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M. bovis AF2122 / 97 Mb2962 (drrB)

annotation: daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB
coordinates: 3229779 - 3230648
length: 289

MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIP
WNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVA
VDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILI
FGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALS
STIVLARRP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2962drrB-100% (289)daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB
M. bovis AF2122 / 97Mb2963drrC5e-1527.64% (246) daunorubicin-DIM-transport integral membrane protein ABC

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_3388-7e-6245.83% (264) ABC-2 type transporter
M. tuberculosis H37RvRv2937drrB1e-164100.00% (289) daunorubicin-DIM-transport integral membrane protein ABC
M. leprae Br4923MLBr_02351-1e-10463.67% (289) putative antibiotic resistance membrane protein
M. abscessus ATCC 19977-----
M. marinum MMMAR_1770drrB1e-11368.42% (285) daunorubicin-DIM-transport integral membrane protein ABC
M. avium 104MAV_3251-6e-2830.86% (243) ABC transporter efflux protein, DrrB family protein
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2013drrB1e-11268.07% (285) daunorubicin-DIM-transport integral membrane protein ABC
M. vanbaalenii PYR-1Mvan_3121-6e-6545.83% (264) multidrug ABC transporter inner membrane protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3388|M.gilvum_PYR-GCK         --MTAQSTVKTAPRRAAIPQAVRPRVSAIQQWWVLTVR-MIIPTLRNGEL
Mvan_3121|M.vanbaalenii_PYR-1      --MIVDS---------AIPAAVRPPVSAVQQWWVLTVR-MITPTLRNGEL
Mb2962|M.bovis_AF2122/97           MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRR-FAAPSLLNGEV
Rv2937|M.tuberculosis_H37Rv        MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRR-FAAPSLLNGEV
MMAR_1770|M.marinum_M              MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGR-FTKPRLRDPEL
MUL_2013|M.ulcerans_Agy99          MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGR-FTKPRLRDPEL
MLBr_02351|M.leprae_Br4923         MSMPALAPIPASRWP--STIMAKPRRSTLRQWWALTTRYYTDIKLFVFEK
MAV_3251|M.avium_104               ----------------------------MSALAALTER-SLKSAARDGEM
                                                                    .*  *          * 

Mflv_3388|M.gilvum_PYR-GCK         ATQVVGSIVFTVGYYLP----LKQMMGAVQP--LSSYAQYLTPLIVLQAI
Mvan_3121|M.vanbaalenii_PYR-1      ATQIVGSIVFTIGYYLP----LKQMMGAVQP--LSGYAQYLTPLIVLQAI
Mb2962|M.bovis_AF2122/97           LTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAV
Rv2937|M.tuberculosis_H37Rv        LTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAV
MMAR_1770|M.marinum_M              ITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVASSLGQYIAPLIVLQSI
MUL_2013|M.ulcerans_Agy99          ITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVPSSLGQYIAPLIVLQSI
MLBr_02351|M.leprae_Br4923         TIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSGIASNLGQYVTPLIVLQSI
MAV_3251|M.avium_104               IFEILSPAAYLAGFSVA--------LHGLIDTGRISYSQYLLPAVVAQSM
                                      : ..  :  *  :.        : .       . .**: * :. *::

Mflv_3388|M.gilvum_PYR-GCK         WFAAISAAFRSATDSVQGINRRFRAMPIPSSTPLAARMTASMYRCCIALA
Mvan_3121|M.vanbaalenii_PYR-1      WFAAISAAFRSATDSVQGINRRFRAMPIPALTPLASRMTASMYRCVVALI
Mb2962|M.bovis_AF2122/97           SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
Rv2937|M.tuberculosis_H37Rv        SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
MMAR_1770|M.marinum_M              SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
MUL_2013|M.ulcerans_Agy99          SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
MLBr_02351|M.leprae_Br4923         AFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMG
MAV_3251|M.avium_104               IFVGLMTADRAARDHLFGFGERIRTLPVPAAATVTARVTATLMRGSFCLV
                                    *..: :. *:* * : *...*:: :*:.. :.: :*:  :: *    : 

Mflv_3388|M.gilvum_PYR-GCK         VSVGCGYVIGFRFEAGVLGILGFVGLALLIGAALAIIGDLIGVATQNPEA
Mvan_3121|M.vanbaalenii_PYR-1      VSVACGYVIGFRFDNGVLGIVGFVALVLLIGAALALIGDLIGIATQNPEA
Mb2962|M.bovis_AF2122/97           ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
Rv2937|M.tuberculosis_H37Rv        ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
MMAR_1770|M.marinum_M              VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
MUL_2013|M.ulcerans_Agy99          VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
MLBr_02351|M.leprae_Br4923         VALICGHVIGFQFHRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDA
MAV_3251|M.avium_104               MALVAGYVLGFRLAGGLVYSAAFVFISLLLCLAVTLGADALGSSAKSVQG
                                   ::: .*:.:**::  * :   .:  : : :  .::: .* :*   :. :.

Mflv_3388|M.gilvum_PYR-GCK         TAPMMLIPQLTLGLASVGLQPVEQFPDWIQGFVRNQPLSQWVYALQALAG
Mvan_3121|M.vanbaalenii_PYR-1      TAPMMLIPQLTLGLASVGLQPVERFPEWIQGFVRNQPLSQWVYGLQALAG
Mb2962|M.bovis_AF2122/97           MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
Rv2937|M.tuberculosis_H37Rv        MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
MMAR_1770|M.marinum_M              MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
MUL_2013|M.ulcerans_Agy99          MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
MLBr_02351|M.leprae_Br4923         MLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFVVALRALAG
MAV_3251|M.avium_104               ASHLLFVPQLLLFMLSTGIAPEQTFPGWLRPYVRNQPVSQFAETLRGLAR
                                      :: :* * : : * *: * : ** *:: :* ***::*:.  *:.** 

Mflv_3388|M.gilvum_PYR-GCK         DSTDAAPDPTVAVLGSAVAWAVGCIVVALTLHVWVSRRRRS-
Mvan_3121|M.vanbaalenii_PYR-1      DSSGNAPEATFAVLGPGLAWVLGCIVVALALHTWVSRKRRSE
Mb2962|M.bovis_AF2122/97           DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP--
Rv2937|M.tuberculosis_H37Rv        DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP--
MMAR_1770|M.marinum_M              DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP--
MUL_2013|M.ulcerans_Agy99          DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP--
MLBr_02351|M.leprae_Br4923         ETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT--
MAV_3251|M.avium_104               G------HVIVGNVAATLAWCVGAVLVFGAITLRMQRRG---
                                                : . ::*  .  :.       :  :