For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MGRVQGKVAFITGAARGQGRSHAVRLAEEGADIIAVDLCENVDTIGYPMATAEDLEETAAFVEKTGQRIV TAKADVRDAAQLKKALEDGIAQLGGVDIVVAQAGIAGMKGNPPMQAWTDVINTNLVGTINAIQVALPHLK EGAAIVATGSTAALMDAHNKPNPGNDPGGMAYMTSKRLLSQYVHDLATELAVRGIRANVVHPTNCNTDML QSPPMYKSFRPDLENPTRADAEPVFGVQQAMKVNFIEPEDISNAILWLVSDEARYVTGMQLRVDAGGYLK WYDYHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4158 | - | - | 100% (286) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2006 | - | 3e-81 | 52.50% (280) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4222 | - | 9e-63 | 44.56% (285) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 3e-56 | 44.57% (276) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2500 | - | 1e-142 | 85.61% (285) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2750 | - | 3e-56 | 44.57% (276) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-11 | 30.43% (207) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3081 | - | 2e-56 | 43.77% (281) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 7e-61 | 47.55% (286) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2946 | - | 6e-87 | 57.24% (283) | carveol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4801 | - | 1e-137 | 82.39% (284) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_4131 | - | 1e-139 | 82.46% (285) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3392 | fabG | 1e-55 | 44.24% (278) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4754|M.marinum_M --------------------------------------------------
Mvan_4158|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2500|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4801|M.smegmatis_MC2_155 --------------------------------------------------
TH_4131|M.thermoresistible__bu --------------------------------------------------
MAV_2946|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb2771|M.bovis_AF2122/97 ----------------MIDR----PLEGKVAFITGAARGLGRAHAVRLAA
Rv2750|M.tuberculosis_H37Rv ----------------MIDR----PLEGKVAFITGAARGLGRAHAVRLAA
MUL_3392|M.ulcerans_Agy99 -------------MSRPLDG----PLSGRVAFITGAARGQGRAHALRLAR
MAB_3081|M.abscessus_ATCC_1997 ------------------MG----KLDGKVAFITGAARGQGRAHAIKLAS
MMAR_4754|M.marinum_M -------------MTEQLGG----RVAGKVAFITGAARGQGRSHAVRLAQ
Mvan_4158|M.vanbaalenii_PYR-1 ------------------MG----RVQGKVAFITGAARGQGRSHAVRLAE
Mflv_2500|M.gilvum_PYR-GCK ------------------MG----RVQGKVAFITGAARGQGRSHAVRLAE
MSMEG_4801|M.smegmatis_MC2_155 ------------------MGSAEGRVAGKVAFITGAARGQGRSHAVRLAE
TH_4131|M.thermoresistible__bu ------------------VG----RVEGKVAFITGAARGQGRSHAVRLAE
MAV_2946|M.avium_104 ------------------MG----RVTGKVAVISGAARGQGRSHARMLAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. . :. ::**. * ** * **
Mb2771|M.bovis_AF2122/97 DGANIIAVDICEQIAS-VPYPLSTADDLAATVELVEDAGGGIVARQGDVR
Rv2750|M.tuberculosis_H37Rv DGANIIAVDICEQIAS-VPYPLSTADDLAATVELVEDAGGGIVARQGDVR
MUL_3392|M.ulcerans_Agy99 DGADVIAVDLCDQIAS-VPYPLGTAEELATTVKLVEDTGARIVASQADVR
MAB_3081|M.abscessus_ATCC_1997 EGASIIAVDICAQIPS-VEYPMATTEDLDLTVKEVDALGRAISAHETDVR
MMAR_4754|M.marinum_M EGADIIAVDVCKPIVENTTIPASTPEDLAETADLVKGHNRRIFTAEADVR
Mvan_4158|M.vanbaalenii_PYR-1 EGADIIAVDLCENVDT-IGYPMATAEDLEETAAFVEKTGQRIVTAKADVR
Mflv_2500|M.gilvum_PYR-GCK EGADIIAVDICRDYDT-VGYRMATPEDLEETKNFVEKTGQRIVTAQADVR
MSMEG_4801|M.smegmatis_MC2_155 EGADIIAVDLCQDIDS-IGYSLATPEDLEETARYVEKAGRRIVTAQADVR
TH_4131|M.thermoresistible__bu EGADIIAVDICADIET-IGYSMAKPEDLEETAKLVEKTGRGVYTAQADVR
MAV_2946|M.avium_104 EGADIIAVDLCADIET-NEYPLARPEDLDETARLVEKEGQRAITAVADVR
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAK-------------NTAAQIVASGGVAYAYALDVS
**.::. *: * : . : **
Mb2771|M.bovis_AF2122/97 DRASLSVALQAGLDEFGRLDIVVANAGI----AMMQ--AGDDGWRDVIDV
Rv2750|M.tuberculosis_H37Rv DRASLSVALQAGLDEFGRLDIVVANAGI----AMMQ--AGDDGWRDVIDV
MUL_3392|M.ulcerans_Agy99 DREALAAALQAGIDELGQVDIVVANAGI----APMQ--SGDDGWRDVIDV
MAB_3081|M.abscessus_ATCC_1997 DREALQAAFDAGVHDLGPVDIVVANAGI----ATLTPECGDDGWRDVLDV
MMAR_4754|M.marinum_M DYDALKAAVDAGVDELGRLDIIVANAGIGNGGATLD-KTSEHDWQEMIDV
Mvan_4158|M.vanbaalenii_PYR-1 DAAQLKKALEDGIAQLGGVDIVVAQAGI----AGMKGNPPMQAWTDVINT
Mflv_2500|M.gilvum_PYR-GCK NEAELRAALEAGLAEFGKVDIVVAQAGI----AAMKGQPAMQAWTDGINT
MSMEG_4801|M.smegmatis_MC2_155 DAAQLKEALERGVSELGKLDIVVAQAGI----AAMKGNPPLQAWTDGINT
TH_4131|M.thermoresistible__bu NADQLRTALEGGLKEFGKVDIVVAQAGV----AGMKGQPPLQAWTDVMNT
MAV_2946|M.avium_104 DRVVLSAAIDAGVAEFGHLDIVVANAGI----CPLTAGLPPQAFADAVDV
MLBr_00862|M.leprae_Br4923 DAAAVEAFAEQVSAKHGVPDIVVNNAGIG--QAGRFLDTPPEEFDRVLAV
: : : . * **:* :**: . . : : .
Mb2771|M.bovis_AF2122/97 NLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGIG--------SSDP
Rv2750|M.tuberculosis_H37Rv NLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGIG--------SSDP
MUL_3392|M.ulcerans_Agy99 NLSGAYYTVEVAIPTMIEQGRGGSIVLISSAAGLVGIS--------SADA
MAB_3081|M.abscessus_ATCC_1997 NLTGVYHTIEVARPSMVQRGAGGSIVLTSSVAGLTGMV--------MDNP
MMAR_4754|M.marinum_M NLSGVWKSVKAAVPHLIAGGNGGSIVLTSSVGGMKAYP--------HCG-
Mvan_4158|M.vanbaalenii_PYR-1 NLVGTINAIQVALPHLK---EGAAIVATGSTAALMDAHNKPNPGN---DP
Mflv_2500|M.gilvum_PYR-GCK NFVGTINAIQVALPHLK---EGASIIATASAAALMDAHNKPNPGG---DP
MSMEG_4801|M.smegmatis_MC2_155 NLVGTINAIQVALPHLS---EGASIVATASAAALMDAHNKPNPGA---DP
TH_4131|M.thermoresistible__bu NLVGTMNAIQVALPHLK---EGASIIATASAAALMDAHQKPNPGA---DP
MAV_2946|M.avium_104 DLGGVLNLVHASLKHLR---AGASIIVIGSNAAFMSSLNTSGAGSGIGGP
MLBr_00862|M.leprae_Br4923 NLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQS-----------
:: *. .. : *. *: .* ..
Mb2771|M.bovis_AF2122/97 GSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQ
Rv2750|M.tuberculosis_H37Rv GSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQ
MUL_3392|M.ulcerans_Agy99 GAIGYVASKHALVGLMRVYANLLAPHSIRVNSLHPSGVDPPMINNEFIRH
MAB_3081|M.abscessus_ATCC_1997 GGLAYTAAKHGLVGLMRSYANMLAPHNIRVNTIHPSGVATPMLINPVTEK
MMAR_4754|M.marinum_M ---NYVAAKHGVVGLMRSFAVELGQHMIRVNSVHPTHVRTPMLHNEGTFK
Mvan_4158|M.vanbaalenii_PYR-1 GGMAYMTSKRLLSQYVHDLATELAVRGIRANVVHPTNCNTDMLQSPPMYK
Mflv_2500|M.gilvum_PYR-GCK GGMGYMISKRLISEYVHALATELAVRGIRANVIHPTNCNTDMLQSEPMYR
MSMEG_4801|M.smegmatis_MC2_155 GGMGYMVSKRMISEYVHYLATELTPLGIRANVIHPTNCNTDMLQSEPMYR
TH_4131|M.thermoresistible__bu GGMAYMSSKRLLAQYVHDLATELAVRGIRANVIHPTNCNTDMLQSEPMYR
MAV_2946|M.avium_104 GGAGYAFAKLAAAHYVNDFALALAPFSIRMNAVHPTNVNTDMLHSPPMYR
MLBr_00862|M.leprae_Br4923 -LSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDT
* :* * : . : * . :: .
Mb2771|M.bovis_AF2122/97 WLT--TADMDAPHNLG------NALPVELVQ---PTDIANAVAWLASEEA
Rv2750|M.tuberculosis_H37Rv WLT--TADMDAPHNLG------NALPVELVQ---PTDIANAVAWLASEEA
MUL_3392|M.ulcerans_Agy99 WLADLVAETGSGPGAG------NALPVQILQ---ADDIAGALAWLVSDEA
MAB_3081|M.abscessus_ATCC_1997 LFAD--GSPEGMSDTG------NALPVVLME---PEDMANTVAWLVSEDA
MMAR_4754|M.marinum_M MFRP-DLENPGPDDMAPICQLFHTLPIPWVE---AEDISNAVLFLASDES
Mvan_4158|M.vanbaalenii_PYR-1 SFRP-DLENPTRADAEPVFGVQQAMKVNFIE---PEDISNAILWLVSDEA
Mflv_2500|M.gilvum_PYR-GCK SFRP-DLENPTRADAEPVFGVQQAMKVNFIE---PEDISNAVLWLASDES
MSMEG_4801|M.smegmatis_MC2_155 SFRP-DLEHPTRADAEPVFYVQQAMKVPWVE---PSDISNAVLWLASDES
TH_4131|M.thermoresistible__bu SFRP-DLENPTRADAEPVFGVQQAMRVPYVE---PEDISNAVLWLASEEA
MAV_2946|M.avium_104 AFRP-DLPAPTREDAEPVFPLVQAMPVPYVE---PEDISEAVLFLASDAA
MLBr_00862|M.leprae_Br4923 PTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEA
. : . .: :
Mb2771|M.bovis_AF2122/97 RYVTGVTLPVDAGFVNKR------
Rv2750|M.tuberculosis_H37Rv RYVTGVTLPVDAGFVNKR------
MUL_3392|M.ulcerans_Agy99 RYITGVALPVDAGCVNKR------
MAB_3081|M.abscessus_ATCC_1997 RYITGVALPVDAGFTNRR------
MMAR_4754|M.marinum_M RYITGVTLPVDAGGCLK-------
Mvan_4158|M.vanbaalenii_PYR-1 RYVTGMQLRVDAGGYLKWYDYHA-
Mflv_2500|M.gilvum_PYR-GCK RYVTGMQLRVDAGGYLKWYDYHV-
MSMEG_4801|M.smegmatis_MC2_155 RFVTGMQLRVDAGGYLKWYDYHV-
TH_4131|M.thermoresistible__bu RYVTGMQLRVDAGGYLKWYDYHV-
MAV_2946|M.avium_104 RYITGQQLRVDAGGFLKVKPWSGG
MLBr_00862|M.leprae_Br4923 YALYGISRVLPQVLRSTARIRVI-
: * :