|M.vanbaalenii_PYR-1 DTPGGTPP---IAP----GAPG-APVAPLAG-PAPAPAP--------VPA
MSMEG_5700|M.smegmatis_MC2_155 DVPGGAAPNRPVAPPPAPGDPALAPAPAPLGAPAPAPAPEPAPVGAPAPV
MAV_0996|M.avium_104 ----------------------------------PAPSA-----------
MAB_0869c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0357|M.thermoresistible__bu --------------------------------------------------
Mb0891c|M.bovis_AF2122/97 --------
Rv0867c|M.tuberculosis_H37Rv --------
MMAR_4665|M.marinum_M --------
MUL_0283|M.ulcerans_Agy99 --------
MLBr_02151|M.leprae_Br4923 --------
Mflv_1703|M.gilvum_PYR-GCK PAPVLPPA
Mvan_5049|M.vanbaalenii_PYR-1 PAPVLPPA
MSMEG_5700|M.smegmatis_MC2_155 GAPVPPPA
MAV_0996|M.avium_104 --------
MAB_0869c|M.abscessus_ATCC_199 --------
TH_0357|M.thermoresistible__bu --------