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TALDTEAHAAVRPQPVPIRPTNLAQQSWIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFGASITNT GGASYREFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGRSIASVIHSSLGVLVM ALTGLAIGWRIRNGVAEAVLAFALLLLFGFGMIWFGILIGSLLRTVEAVNGVMFTALFPVTFLANTFVPT EPMPRWLRVIAEWNPVSSLAQAMRELWGNGGPAPAGAQLPLHHPVLATVLWSLALTAVFAPFALYAYKRR TGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4795 | - | - | 100% (284) | ABC-2 type transporter |
| M. vanbaalenii PYR-1 | Mvan_3120 | - | 1e-19 | 27.34% (256) | multidrug ABC transporter inner membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3121 | - | 2e-19 | 28.35% (261) | multidrug ABC transporter inner membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2962 | drrB | 6e-15 | 23.25% (271) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. gilvum PYR-GCK | Mflv_1937 | - | 1e-152 | 93.31% (284) | ABC-2 type transporter |
| M. tuberculosis H37Rv | Rv2937 | drrB | 7e-15 | 23.25% (271) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02350 | - | 3e-16 | 26.72% (262) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | MAB_1690 | - | 6e-06 | 22.46% (187) | ABC transporter transmembrane protein |
| M. marinum M | MMAR_3262 | - | 4e-71 | 49.60% (252) | integral membrane protein ABC transporter |
| M. avium 104 | MAV_2004 | - | 2e-19 | 26.69% (251) | ABC-2 type transporter |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 9e-16 | 25.67% (187) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2013 | drrB | 3e-16 | 25.51% (294) | daunorubicin-DIM-transport integral membrane protein ABC |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 MSALVALTLRTMSGSRRDADLLFAALAPVGCFLGFTLVLGGLIRTGSMSY
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 PQYVLPVVIVQAMLFGAMTTADRAARDRLSGFGSRLRTLPLPASVPLGAR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 MLYCLTRALIALAATMAAGWSFGFRMQGGPADAVLFVTIVVVFAMAVCLG
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 ADALGSRVGTVESSSQLLLLPQLVLVLLSTGIAPAESFPAWMAPFIRNQP
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1937|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3262|M.marinum_M --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 VSQVTEALRGLATGHVAGGSLAAALTWCLGLLAVFGVVAVRMQRRVDAGR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4795|M.vanbaalenii_PYR-1 ----------------------MTALDTEAHAAVRPQPVPIRPTNLAQQS
Mflv_1937|M.gilvum_PYR-GCK ----------------------MTAVDSQTHTPVQPRPVPIRPTNLAQQS
MMAR_3262|M.marinum_M --------------------------------------------------
Mb2962|M.bovis_AF2122/97 -----------MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRF
Rv2937|M.tuberculosis_H37Rv -----------MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRF
MUL_2013|M.ulcerans_Agy99 -----------MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGRF
MLBr_02350|M.leprae_Br4923 --------------------MITMISQTVGLVPASLQYPNNSVRALVSQT
MAV_2004|M.avium_104 SRAHRAVRKAPRDAAPAGDVGVNPVGKSAECLARQEVTRVGCLKGFVGQS
MSMEG_6510|M.smegmatis_MC2_155 ----------------------------MSVELVRAPRGLRRVRAVAMRM
MAB_1690|M.abscessus_ATCC_1997 ------------------------------------------MTALSNTA
Mvan_4795|M.vanbaalenii_PYR-1 WIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFG--ASITNTGGASY
Mflv_1937|M.gilvum_PYR-GCK WIMVKRNMIHTKRMPEMLSDVTAQPIMFVLLFAFVFG--ASITNTGGASY
MMAR_3262|M.marinum_M --MLKRNLIRVRRRPETLMQLLLQPIAFMLFFTFIVG--RSISENAAPHY
Mb2962|M.bovis_AF2122/97 AAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVG--GASSGVASNLG
Rv2937|M.tuberculosis_H37Rv AAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVG--GASSGVASNLG
MUL_2013|M.ulcerans_Agy99 TKPRLRDPELITMVGAPVVFTVGFYIPFAIPWNHYVG--GGASGVPSSLG
MLBr_02350|M.leprae_Br4923 LLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLG--NLAYVVTYDSG
MAV_2004|M.avium_104 ASEAGRLLRRWRRDPVVAVQALLFPTLLLVIYKLLVG--KSVLAVTGHDS
MSMEG_6510|M.smegmatis_MC2_155 GAFALVELQKLRHDRTELFTRMVQPALWLLIFGQTFSR-LHVVDTGGVPY
MAB_1690|M.abscessus_ATCC_1997 RLFRRYVVVGLRQPVFGFIFPIVFPVVLVIFVRSMFQRVADLPGFPLSSY
: .
Mvan_4795|M.vanbaalenii_PYR-1 REFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGR
Mflv_1937|M.gilvum_PYR-GCK REFLLPGIQAQTIVFSAFVVASGITADVEKGIIDRFRSLPISRSSVLIGR
MMAR_3262|M.marinum_M REYLLPGIQAQAIVATIILVGAAISADVENDVFIRFRSLPISNSAPLIAR
Mb2962|M.bovis_AF2122/97 QY-ITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLAR
Rv2937|M.tuberculosis_H37Rv QY-ITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLAR
MUL_2013|M.ulcerans_Agy99 QY-IAPLIVLQSISFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVAR
MLBr_02350|M.leprae_Br4923 LYSFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLAR
MAV_2004|M.avium_104 LYGLVPMCAVVGAVFGTIGAGLALPSERESGVLTRLWVQPVHRASPVAGR
MSMEG_6510|M.smegmatis_MC2_155 LAFLAPGIIAQSALFISIFYGIQIIWDRDAGILAKLMVTPAPASALVAGK
MAB_1690|M.abscessus_ATCC_1997 TAYIAPGLIMLIPMLGAGYGAGTLIDEIRSGFTDRLRLYGVSTGQIMAAK
: * . : .. :: : .:
Mvan_4795|M.vanbaalenii_PYR-1 SIASVIHSSLGVLVMALTGLAIGWRIRNGVAEAVLAFALLLLFGFGMIWF
Mflv_1937|M.gilvum_PYR-GCK SIASVIHSSLGALVMALTGLAIGWRIRNGVGEAVLAFALLMLFGFGMIWF
MMAR_3262|M.marinum_M GLVSLLYAAIVYILIGISGMLIGWRMHGSLADAVLAFVLVLVFGVGFMWL
Mb2962|M.bovis_AF2122/97 VWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFA
Rv2937|M.tuberculosis_H37Rv VWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFA
MUL_2013|M.ulcerans_Agy99 VTAAIYRCCVGLTVALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFG
MLBr_02350|M.leprae_Br4923 ILANTIRTFVTTLVMLVTGVILGFRFRQGVIASLMWVSVPVIFGIAIAVM
MAV_2004|M.avium_104 LVAEAARTVASAFVLTVFGIALGLRFNDGWIAMLAFVLVPVTISAGMATL
MSMEG_6510|M.smegmatis_MC2_155 AFAAGVRSVVQVIGVVALAYLMGIALTLNPLRILAAMGVVVLGAAFFACL
MAB_1690|M.abscessus_ATCC_1997 IGFEMFRILPAAVIVIGLLAFLDAPLRSGLLTGVFLVLVMFLWSAAYSSL
:. : . : : . .
Mvan_4795|M.vanbaalenii_PYR-1 GILIGSLLRTVEAVNGVMFTALFPVTFLANTFVPTEPMPRWLRVIAEWNP
Mflv_1937|M.gilvum_PYR-GCK GILIGSLMRSVEAVNGVMFTALFPVTFLANTFVPTEPMPHWLRVIAEWNP
MMAR_3262|M.marinum_M GMVVGLMVRTVEVVGAAVFLITLPIISISNCFVPTQPMPHALRVIAEWNP
Mb2962|M.bovis_AF2122/97 ADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQP
Rv2937|M.tuberculosis_H37Rv ADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQP
MUL_2013|M.ulcerans_Agy99 ADLLGTGTKNPDAMLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQP
MLBr_02350|M.leprae_Br4923 VTTVALYTEQ-TFVVEAVELVQAIAVFLSTGLVPLNQYPGWIQPLVAHQP
MAV_2004|M.avium_104 VTAIAARADG-KAMVTWLGAGCVVLLFLNTGVAPAEVFPGWLQPVVRYSP
MSMEG_6510|M.smegmatis_MC2_155 SMTLAGLVRKRDRLMGIGQAITMPLFFASNALYPVDIMPTWLRWLSAVNP
MAB_1690|M.abscessus_ATCC_1997 FYLVALRTLNPQAPVAMLP-LALPVLFVSQALMPSVFLSDWLRISINANP
:. . * . :: .*
Mvan_4795|M.vanbaalenii_PYR-1 VSSLAQAMRELWGNGGPAPAGAQLPLHHPVLATVLWSLALTAVFAPFALY
Mflv_1937|M.gilvum_PYR-GCK VSSLAQAMRELWGNGGPAPASAQLPLHYPVASTILWSLALTAVFAPFALY
MMAR_3262|M.marinum_M LSSLALALRKLTIDEPMAPPSAQLPLHHPALSTLIYSIVLTALLAPIAIR
Mb2962|M.bovis_AF2122/97 ISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLA
Rv2937|M.tuberculosis_H37Rv ISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLA
MUL_2013|M.ulcerans_Agy99 ITQFVVALRALAGDTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLS
MLBr_02350|M.leprae_Br4923 VSYAIAAMRGLSMGGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH-
MAV_2004|M.avium_104 ISPTIEAMRALAQGGPVLSPLWQAGLWGGVLVAVFAPIAVRGYRAAAEAG
MSMEG_6510|M.smegmatis_MC2_155 LSYEVNALRGLLIG---TPTNWVLDITVLVAAAVLGVVAASALLRRLVR-
MAB_1690|M.abscessus_ATCC_1997 FSHIVSAASTIMYGDFDAMLVVKGVLVAIGMFALLQIPIHLVIRRKIGK-
.: * : . :
Mvan_4795|M.vanbaalenii_PYR-1 AYKRRTGG
Mflv_1937|M.gilvum_PYR-GCK AYKRRTGG
MMAR_3262|M.marinum_M AYIRRTSL
Mb2962|M.bovis_AF2122/97 RRP-----
Rv2937|M.tuberculosis_H37Rv RRP-----
MUL_2013|M.ulcerans_Agy99 RRP-----
MLBr_02350|M.leprae_Br4923 --------
MAV_2004|M.avium_104 C-------
MSMEG_6510|M.smegmatis_MC2_155 --------
MAB_1690|M.abscessus_ATCC_1997 --------