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TIRTKFTETFGVEHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPTPADLANEIAKTRDLTDKPFGV NLTILPAINPPPYDEYRQVIVDAGIKIVETAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGI SIDGFECAGHPGEDDVPGLVLIPAAADKIEIPMIASGGFADARGLVAALALGADGINMGSRFMCTVESCI HQNVKEAIVAGDERGTELIFRSLHNTARVASNEVSREVVQILKDGGQFEDVKDLVAGVRGRKVFDDGDID AGIWTVGTAMGLINDIPTVGELVSRIVGEAEQLITGRLGEMVTPTAARV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4576 | - | - | 100% (330) | 2-nitropropane dioxygenase, NPD |
| M. vanbaalenii PYR-1 | Mvan_5586 | - | 4e-43 | 33.44% (302) | 2-nitropropane dioxygenase, NPD |
| M. vanbaalenii PYR-1 | Mvan_5269 | - | 3e-35 | 30.17% (348) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3583 | - | 1e-37 | 30.29% (350) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2128 | - | 0.0 | 94.85% (330) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv3553 | - | 1e-37 | 30.29% (350) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4001c | - | 2e-42 | 33.86% (319) | putative 2-nitropropane dioxygenase, NPD |
| M. marinum M | MMAR_5042 | - | 1e-37 | 30.57% (350) | 2-nitropropane dioxygenase |
| M. avium 104 | MAV_0607 | - | 1e-37 | 31.14% (350) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_5182 | - | 1e-168 | 89.51% (324) | 2-nitropropane dioxygenase |
| M. thermoresistible (build 8) | TH_2580 | - | 1e-161 | 84.97% (326) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_4116 | - | 6e-37 | 30.29% (350) | 2-nitropropane dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3583|M.bovis_AF2122/97 --MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLG-ILASAT
Rv3553|M.tuberculosis_H37Rv --MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLG-ILASAT
MMAR_5042|M.marinum_M --MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLG-ILASAT
MUL_4116|M.ulcerans_Agy99 --MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLG-ILASAT
MAV_0607|M.avium_104 MDMRLRTPLTELVGVEHPVVQTGMGWVAGARLVSATANAGGLG-ILASAT
Mvan_4576|M.vanbaalenii_PYR-1 --MTIRTKFTETFGVEHPIAQGGMQWVGRAELVAAVANAGALGFITALTQ
Mflv_2128|M.gilvum_PYR-GCK --MTITTKFTETFGVEHPIAQGGMQWVGRAELVAAVANAGALGFITALTQ
MSMEG_5182|M.smegmatis_MC2_155 --MALTTKFTEAFGVTHPIAQGGMQWVGRAELVAAVANAGALGFITALTQ
TH_2580|M.thermoresistible__bu --MALKTKFTEAFGVEHPIVQGGMQWVGRAELVAAVANAGALGFLTALTQ
MAB_4001c|M.abscessus_ATCC_199 ---MITNRVTELLGVERPIVQAPMGWIARSQLASAVCNAGGLGIIETSSG
: . .*: .*: :*:.* * *:. :.*.:*..***.** : : :
Mb3583|M.bovis_AF2122/97 MTLDELAAAITKVKAVTDKPFGVNIR----ADAADAGDRVELMIREGVRV
Rv3553|M.tuberculosis_H37Rv MTLDELAAAITKVKAVTDKPFGVNIR----ADAADAGDRVELMIREGVRV
MMAR_5042|M.marinum_M MTLDELATAIGKVKATTDKPFGVNIR----ADAADASDRVELMIREGVKV
MUL_4116|M.ulcerans_Agy99 MTLDELATAIGKVKATTDKPFGVNIR----ADAADASDRVELMIREGVKV
MAV_0607|M.avium_104 MTLDELATAIAKVKAATDKPFGVNIR----ADAADAADRVDLMIREGVKV
Mvan_4576|M.vanbaalenii_PYR-1 PTPADLANEIAKTRDLTDKPFGVNLTILPAINPPPYDEYRQVIVDAGIKI
Mflv_2128|M.gilvum_PYR-GCK PTPADLANEIARTRDLTDKPFGVNLTILPAINPPPYDEYRQVIVDAGIKI
MSMEG_5182|M.smegmatis_MC2_155 PTPADLANEIARCRDLTDKPFGVNLTILPSINPPPYDEYRQVIVDSGVKI
TH_2580|M.thermoresistible__bu PTPEALAKEIARTREMTDKPFGVNLTILPTINPPPYDEYRQVIVESGIKI
MAB_4001c|M.abscessus_ATCC_199 -ELDAIKDEIRAMREFTDKPFGVNIAQAFVRDPS----IAQFVVDQGVTF
: * : ********: :.. :.:: *: .
Mb3583|M.bovis_AF2122/97 ASFALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEG
Rv3553|M.tuberculosis_H37Rv ASFALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEG
MMAR_5042|M.marinum_M ASFALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEG
MUL_4116|M.ulcerans_Agy99 ASFALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEG
MAV_0607|M.avium_104 ASFALAPKQELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEG
Mvan_4576|M.vanbaalenii_PYR-1 VETAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFEC
Mflv_2128|M.gilvum_PYR-GCK VETAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFEC
MSMEG_5182|M.smegmatis_MC2_155 VETAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFEC
TH_2580|M.thermoresistible__bu VETAGSNPAPHLPMFHENGVKVLHKCTSVRHAVKAQSLGVDGISIDGFEC
MAB_4001c|M.abscessus_ATCC_199 VTTSAGDPNKYTRVLKDNGLTVFHVVPTLAAALKAVDAGVDGLVVEGVEG
. : . ::: * *: : * *. *.*.: ::* *
Mb3583|M.bovis_AF2122/97 GGHTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAA
Rv3553|M.tuberculosis_H37Rv GGHTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAA
MMAR_5042|M.marinum_M GGHTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGRGLAAALSYGAA
MUL_4116|M.ulcerans_Agy99 GGHTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGHGLAAALSYGAA
MAV_0607|M.avium_104 GGHTGP--VATTLLLPSVLDAVRGTGIPVIAAGGFFDGRGLAAALSYGAA
Mvan_4576|M.vanbaalenii_PYR-1 AGHPGEDDVPGLVLIPAAADKIE---IPMIASGGFADARGLVAALALGAD
Mflv_2128|M.gilvum_PYR-GCK AGHPGEDDVPGLVLIPAAADKIE---IPMIASGGFADGRGLAAALALGAD
MSMEG_5182|M.smegmatis_MC2_155 AGHPGEDDIPGLVLIPAAADKIE---IPMIASGGFADGRGLAAALALGAD
TH_2580|M.thermoresistible__bu AGHPGEDDIPGLVLIPAAADKIT---IPMIASGGFADARGLVAALALGAD
MAB_4001c|M.abscessus_ATCC_199 GGFKDPKGASTMVLLPLVRSHVD---IPIIAAGGICDGVSMAAAFALGAE
.*. . . :*:* . . : **:**:**: *. .:.**:. **
Mb3583|M.bovis_AF2122/97 GVAMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTEL
Rv3553|M.tuberculosis_H37Rv GVAMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTEL
MMAR_5042|M.marinum_M GVAMGTRFLLTSDSTVPEAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGL
MUL_4116|M.ulcerans_Agy99 GVAMGTRFLLTSDSTVPDAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGL
MAV_0607|M.avium_104 GVAMGTRFLLTSDSTVPDAVKKRYLEAALDGTVVTTRVDGMPHRVLRTGL
Mvan_4576|M.vanbaalenii_PYR-1 GINMGSRFMCTVESCIHQNVKEAIVAGDERGTELIFRSLHNTARVASNEV
Mflv_2128|M.gilvum_PYR-GCK GVNMGSRFMCTVESCIHQNVKEAIVAGDERGTELIFRSLHNTARVASNVV
MSMEG_5182|M.smegmatis_MC2_155 GINMGSRFMCTVESSIHQNVKEAIVAGDERGTELIFRTLHNTARVASNKV
TH_2580|M.thermoresistible__bu GINMGSRFMCTVESPIHQKVKEAIVAGTELDTELIFRPLRNTSRVASNAV
MAB_4001c|M.abscessus_ATCC_199 GVQMGTRMMSAAESPIHHNWKAAVVAARETDTVLLNRLTKPGLRALRSAR
*: **:*:: : :* : . * : . .* : * *. .
Mb3583|M.bovis_AF2122/97 VEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWS
Rv3553|M.tuberculosis_H37Rv VEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWS
MMAR_5042|M.marinum_M VEKLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWS
MUL_4116|M.ulcerans_Agy99 VEKLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWS
MAV_0607|M.avium_104 VEKLESGSPVRGLTAAVRNAAKFKHMSKMTWRSMISDGLAMRHGKEMTWS
Mvan_4576|M.vanbaalenii_PYR-1 SREVVQILKDGGQFEDVKDLVAGVRGRKVFDD------------------
Mflv_2128|M.gilvum_PYR-GCK SREVVQILKEGGQFEDVKDLVAGVRGRKVFDD------------------
MSMEG_5182|M.smegmatis_MC2_155 SREVVEILNKGGQFEDVKDLVAGVRGRKVFEN------------------
TH_2580|M.thermoresistible__bu SREVVEILNRGGKFEDVKDLVAGTRGAKVYET------------------
MAB_4001c|M.abscessus_ATCC_199 TEEMER--------RDLVSLLETGDPLDLYFG------------------
.:: : . .:
Mb3583|M.bovis_AF2122/97 QVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVL
Rv3553|M.tuberculosis_H37Rv QVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVL
MMAR_5042|M.marinum_M QVVMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVH
MUL_4116|M.ulcerans_Agy99 QVLMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVH
MAV_0607|M.avium_104 QVVMAANTPMLLKAGLVEGNTEAGVLASGQVAGILEDLPSCAELIDSIVR
Mvan_4576|M.vanbaalenii_PYR-1 ------------------GDIDAGIWTVGTAMGLINDIPTVGELVSRIVG
Mflv_2128|M.gilvum_PYR-GCK ------------------GDIDAGIWTVGTAMGLINDIPTVGDLVSRIVG
MSMEG_5182|M.smegmatis_MC2_155 ------------------GDVDAGIWTVGTAMGLIDDIPTVQDLVTRIVR
TH_2580|M.thermoresistible__bu ------------------GDLDAGIWWVGTSMGLINDIPTVGELVSRMVA
MAB_4001c|M.abscessus_ATCC_199 ------------------GNMETFVPLGGQVAGRIGGVESVKDILDATMD
*: :: : * * : .: : ::: :
Mb3583|M.bovis_AF2122/97 DAITHLQTASALVE--------------
Rv3553|M.tuberculosis_H37Rv DAITHLQTASALVE--------------
MMAR_5042|M.marinum_M DAIEHLRAAAALVE--------------
MUL_4116|M.ulcerans_Agy99 DAIEHLRAAAALVE--------------
MAV_0607|M.avium_104 DAIAHLRSASGLIEE-------------
Mvan_4576|M.vanbaalenii_PYR-1 EAEQLITGRLGEMVT---PTAARV----
Mflv_2128|M.gilvum_PYR-GCK DAEEIISGRLAGMVS---PVAQRV----
MSMEG_5182|M.smegmatis_MC2_155 DAEVLISGRLLNMISADEPDAEKETVPA
TH_2580|M.thermoresistible__bu EAEDLIAGRLAELIEPSVDEAGSA----
MAB_4001c|M.abscessus_ATCC_199 EFTAVIGKLAAQYV--------------
: :