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TVESSPPASYRVSGKHRRAHVWENSPRQLVPQVAVLTGRILRRWSRDPATLVQSMVMPAVFLIALDIVLG DVIEAVTGHSGLYGQVPLVALVGGMTGSIIGAVGIMRERDAGLLSRLWVVPVHRAAGLLARLAADFIRIT AITLVVMSVGLVLGFRFEQGIPAAIAWVFMPALFGVTLSAAVLTLALLSSSTIAPQATEILIAILMFFSI GFVPLDQYPEWLQPFVEHQPVSTTIEAMKGLSLEGPIAQPVLFSVLWAAGIAAVCAVPLAIGYRRASKRG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3387 | - | - | 100% (281) | multidrug ABC transporter inner membrane protein |
| M. gilvum PYR-GCK | Mflv_3388 | - | 5e-17 | 29.55% (247) | ABC-2 type transporter |
| M. gilvum PYR-GCK | Mflv_1937 | - | 5e-17 | 25.00% (260) | ABC-2 type transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2963 | drrC | 5e-73 | 49.02% (255) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. tuberculosis H37Rv | Rv2938 | drrC | 5e-73 | 49.02% (255) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02350 | - | 2e-72 | 50.20% (253) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1769 | drrC | 5e-75 | 51.37% (255) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. avium 104 | MAV_2004 | - | 1e-47 | 39.45% (256) | ABC-2 type transporter |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 9e-10 | 26.58% (237) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2012 | drrC | 3e-75 | 51.37% (255) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. vanbaalenii PYR-1 | Mvan_3120 | - | 1e-137 | 88.13% (278) | multidrug ABC transporter inner membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 MSALVALTLRTMSGSRRDADLLFAALAPVGCFLGFTLVLGGLIRTGSMSY
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 PQYVLPVVIVQAMLFGAMTTADRAARDRLSGFGSRLRTLPLPASVPLGAR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 MLYCLTRALIALAATMAAGWSFGFRMQGGPADAVLFVTIVVVFAMAVCLG
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 ADALGSRVGTVESSSQLLLLPQLVLVLLSTGIAPAESFPAWMAPFIRNQP
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 VSQVTEALRGLATGHVAGGSLAAALTWCLGLLAVFGVVAVRMQRRVDAGR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK -------------MTVESSP---PASYRVSGKHRRAHVWENSPRQLVPQV
Mvan_3120|M.vanbaalenii_PYR-1 -------------MTLESPESLVSAPYRPGGRHRREKVWENSPKRLVPQV
MMAR_1769|M.marinum_M ----------------MTSQEIAFAPAQSQHTD-------HSARLLIWQT
MUL_2012|M.ulcerans_Agy99 -------------MIGMTSQEIAFAPAQSQHTD-------HSARLLIWQT
Mb2963|M.bovis_AF2122/97 -------------MITTTSQEIELAPTRLPGSQ-------NAARLFVAQT
Rv2938|M.tuberculosis_H37Rv -------------MITTTSQEIELAPTRLPGSQ-------NAARLFVAQT
MLBr_02350|M.leprae_Br4923 -------------MITMISQTVGLVPASLQYPN-------NSVRALVSQT
MAV_2004|M.avium_104 SRAHRAVRKAPRDAAPAGDVGVNPVGKSAECLARQEVTRVGCLKGFVGQS
MSMEG_6510|M.smegmatis_MC2_155 -----------------MSVELVRAPRG-----------LRRVRAVAMRM
. : . :
Mflv_3387|M.gilvum_PYR-GCK AVLTGRILRRWSRDPATLVQSMVMPAVFLIALDIVLGDVIEAVTG-HSGL
Mvan_3120|M.vanbaalenii_PYR-1 AVLTGRILRRWSRDPATLVQSLVMPAVFLVALDIVLGDVIEQVTG-HSGL
MMAR_1769|M.marinum_M LVQTQRILTRWSRDFVTLIEALVFPILFMLVLKIVLGNLIYAVTH-HDAM
MUL_2012|M.ulcerans_Agy99 LVQTQRILTRWSRDFVTLIEALVFPILFMLVLKIVLGNLIYAVTH-HDAM
Mb2963|M.bovis_AF2122/97 LLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTH-DSGL
Rv2938|M.tuberculosis_H37Rv LLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTH-DSGL
MLBr_02350|M.leprae_Br4923 LLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLGNLAYVVTY-DSGL
MAV_2004|M.avium_104 ASEAGRLLRRWRRDPVVAVQALLFPTLLLVIYKLLVGKSVLAVTG-HDSL
MSMEG_6510|M.smegmatis_MC2_155 GAFALVELQKLRHDRTELFTRMVQPALWLLIFGQTFSRLHVVDTGGVPYL
: * : :* . :: * : :: .. * :
Mflv_3387|M.gilvum_PYR-GCK YGQVPLVALVGGMTGSIIGAVGIMRERDAGLLSRLWVVPVHRAAGLLARL
Mvan_3120|M.vanbaalenii_PYR-1 YGQVPLVALVGGMTGAIIGAVGIMREREAGLLSRFWVVPVHRAAGLLARL
MMAR_1769|M.marinum_M YSIVPLIALGAAITGSAFVAIDLMRERTSGLLSRLWVLPVHRMSGLMARI
MUL_2012|M.ulcerans_Agy99 YSIVPLIALGAAITGSAFVAIDLMRERTSGLLSRLWVLPVHRMSGLMARI
Mb2963|M.bovis_AF2122/97 YSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRI
Rv2938|M.tuberculosis_H37Rv YSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRI
MLBr_02350|M.leprae_Br4923 YSFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLARI
MAV_2004|M.avium_104 YGLVPMCAVVGAVFGTIGAGLALPSERESGVLTRLWVQPVHRASPVAGRL
MSMEG_6510|M.smegmatis_MC2_155 AFLAPGIIAQSALFISIFYGIQIIWDRDAGILAKLMVTPAPASALVAGKA
.* ..: : .: : :* *:*::: * * : : .:
Mflv_3387|M.gilvum_PYR-GCK AADFIRITAITLVVMSVGLVLGFRFEQGIPAAIAWVFMPALFGVTLSAAV
Mvan_3120|M.vanbaalenii_PYR-1 AADFVRIVVITLVVMVVGLALGFRFEQGILAAVVWVFMPALFGVALSAAV
MMAR_1769|M.marinum_M LADAVRILFTTLVMLGVGILMGFEFRQGLIASLMWLCVPVTLGIAFAVMV
MUL_2012|M.ulcerans_Agy99 LADAVRILFTTLVMLGVGILMGFEFRQGLIASLMWLCVPVTLGIAFAVMV
Mb2963|M.bovis_AF2122/97 LANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMV
Rv2938|M.tuberculosis_H37Rv LANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMV
MLBr_02350|M.leprae_Br4923 LANTIRTFVTTLVMLVTGVILGFRFRQGVIASLMWVSVPVIFGIAIAVMV
MAV_2004|M.avium_104 VAEAARTVASAFVLTVFGIALGLRFNDGWIAMLAFVLVPVTISAGMATLV
MSMEG_6510|M.smegmatis_MC2_155 FAAGVRSVVQVIGVVALAYLMGIALTLNPLRILAAMGVVVLGAAFFACLS
* * .: : . :*: : . : : : . . ::
Mflv_3387|M.gilvum_PYR-GCK LTLALLSSSTIAPQATEILIAILMFFS-IGFVPLDQYPEWLQPFVEHQPV
Mvan_3120|M.vanbaalenii_PYR-1 LTLALFSSSTIAPQATEIVIAILMFFS-IGFVPLDQYPKWLQPFVEHQPV
MMAR_1769|M.marinum_M TTVALYSSQAVIVEGVELTQAIAIFFS-TGLIPLDQYPHWIQPVVAHQPV
MUL_2012|M.ulcerans_Agy99 TTVALYSSQAVIVEGVELTQAIAIFFS-TGLIPLDQYPHWIQPVVAHQPV
Mb2963|M.bovis_AF2122/97 TTVALYTAQTVVVEGVELVQAIAIFFS-TGLVPLNSYPGWIQPFVAHQPV
Rv2938|M.tuberculosis_H37Rv TTVALYTAQTVVVEGVELVQAIAIFFS-TGLVPLNSYPGWIQPFVAHQPV
MLBr_02350|M.leprae_Br4923 TTVALYTEQTFVVEAVELVQAIAVFLS-TGLVPLNQYPGWIQPLVAHQPV
MAV_2004|M.avium_104 TAIAARADGKAMVTWLGAGCVVLLFLN-TGVAPAEVFPGWLQPVVRYSPI
MSMEG_6510|M.smegmatis_MC2_155 MTLAGLVRKRDRLMGIGQAITMPLFFASNALYPVDIMPTWLRWLSAVNPL
::* .: :*: .. * : * *:: . .*:
Mflv_3387|M.gilvum_PYR-GCK STTIEAMKGLSLEGPIAQPVLFSVLWAAGIAAVCAVPLAIGYRRASKRG-
Mvan_3120|M.vanbaalenii_PYR-1 STTIKAMKGLSLEGPIAQPVLLSVLWAAGIAAVCAVPLAIGFRKASKRG-
MMAR_1769|M.marinum_M SYAVSAMRGLSMGGPVLLPMIGVLLWTAGICAVCAVPLAVGWRRASTH--
MUL_2012|M.ulcerans_Agy99 SYAVSAMRGLSMGGPVLLPMIGVLLWTAGICAVCAVPLAVGWRRASTH--
Mb2963|M.bovis_AF2122/97 SYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH--
Rv2938|M.tuberculosis_H37Rv SYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH--
MLBr_02350|M.leprae_Br4923 SYAIAAMRGLSMGGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH--
MAV_2004|M.avium_104 SPTIEAMRALAQGGPVLSPLWQAGLWGGVLVAVFAPIAVRGYRAAAEAGC
MSMEG_6510|M.smegmatis_MC2_155 SYEVNALRGLLIGTPTNWVLDITVLVAAAVLGVVAASALLRRLVR-----
* : *::.: * : : . : *