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MAGRVEGKVAFVTGAGRGQGRSHALKLAEEGADIIAIDVCKNIDHVQLELASPGDLLETKERVEALGRRI VIDEVDVRDFDRMKAVVDRGVAELGRLDIILANAGIGNGGQTVEAIEEAEWQTMMDINLTGVWKTVKAGI PHMIAGGRGGSIVLTSSVAGMKAYPQMGQYVSAKHGVVGLMRSCAVELAQHMIRVNSVHPTHVNSPMVMN DETFRMFRPDLENPGPDDIAAICQMFHTMPRPWVEVEDITNAVMFFASDDSRYVTGVSMPIDLGSCLK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2463 | - | - | 100% (278) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2430 | - | e-110 | 65.83% (278) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1589 | - | e-104 | 63.08% (279) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 3e-57 | 45.26% (274) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 3e-57 | 45.26% (274) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01740 | - | 2e-22 | 32.56% (215) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0072c | - | 2e-74 | 49.82% (275) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4754 | - | 1e-114 | 68.82% (279) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0896 | - | 1e-115 | 70.21% (282) | carveol dehydrogenase ((+)-trans-carveol dehydrogenase) |
| M. smegmatis MC2 155 | MSMEG_4849 | - | 1e-111 | 67.97% (281) | carveol dehydrogenase |
| M. thermoresistible (build 8) | TH_3237 | - | 1e-115 | 67.63% (278) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3392 | fabG | 1e-55 | 42.35% (281) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_4191 | - | 1e-148 | 91.01% (278) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2771|M.bovis_AF2122/97 ---MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASV
Rv2750|M.tuberculosis_H37Rv ---MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQIASV
MUL_3392|M.ulcerans_Agy99 MSRPLDGPLSGRVAFITGAARGQGRAHALRLARDGADVIAVDLCDQIASV
Mflv_2463|M.gilvum_PYR-GCK ----MAGRVEGKVAFVTGAGRGQGRSHALKLAEEGADIIAIDVCKNIDHV
Mvan_4191|M.vanbaalenii_PYR-1 ----MPGRVEGKVAFVTGAARGQGRSHAIKLAEEGADIIAIDVCKNVDNV
MAV_0896|M.avium_104 ----MTGRVEGKVAFVTGAARGQGRSHAVRLAQEGADIIAVDICKPIRAG
MSMEG_4849|M.smegmatis_MC2_155 ----MSGRVEGKVAFVTGAARGQGRSHALRLAQEGADIIAIDICGPIRPG
MMAR_4754|M.marinum_M MTEQLGGRVAGKVAFITGAARGQGRSHAVRLAQEGADIIAVDVCKPIVEN
TH_3237|M.thermoresistible__bu ----MAGRLEGKVAFITGAARGQGRAHAVRMAQEGADIIAVDICRQIDSV
MAB_0072c|M.abscessus_ATCC_199 ----MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHTT
MLBr_01740|M.leprae_Br4923 -MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDR-------
. *: .::***. * **: *:::* **:: *
Mb2771|M.bovis_AF2122/97 ----PYPLSTADDLAATVELVEDAGGGIVAR-QGDVRDRASLSVALQAGL
Rv2750|M.tuberculosis_H37Rv ----PYPLSTADDLAATVELVEDAGGGIVAR-QGDVRDRASLSVALQAGL
MUL_3392|M.ulcerans_Agy99 ----PYPLGTAEELATTVKLVEDTGARIVAS-QADVRDREALAAALQAGI
Mflv_2463|M.gilvum_PYR-GCK ----QLELASPGDLLETKERVEALGRRIVID-EVDVRDFDRMKAVVDRGV
Mvan_4191|M.vanbaalenii_PYR-1 ----QLDLATPGDLLETKARVEALGRRIIAE-EVDVRDYDAMKAVVDRGV
MAV_0896|M.avium_104 VVDTAIPASTPEDLAETADLVKGHNRRIVTA-EVDVRDYDALKAAVDSGV
MSMEG_4849|M.smegmatis_MC2_155 -AETAIPASTSDDLAETANLVKGLDRRVVTA-EVDVRDAAAIKAAVDSGV
MMAR_4754|M.marinum_M ---TTIPASTPEDLAETADLVKGHNRRIFTA-EADVRDYDALKAAVDAGV
TH_3237|M.thermoresistible__bu ----QIPLASPEDLAETADLVKGLNRRIYTA-EVDVRDFDALKAAVDTGV
MAB_0072c|M.abscessus_ATCC_199 ----ITPPATRADLDKTSELVESAGRRVIPG-VVDVRNLRDVQTFTQDAV
MLBr_01740|M.leprae_Br4923 ---------HCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIH
* * .. . : *: : : .
Mb2771|M.bovis_AF2122/97 DEFGRLDIVVANAGIAMMQ-----AGDDGWRDVIDVNLTGVFHTVQVAIP
Rv2750|M.tuberculosis_H37Rv DEFGRLDIVVANAGIAMMQ-----AGDDGWRDVIDVNLTGVFHTVQVAIP
MUL_3392|M.ulcerans_Agy99 DELGQVDIVVANAGIAPMQ-----SGDDGWRDVIDVNLSGAYYTVEVAIP
Mflv_2463|M.gilvum_PYR-GCK AELGRLDIILANAGIGNGGQTVEAIEEAEWQTMMDINLTGVWKTVKAGIP
Mvan_4191|M.vanbaalenii_PYR-1 AELGRLDIILANAGIGNGGQTVETLEEDVWQTMMDVNLTGVWKTVKAGIP
MAV_0896|M.avium_104 EQLGRLDIIVANAGIGNGGDTLDKTSEEDWTEMIDINLAGVWKTVKAGVP
MSMEG_4849|M.smegmatis_MC2_155 EQLGRLDIIVANAGIGNGGDTLDQTSEEDWDEMIDINLSGVWKSVKAGVP
MMAR_4754|M.marinum_M DELGRLDIIVANAGIGNGGATLDKTSEHDWQEMIDVNLSGVWKSVKAAVP
TH_3237|M.thermoresistible__bu EQLGRLDIIVANAGIGNGGETLDKTSEGDWTDMIDVNLAGVWKTVKAGVP
MAB_0072c|M.abscessus_ATCC_199 TEFGGLDIVCATAGITSRRMLLDMP-ESDWQTMLDVNLTGVWHTTRAATP
MLBr_01740|M.leprae_Br4923 ARHPSMDIVMNIAGVSVWG-TVDRLTHDQWSNVVAINLMGPIHIIETFVP
. :**: **: . * :: :** * .. *
Mb2771|M.bovis_AF2122/97 TLIEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANH
Rv2750|M.tuberculosis_H37Rv TLIEQGTGGSIVLISSAAGLVGIGSSDPGSLGYAAAKHGVVGLMRAYANH
MUL_3392|M.ulcerans_Agy99 TMIEQGRGGSIVLISSAAGLVGISSADAGAIGYVASKHALVGLMRVYANL
Mflv_2463|M.gilvum_PYR-GCK HMIAGGRGGSIVLTSSVAGMKAYPQMG----QYVSAKHGVVGLMRSCAVE
Mvan_4191|M.vanbaalenii_PYR-1 HMIAGGRGGSIVLTSSVAGLKAYPQMS----QYVSAKHGVVGLMRSCATE
MAV_0896|M.avium_104 HMIAGGRGGSIILTSSVGGLKAYPHTG----HYVAAKHGVVGLMRAFGVE
MSMEG_4849|M.smegmatis_MC2_155 HIVAGGRGGSIVLTSSVGGLKAYPHCG----NYVAAKHGVVGLMRGFAVE
MMAR_4754|M.marinum_M HLIAGGNGGSIVLTSSVGGMKAYPHCG----NYVAAKHGVVGLMRSFAVE
TH_3237|M.thermoresistible__bu HILAGGRGGSIILTSSVGGLKAYPHTG----HYVAAKHGVVGLMRTFAVE
MAB_0072c|M.abscessus_ATCC_199 HLIARG-GGAMVLVSSIAGLRGLVGVS----HYVAAKHGVVGLMRSLAIE
MLBr_01740|M.leprae_Br4923 AILAAGRGGHLVNVSSAAGLVALPWHA----AYSASKYGLRGLSEVLRFD
:: * ** :: ** .*: . * ::*:.: ** .
Mb2771|M.bovis_AF2122/97 LAPQNIRVNSVHPCGVDTPMINNEFFQQWLT-------TADMDAPHNLGN
Rv2750|M.tuberculosis_H37Rv LAPQNIRVNSVHPCGVDTPMINNEFFQQWLT-------TADMDAPHNLGN
MUL_3392|M.ulcerans_Agy99 LAPHSIRVNSLHPSGVDPPMINNEFIRHWLAD-----LVAETGSGPGAGN
Mflv_2463|M.gilvum_PYR-GCK LAQHMIRVNSVHPTHVNSPMVMNDETFRMFRPDLENPGPDDIAAICQMFH
Mvan_4191|M.vanbaalenii_PYR-1 LGQHMIRVDSVHPTHVNSPMVMNDETFRMFRPDLENPGPDDIAPICQMFH
MAV_0896|M.avium_104 LGQHMIRVNSVHPTHVKTPMLHNEGTFKMFRPDLENPGPDDMAPICQMFH
MSMEG_4849|M.smegmatis_MC2_155 LGQHNIRVNTVHPTHVATPMLHNEGTFKMFRPDLENPGPDDMAPICQMFH
MMAR_4754|M.marinum_M LGQHMIRVNSVHPTHVRTPMLHNEGTFKMFRPDLENPGPDDMAPICQLFH
TH_3237|M.thermoresistible__bu LGQHNIRVNSVHPTNVNTPLFMNEPTMKLFRPDLENPGPEDLKVVAQMMH
MAB_0072c|M.abscessus_ATCC_199 LAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMN
MLBr_01740|M.leprae_Br4923 LARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSA
*. * *. : * * .*:. . :
Mb2771|M.bovis_AF2122/97 ALPVELVQPTDIANAVAWLASEEARYVTGVT-------------------
Rv2750|M.tuberculosis_H37Rv ALPVELVQPTDIANAVAWLASEEARYVTGVT-------------------
MUL_3392|M.ulcerans_Agy99 ALPVQILQADDIAGALAWLVSDEARYITGVA-------------------
Mflv_2463|M.gilvum_PYR-GCK TMPRPWVEVEDITNAVMFFASDDSRYVTGVS-------------------
Mvan_4191|M.vanbaalenii_PYR-1 TMPRPWVEVEDITNAVMFFASDDSRYVTGVA-------------------
MAV_0896|M.avium_104 TLPIPWVEPIDISNAVLFFASDEARYITGVT-------------------
MSMEG_4849|M.smegmatis_MC2_155 TLPIPWVEPIDISNAVLFLASDEARYITGVT-------------------
MMAR_4754|M.marinum_M TLPIPWVEAEDISNAVLFLASDESRYITGVT-------------------
TH_3237|M.thermoresistible__bu TLPIGWVEPEDIANAVLFLASDEARYITGVT-------------------
MAB_0072c|M.abscessus_ATCC_199 LLDLPWVEPLDIANASLFLASDEARYITSVS-------------------
MLBr_01740|M.leprae_Br4923 ERAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFT
: . .*.: * : ..
Mb2771|M.bovis_AF2122/97 -------------LPVDAGFVNKR----------
Rv2750|M.tuberculosis_H37Rv -------------LPVDAGFVNKR----------
MUL_3392|M.ulcerans_Agy99 -------------LPVDAGCVNKR----------
Mflv_2463|M.gilvum_PYR-GCK -------------MPIDLGSCLK-----------
Mvan_4191|M.vanbaalenii_PYR-1 -------------MPIDLGSCLK-----------
MAV_0896|M.avium_104 -------------LPIDAGSCLK-----------
MSMEG_4849|M.smegmatis_MC2_155 -------------LPVDAGSCLK-----------
MMAR_4754|M.marinum_M -------------LPVDAGGCLK-----------
TH_3237|M.thermoresistible__bu -------------LPVDGGSCLK-----------
MAB_0072c|M.abscessus_ATCC_199 -------------LPVDAGSTQR-----------
MLBr_01740|M.leprae_Br4923 RALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN
*:. * :