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VSRSDSAARHQRGVRTFAEVMTFDPPDDASPCASGLIDFVFGEVWSRPGLSRRDRRFVTLACVAAADAQA PLEQHVYAALNSGDLSITEMREAVLHFAVYAGWPKASRFNIVVDQQWARIAAERGEPTPDPEPLLPLVTA ADPEQRLRGGERSFKDINCLPFAPPRDNPYSGAGILNFVFGEMWLRPGLGMKERRLITVACVAFQDAEIP IMSHVYAALKSGDVSFREMDEVALQFAAYYGCAKADHLNQALAEQKQRVIAENHSDATPVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3552 | pcaC | - | 100% (271) | hypothetical protein MAV_3552 |
| M. avium 104 | MAV_0716 | pcaC | 2e-13 | 35.83% (120) | hypothetical protein MAV_0716 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0794 | - | 4e-15 | 36.61% (112) | 4-carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_1906 | - | 1e-107 | 72.05% (254) | carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 4e-15 | 36.61% (112) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1221 | - | 2e-14 | 36.70% (109) | 4-carboxymuconolactone decarboxylase |
| M. marinum M | MMAR_4925 | - | 3e-12 | 35.45% (110) | 4-carboxymuconolactone decarboxylase |
| M. smegmatis MC2 155 | MSMEG_5814 | pcaC | 1e-109 | 74.41% (254) | hypothetical protein MSMEG_5814 |
| M. thermoresistible (build 8) | TH_1260 | - | 6e-12 | 33.02% (106) | POSSIBLE 4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) |
| M. ulcerans Agy99 | MUL_0480 | - | 1e-11 | 34.55% (110) | 4-carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_3396 | - | 1e-104 | 70.92% (251) | carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1906|M.gilvum_PYR-GCK -----MIT----DRMDRGRRAYADIMTVPAPEDTS-PTARHLLDFVFAEV
MSMEG_5814|M.smegmatis_MC2_155 -----MTTPD-TERLERGKRAFADVMTFPAPDDFS-PAMTHLLDFVFAEV
Mvan_3396|M.vanbaalenii_PYR-1 -----MTS------TARAEAAFTDIMTFPPPEVTS-PAAAHILAFVFADV
MAV_3552|M.avium_104 -----MSRSDSAARHQRGVRTFAEVMTFDPPDDAS-PCASGLIDFVFGEV
Mb0794|M.bovis_AF2122/97 ---------MMDELRRTGLDKMNEVYAWDMPDMPG-EFFALTVDHLFGRI
Rv0771|M.tuberculosis_H37Rv ---------MMDELRRTGLDKMNEVYAWDMPDMPG-EFFALTVDHLFGRI
MMAR_4925|M.marinum_M ----------MDELRRKGLDKMNEVYGWEMPNIEGDAYFDLTVDHLFGTI
MUL_0480|M.ulcerans_Agy99 ----------MDELRRKGLDKMNEVYGWEMPNIEGDAYFDLTVDHLFGTI
TH_1260|M.thermoresistible__bu ----------MDELRRRGLEKMNEVYGWEMPNIEGDPYFDLTVDHLFGTI
MAB_1221|M.abscessus_ATCC_1997 MVCHTRKGQVMDELRRQGLDKMKEVYGWDMPDIPG-DYFKYTIDHLFGTI
. :: *: . : .:*. :
Mflv_1906|M.gilvum_PYR-GCK WQRPGLTRRERRFVTLPCVAAADAEAPMRDHIYAALNSGDLGIDEMREAV
MSMEG_5814|M.smegmatis_MC2_155 WQRPALTRRQRRFVTLPCVAAADAEGPLRDHVYAALNSGDISIVEMRETV
Mvan_3396|M.vanbaalenii_PYR-1 WQRPGLSRRDRHFVTLPCVAAADAEGPLRDHVYAALNSGEVTITEMREAV
MAV_3552|M.avium_104 WSRPGLSRRDRRFVTLACVAAADAQAPLEQHVYAALNSGDLSITEMREAV
Mb0794|M.bovis_AF2122/97 WTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELRELA
Rv0771|M.tuberculosis_H37Rv WTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELRELA
MMAR_4925|M.marinum_M WTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAALLNGELTEAELKEMA
MUL_0480|M.ulcerans_Agy99 WTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAAPLNGELTEAELKEMA
TH_1260|M.thermoresistible__bu WTRPGLSMRDKRIMTLTAVTAVGNSDLAEIQANAALANGELTEDELKEMA
MAB_1221|M.abscessus_ATCC_1997 WTRPELSMRDRRLLLLGAVSALGLDEILEIQTSAALKNGELTEAELREVA
* ** *: *:::: : ::* . . : *. ..:: *::* .
Mflv_1906|M.gilvum_PYR-GCK LHFAVYAGWPKASRFNMVVDEQWDRIHRERGVPVPPAPPLLPLTTPSDPE
MSMEG_5814|M.smegmatis_MC2_155 LHFAVYGGWPKASRFNSAVDEQWARIHDERGLAVPAPEPLLPLTTPSDPE
Mvan_3396|M.vanbaalenii_PYR-1 LHFAVYGGWPKASRFNMIVDEQWHRIHGERGVEVPPPPPLLPLTTPSDPE
MAV_3552|M.avium_104 LHFAVYAGWPKASRFNIVVDQQWARIAAERGEPTPDPEPLLPLVTAADPE
Mb0794|M.bovis_AF2122/97 VFITHYVGFPLGSRLNSAIERVAAKRKQ-----AAENGSLPDTKANVAEV
Rv0771|M.tuberculosis_H37Rv VFITHYVGFPLGSRLNSAIERVAAKRKQ-----AAENGSLPDTKANVAEV
MMAR_4925|M.marinum_M VFLTHYLGFPLGSGLNGAVDTVVARRKK-----AAAKGAGEDKKGNVDDA
MUL_0480|M.ulcerans_Agy99 VFLTHYLGFPLGSGLNGAVDTVVARRKK-----AAAKGAGEDKKGNVDDA
TH_1260|M.thermoresistible__bu VFLTHYLGFPLGSKLDGAVSKVIKNRRK-----AAAEGKGEDRKANVDAA
MAB_1221|M.abscessus_ATCC_1997 IFITHYVGWPLGQRVNKHVEMAVAKQNE-----ARR------TKESSDD-
:.:: * *:* .. .: :. . .
Mflv_1906|M.gilvum_PYR-GCK ARLSVGEQSFKDVNCLPYAPQRDNPFQGAGILNFVFGEMWLRPNLGMKER
MSMEG_5814|M.smegmatis_MC2_155 ERLAVGEQSFKDINCLPYAPMRDNPFQGAGILNFVFGEMWLRPGLGMKER
Mvan_3396|M.vanbaalenii_PYR-1 ARLAAGEQSFKDVNCLPFAPARDDPFHGAGILNFVFGEMWLRPALGMRER
MAV_3552|M.avium_104 QRLRGGERSFKDINCLPFAPPRDNPYSGAGILNFVFGEMWLRPGLGMKER
Mb0794|M.bovis_AF2122/97 LAKESGK-----SS------------------------------------
Rv0771|M.tuberculosis_H37Rv LAKESGK-----SS------------------------------------
MMAR_4925|M.marinum_M LKMHSGG----KPD------------------------------------
MUL_0480|M.ulcerans_Agy99 LKMHSGS----KPD------------------------------------
TH_1260|M.thermoresistible__bu VRMHSGETIHDQHDQ-----------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1906|M.gilvum_PYR-GCK RLITVACVAFQDSPYPILSHVYAALKSRDLSFEELDEVALHFAVHYGWPK
MSMEG_5814|M.smegmatis_MC2_155 RLITVACVAFQDAPYPILSHVYAALKSRDVSFAEMDELALHFAAHYGWPK
Mvan_3396|M.vanbaalenii_PYR-1 RLITVACVAFQDAPYPIISHVYAALKSRDLSFTEMDELTLHFAAYYGWPK
MAV_3552|M.avium_104 RLITVACVAFQDAEIPIMSHVYAALKSGDVSFREMDEVALQFAAYYGCAK
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
TH_1260|M.thermoresistible__bu --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1906|M.gilvum_PYR-GCK GSHLNQVIAEQKERVTNEWAAEGGAAQ-
MSMEG_5814|M.smegmatis_MC2_155 ASHLNQVIDDQKRRVSDEWAAEPQVAS-
Mvan_3396|M.vanbaalenii_PYR-1 AAHLSQVAAEQKSRVTEEWAAEGHGQSA
MAV_3552|M.avium_104 ADHLNQALAEQKQRVIAENHSDATPVG-
Mb0794|M.bovis_AF2122/97 ----------------------------
Rv0771|M.tuberculosis_H37Rv ----------------------------
MMAR_4925|M.marinum_M ----------------------------
MUL_0480|M.ulcerans_Agy99 ----------------------------
TH_1260|M.thermoresistible__bu ----------------------------
MAB_1221|M.abscessus_ATCC_1997 ----------------------------