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VSAPVLVIGANGYLGSHVTRKLVAAGNDVRVMVRDGANTVGIDDLAVTRYVGDIWNTDVLREAMTGCEVV YYCVVDTRGWLRDPAPLFRTNVEGTRNVLDVAVEPGIAATLRKFVFTSSCVTVGRTRGRVATEADVISDP ADLKSLTPYVRSRVQAENLVMEYARERGLPAVAMCVSTTYGAGDWGRTPHGAIIAGAAFGKLPFVMGGIE LEAVGIDDAAQAMLLAARKGRAGERYLISEKMISNADVVRIAAEAAGVPAPTKKIPLVLSYAMAALGSAK SRLKGTDERMSLGSLRLMRAEAPVDCSKARRELGWQPRPVEESIREAAKFWVGLKAAKRQRTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1108 | - | - | 100% (343) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_2375 | - | 2e-84 | 50.76% (327) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_0367 | - | 6e-52 | 44.32% (264) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0144 | - | 1e-120 | 63.11% (347) | putative oxidoreductase |
| M. tuberculosis H37Rv | Rv0139 | - | 1e-121 | 63.40% (347) | oxidoreductase |
| M. leprae Br4923 | MLBr_01964 | rmlB | 1e-08 | 23.77% (265) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 1e-23 | 30.09% (329) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_0349 | - | 1e-120 | 65.96% (332) | oxidoreductase |
| M. avium 104 | MAV_5157 | - | 1e-124 | 67.76% (335) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_6474 | - | 1e-143 | 75.81% (339) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_2143 | - | 9e-86 | 52.41% (332) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4771 | - | 1e-119 | 65.36% (332) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5705 | - | 1e-165 | 86.53% (334) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1108|M.gilvum_PYR-GCK -MSAPVLVIGANGYLGSHVTRKLVAA----GNDVRVMVRDGANTVGIDDL
Mvan_5705|M.vanbaalenii_PYR-1 -MTA--LVIGANGYLGSHVTRRLVAD----GQDVRVMVREGANTIGIDDL
MSMEG_6474|M.smegmatis_MC2_155 -MSTS-LVIGANGFLGSHVLRQLVADNT-DGSEIRAMVRPGANTVGIDDL
MMAR_0349|M.marinum_M MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDDL
MUL_4771|M.ulcerans_Agy99 MSVGPKLVIGANGFLGSHVTRMLIEDGA----QVRVMVRPTANTRSIDDL
MAV_5157|M.avium_104 MSGKPKLVIGANGFLGSHVTRQLVADGA----QVRAMVRAGANTRGIDDL
Mb0144|M.bovis_AF2122/97 MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDL
Rv0139|M.tuberculosis_H37Rv MN-APKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDL
TH_2143|M.thermoresistible__bu -VAKKKLVIGASGFLGSHVTRQLVREGH----DVRVMVRTTSMTRGIDDL
MAB_0718c|M.abscessus_ATCC_199 ---MKTAVTGAAGFIGTNLVNLLVDNGH----EVIAIDRVVPASP-ETRE
MLBr_01964|M.leprae_Br4923 -MTMRLLVTGGAGFIGANFVHNAVRDHPDDTVTVLDAMTYAGRHESLADV
* *. *::*::. . : :
Mflv_1108|M.gilvum_PYR-GCK A--VTRYVGDIWNTDVLREAMTGCEVVYYCVVDTRGW--LRDPAPLFRTN
Mvan_5705|M.vanbaalenii_PYR-1 T--VTRFVGDIWDDDVLREAMTGCDVVYYCVVDTRGW--LRDPAPLFRTN
MSMEG_6474|M.smegmatis_MC2_155 D--VTRFTGDIFDTEVLRAAMTGCDVVYYCVVDTRGW--LRHPAPLFRTN
MMAR_0349|M.marinum_M P--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHTN
MUL_4771|M.ulcerans_Agy99 P--VTRFHGDIFDTAVVREAMQGCDDVYYCVVDARAW--LRDPAPLFHTN
MAV_5157|M.avium_104 S--LTRFHGDVFDTAVLSEAMDGVDDVYYCVVDTRAW--VRDTSPLFRTN
Mb0144|M.bovis_AF2122/97 P--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRTN
Rv0139|M.tuberculosis_H37Rv P--LTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAW--LRDPSPLFRTN
TH_2143|M.thermoresistible__bu D--VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMW--LRDPAPLFRTN
MAB_0718c|M.abscessus_ATCC_199 A--VTWVSGDVLDPDSMTKALDGVEVVYHLVAVITLK--HED-ELCWRIN
MLBr_01964|M.leprae_Br4923 DHAVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVDNALDDPEPFLRTN
: *:: : : : : * : .. . : *
Mflv_1108|M.gilvum_PYR-GCK VEGTRNVLDVAVEPGIAATLRKFVFTSSCVTVGRTRGRVATEADVISDPA
Mvan_5705|M.vanbaalenii_PYR-1 VEGTRNVLNIAVEPAVAAGLRKFVFTSSYVTVGRRRGRVATEADVIAD--
MSMEG_6474|M.smegmatis_MC2_155 VEGTRHVLDVALEPGIG--LRKFVYTSSYVTVGRRRGCVATEDDVIDL--
MMAR_0349|M.marinum_M VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS--
MUL_4771|M.ulcerans_Agy99 VEGLRNVLDVAKN----AGLRRFVFTSSYATVDRRHGHVATEEDRIGS--
MAV_5157|M.avium_104 VEGLRNVLDVAVTQ---PELRKFIFTSTYATVGRRRGHVATEDDVIGT--
Mb0144|M.bovis_AF2122/97 VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT--
Rv0139|M.tuberculosis_H37Rv VAGLRNVLDVATD----ASLRRFVFTSSYATVGRRRGHVATEEDRVDT--
TH_2143|M.thermoresistible__bu VEGLRHVLDAAVE----ADLNRFLFTSTTGTMAINPYRPVTEDDPHNW--
MAB_0718c|M.abscessus_ATCC_199 TEGARTVAQAALT----VGARRMVHCSSIDSYSNSVATIDEKSPRSAA--
MLBr_01964|M.leprae_Br4923 VIGTFTILEAVRHHS--VRLHHISTDEVYGDLELDEPTRFTESTPYNP--
. * : : . .:: . :
Mflv_1108|M.gilvum_PYR-GCK DLKSLTPYVRSRVQAENLVMEYARERGLPAVAMCVSTTYGAGDWG-RTPH
Mvan_5705|M.vanbaalenii_PYR-1 --RGLTPYVRSRVQAENLVLEYARTRGLPAVAMCVSTTYGAGDWG-RTPH
MSMEG_6474|M.smegmatis_MC2_155 --RGVTPYVRSRVQAEELVLRYATERGLPAVAMCVSTTYGSGDWG-RTPH
MMAR_0349|M.marinum_M --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG-RTPH
MUL_4771|M.ulcerans_Agy99 --RRVSSYVQSRVQAEDLVMDYVAQHGLPAVAMCVSTTYGSGDWG-RTPH
MAV_5157|M.avium_104 --RGLSDYVKSRVQAENLVMRYVAEAGLPAVAMCVSTTYGSGDWG-RTPH
Mb0144|M.bovis_AF2122/97 --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG-RTPH
Rv0139|M.tuberculosis_H37Rv --RKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWG-RTPH
TH_2143|M.thermoresistible__bu --TEGGAYIEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQ-PTPH
MAB_0718c|M.abscessus_ATCC_199 --ADLPVYQRSKWGGEVAVRETIAS-GLDAVICNPTGVYGPVDLPNLSRI
MLBr_01964|M.leprae_Br4923 ----SSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGPYQHV-EKFI
* :: .: * *: *. : ** : .
Mflv_1108|M.gilvum_PYR-GCK GAIIAGAAFGKLP--FVMGGIELEAVGIDDAAQAMLLAARKGRAGERYLI
Mvan_5705|M.vanbaalenii_PYR-1 GAIIAGAAFGKLP--FVLGGIELEAVGVEDAAHALLLAAEKGRVGERYLI
MSMEG_6474|M.smegmatis_MC2_155 GAVIAGAAFGKLP--FVMSGIDLEAVGVDDAARALILAAESGRPGERYLI
MMAR_0349|M.marinum_M GAFIAGAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLI
MUL_4771|M.ulcerans_Agy99 GAFIVGAVFGKLP--FLMNGIKLEVVGVDDAARAMILAAERGRSGQRYLI
MAV_5157|M.avium_104 GAFIAGAVFGKLP--FTMEGIQLEVVGVTDAAKAMVLAADRGRVGERYLI
Mb0144|M.bovis_AF2122/97 GAFIAGAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGHNGERYLI
Rv0139|M.tuberculosis_H37Rv GAFIAGAVFGRLP--FTMRGIRLEAVGVDDAARALILAAERGRNGERYLI
TH_2143|M.thermoresistible__bu GRLLAMVATGRFP--FYLG-WSAEVVGIEDAARAMLLAAEQGRVGERYII
MAB_0718c|M.abscessus_ATCC_199 NQLLFDSARGRLP--GMVN-SQYDLVDARDVAAGLYLAGEKGRTGENYLL
MLBr_01964|M.leprae_Br4923 PRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQIGRTYLI
: *: * : : * .: *: *. *::
Mflv_1108|M.gilvum_PYR-GCK SEKMIS-NADVVRIAAEAAGVPAPTKKIPLVLSYAMAALGSAKSRLKGTD
Mvan_5705|M.vanbaalenii_PYR-1 SEKMIS-NADVVRIAAEAAGVPAPSRTMPLPLSYAMAALGSLKGRLKGTD
MSMEG_6474|M.smegmatis_MC2_155 SEKLIS-NAEVARIAAEAAGVAPPRRSIPLPVSYLLAAIGTVKGKLRGTD
MMAR_0349|M.marinum_M SERMIA-LKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKD
MUL_4771|M.ulcerans_Agy99 SERMVA-LKEVVRIAADEAGVAPPQRTISVPTLYALGALGSLRARLTGKD
MAV_5157|M.avium_104 SERMIA-LKEVVRIAADEAGVPPPRRSISVPTLYALGALGDLRARLTGKD
Mb0144|M.bovis_AF2122/97 SERMMP-LQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKD
Rv0139|M.tuberculosis_H37Rv SERMMP-LQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKD
TH_2143|M.thermoresistible__bu SDRYLH-TREVHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRRD
MAB_0718c|M.abscessus_ATCC_199 GGHMGS-LLQVCRLAARRAGKRGPRFAVPMGLLNAAIPVIEPIGKLL-KN
MLBr_01964|M.leprae_Br4923 GAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDPTPLYNEL
. . * * *
Mflv_1108|M.gilvum_PYR-GCK ERMSLGSLRLMRAEAPVDCSKARRELGWQPRPVEESIREAAKFWVGLKAA
Mvan_5705|M.vanbaalenii_PYR-1 ERLSLDSLRLMRAEAPVDCGKAKRELGWQPRPVEESIREAAKFWVGLRAA
MSMEG_6474|M.smegmatis_MC2_155 ERLSLRSLRLMRAECELDHSKAVRELGWQPRPVEESIAEAAKFWVGLRAA
MMAR_0349|M.marinum_M AELSLESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKN
MUL_4771|M.ulcerans_Agy99 AELSLESVRMMRAEAEVDHAKAVRELGWQPRPVEESIREAARFWASMRKN
MAV_5157|M.avium_104 AELSLASVRMMRAEAPVDHSKAVRELGWQPRPVEESIREAARFWAAMRNA
Mb0144|M.bovis_AF2122/97 TELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTV
Rv0139|M.tuberculosis_H37Rv TELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTV
TH_2143|M.thermoresistible__bu LMFAHVGLKMAELMSPLDHSKAERELGFKPEPVEDSIAKAARFFLEQHR-
MAB_0718c|M.abscessus_ATCC_199 DALSRAAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGSGRL
MLBr_01964|M.leprae_Br4923 CWAPKHANFDEGLRATIDWYRNN-ESWWRP------LKDAVEARYEERGR
. . :* : * :.* : . .
Mflv_1108|M.gilvum_PYR-GCK KRQRTA----
Mvan_5705|M.vanbaalenii_PYR-1 KRAGKAAG--
MSMEG_6474|M.smegmatis_MC2_155 KQARRGG---
MMAR_0349|M.marinum_M TQGARTGQSE
MUL_4771|M.ulcerans_Agy99 TQGARTGQPE
MAV_5157|M.avium_104 KGKSATPR--
Mb0144|M.bovis_AF2122/97 GKDPAAS---
Rv0139|M.tuberculosis_H37Rv GKDPAAS---
TH_2143|M.thermoresistible__bu ----------
MAB_0718c|M.abscessus_ATCC_199 ----------
MLBr_01964|M.leprae_Br4923 ----------