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SISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGRFTKPRLRDPELITMVGAPVVFTVGFYIPFAIPW NHYVGGGASGVPSSLGQYIAPLIVLQSISFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAI YRCCVGLTVALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDAMLPLLSLPILIF GLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAGDTTKAAIPVTWTVMTPTLAWLAGFALFLVPVS IIVLSRRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2013 | drrB | - | 100% (289) | daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB |
| M. ulcerans Agy99 | MUL_2012 | drrC | 2e-11 | 27.41% (197) | daunorubicin-DIM-transport integral membrane protein ABC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2962 | drrB | 1e-112 | 68.07% (285) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. gilvum PYR-GCK | Mflv_3388 | - | 6e-72 | 50.73% (274) | ABC-2 type transporter |
| M. tuberculosis H37Rv | Rv2937 | drrB | 1e-112 | 68.07% (285) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02351 | - | 1e-113 | 69.29% (280) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1770 | drrB | 1e-166 | 99.65% (289) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. avium 104 | MAV_3251 | - | 2e-32 | 32.66% (248) | ABC transporter efflux protein, DrrB family protein |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 9e-06 | 25.86% (232) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3121 | - | 1e-69 | 51.18% (254) | multidrug ABC transporter inner membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3388|M.gilvum_PYR-GCK --MTAQSTVKTAPRRAAIPQAVRPRVSAIQQWWVLTVR-MIIPTLRNGEL
Mvan_3121|M.vanbaalenii_PYR-1 --MIVDS---------AIPAAVRPPVSAVQQWWVLTVR-MITPTLRNGEL
MUL_2013|M.ulcerans_Agy99 MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGR-FTKPRLRDPEL
MMAR_1770|M.marinum_M MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGR-FTKPRLRDPEL
Mb2962|M.bovis_AF2122/97 MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRR-FAAPSLLNGEV
Rv2937|M.tuberculosis_H37Rv MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRR-FAAPSLLNGEV
MLBr_02351|M.leprae_Br4923 MSMPALAPIPASRWP--STIMAKPRRSTLRQWWALTTRYYTDIKLFVFEK
MAV_3251|M.avium_104 ----------------------------MSALAALTER-SLKSAARDGEM
MSMEG_6510|M.smegmatis_MC2_155 ----------MSVELVRAPRGLRRVRAVAMRMGAFALVELQKLRHDRTEL
.: *
Mflv_3388|M.gilvum_PYR-GCK ATQVVGSIVFTVGYYLP----LKQMMGAVQP--LSSYAQYLTPLIVLQAI
Mvan_3121|M.vanbaalenii_PYR-1 ATQIVGSIVFTIGYYLP----LKQMMGAVQP--LSGYAQYLTPLIVLQAI
MUL_2013|M.ulcerans_Agy99 ITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVPSSLGQYIAPLIVLQSI
MMAR_1770|M.marinum_M ITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVASSLGQYIAPLIVLQSI
Mb2962|M.bovis_AF2122/97 LTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAV
Rv2937|M.tuberculosis_H37Rv LTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAV
MLBr_02351|M.leprae_Br4923 TIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSGIASNLGQYVTPLIVLQSI
MAV_3251|M.avium_104 IFEILSPAAYLAGFSVA--------LHGLIDTGRISYSQYLLPAVVAQSM
MSMEG_6510|M.smegmatis_MC2_155 FTRMVQPALWLLIFGQTFS------RLHVVDTGGVPYLAFLAPGIIAQSA
: . : . :: * : *:
Mflv_3388|M.gilvum_PYR-GCK WFAAISAAFRSATDSVQGINRRFRAMPIPSSTPLAARMTASMYRCCIALA
Mvan_3121|M.vanbaalenii_PYR-1 WFAAISAAFRSATDSVQGINRRFRAMPIPALTPLASRMTASMYRCVVALI
MUL_2013|M.ulcerans_Agy99 SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
MMAR_1770|M.marinum_M SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
Mb2962|M.bovis_AF2122/97 SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
Rv2937|M.tuberculosis_H37Rv SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
MLBr_02351|M.leprae_Br4923 AFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMG
MAV_3251|M.avium_104 IFVGLMTADRAARDHLFGFGERIRTLPVPAAATVTARVTATLMRGSFCLV
MSMEG_6510|M.smegmatis_MC2_155 LFISIFYGIQIIWDRDAGILAKLMVTPAPASALVAGKAFAAGVRSVVQVI
* .: . : * *. :: * .. : : .: : * :
Mflv_3388|M.gilvum_PYR-GCK VSVGCGYVIGFRFEAGVLGILGFVGLALLIGAALAIIGDLIGVATQNPEA
Mvan_3121|M.vanbaalenii_PYR-1 VSVACGYVIGFRFDNGVLGIVGFVALVLLIGAALALIGDLIGIATQNPEA
MUL_2013|M.ulcerans_Agy99 VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
MMAR_1770|M.marinum_M VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
Mb2962|M.bovis_AF2122/97 ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
Rv2937|M.tuberculosis_H37Rv ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
MLBr_02351|M.leprae_Br4923 VALICGHVIGFQFHRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDA
MAV_3251|M.avium_104 MALVAGYVLGFRLAGGLVYSAAFVFISLLLCLAVTLGADALGSSAKSVQG
MSMEG_6510|M.smegmatis_MC2_155 GVVALAYLMGIALTLNPLRILAAMGVVVLGAAFFACLSMTLAGLVRKRDR
: .: :*: : . : . : : .: . :. :. :
Mflv_3388|M.gilvum_PYR-GCK TAPMMLIPQLTLGLASVGLQPVEQFPDWIQGFVRNQPLSQWVYALQALAG
Mvan_3121|M.vanbaalenii_PYR-1 TAPMMLIPQLTLGLASVGLQPVERFPEWIQGFVRNQPLSQWVYGLQALAG
MUL_2013|M.ulcerans_Agy99 MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
MMAR_1770|M.marinum_M MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
Mb2962|M.bovis_AF2122/97 MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
Rv2937|M.tuberculosis_H37Rv MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
MLBr_02351|M.leprae_Br4923 MLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFVVALRALAG
MAV_3251|M.avium_104 ASHLLFVPQLLLFMLSTGIAPEQTFPGWLRPYVRNQPVSQFAETLRGLAR
MSMEG_6510|M.smegmatis_MC2_155 LMGIGQAITMPLFFASNALYPVDIMPTWLRWLSAVNPLSYEVNALRGLLI
: : : : * .: * . :* *:: :*:: . *:.*
Mflv_3388|M.gilvum_PYR-GCK DSTDAAPDPTVAVLGSAVAWAVGCIVVALTLHVWVSRRRRS-
Mvan_3121|M.vanbaalenii_PYR-1 DSSGNAPEATFAVLGPGLAWVLGCIVVALALHTWVSRKRRSE
MUL_2013|M.ulcerans_Agy99 DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP--
MMAR_1770|M.marinum_M DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP--
Mb2962|M.bovis_AF2122/97 DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP--
Rv2937|M.tuberculosis_H37Rv DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP--
MLBr_02351|M.leprae_Br4923 ETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT--
MAV_3251|M.avium_104 G------HVIVGNVAATLAWCVGAVLVFGAITLRMQRRG---
MSMEG_6510|M.smegmatis_MC2_155 G-----TPTNWVLDITVLVAAAVLGVVAASALLRRLVR----
. :. :. :