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M. gilvum PYR-GCK Mflv_0345 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 346152 - 347321
length: 389

VADTAGEWVFSDEQNQLRAAVRAFCADHVDESSVRAAMESDPPFDAKVWSRLGSELGVLGMAVPESAGGA
GGNLVDQAVAVEQLGAALACGPLFGTVYLAIPALVAASGGQELLGPLVDGTRTAAFAVRDDAGAFDASSV
EVQAVPTEQGWALSGTVERVVDAGAADVLLVAATTPDGVGLFVVEADSLGVQRIRLTTLDLTRPQATVGL
LDAPAQLIAGPEEAERVITHALQVGAALLAVEQVGAAQHLLDLSVDYAKNRLQFGRPIGSFQAVKHRLAD
DLVAVEHARSTAYHAVWALSDGSDDPALAVSIAQATTSAAFVRVATDTIQVHGGIGFTWEHQAHLYYKRA
YTDAALLGGAEEHRARVADFVLVVAPEKDAPRVATGMPS

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_0345 - - 100% (389) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_2335 - 2e-56 39.17% (360) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1460 - 5e-46 38.08% (365) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1968c fadE18 6e-57 39.18% (365) acyl-CoA dehydrogenase FADE18
M. tuberculosis H37Rv Rv1933c fadE18 6e-57 39.18% (365) acyl-CoA dehydrogenase FADE18
M. leprae Br4923 MLBr_00737 fadE25 9e-23 25.21% (353) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_3123 - 5e-79 44.86% (370) putative acyl-CoA dehydrogenase
M. marinum M MMAR_1954 fadE18_1 4e-65 41.85% (368) acyl-CoA dehydrogenase FadE18_1
M. avium 104 MAV_1838 - 2e-65 40.11% (369) acyl-CoA dehydrogenase protein
M. smegmatis MC2 155 MSMEG_6585 - 1e-150 72.34% (394) acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_0804 - 1e-143 70.13% (385) acyl-CoA dehydrogenase
M. ulcerans Agy99 MUL_2176 fadE18_1 2e-65 41.85% (368) acyl-CoA dehydrogenase FadE18_1
M. vanbaalenii PYR-1 Mvan_0393 - 0.0 82.05% (390) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1968c|M.bovis_AF2122/97           --------------------------------------MDFRYSTEQDDF
Rv1933c|M.tuberculosis_H37Rv        --------------------------------------MDFRYSTEQDDF
Mflv_0345|M.gilvum_PYR-GCK          --------------------------------MADTAG-EWVFSDEQNQL
Mvan_0393|M.vanbaalenii_PYR-1       --------------------------------MADSQGAEYVFTEEQGQL
MSMEG_6585|M.smegmatis_MC2_155      MAEELVDQPDKVAEELVDQPDKVAEELVDQPDKVAETT-EFRFTDEQGQL
TH_0804|M.thermoresistible__bu      -----------VAEELAEQPDNAAEELAEQPDNAAGLSPTFTFTEEQQQL
MMAR_1954|M.marinum_M               -----------------------------------MSTGDLLYSDTEEAL
MUL_2176|M.ulcerans_Agy99           -----------------------------------MSTGDLLYSDTEEAL
MAV_1838|M.avium_104                -----------------------------------MTG---LSLDESREL
MAB_3123|M.abscessus_ATCC_1997      -------MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDL
MLBr_00737|M.leprae_Br4923          ----------------------------MVGWSGNPLFDLFKLPEEHNEL
                                                                                     :

Mb1968c|M.bovis_AF2122/97           RASLRGFLGRGAPVREMAAADGS--------DRRLWQRLCTELELPALHV
Rv1933c|M.tuberculosis_H37Rv        RASLRGFLGRGAPVREMAAADGS--------DRRLWQRLCTELELPALHV
Mflv_0345|M.gilvum_PYR-GCK          RAAVRAFCADHVDESSVRAAMES----DPPFDAKVWSRLGSELGVLGMAV
Mvan_0393|M.vanbaalenii_PYR-1       RAAVRRFCADHIDETAVRAQMAS----EPRFDPKVWARLGSELGVLGMSV
MSMEG_6585|M.smegmatis_MC2_155      RAAVRKFGAEYFDEQTVRRLMES----EPRFDPAVWARLGAELGVLGLAV
TH_0804|M.thermoresistible__bu      RAAVRRFCTEHFDEQTVRRLMES----EPRFDPKVWARLGAELGVLGMSV
MMAR_1954|M.marinum_M               RASVGQLFAERCPPESVVAAYDS----PPADFAKLWRTLAAELGVAGLLV
MUL_2176|M.ulcerans_Agy99           RASVGQLFAERCPPESVVAAYDS----PPADFAKLWRTLAAELGVAGLLV
MAV_1838|M.avium_104                ARSVRAACERFAPEERVRAIAYNGGGVDAGFDTELWKVLCAQVGVAAIGM
MAB_3123|M.abscessus_ATCC_1997      RSLVRSWCERVWTPKHVRQIAEAG-----SVDLDAWRALGSELGVVGLSL
MLBr_00737|M.leprae_Br4923          RATIRALAEKEIAPHAADVDQRAR------FPEEALAALNAS-GFNAIHV
                                       :                                  * :.  . .: :

Mb1968c|M.bovis_AF2122/97           PPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQR-
Rv1933c|M.tuberculosis_H37Rv        PPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQR-
Mflv_0345|M.gilvum_PYR-GCK          PESAGGAGGNLVDQAVAVEQLGAALACGPLFGTVYLAIPALVAASGG---
Mvan_0393|M.vanbaalenii_PYR-1       PESHGGAGGTLVDQAVAVEQLGAALACGPLFGTVYLAIPALVASSQP---
MSMEG_6585|M.smegmatis_MC2_155      PEADGGAGGTLVDQAVAVEELGAALACGPLIGTVYLSIPALVAASAGPV-
TH_0804|M.thermoresistible__bu      PEADGGVGGTLVDQAVAVEEFGAALACGPFFGTVYLAVPALAAASAGPV-
MMAR_1954|M.marinum_M               PESLGGAGASAREAAVVMEEVGRAVAPVPFLSSAVLATVALLHSGET---
MUL_2176|M.ulcerans_Agy99           PESLGGAGASAREAAVVMEEVGRAVAPVPFLSSAVLATVALLHSGET---
MAV_1838|M.avium_104                PEDLGGAGFDATALGVVAHELGRALAPVPFVASAVLATGLLLATRESDPD
MAB_3123|M.abscessus_ATCC_1997      PEQHGGGGLGVIELSIVAEELGRALACLPWISSAALGATALVSSGDDSA-
MLBr_00737|M.leprae_Br4923          PEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEEL
                                    *   ** *       :.  :.. . :  .   :.                

Mb1968c|M.bovis_AF2122/97           -KRLLAGLLTGARIGTIAVSGHDVASATTVRAVR---RDGRPALTGECTP
Rv1933c|M.tuberculosis_H37Rv        -KRLLAGLLTGARIGTIAVSGHDVASATTVRAVR---RDGRPALTGECTP
Mflv_0345|M.gilvum_PYR-GCK          -QELLGPLVDGTRTAAFAVRDDAGAFDASSVEVQAVPTEQGWALSGTVER
Mvan_0393|M.vanbaalenii_PYR-1       -GDLLAPLIEGIRTAAFAVPDAGGDFDADAVTVEAIPTDQGWTLTGTVQR
MSMEG_6585|M.smegmatis_MC2_155      RDELLGALVEGARTAAFAVPDRAGAFDPALVGVT---ASADATLTGTVER
TH_0804|M.thermoresistible__bu      RDELLGPLLEGARTAAVILADRAGVFDPTAVTVT---TDG-ATLTGTASQ
MMAR_1954|M.marinum_M               --ETLSELAQGELTAALVVPLATAPGDPVAGVSR-----GSAGLSGRVCG
MUL_2176|M.ulcerans_Agy99           --ETLSELAQGELTAALVVPLATAPGDPVAGASR-----GSAGLSGRVCG
MAV_1838|M.avium_104                SEQRLSGLMEGHRTAAAAVTGDGGLWQRDSVTLVANANIDGWAVNGTVRH
MAB_3123|M.abscessus_ATCC_1997      LAEWVPALAAGEKTITLAG-GRTRLADAITVSAES--DTDGWKLTGDTEH
MLBr_00737|M.leprae_Br4923          KKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCW
                                        :  *       :                           :.*    

Mb1968c|M.bovis_AF2122/97           VLHGHVADLFVVPAVAD-----GSIVLHVVAADAPGVTVTPLPSFDITR-
Rv1933c|M.tuberculosis_H37Rv        VLHGHVADLFVVPAVAD-----GSIVLHVVAADAPGVTVTPLPSFDITR-
Mflv_0345|M.gilvum_PYR-GCK          VVDAGAADVLLVAATTP-----DGVGLFVVEADSLGVQRIRLTTLDLTR-
Mvan_0393|M.vanbaalenii_PYR-1       VVDAGAADVVLVAAAGP-----DGLGLYAIEADNIGVQRIPLTTLDLTR-
MSMEG_6585|M.smegmatis_MC2_155      IVDGAAADVFLVAATAP-----DGVALYAVDAS--DVQRTPLTTLDLTR-
TH_0804|M.thermoresistible__bu      VVDVDAADDLLVAADGP-----DGVGLYAVDATGPGVTRTPLVTMDLTR-
MMAR_1954|M.marinum_M               VAGAREADVLVVPVAGA-----DGVELHTVRANAPGVEIVPLLAFDMTR-
MUL_2176|M.ulcerans_Agy99           VAGAREADVLVVPVAGA-----DGVELHTVRANAPGVEIVPLLAFDMTR-
MAV_1838|M.avium_104                VLNGCAANDLVVVAKAD-----DQPALFLIDPMAEGVAVEAERVLDGTR-
MAB_3123|M.abscessus_ATCC_1997      VPDGATADVILVLADTD-----SGPSLFAVDGDAPGVDRHSLATLDMTR-
MLBr_00737|M.leprae_Br4923          ITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKG
                                    :     :    * .        .    . :     ..           : 

Mb1968c|M.bovis_AF2122/97           -PVATLRLAGS---PAEPLTAGTPDD--MERVLDVARVLLAAEMLGGAEA
Rv1933c|M.tuberculosis_H37Rv        -PVATLRLAGS---PAEPLTAGTPDD--MERVLDVARVLLAAEMLGGAEA
Mflv_0345|M.gilvum_PYR-GCK          -PQATVGLLDA---PAQLIAGPEEAERVITHALQVGAALLAVEQVGAAQH
Mvan_0393|M.vanbaalenii_PYR-1       -PQATVGLFHA---PARLVAGPAEAERVITHALQIGAALLAVEQVGAAQH
MSMEG_6585|M.smegmatis_MC2_155      -PQATIALTDT---PGRLVSGPGEAERVIGHALQVGAALLAVEQVGAAQH
TH_0804|M.thermoresistible__bu      -PQAAVRFSGA---PARLVAEPGTAERVITRALQVGAALLAVEQVGAAQH
MMAR_1954|M.marinum_M               -PLADVVFSGA---ASAPVG-LGSAEAALAEALQTGAALLASEQLGIAQW
MUL_2176|M.ulcerans_Agy99           -PLADVVFSGA---ASAPVG-LGSAEAALAEALQTGAALLASEQLGIAQW
MAV_1838|M.avium_104                -PMATITFTGA---TALKLTGREAVDTIIEHNIDVALAVLSAEQVGACER
MAB_3123|M.abscessus_ATCC_1997      -RQANIHFNSA---PARLIGAQGRGAEAVATALDVAATVLAAEQAGIAAH
MLBr_00737|M.leprae_Br4923          SPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQG
                                       : : :          :             ::     :. :  * .  

Mb1968c|M.bovis_AF2122/97           CLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSA
Rv1933c|M.tuberculosis_H37Rv        CLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDATRATVMFAAMSA
Mflv_0345|M.gilvum_PYR-GCK          LLDLSVDYAKNRLQFGRPIGSFQAVKHRLADDLVAVEHARSTAYHAVWAL
Mvan_0393|M.vanbaalenii_PYR-1       LLDLTVDYAKNRLQFGRPIGSFQAVKHRLADDLVALEHARSTAYHAVWAL
MSMEG_6585|M.smegmatis_MC2_155      LLDLSVDYAKSRLQFGRPIGSFQAVKHRLADDLVDLEHARSAAYHAVWAL
TH_0804|M.thermoresistible__bu      LLDLSVDYAKSRLQFGRPIGSFQAVKHRLADMLVDVEHARSTAYHAVWAL
MMAR_1954|M.marinum_M               CFDTTLAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTC
MUL_2176|M.ulcerans_Agy99           CFDTTLAYTKQRKQFGRAIGSYQAIKHRLADLWLEVGSARAAARYGADTC
MAV_1838|M.avium_104                VLEIACEYARTREQFGRPIGSFQAIKHKCADMLVDLEWARSASQAALEAV
MAB_3123|M.abscessus_ATCC_1997      MLDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSH
MLBr_00737|M.leprae_Br4923          ALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARA
                                     :: :  *:  * **.. *.::*:::.  **       .*     .    

Mb1968c|M.bovis_AF2122/97           ANGD----ELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLY
Rv1933c|M.tuberculosis_H37Rv        ANGD----ELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLY
Mflv_0345|M.gilvum_PYR-GCK          SDGS---DDPALAVSIAQATTSAAFVRVATDTIQVHGGIGFTWEHQAHLY
Mvan_0393|M.vanbaalenii_PYR-1       TDGS---DDPALAVSIAQATCSEALVRVATDTIQVHGGIGFTWEHQAHLY
MSMEG_6585|M.smegmatis_MC2_155      ADGS---DDPALAASIAQATASAALTKIATDTIQVHGGIGFTWEHQAHLY
TH_0804|M.thermoresistible__bu      ADPAGELDDPALATGIAQAVCSAAFSRVAADTIQVHGGIGFTWEHSAHLY
MMAR_1954|M.marinum_M               ARGD---EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLY
MUL_2176|M.ulcerans_Agy99           ARGD---EDAAIAAAIAAAYCGDVAVHAAEECVQLHGGIGMTWEYPAHLY
MAV_1838|M.avium_104                VSGE-----RDWRASMAKAVCSESLRNAAHANVQIHGGIGFTWEDSAHLY
MAB_3123|M.abscessus_ATCC_1997      DHPS--LDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLY
MLBr_00737|M.leprae_Br4923          ERGE---PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERF
                                                    :    .      :   :* .*. . * :   . :

Mb1968c|M.bovis_AF2122/97           YRRAKTTEALFGSSARNRALLAERAGLVKA------------------
Rv1933c|M.tuberculosis_H37Rv        YRRAKTTEALFGSSARNRALLAERAGLVKA------------------
Mflv_0345|M.gilvum_PYR-GCK          YKRAYTDAALLGGAEEHRARVADFVLV-----VAPEKDAPRVATGMPS
Mvan_0393|M.vanbaalenii_PYR-1       YKRAYTDAALLGSAEAHRARVAELVLD-----VAPRKDAPRVATGMPS
MSMEG_6585|M.smegmatis_MC2_155      FKRATTDAALLGTAEAHRDRIAELILDRAVSDQATIDRAPRVATGTN-
TH_0804|M.thermoresistible__bu      YKRAATDAALLGTAEQHRDRVAALALD-----TASPDRVPRVATGSG-
MMAR_1954|M.marinum_M               LKRAKSDQLALGTAYRHRGRLAKLVNLP-------------VS-----
MUL_2176|M.ulcerans_Agy99           LKRAKSDQLALGTAYRHRGRLAKLVNLP-------------VS-----
MAV_1838|M.avium_104                LRRARTDEVLLGGPGQHWDRVGLRVL----------------------
MAB_3123|M.abscessus_ATCC_1997      YKRAVSNSALFGGRAVHAERIAKEVIDA--------------------
MLBr_00737|M.leprae_Br4923          MRDAKITQIYEGTNQIQRVVMSRALLR---------------------
                                     : *       *    :   :.

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_0345	-	-	100% (389)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_2335	-	2e-56	39.17% (360)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1460	-	5e-46	38.08% (365)	acyl-CoA dehydrogenase domain-containing protein