For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SALGRLTHSVKKAWPFEVLPRTAWARQSPTVGQASPQLIEAALARSQARPSGNWYVIAAGADVGAKPVGA TVAGAELVCWRGADGEVHAGPASCPHLGADLCTGTVDRGQLVCPWHGLRLTGRSRPDWPSVPTFDDGVLV WARLDRIGGEAPTEAPIVPVRPEAPTIAAVTTLHGACEAVDIIANRMDPWHGGWFHPYSFTKLDVLSAPG EDGDIPEELDRFLVAVTFRIGRLGVPVIAEFTSPEPRTLVMRIVDGEGTGSVVETHATPQGYDRDGRPRA TVTEAVVAHSDRPGFARAMRVAPMITPFMRHAANRLWRDDLVYAERLQTVREQKASGAADLLRPLPEPTR GDRQPPAAAPGSAPTD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1843 | - | - | 100% (367) | Rieske (2Fe-2S) domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4566 | - | 2e-07 | 28.42% (183) | Rieske (2Fe-2S) domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2753 | - | 5e-05 | 32.91% (79) | Rieske (2Fe-2S) region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3556 | - | 2e-06 | 29.90% (97) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3526 | - | 2e-06 | 29.90% (97) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0080c | - | 4e-08 | 34.31% (102) | putative oxygenase |
| M. marinum M | MMAR_3971 | - | 8e-12 | 29.61% (206) | oxidoreductase |
| M. avium 104 | MAV_3891 | - | 1e-118 | 61.98% (334) | methylesterase |
| M. smegmatis MC2 155 | MSMEG_2343 | - | 1e-116 | 60.31% (325) | methylesterase |
| M. thermoresistible (build 8) | TH_1484 | - | 1e-121 | 61.58% (341) | methylesterase |
| M. ulcerans Agy99 | MUL_3829 | - | 7e-12 | 29.13% (206) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1581 | - | 1e-118 | 60.61% (330) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3891|M.avium_104 MNIRAQLRHLRPSVRAKDWPLQVIPRTPWADQRPTFREAQPAVIDAALQR
MSMEG_2343|M.smegmatis_MC2_155 MKIGDR--------WPKDWPLQLISSPRWSEQRPTYGEAKPAIIEAALRR
TH_1484|M.thermoresistible__bu MSIAANLR----SRWAKTVPFQVLPPLRWAAQRPTFRAAEPAVIAGALTR
Mvan_1581|M.vanbaalenii_PYR-1 MSVLSGLR----ARAAKAWPFEFLPAASWSAQPPTYQDANPAVIDTALQR
Mflv_1843|M.gilvum_PYR-GCK MSALGRLT----HSVKKAWPFEVLPRTAWARQSPTVGQASPQLIEAALAR
Mb3556|M.bovis_AF2122/97 ----------------------------MSTDTSG-----VGVREIDAGA
Rv3526|M.tuberculosis_H37Rv ----------------------------MSTDTSG-----VGVREIDAGA
MAB_0080c|M.abscessus_ATCC_199 ----------------------------MTTAQSATEFDPATVRSIEADA
MMAR_3971|M.marinum_M ----------------------MAPSTSNSASSSAEEHSEQEFGPSGIAL
MUL_3829|M.ulcerans_Agy99 ----------------------MAPSTSNSASNSAEELSEQEFGPSGIAL
: . .
MAV_3891|M.avium_104 CRRQPTGNWYAFAASTHVERGRPLGARVAGVDLVAWRDARGALCVGPRSC
MSMEG_2343|M.smegmatis_MC2_155 SQRRPTGNWYVLGANREIRADRPFGTTIGGIEVVAWRDRQGHLRVGPRSC
TH_1484|M.thermoresistible__bu SQRRPGGNWFAFAAADRIG-DRPLGTRVGGVELVAWRGADGTLRVGPGAC
Mvan_1581|M.vanbaalenii_PYR-1 TLGRPGGNWFVIAASADIT-TKAFGTSVAGRELVAWRGSDGALLVAPRAC
Mflv_1843|M.gilvum_PYR-GCK SQARPSGNWYVIAAGADVG-AKPVGATVAGAELVCWRGADGEVHAGPASC
Mb3556|M.bovis_AF2122/97 LPTRYARGWHCLGVAKDYLEGKPHGVEAFGTKLVVFADSHGDLKVLDGYC
Rv3526|M.tuberculosis_H37Rv LPTRYARGWHCLGVAKDYLEGKPHGVEAFGTKLVVFADSHGDLKVLDGYC
MAB_0080c|M.abscessus_ATCC_199 APARFARGWYCLGLIKDFGDGKPHAVNAFGQKLVVFRPAGGKVSVLDAYC
MMAR_3971|M.marinum_M SPYRFPTGWFIVAFSSELGAGEVKRVHYFGEELVLFRTASGRVHALDAYC
MUL_3829|M.ulcerans_Agy99 SPYRFPTGWFIVAFSSELGAGEVKRVHSFGEELVLFRTASGRVHALDAYC
: .*. .. . . * .:* : * : . *
MAV_3891|M.avium_104 PHLGADLATG-TVCGGTLICRWHGLPLDG-------------RAREFGWA
MSMEG_2343|M.smegmatis_MC2_155 PHLGADLATG-VVDDGSLICRWHGLPLTG-------------KTCEFGWA
TH_1484|M.thermoresistible__bu PHLGADLSTG-RVDHGTLVCPWHGLRLDG-------------GCREFGWS
Mvan_1581|M.vanbaalenii_PYR-1 PHLGADLATA-PVDCGTLVCPWHGLRLG--------------ERRHGAWK
Mflv_1843|M.gilvum_PYR-GCK PHLGADLCTG-TVDRGQLVCPWHGLRLTG-------------RSRP-DWP
Mb3556|M.bovis_AF2122/97 RHMGGDLSEG-TVKGDEVACPFHDWRWGGDGRCKLVPYARR-TPRMARTR
Rv3526|M.tuberculosis_H37Rv RHMGGDLSEG-TVKGDEVACPFHDWRWGGDGRCKLVPYARR-TPRMARTR
MAB_0080c|M.abscessus_ATCC_199 RHMGGDLSQG-EVKGDEIACPFHDWRWGGDGRCKKVPYSRR-TPKLARTA
MMAR_3971|M.marinum_M QHLGANLGVGGTVEGEHIVCPWHGWQWRGDGTNALIPYSKIGCKNNVGIR
MUL_3829|M.ulcerans_Agy99 QHLGANLGVGGTVEGEHIVCPWHGWQWRGDGTNALIPYSKIGCKKNVRIR
*:*.:* . * : * :*.
MAV_3891|M.avium_104 PVPSHDDGTLAWVRLDAV--GGETPSPRPVIPPRPAGHTLASVAHLVG--
MSMEG_2343|M.smegmatis_MC2_155 PLPSHDDGVLAWVRLDEL--GGEDPLTVPVVPTRPAGETLHALTRLVG--
TH_1484|M.thermoresistible__bu PYPSHDDGVLAWVRLDRV--GGENPTDRPVPAPRPAGVRLAAVTRLVG--
Mvan_1581|M.vanbaalenii_PYR-1 PYPAHDDGVLCWVRLDDLDTGASAPTEQPVIPLRPGEPALAAVTRMEG--
Mflv_1843|M.gilvum_PYR-GCK SVPTFDDGVLVWARLDRI--GGEAPTEAPIVPVRPEAPTIAAVTTLHG--
Mb3556|M.bovis_AF2122/97 SWTTDVRSGLLFVWHDHE---GNPPDPAVRIPEIPEAASDEWTDWRWNRI
Rv3526|M.tuberculosis_H37Rv SWTTDVRSGLLFVWHDHE---GNPPDPAVRIPEIPEAASDEWTDWRWNRI
MAB_0080c|M.abscessus_ATCC_199 TWITLEQDGMLFIWHDPQ---GNPPPEDVAIPRIEGATSPEWTDWHWYTT
MMAR_3971|M.marinum_M SYPSIQWYGFILVWHERH---GRPP--YWEPPVLPELETNEYYPLHPHTR
MUL_3829|M.ulcerans_Agy99 SYPSIQWYGFILVWQERH---GRPP--YWQPPVLPELETNEYYSLHPHTR
. : : : . * .
MAV_3891|M.avium_104 -----VCEPADIIANRLDPWHGAWFHPYSFTRLEVLAT------------
MSMEG_2343|M.smegmatis_MC2_155 -----VCEPSDIIANRLDPWHGNWFHPYSFTRLEVLST------------
TH_1484|M.thermoresistible__bu -----RCEPHDIIANRLDPWHGAWFHPYSFTRLEVVSA------------
Mvan_1581|M.vanbaalenii_PYR-1 -----VCEPRDIVANRLDPWHGAWFHPYSFSRLRVLSA------------
Mflv_1843|M.gilvum_PYR-GCK -----ACEAVDIIANRMDPWHGGWFHPYSFTKLDVLSA------------
Mb3556|M.bovis_AF2122/97 LIEGSNCR--DIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVG
Rv3526|M.tuberculosis_H37Rv LIEGSNCR--DIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVG
MAB_0080c|M.abscessus_ATCC_199 VVN-TNCR--EIIDNVVDMAHFFYVHGAVPTYFKNIFEGHIATQYMN-TG
MMAR_3971|M.marinum_M MLNRVKVHPQMIIENAADPYHVQYVHKAASPANTASFE--VSGYHLHATV
MUL_3829|M.ulcerans_Agy99 MLNRVKVHPQMIIENAADPYHVQYVHKAASPANTASFE--VSGYHLHATV
. *: * * * :.* .
MAV_3891|M.avium_104 --------PTE------EADRFLVAVTFRMGRLGVPVVAEFDCPEARTIV
MSMEG_2343|M.smegmatis_MC2_155 --------PTE------EDDRFLLSVTFRLGRLGVPVVAEFTCPSARTIV
TH_1484|M.thermoresistible__bu --------PPPGIEVPPEEDRFLVAVTFRMGRLGVPVIAEFTAPGPRTIV
Mvan_1581|M.vanbaalenii_PYR-1 --------PPAEDGLAQDLDRFVVEVTFHIGRLGVPVIAEFTTPGPRTVV
Mflv_1843|M.gilvum_PYR-GCK --------PGEDGDIPEELDRFLVAVTFRIGRLGVPVIAEFTSPEPRTLV
Mb3556|M.bovis_AF2122/97 RPDVDD-LGTSYGEAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCH
Rv3526|M.tuberculosis_H37Rv RPDVDD-LGTSYGEAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCH
MAB_0080c|M.abscessus_ATCC_199 EPRADLPIPEGVQMTGQTSVASYYGPSFMIDDLTYHFVGYDSNSILINCH
MMAR_3971|M.marinum_M NANFGGGRTKTWLTPNGPVDAKIIYDNYSLGLGIVRFPSELVATVQVTGQ
MUL_3829|M.ulcerans_Agy99 NANFGGGRTKTWLTPNGPVDAKIVYDNYSLGLGIVRFPSELVATVQVTGQ
.: :. . .
MAV_3891|M.avium_104 MRIVDGEGTGSVVETHATPIGSGPD-GRPRTAVLEAVIAHSDRPGFARAL
MSMEG_2343|M.smegmatis_MC2_155 MRIVDGEGAGSIVETHATPLGPGTD-GRPRTAVVEAVVAQSDRAGFRHAR
TH_1484|M.thermoresistible__bu MRIVDGEGAGSVVETHATPIGPGAD-GAPRTAVLEAVVAHSNRPNFVHAL
Mvan_1581|M.vanbaalenii_PYR-1 MHIVEGEGRGSVVETHATPLGPGVD-GRPRTAVIEAVIAHSDRPHFGAGL
Mflv_1843|M.gilvum_PYR-GCK MRIVDGEGTGSVVETHATPQGYDRD-GRPRATVTEAVVAHSDRPGFARAM
Mb3556|M.bovis_AF2122/97 YPVTQNSFVLQWGVIVEKPKGMSEEMTDKLSRVFTEGVSKGFLQDVEIWK
Rv3526|M.tuberculosis_H37Rv YPVTQNSFVLQWGVIVEKPKGMSEEMTDKLSRVFTEGVSKGFLQDVEIWK
MAB_0080c|M.abscessus_ATCC_199 YPIDANSFVLQYGIIVKKSAGLSDDDALAAAITLGDWIKAGFEQDVQIWK
MMAR_3971|M.marinum_M TPVDEDYTDYFYTQASIREPGDAGDVPTGRAARFLALQQEVIKQDFFTWE
MUL_3829|M.ulcerans_Agy99 TPVDEDYTDYFYTQASIRELGDAGDVPTGRAARFLALQQEVIKQDFFTWE
: . * : : .
MAV_3891|M.avium_104 WAAPLLTPVMRYAAGRLWRDDLAYAERRYEVRSQ---------------N
MSMEG_2343|M.smegmatis_MC2_155 RAAALITPLMRHAANRLWRDDLVYAERRYQIRHH---------------Q
TH_1484|M.thermoresistible__bu RGAALIRPLMRRAATRLWRDDLAYAERLYRLRAD---------------R
Mvan_1581|M.vanbaalenii_PYR-1 VAAPLIRPLMRHAAGRLWRDDLAYAERLFEQRS-----------------
Mflv_1843|M.gilvum_PYR-GCK RVAPMITPFMRHAANRLWRDDLVYAERLQTVREQKASGAADLLRPLPEPT
Mb3556|M.bovis_AF2122/97 HKTRIDNPLLVEEDG-AVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTK
Rv3526|M.tuberculosis_H37Rv HKTRIDNPLLVEEDG-AVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTK
MAB_0080c|M.abscessus_ATCC_199 NKARIDNPLLCEEDG-PVYQLRRWYEQFYVDVADVTAEMTDRFEYEVDTT
MMAR_3971|M.marinum_M NMKYLEKPNLAPEEARDYAALRRWAHRFYPAAQTSTADFGYTADGLPDPA
MUL_3829|M.ulcerans_Agy99 NMKYLEKPYLAPEEARDYAALRRWAHRFYPGAQTSPADFGYTADGLPDPA
: * : : .:
MAV_3891|M.avium_104 H---------------------------
MSMEG_2343|M.smegmatis_MC2_155 RDHRRTTGQGP-----------------
TH_1484|M.thermoresistible__bu RGGAAGSADGAGVVQ-------------
Mvan_1581|M.vanbaalenii_PYR-1 ----------------------------
Mflv_1843|M.gilvum_PYR-GCK RGDRQPPAAAPGSAPTD-----------
Mb3556|M.bovis_AF2122/97 RANEFWNAEVEKNLKSREVSDDVPAEQH
Rv3526|M.tuberculosis_H37Rv RANEFWNAEVEKNLKSREVSDDVPAEQH
MAB_0080c|M.abscessus_ATCC_199 RPGEAWKAQVEENLAA--MAGGAPS---
MMAR_3971|M.marinum_M ASKA------------------------
MUL_3829|M.ulcerans_Agy99 ASKA------------------------