For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LITDRMDRGRRAYADIMTVPAPEDTSPTARHLLDFVFAEVWQRPGLTRRERRFVTLPCVAAADAEAPMRD HIYAALNSGDLGIDEMREAVLHFAVYAGWPKASRFNMVVDEQWDRIHRERGVPVPPAPPLLPLTTPSDPE ARLSVGEQSFKDVNCLPYAPQRDNPFQGAGILNFVFGEMWLRPNLGMKERRLITVACVAFQDSPYPILSH VYAALKSRDLSFEELDEVALHFAVHYGWPKGSHLNQVIAEQKERVTNEWAAEGGAAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1906 | - | - | 100% (267) | carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_1912 | - | 2e-08 | 33.33% (90) | carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_1603 | - | 7e-08 | 34.18% (79) | carboxymuconolactone decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0794 | - | 1e-09 | 32.05% (78) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 1e-09 | 32.05% (78) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1221 | - | 1e-09 | 33.33% (81) | 4-carboxymuconolactone decarboxylase |
| M. marinum M | MMAR_4925 | - | 2e-08 | 37.18% (78) | 4-carboxymuconolactone decarboxylase |
| M. avium 104 | MAV_3552 | pcaC | 1e-107 | 72.05% (254) | hypothetical protein MAV_3552 |
| M. smegmatis MC2 155 | MSMEG_5814 | pcaC | 1e-129 | 81.54% (260) | hypothetical protein MSMEG_5814 |
| M. thermoresistible (build 8) | TH_0621 | - | 6e-10 | 41.77% (79) | 4-carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_0480 | - | 7e-08 | 35.90% (78) | 4-carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_3396 | - | 1e-124 | 80.08% (256) | carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1906|M.gilvum_PYR-GCK -----MIT----DRMDRGRRAYADIMTVPAPE--------DTS-PTARHL
MSMEG_5814|M.smegmatis_MC2_155 -----MTTPD-TERLERGKRAFADVMTFPAPD--------DFS-PAMTHL
Mvan_3396|M.vanbaalenii_PYR-1 -----MTS------TARAEAAFTDIMTFPPPE--------VTS-PAAAHI
MAV_3552|M.avium_104 -----MSRSDSAARHQRGVRTFAEVMTFDPPD--------DAS-PCASGL
Mb0794|M.bovis_AF2122/97 ---------MMDELRRTGLDKMNEVYAWDMPD--------MPG-EFFALT
Rv0771|M.tuberculosis_H37Rv ---------MMDELRRTGLDKMNEVYAWDMPD--------MPG-EFFALT
MMAR_4925|M.marinum_M ----------MDELRRKGLDKMNEVYGWEMPN--------IEGDAYFDLT
MUL_0480|M.ulcerans_Agy99 ----------MDELRRKGLDKMNEVYGWEMPN--------IEGDAYFDLT
MAB_1221|M.abscessus_ATCC_1997 MVCHTRKGQVMDELRRQGLDKMKEVYGWDMPD--------IPG-DYFKYT
TH_0621|M.thermoresistible__bu -------------MREQGLQVFRELLPGVLPDGDVDFRDGSFGDELLEIG
. :: *: .
Mflv_1906|M.gilvum_PYR-GCK LDFVFAEVWQRPGLTRRERRFVTLPCVAAADAEAPMRDHIYAALNSGDLG
MSMEG_5814|M.smegmatis_MC2_155 LDFVFAEVWQRPALTRRQRRFVTLPCVAAADAEGPLRDHVYAALNSGDIS
Mvan_3396|M.vanbaalenii_PYR-1 LAFVFADVWQRPGLSRRDRHFVTLPCVAAADAEGPLRDHVYAALNSGEVT
MAV_3552|M.avium_104 IDFVFGEVWSRPGLSRRDRRFVTLACVAAADAQAPLEQHVYAALNSGDLS
Mb0794|M.bovis_AF2122/97 VDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELT
Rv0771|M.tuberculosis_H37Rv VDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELT
MMAR_4925|M.marinum_M VDHLFGTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAALLNGELT
MUL_0480|M.ulcerans_Agy99 VDHLFGTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAAPLNGELT
MAB_1221|M.abscessus_ATCC_1997 IDHLFGTIWTRPELSMRDRRLLLLGAVSALGLDEILEIQTSAALKNGELT
TH_0621|M.thermoresistible__bu IDNVFGRLWTRDGLSRRDRSLVTLGILIALRATDELRFHVQIARNNG-LT
: :*. :* * *: *:* : : : * . : . .. :
Mflv_1906|M.gilvum_PYR-GCK IDEMREAVLHFAVYAGWPKASRFNMVVDEQWDRIHRERGVPVPPAPPLLP
MSMEG_5814|M.smegmatis_MC2_155 IVEMRETVLHFAVYGGWPKASRFNSAVDEQWARIHDERGLAVPAPEPLLP
Mvan_3396|M.vanbaalenii_PYR-1 ITEMREAVLHFAVYGGWPKASRFNMIVDEQWHRIHGERGVEVPPPPPLLP
MAV_3552|M.avium_104 ITEMREAVLHFAVYAGWPKASRFNIVVDQQWARIAAERGEPTPDPEPLLP
Mb0794|M.bovis_AF2122/97 IDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLP------
Rv0771|M.tuberculosis_H37Rv IDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLP------
MMAR_4925|M.marinum_M EAELKEMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGE------
MUL_0480|M.ulcerans_Agy99 EAELKEMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGE------
MAB_1221|M.abscessus_ATCC_1997 EAELREVAIFITHYVGWPLGQRVNKHVEMAVAKQNEARR-----------
TH_0621|M.thermoresistible__bu EDEIAEVIYHATGYAGFPNASTAMKVAKEVLAEEH---------------
*: * . : * *:* .. . .
Mflv_1906|M.gilvum_PYR-GCK LTTPSDPEARLSVGEQSFKDVNCLPYAPQRDNPFQGAGILNFVFGEMWLR
MSMEG_5814|M.smegmatis_MC2_155 LTTPSDPEERLAVGEQSFKDINCLPYAPMRDNPFQGAGILNFVFGEMWLR
Mvan_3396|M.vanbaalenii_PYR-1 LTTPSDPEARLAAGEQSFKDVNCLPFAPARDDPFHGAGILNFVFGEMWLR
MAV_3552|M.avium_104 LVTAADPEQRLRGGERSFKDINCLPFAPPRDNPYSGAGILNFVFGEMWLR
Mb0794|M.bovis_AF2122/97 -DTKANVAEVLAKESGKSS-------------------------------
Rv0771|M.tuberculosis_H37Rv -DTKANVAEVLAKESGKSS-------------------------------
MMAR_4925|M.marinum_M -DKKGNVDDALKMHSGGKPD------------------------------
MUL_0480|M.ulcerans_Agy99 -DKKGNVDDALKMHSGSKPD------------------------------
MAB_1221|M.abscessus_ATCC_1997 --TKESSDD-----------------------------------------
TH_0621|M.thermoresistible__bu -SRAADADKQSRLGESNP--------------------------------
.
Mflv_1906|M.gilvum_PYR-GCK PNLGMKERRLITVACVAFQDSPYPILSHVYAALKSRDLSFEELDEVALHF
MSMEG_5814|M.smegmatis_MC2_155 PGLGMKERRLITVACVAFQDAPYPILSHVYAALKSRDVSFAEMDELALHF
Mvan_3396|M.vanbaalenii_PYR-1 PALGMRERRLITVACVAFQDAPYPIISHVYAALKSRDLSFTEMDELTLHF
MAV_3552|M.avium_104 PGLGMKERRLITVACVAFQDAEIPIMSHVYAALKSGDVSFREMDEVALQF
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Mflv_1906|M.gilvum_PYR-GCK AVHYGWPKGSHLNQVIAEQKERVTNEWAAEGGAAQ-
MSMEG_5814|M.smegmatis_MC2_155 AAHYGWPKASHLNQVIDDQKRRVSDEWAAEPQVAS-
Mvan_3396|M.vanbaalenii_PYR-1 AAYYGWPKAAHLSQVAAEQKSRVTEEWAAEGHGQSA
MAV_3552|M.avium_104 AAYYGCAKADHLNQALAEQKQRVIAENHSDATPVG-
Mb0794|M.bovis_AF2122/97 ------------------------------------
Rv0771|M.tuberculosis_H37Rv ------------------------------------
MMAR_4925|M.marinum_M ------------------------------------
MUL_0480|M.ulcerans_Agy99 ------------------------------------
MAB_1221|M.abscessus_ATCC_1997 ------------------------------------
TH_0621|M.thermoresistible__bu ------------------------------------