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MTAVDSQTHTPVQPRPVPIRPTNLAQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITN TGGASYREFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGALV MALTGLAIGWRIRNGVGEAVLAFALLMLFGFGMIWFGILIGSLMRSVEAVNGVMFTALFPVTFLANTFVP TEPMPHWLRVIAEWNPVSSLAQAMRELWGNGGPAPASAQLPLHYPVASTILWSLALTAVFAPFALYAYKR RTGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1937 | - | - | 100% (284) | ABC-2 type transporter |
| M. gilvum PYR-GCK | Mflv_3388 | - | 3e-18 | 26.39% (288) | ABC-2 type transporter |
| M. gilvum PYR-GCK | Mflv_3387 | - | 5e-17 | 25.00% (260) | multidrug ABC transporter inner membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2962 | drrB | 1e-15 | 23.62% (271) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. tuberculosis H37Rv | Rv2937 | drrB | 1e-15 | 23.62% (271) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02350 | - | 7e-16 | 26.72% (262) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | MAB_2753 | - | 1e-06 | 23.73% (236) | ABC transporter permease |
| M. marinum M | MMAR_3262 | - | 2e-70 | 48.81% (252) | integral membrane protein ABC transporter |
| M. avium 104 | MAV_3252 | - | 7e-21 | 24.32% (259) | daunorubicin resistance protein C |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 2e-15 | 24.66% (219) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | TH_0342 | - | 2e-06 | 22.65% (234) | PROBABLE UNIDENTIFIED ANTIBIOTIC-TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2013 | drrB | 6e-18 | 26.03% (292) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. vanbaalenii PYR-1 | Mvan_4795 | - | 1e-152 | 93.31% (284) | ABC-2 type transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1937|M.gilvum_PYR-GCK ----MTAVDSQTHTPVQPRPVPIRPTNLAQQSWIMVKRNMIHTKRM--PE
Mvan_4795|M.vanbaalenii_PYR-1 ----MTALDTEAHAAVRPQPVPIRPTNLAQQSWIMVKRNMIHTKRM--PE
MMAR_3262|M.marinum_M ----------------------------------MLKRNLIRVRRR--PE
Mb2962|M.bovis_AF2122/97 MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVL
Rv2937|M.tuberculosis_H37Rv MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVL
MUL_2013|M.ulcerans_Agy99 MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGRFTKPRLRDPELI
MLBr_02350|M.leprae_Br4923 --MITMISQTVGLVPASLQYPNNSVRALVSQTLLQTKRLLTRWARD--YV
MAV_3252|M.avium_104 ----------------MMAHRLETQGSLLTESWVQAGRLLLRWRRD--QA
MAB_2753|M.abscessus_ATCC_1997 -----MTDTTTPRFDPGTFTPDPRPSAVHTMLFAQFWLELKLLLRN--GE
TH_0342|M.thermoresistible__bu ---------VTNRFPAGTFTPDPRPAPVPRMLAAQYGLELKLLLRN--GE
MSMEG_6510|M.smegmatis_MC2_155 --------MSVELVRAPRGLRRVRAVAMRMGAFALVELQKLRHDRT----
Mflv_1937|M.gilvum_PYR-GCK MLSDVTAQPIM-----FVLLFAFVFGASITNTGGASYREFLLPGIQAQTI
Mvan_4795|M.vanbaalenii_PYR-1 MLSDVTAQPIM-----FVLLFAFVFGASITNTGGASYREFLLPGIQAQTI
MMAR_3262|M.marinum_M TLMQLLLQPIA-----FMLFFTFIVGRSISENAAPHYREYLLPGIQAQAI
Mb2962|M.bovis_AF2122/97 TTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQY-ITPLVTLQAV
Rv2937|M.tuberculosis_H37Rv TTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQY-ITPLVTLQAV
MUL_2013|M.ulcerans_Agy99 TMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVPSSLGQY-IAPLIVLQSI
MLBr_02350|M.leprae_Br4923 TIIGALVLPIL-----FLVVLNIVLGNLAYVVTYDSGLYSFVPLITLGAA
MAV_3252|M.avium_104 VLMGSLLLPVF-----LLFCYQIVLGEQVHRVTGAQSVYGVVPMCAVISA
MAB_2753|M.abscessus_ATCC_1997 QLLLTMFIPIT-----LLIGLTLLP---LGQFPGSRTDIFVPAIMALAVI
TH_0342|M.thermoresistible__bu QLLLTLFIPIT-----LLVGLILLP---LGDFGDDRASRFVPAIMALAVI
MSMEG_6510|M.smegmatis_MC2_155 ELFTRMVQPAL----WLLIFGQTFSRLHVVDTGGVPYLAFLAPGIIAQSA
: . . .
Mflv_1937|M.gilvum_PYR-GCK VFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGAL
Mvan_4795|M.vanbaalenii_PYR-1 VFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGVL
MMAR_3262|M.marinum_M VATIILVGAAISADVENDVFIRFRSLPISNSAPLIARGLVSLLYAAIVYI
Mb2962|M.bovis_AF2122/97 SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
Rv2937|M.tuberculosis_H37Rv SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
MUL_2013|M.ulcerans_Agy99 SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
MLBr_02350|M.leprae_Br4923 ITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLARILANTIRTFVTTL
MAV_3252|M.avium_104 LFGSLGNSVGITMDRQSRLLSRMWVLPIHRASAITGWVMAEVVRALIGTT
MAB_2753|M.abscessus_ATCC_1997 STAFTGQAIAVGFDRRYGALKRLGATALPVWGIIAGKALAVVTVVVLQAA
TH_0342|M.thermoresistible__bu STAFTGQAIAVAFDRRYGALKRLGATALPVWGIIVGKSLAVVTVVFVQSV
MSMEG_6510|M.smegmatis_MC2_155 LFISIFYGIQIIWDRDAGILAKLMVTPAPASALVAGKAFAAGVRSVVQVI
. : :: . : . .
Mflv_1937|M.gilvum_PYR-GCK VMALTGLAIGWRIRNGVGEAVLAFALLMLFGFGMIWFGILIGSLMRSVEA
Mvan_4795|M.vanbaalenii_PYR-1 VMALTGLAIGWRIRNGVAEAVLAFALLLLFGFGMIWFGILIGSLLRTVEA
MMAR_3262|M.marinum_M LIGISGMLIGWRMHGSLADAVLAFVLVLVFGVGFMWLGMVVGLMVRTVEV
Mb2962|M.bovis_AF2122/97 ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
Rv2937|M.tuberculosis_H37Rv ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
MUL_2013|M.ulcerans_Agy99 VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
MLBr_02350|M.leprae_Br4923 VMLVTGVILGFRFRQGVIASLMWVSVPVIFGIAIAVMVTTVALYT-EQTF
MAV_3252|M.avium_104 LITVIGLAMGLRFSQGWPAALLFLLVPSIVVTGFTALVMAMAIRN-NGRA
MAB_2753|M.abscessus_ATCC_1997 VIGAIGGALGWRPH---PVGLLVGAVVIAIGTAAFVAMGLLLGGTLRAEI
TH_0342|M.thermoresistible__bu VLGAIGAALGWRPQ---PAGLLLGAVIIALGTAVFAALGLLLGGTLRAEI
MSMEG_6510|M.smegmatis_MC2_155 GVVALAYLMGIALTLNPLRILAAMGVVVLGAAFFACLSMTLAGLVRKRDR
. :* : : :
Mflv_1937|M.gilvum_PYR-GCK VNGVMFTALFPVTFLANTFVPTEPMPHWLRVIAEWNPVSSLAQAMRELWG
Mvan_4795|M.vanbaalenii_PYR-1 VNGVMFTALFPVTFLANTFVPTEPMPRWLRVIAEWNPVSSLAQAMRELWG
MMAR_3262|M.marinum_M VGAAVFLITLPIISISNCFVPTQPMPHALRVIAEWNPLSSLALALRKLTI
Mb2962|M.bovis_AF2122/97 MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
Rv2937|M.tuberculosis_H37Rv MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
MUL_2013|M.ulcerans_Agy99 MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
MLBr_02350|M.leprae_Br4923 VVEAVELVQAIAVFLSTGLVPLNQYPGWIQPLVAHQPVSYAIAAMRGLSM
MAV_3252|M.avium_104 AMTWLLGITFALVFVNPGATPIKLFPHWAQPLIRMQPVSPPIETMRALAH
MAB_2753|M.abscessus_ATCC_1997 VLALANLLWFIFAGLG---------ALTLEDGRTTDAIPRAVVLLARLSP
TH_0342|M.thermoresistible__bu VLAVANLLWFVFAAFG---------ALTVEP--EGDVVPAAAALVARLTP
MSMEG_6510|M.smegmatis_MC2_155 LMGIGQAITMPLFFASNALYPVDIMPTWLRWLSAVNPLSYEVNALRGLLI
. . : :. : *
Mflv_1937|M.gilvum_PYR-GCK NGGPAPASAQLPLHYPVASTILWSLALTAVFAPFALYAYKRRTGG
Mvan_4795|M.vanbaalenii_PYR-1 NGGPAPAGAQLPLHHPVLATVLWSLALTAVFAPFALYAYKRRTGG
MMAR_3262|M.marinum_M DEPMAPPSAQLPLHHPALSTLIYSIVLTALLAPIAIRAYIRRTSL
Mb2962|M.bovis_AF2122/97 DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP-----
Rv2937|M.tuberculosis_H37Rv DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP-----
MUL_2013|M.ulcerans_Agy99 DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP-----
MLBr_02350|M.leprae_Br4923 GGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH---------
MAV_3252|M.avium_104 GGPIAWPLEITVAWAVVLVAVFIPVAVRGYRLAAEASG-------
MAB_2753|M.abscessus_ATCC_1997 SGALSEALAAAMTLSVDWFAIAVLAVWGALAGYGALRWFKFT---
TH_0342|M.thermoresistible__bu SGALTDALSQAMTLSVNWFAVAVLAVWGVLGAVCALRWFRFT---
MSMEG_6510|M.smegmatis_MC2_155 GTPTNWVLDITVLVAAAVLGVVAASALLRRLVR------------
.