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VMRTLHIGDDGWPLMGEVIGRGELIIMLHGGGPDHYSMRPLTTRLAGRYRVALPDIRGYGASRCPDPTLH LWDQYVTDTVAIMHALDATSAHLVGAGLGGTIALRTCLQHPRIARPAVIISAEAIEDDADKAADAKLMDR FADRARSRGLQAAWELCVPHLQPLIANLVTEAIPRADAQSAAAAAVIGHDRAFATVEELRRIDTPTLIIA GDDPRHPAQLARTLADVLAHGVLAEATMSDLLDNAEDLARACAPEIEQFLATTSDPDT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2846 | - | - | 100% (269) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_0909 | - | e-134 | 87.59% (266) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_1348 | - | 1e-11 | 27.59% (261) | 3-oxoadipate enol-lactonase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 2e-09 | 26.56% (128) | hydrolase |
| M. tuberculosis H37Rv | Rv2715 | - | 2e-09 | 26.56% (128) | hydrolase |
| M. leprae Br4923 | MLBr_02297 | - | 1e-08 | 36.36% (99) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1169 | - | 9e-10 | 27.14% (199) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5158 | ephE | 2e-09 | 38.38% (99) | epoxide hydrolase EphE |
| M. avium 104 | MAV_2517 | - | 9e-10 | 32.85% (137) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 3e-12 | 27.38% (252) | 3-oxoadipate enol-lactonase |
| M. thermoresistible (build 8) | TH_0963 | ephE | 4e-10 | 37.62% (101) | POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4244 | ephE | 1e-09 | 38.38% (99) | epoxide hydrolase EphE |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 2e-09 | 33.33% (105) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 ------MTERKRNLRPVRDVAPPTLQFRTVHGYR------RAFRIAGSGP
Rv2715|M.tuberculosis_H37Rv ------MTERKRNLRPVRDVAPPTLQFRTVHGYR------RAFRIAGSGP
Mvan_2912|M.vanbaalenii_PYR-1 ------MHD--------------DVKYLDLHGDR------VAYREAGQGP
MMAR_5158|M.marinum_M MPAPDPSITRIDGPWRHLDIHANGIRFHVVEAIP---AGQRDNAPSTTQP
MUL_4244|M.ulcerans_Agy99 MPAPDPSITRIDGPWRHLDIHANGIRFHVVEAVP---AGQRDNAPSTTQP
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATARP
TH_0963|M.thermoresistible__bu MPPPDPSVTRIDGPWRHHEVHANGIRFHVVEAEP---DEADRRIPRTERP
MAV_2517|M.avium_104 -----------------MTTSNMADHAVTVNGKS------IFFAEKGTGA
MSMEG_1897|M.smegmatis_MC2_155 --------------------MSSVAVHHVVTGRS-------------DGP
Mflv_2846|M.gilvum_PYR-GCK --------------------MVMRTLHIGDDGWP------LMGEVIGRGE
MAB_1169|M.abscessus_ATCC_1997 ----MSKAEVREIGVSETGFVRRPDPDGAAVAYR------TYGRSRPGVV
.
Mb2734|M.bovis_AF2122/97 AILLIHGIGDNSTTWNGVHAK---LAQRFTVIAPDLLGHGQSDK--PRAD
Rv2715|M.tuberculosis_H37Rv AILLIHGIGDNSTTWNGVHAK---LAQRFTVIAPDLLGHGQSDK--PRAD
Mvan_2912|M.vanbaalenii_PYR-1 AVLLIHGMGGSSLTWKALLPH---LATRYRVIAPDLLGHGQSDK--PRGD
MMAR_5158|M.marinum_M LVMLLHGFGSFWWSWRHQLR----GLTGARVVAVDLRGYGGSDK--PPRG
MUL_4244|M.ulcerans_Agy99 LVMLLHGFGSFWWSWRHQLR----GLTGARVVAVDLRGYGGSDK--PPRG
MLBr_02297|M.leprae_Br4923 LVMLLHGFGSFWWSWRHQLR----GLTEARLVAVDLRGYGGSDK--PPRG
TH_0963|M.thermoresistible__bu LVILLHGFGSFWYSWRHQLTGLT-GLTGARVVAVDLRGYGGSDK--PPRG
MAV_2517|M.avium_104 PVLLLHGGGPGASGVSNYSRNIDPLAEKFRVIVPDMPGYGRSAKG-VDQS
MSMEG_1897|M.smegmatis_MC2_155 AVVFSNSLGSTHRMWDPQLAA---FEERFRVVRYDTRGHGQSPV--PEGP
Mflv_2846|M.gilvum_PYR-GCK LIIMLHGGGPDHYSMRPLTTR---LAGRYRVALPDIRGYGASRCP-DPTL
MAB_1169|M.abscessus_ATCC_1997 DVVLVHGSLQNSAVWSKHGYIAQ-LSQQYRVTTIDVRGHGASEKPDHPGG
::: :. : * *:* *
Mb2734|M.bovis_AF2122/97 YSVAAYANGMRDLLSVLDIERVTIVGHSLGGGVAMQFAYQFPQLVDRLIL
Rv2715|M.tuberculosis_H37Rv YSVAAYANGMRDLLSVLDIERVTIVGHSLGGGVAMQFAYQFPQLVDRLIL
Mvan_2912|M.vanbaalenii_PYR-1 YSLGAFAVWLRDLLDLLGIARVTLVGHSLGGGVAMQFVHQHPDYCERLVL
MMAR_5158|M.marinum_M YDGWTLAGDTAGLIRALGHSSATLVGHADGGLACWTTALLHPRLVRAIAL
MUL_4244|M.ulcerans_Agy99 YDGWTLAGDTAGLIRALGHSSATLVGHADGGLACWTTALLHPRLVRAIAL
MLBr_02297|M.leprae_Br4923 YDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATALLHPRLVRAIAL
TH_0963|M.thermoresistible__bu YDGWTLAGDTAGLVRALGHPRAALVGHADGGLVCWATAVLHPRVVRSIAL
MAV_2517|M.avium_104 DPFGYLADTMRGLLDELGIDSAHLVGNSYGGSCALRLALDNPRRVGKLVL
MSMEG_1897|M.smegmatis_MC2_155 YTIDDLADDVVALLDTLGIERAHVVGLSLGGMTAMRLSARNPQRVDRIAL
Mflv_2846|M.gilvum_PYR-GCK HLWDQYVTDTVAIMHALDATSAHLVGAGLGGTIALRTCLQHPRIARPAVI
MAB_1169|M.abscessus_ATCC_1997 YAIASSARDVCAVLDHLQVHQAHYLGYSLGGRIGLTLAATAPERLTSLVV
. :: * . :* . ** * :
Mb2734|M.bovis_AF2122/97 VSAGGVTKDVNIVFRLASLPMGSEAMALLRLPLVLPAVQIAG-------R
Rv2715|M.tuberculosis_H37Rv VSAGGVTKDVNIVFRLASLPMGSEAMALLRLPLVLPAVQIAG-------R
Mvan_2912|M.vanbaalenii_PYR-1 ISSGGLGPELGRSLRLLSTPG----IELLLPVAAAPSVVAVG-------E
MMAR_5158|M.marinum_M ISSPHPAALRRSTLTRRDQGRALLPTLLRYQVPLWPERLLTRDNAEEIER
MUL_4244|M.ulcerans_Agy99 ISSPHPAALRRSTLTRRDQGRALLPTLLRYQVPLWPERLLTRDNAEEIER
MLBr_02297|M.leprae_Br4923 INSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNNAAEIER
TH_0963|M.thermoresistible__bu VSSPHPAALRASALSNRAQARALLPSLLSYQLPRWPERMLTKDDGARLER
MAV_2517|M.avium_104 MGPGGIGTTRG-------LPTAGLNSLLAYYGGRGPSRDKLE-------A
MSMEG_1897|M.smegmatis_MC2_155 LCTATHLPPSS--------AWTERAAAVRTHGSAAVAESVVG-------R
Mflv_2846|M.gilvum_PYR-GCK ISAEAIEDDAD---------KAADAKLMDRFADRARS-------------
MAB_1169|M.abscessus_ATCC_1997 AGSSHRP------------QRGAVDVLIFPNAIRVVEESGLP-------A
. :
Mb2734|M.bovis_AF2122/97 IVGKAIGTTSLG-HDLPN---VLRILDDLPEPTASAAFGRTLRAVVDWRG
Rv2715|M.tuberculosis_H37Rv IVGKAIGTTSLG-HDLPN---VLRILDDLPEPTASAAFGRTLRAVVDWRG
Mvan_2912|M.vanbaalenii_PYR-1 RVRSWLGARGLASPEVGE---TWNAYASLSDPQTRTAFLRTLRSVVDAQG
MMAR_5158|M.marinum_M LIRSRTSAKWAASEDFSQSIGYLRRAIQIPAAAHCALEYQRWAVRSQLRG
MUL_4244|M.ulcerans_Agy99 LIRSRTSAKWAASEDFSQSIGYLRRAIQIPAAAHCALEYQRWAVRSQLRR
MLBr_02297|M.leprae_Br4923 LVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAVRSQLRN
TH_0963|M.thermoresistible__bu LVRSRAGAQWPATQDFATTVGHLRRAIQIPSAAHSALEYQRWAVRSQLRS
MAV_2517|M.avium_104 FIRNYLVYDGASVPDELID---LRYQASVDPEVVADPPLRRPSGPMALRT
MSMEG_1897|M.smegmatis_MC2_155 WFTPGFLAADPG-----------RKAAYQQMIAATPAEGYAGCCEAIAAL
Mflv_2846|M.gilvum_PYR-GCK --RGLQAAWELCVPHLQP-----LIANLVTEAIPRADAQSAAAAAVIGHD
MAB_1169|M.abscessus_ATCC_1997 FIDGWESHRGQR------------MASGFRATIEALGQRGLAALLRQWDD
Mb2734|M.bovis_AF2122/97 QMVTMLDRCY--LTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGSQLEIF
Rv2715|M.tuberculosis_H37Rv QMVTMLDRCY--LTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGSQLEIF
Mvan_2912|M.vanbaalenii_PYR-1 QAVSALNRLH--FTLGLPTLLIWGDQDRLIPPAHGEAAHAALPGSRLVIL
MMAR_5158|M.marinum_M EGHRFMRSMN--QRPGVPILHLRGDADPYVLAAPVERTQRYAPHGRYVSV
MUL_4244|M.ulcerans_Agy99 EGHRFMRSMN--QRPGVPILHLRGDADPYVLAAPVERTQRYAPHGRYVSV
MLBr_02297|M.leprae_Br4923 EGRKFMKSMS--RPFSVPLLHVRGDADPYLLADSVDRTRRYAPHGRYVSV
TH_0963|M.thermoresistible__bu EGHRFMRLMT--RPVRVPVLHLHGESDPYVLADPVHRTQRHAPHGRYVSV
MAV_2517|M.avium_104 LWRMDLARDRRLKRLRTPTLVLWGRDDKVNRPAGGPMLLNLMPNAELVMT
MSMEG_1897|M.smegmatis_MC2_155 DLRADLARIT------APTLAIAGTDDPATPPDRLAEITAAVRGARLVQV
Mflv_2846|M.gilvum_PYR-GCK RAFATVEELR---RIDTPTLIIAG-DDPRHPAQLARTLADVLAHGVLAEA
MAB_1169|M.abscessus_ATCC_1997 EPGVTEEALL---QIETPTLFFAGSEDPMRLAE-SREAAVRMPRAYFALL
* . * * .
Mb2734|M.bovis_AF2122/97 EGSGHFP-FHDDPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATV
Rv2715|M.tuberculosis_H37Rv EGSGHFP-FHDDPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATV
Mvan_2912|M.vanbaalenii_PYR-1 PAVGHFP-QVEAPLAVADTLDDFIANSSP------------WHGPPRHAD
MMAR_5158|M.marinum_M AGVGHYS-HEEAPEEINRHLMRFFEQTRDARLS-----------------
MUL_4244|M.ulcerans_Agy99 AGVGHYS-HEEAPEEINRHLMRFFEQTRDARLS-----------------
MLBr_02297|M.leprae_Br4923 SDAGHFS-HEEAPEEINRYLTRFLKQVHGPRLS-----------------
TH_0963|M.thermoresistible__bu PGAGHFA-HEEAPAVVNEELGRFLTGRTGR--------------------
MAV_2517|M.avium_104 SRTGHWV-QWERADLFNKLVTEFLHNTSVFAQ------------------
MSMEG_1897|M.smegmatis_MC2_155 TPGAHLA-NVEQADAITPTLLEHLGTEQS---------------------
Mflv_2846|M.gilvum_PYR-GCK TMSDLLDNAEDLARACAPEIEQFLATTSDPDT------------------
MAB_1169|M.abscessus_ATCC_1997 EGCNHGQ-TVTMRERILDRAEAFFRLSEFSDIEKLRVAG-----------
.:
Mb2734|M.bovis_AF2122/97 TGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv TGSADTRVAVLNAIGSNERSAT
Mvan_2912|M.vanbaalenii_PYR-1 HAEAD-----------------
MMAR_5158|M.marinum_M ----------------------
MUL_4244|M.ulcerans_Agy99 ----------------------
MLBr_02297|M.leprae_Br4923 ----------------------
TH_0963|M.thermoresistible__bu ----------------------
MAV_2517|M.avium_104 ----------------------
MSMEG_1897|M.smegmatis_MC2_155 ----------------------
Mflv_2846|M.gilvum_PYR-GCK ----------------------
MAB_1169|M.abscessus_ATCC_1997 ----------------------