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LKRNLIRVRRRPETLMQLLLQPIAFMLFFTFIVGRSISENAAPHYREYLLPGIQAQAIVATIILVGAAIS ADVENDVFIRFRSLPISNSAPLIARGLVSLLYAAIVYILIGISGMLIGWRMHGSLADAVLAFVLVLVFGV GFMWLGMVVGLMVRTVEVVGAAVFLITLPIISISNCFVPTQPMPHALRVIAEWNPLSSLALALRKLTIDE PMAPPSAQLPLHHPALSTLIYSIVLTALLAPIAIRAYIRRTSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3262 | - | - | 100% (254) | integral membrane protein ABC transporter |
| M. marinum M | MMAR_1769 | drrC | 9e-09 | 23.96% (217) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. marinum M | MMAR_1770 | drrB | 3e-06 | 22.94% (231) | daunorubicin-DIM-transport integral membrane protein ABC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2962 | drrB | 4e-13 | 26.38% (235) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. gilvum PYR-GCK | Mflv_1937 | - | 2e-70 | 48.81% (252) | ABC-2 type transporter |
| M. tuberculosis H37Rv | Rv2937 | drrB | 4e-13 | 26.38% (235) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02350 | - | 6e-09 | 21.33% (211) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_2004 | - | 1e-15 | 29.95% (197) | ABC-2 type transporter |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 2e-09 | 25.00% (208) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2012 | drrC | 6e-09 | 23.96% (217) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. vanbaalenii PYR-1 | Mvan_4795 | - | 4e-71 | 49.60% (252) | ABC-2 type transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MAV_2004|M.avium_104 MSALVALTLRTMSGSRRDADLLFAALAPVGCFLGFTLVLGGLIRTGSMSY
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MAV_2004|M.avium_104 PQYVLPVVIVQAMLFGAMTTADRAARDRLSGFGSRLRTLPLPASVPLGAR
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MAV_2004|M.avium_104 MLYCLTRALIALAATMAAGWSFGFRMQGGPADAVLFVTIVVVFAMAVCLG
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MAV_2004|M.avium_104 ADALGSRVGTVESSSQLLLLPQLVLVLLSTGIAPAESFPAWMAPFIRNQP
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MAV_2004|M.avium_104 VSQVTEALRGLATGHVAGGSLAAALTWCLGLLAVFGVVAVRMQRRVDAGR
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK ----------------------MTAVDSQTHTPVQPRPVPIRPTNLAQQS
Mvan_4795|M.vanbaalenii_PYR-1 ----------------------MTALDTEAHAAVRPQPVPIRPTNLAQQS
MMAR_3262|M.marinum_M --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------MITMISQTVGLVPASLQYPNNSVRALVSQT
MUL_2012|M.ulcerans_Agy99 --------------------MIGMTSQEIAFAPAQSQHTDHSARLLIWQT
MAV_2004|M.avium_104 SRAHRAVRKAPRDAAPAGDVGVNPVGKSAECLARQEVTRVGCLKGFVGQS
Mb2962|M.bovis_AF2122/97 -------------------MSGPAIDASPALTFNQSSASIQQRRLSTGRQ
Rv2937|M.tuberculosis_H37Rv -------------------MSGPAIDASPALTFNQSSASIQQRRLSTGRQ
MSMEG_6510|M.smegmatis_MC2_155 ----------------------------MSVELVRAPRGLRRVRAVAMRM
Mflv_1937|M.gilvum_PYR-GCK WIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITNTGG-----
Mvan_4795|M.vanbaalenii_PYR-1 WIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITNTGG-----
MMAR_3262|M.marinum_M --MLKRNLIRVRRRPETLMQLLLQPIAFMLFFTFIVGRSISENAA-----
MLBr_02350|M.leprae_Br4923 LLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLGNLAYVVTY-----
MUL_2012|M.ulcerans_Agy99 LVQTQRILTRWSRDFVTLIEALVFPILFMLVLKIVLGNLIYAVTH-----
MAV_2004|M.avium_104 ASEAGRLLRRWRRDPVVAVQALLFPTLLLVIYKLLVGKSVLAVTG-----
Mb2962|M.bovis_AF2122/97 MWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSG
Rv2937|M.tuberculosis_H37Rv MWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSG
MSMEG_6510|M.smegmatis_MC2_155 GAFALVELQKLRHDRTELFTRMVQPALWLLIFGQTFSRLHVVDTGG----
: * :: ..
Mflv_1937|M.gilvum_PYR-GCK --ASYREFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSS
Mvan_4795|M.vanbaalenii_PYR-1 --ASYREFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSS
MMAR_3262|M.marinum_M --PHYREYLLPGIQAQAIVATIILVGAAISADVENDVFIRFRSLPISNSA
MLBr_02350|M.leprae_Br4923 --DSGLYSFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRAS
MUL_2012|M.ulcerans_Agy99 --HDAMYSIVPLIALGAAITGSAFVAIDLMRERTSGLLSRLWVLPVHRMS
MAV_2004|M.avium_104 --HDSLYGLVPMCAVVGAVFGTIGAGLALPSERESGVLTRLWVQPVHRAS
Mb2962|M.bovis_AF2122/97 VASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLT
Rv2937|M.tuberculosis_H37Rv VASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLT
MSMEG_6510|M.smegmatis_MC2_155 --VPYLAFLAPGIIAQSALFISIFYGIQIIWDRDAGILAKLMVTPAPASA
: * . : .: :: * :
Mflv_1937|M.gilvum_PYR-GCK VLIGRSIASVIHSSLGALVMALTGLAIGWRIRNGVGEAVLAFALLMLFGF
Mvan_4795|M.vanbaalenii_PYR-1 VLIGRSIASVIHSSLGVLVMALTGLAIGWRIRNGVAEAVLAFALLLLFGF
MMAR_3262|M.marinum_M PLIARGLVSLLYAAIVYILIGISGMLIGWRMHGSLADAVLAFVLVLVFGV
MLBr_02350|M.leprae_Br4923 GLLARILANTIRTFVTTLVMLVTGVILGFRFRQGVIASLMWVSVPVIFGI
MUL_2012|M.ulcerans_Agy99 GLMARILADAVRILFTTLVMLGVGILMGFEFRQGLIASLMWLCVPVTLGI
MAV_2004|M.avium_104 PVAGRLVAEAARTVASAFVLTVFGIALGLRFNDGWIAMLAFVLVPVTISA
Mb2962|M.bovis_AF2122/97 PLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGA
Rv2937|M.tuberculosis_H37Rv PLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGA
MSMEG_6510|M.smegmatis_MC2_155 LVAGKAFAAGVRSVVQVIGVVALAYLMGIALTLNPLRILAAMGVVVLGAA
: .: . . . :* : . : : : .
Mflv_1937|M.gilvum_PYR-GCK GMIWFGILIGSLMRSVEAVNGVMFTALFPVTFLANTFVPTEPMPHWLRVI
Mvan_4795|M.vanbaalenii_PYR-1 GMIWFGILIGSLLRTVEAVNGVMFTALFPVTFLANTFVPTEPMPRWLRVI
MMAR_3262|M.marinum_M GFMWLGMVVGLMVRTVEVVGAAVFLITLPIISISNCFVPTQPMPHALRVI
MLBr_02350|M.leprae_Br4923 AIAVMVTTVALYTEQTFVVEAVELVQAI-AVFLSTGLVPLNQYPGWIQPL
MUL_2012|M.ulcerans_Agy99 AFAVMVTTVALYSSQAVIVEGVELTQAI-AIFFSTGLIPLDQYPHWIQPV
MAV_2004|M.avium_104 GMATLVTAIAARADGKAMVTWLGAGCVV-LLFLNTGVAPAEVFPGWLQPV
Mb2962|M.bovis_AF2122/97 VLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPF
Rv2937|M.tuberculosis_H37Rv VLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPF
MSMEG_6510|M.smegmatis_MC2_155 FFACLSMTLAGLVRKRDRLMGIGQAITMPLFFASNALYPVDIMPTWLRWL
: :. : . . * . * :: .
Mflv_1937|M.gilvum_PYR-GCK AEWNPVSSLAQAMRELWGNGGPAPASAQLPLHYPVASTILWSLALTAVFA
Mvan_4795|M.vanbaalenii_PYR-1 AEWNPVSSLAQAMRELWGNGGPAPAGAQLPLHHPVLATVLWSLALTAVFA
MMAR_3262|M.marinum_M AEWNPLSSLALALRKLTIDEPMAPPSAQLPLHHPALSTLIYSIVLTALLA
MLBr_02350|M.leprae_Br4923 VAHQPVSYAIAAMRGLSMGG---------PVLASMVAMLVWTAGICASCA
MUL_2012|M.ulcerans_Agy99 VAHQPVSYAVSAMRGLSMGG---------PVLLPMIGVLLWTAGICAVCA
MAV_2004|M.avium_104 VRYSPISPTIEAMRALAQGG---------PVLSPLWQAGLWGGVLVAVFA
Mb2962|M.bovis_AF2122/97 VRNQPISQFVAALRALAGDTTKTASQVSWPVMAP---TLTWLFAFVVILA
Rv2937|M.tuberculosis_H37Rv VRNQPISQFVAALRALAGDTTKTASQVSWPVMAP---TLTWLFAFVVILA
MSMEG_6510|M.smegmatis_MC2_155 SAVNPLSYEVNALRGLLIGT---------PTNWVLDITVLVAAAVLGVVA
.*:* *:* * . * . *
Mflv_1937|M.gilvum_PYR-GCK PFALYAYKRRTGG--
Mvan_4795|M.vanbaalenii_PYR-1 PFALYAYKRRTGG--
MMAR_3262|M.marinum_M PIAIRAYIRRTSL--
MLBr_02350|M.leprae_Br4923 VPLGVGYRRACTH--
MUL_2012|M.ulcerans_Agy99 VPLAVGWRRASTH--
MAV_2004|M.avium_104 PIAVRGYRAAAEAGC
Mb2962|M.bovis_AF2122/97 LSSTIVLARRP----
Rv2937|M.tuberculosis_H37Rv LSSTIVLARRP----
MSMEG_6510|M.smegmatis_MC2_155 ASALLRRLVR-----