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M. gilvum PYR-GCK Mflv_1794 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 1867305 - 1868459
length: 384

MSELETFRAEVRDWCREHVPADWRAAQSGVGEEEFVRFQKAWFAELHSAGYAVPHWPAQWGGGLPVDKQV
VLYQELAAHDAPRLVLAFVGIHHAASTLLVAGTEEQRRRHLPAILDGEIWVQGFSEPEAGSDLAALRTSA
RRVGDEFIVNGQKLWASGGMHADWCLLLARTDPDAPKRKGISYFLLDMTSPGVDVRPIRNAIGDSHFCEI
FLDDVRIPATNLIGAENAGWQVAQETLGAERGMTMLELAERLGNAGFRWLVESAPVDDPIVADRLAGFET
ELAALRGMCRRMVEHGPSGPADPSVVKLYYSELLQRLTDFGAEIGGLPAHTVLTKPMSSGWESGSWVLDF
VGSWEWTIPGGASEIQRTIIGERGLGLPREPSAL

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_1794 - - 100% (384) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_1481 - 6e-62 38.44% (398) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_2287 - 3e-58 38.62% (391) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1969c fadE17 1e-63 39.04% (397) acyl-CoA dehydrogenase FADE17
M. tuberculosis H37Rv Rv1934c fadE17 1e-63 39.04% (397) acyl-CoA dehydrogenase FADE17
M. leprae Br4923 MLBr_00737 fadE25 2e-23 30.67% (225) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0597 - 6e-59 36.99% (392) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_2862 fadE17 8e-61 38.00% (400) acyl-CoA dehydrogenase FadE17
M. avium 104 MAV_2619 - 4e-69 41.84% (392) acyl-CoA dehydrogenase domain-containing protein
M. smegmatis MC2 155 MSMEG_5619 - 0.0 80.52% (385) acyl-CoA dehydrogenase domain-containing protein
M. thermoresistible (build 8) TH_3515 - 0.0 82.34% (385) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_2892 fadE17 2e-59 38.34% (386) acyl-CoA dehydrogenase FadE17
M. vanbaalenii PYR-1 Mvan_4956 - 0.0 87.99% (383) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1969c|M.bovis_AF2122/97           ---MDVSYPPEAEAFRDR--------IREFVAEHLPPGWPGPGAL--PPH
Rv1934c|M.tuberculosis_H37Rv        ---MDVSYPPEAEAFRDR--------IREFVAEHLPPGWPGPGAL--PPH
MMAR_2862|M.marinum_M               ---MDVAYPPEAEEFRER--------VRAFLDEHLPCGWSGPGAL--AVQ
MUL_2892|M.ulcerans_Agy99           ------------------------------MDEHLPCGWSGPGAL--AVQ
MAB_0597|M.abscessus_ATCC_1997      MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
Mflv_1794|M.gilvum_PYR-GCK          ---MSELET-------------FRAEVRDWCREHVPADWRAAQSGV-GEE
Mvan_4956|M.vanbaalenii_PYR-1       --MTAESEDQRDNPTDSQSQAQFRQQVRAWCRDHIPADWRDTQTGV-GDE
MSMEG_5619|M.smegmatis_MC2_155      ---MTHPEN----------LDDFRATVRDWCAAHVPKDWRAAQTGV-SDD
TH_3515|M.thermoresistible__bu      ---MTG-------------LDEFRDEVRTWCAEHIPKDWRAAQTNV-SDD
MAV_2619|M.avium_104                ---MDLDFTP--------DQLEFRDQVRTWLDENKPAEPRPRD-----DA
MLBr_00737|M.leprae_Br4923          --MVGWSGNP------LFDLFKLPEEHNELRATIRALAEKEIAPHAADVD
                                                                                      

Mb1969c|M.bovis_AF2122/97           EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv        EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
MMAR_2862|M.marinum_M               DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MUL_2892|M.ulcerans_Agy99           DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MAB_0597|M.abscessus_ATCC_1997      EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
Mflv_1794|M.gilvum_PYR-GCK          EFVRFQKA--WFAELHSAGYAVPHWPAQWGG-GLPVDKQVVLYQELAAHD
Mvan_4956|M.vanbaalenii_PYR-1       EFVRFQKA--WFAELHSAGYAVPHWPAEWGG-GLPVDRQVVLYQELAAHD
MSMEG_5619|M.smegmatis_MC2_155      EFAAFQKA--WFAELHSAGYAVPHWPAEWGG-GMSVPQQIVLYSELAAHD
TH_3515|M.thermoresistible__bu      DFVAFQQA--WFAELHRAGYAVPHWPAEWGG-GMPVDRQIVLYSELAAHD
MAV_2619|M.avium_104                GIREYDLA--WQRTQAEGGWAGIAWPTEYGGKGLTLLQQLIWYEEYAARG
MLBr_00737|M.leprae_Br4923          QRARFPEEA--LAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
                                        :            .*      * : ** *       :  .* *   

Mb1969c|M.bovis_AF2122/97           APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv        APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
MMAR_2862|M.marinum_M               APEREENDLFGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MUL_2892|M.ulcerans_Agy99           APEREENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MAB_0597|M.abscessus_ATCC_1997      APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
Mflv_1794|M.gilvum_PYR-GCK          AP-RLVLAFVGIHHAASTLLVAGTEEQRRRHLPAILDGE-IWVQGFSEPE
Mvan_4956|M.vanbaalenii_PYR-1       AP-RLVLAFVGIHHAASTLLVAGTDEQRRRHLPAILDGE-IWVQGFSEPE
MSMEG_5619|M.smegmatis_MC2_155      AP-RLVLAFVGIHHAASTLLAAGTDAQRNRHLPAILDGE-IWVQGFSEPE
TH_3515|M.thermoresistible__bu      AP-RLVLAFVGIHHAASTLLVAGTDEQRRRHLPAILDGE-IWVQGFSEPE
MAV_2619|M.avium_104                FP-GIDACFVGNSHAGPTLITRATDEQKSFHLPKILGGEVIWCQGFSEPD
MLBr_00737|M.leprae_Br4923          ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
                                     .                *:  .:   :   ** :         . **  

Mb1969c|M.bovis_AF2122/97           AGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
Rv1934c|M.tuberculosis_H37Rv        AGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
MMAR_2862|M.marinum_M               AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MUL_2892|M.ulcerans_Agy99           AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MAB_0597|M.abscessus_ATCC_1997      AGSDLANVSTSAVLDGGDWVINGQKVWTSLALQSQWCFVVARTEPGSSRH
Mflv_1794|M.gilvum_PYR-GCK          AGSDLAALRTSARRVGDEFIVNGQKLWASGGMHADWCLLLARTDPDAPKR
Mvan_4956|M.vanbaalenii_PYR-1       AGSDLAALRTTARRAGDEFVVNGQKLWASGGMHADWCLLLARTDPDAPKR
MSMEG_5619|M.smegmatis_MC2_155      AGSDLASLRTTARAEGDTFVVNGQKLWASGAMYADWCLLLARTDPNAPKR
TH_3515|M.thermoresistible__bu      AGSDLASLRTTARRDGDRFIVNGQKLWASGAKHADWCLLLARTDPDAPKR
MAV_2619|M.avium_104                AGSDLAALRTKAVVDGEDLVVSGQKLWTSFATVADYQELLVRTDNTGSKH
MLBr_00737|M.leprae_Br4923          AGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN
                                    **** * : * .   *   ::.* * * : .  : :  ::. *:     .

Mb1969c|M.bovis_AF2122/97           ------RGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAG
Rv1934c|M.tuberculosis_H37Rv        ------RGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAG
MMAR_2862|M.marinum_M               ------QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVA
MUL_2892|M.ulcerans_Agy99           ------QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVA
MAB_0597|M.abscessus_ATCC_1997      ------KGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNARTSAD
Mflv_1794|M.gilvum_PYR-GCK          ------KGISYFLLDMTSPGVDVRPIRNAIGD--SHFCEIFLDDVRIPAT
Mvan_4956|M.vanbaalenii_PYR-1       PGARKSAGISYFLMDMTTPGVDVRPIRNAIGD--SHFCEIFLDDVRIPAA
MSMEG_5619|M.smegmatis_MC2_155      ------HGISYFMMDMKTPGVDVRPIRNAVGD--SHFCEIFLNDVVIPSA
TH_3515|M.thermoresistible__bu      ------HGISYFLLDMTTPGVEVRPIRNAIGD--SHFCEIFLNDVVIPET
MAV_2619|M.avium_104                ------KGITWVICDMSTPGIDVRPIETIEGG--SEFCEVFYDDVRIPLS
MLBr_00737|M.leprae_Br4923          -------GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGD
                                           *:: .:      .. : *     *   *   *::  .      

Mb1969c|M.bovis_AF2122/97           NVVGRVGDGWSTAMTLLGFERGSHIATAAIDFER-------DLQRLCELA
Rv1934c|M.tuberculosis_H37Rv        NVVGRVGDGWSTAMTLLGFERGSHIATAAIDFER-------DLQRLCELA
MMAR_2862|M.marinum_M               NVVGEVGSGWTAAMSLLGFERGAQATTGAIDFAR-------DLSRLCDLA
MUL_2892|M.ulcerans_Agy99           NVVGEVGSGWTAAMSLLGFERGAQATTGAIDFAR-------DLSRLCDLA
MAB_0597|M.abscessus_ATCC_1997      LVVGEPGDGWRVAMGTLTFERGVSTLGNQITYAR-------ELSRLAELA
Mflv_1794|M.gilvum_PYR-GCK          NLIGAENAGWQVAQETLGAERGMTMLELAERLG------NAGFRWLV---
Mvan_4956|M.vanbaalenii_PYR-1       NLIGAENNGWQVAQATLGAERGLTMLELAERLG------NAGFRWLV---
MSMEG_5619|M.smegmatis_MC2_155      NLVGPVNKGWQVAQATLGAERGMTMLELAERLG------NAGFRWLVD--
TH_3515|M.thermoresistible__bu      NLVGRENQGWQVAQATLGAERGLTMLELAERLG------TAGFRWLV---
MAV_2619|M.avium_104                NVVGDVGEGWSVAMATLSFERGTAFTANQVRLAKIIEDLIDYARDHVGPD
MLBr_00737|M.leprae_Br4923          RIIGEPGTGFKTALATLDHTR-PTIGAQAVGIAQG------ALDAAIVYT
                                     ::*  . *: .*   *   *                             

Mb1969c|M.bovis_AF2122/97           RDRGLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITK
Rv1934c|M.tuberculosis_H37Rv        RDRGLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITK
MMAR_2862|M.marinum_M               RARGLDSDPRIRDRLAWCYSRTQIMRYRGYRSLTWALNGLLPGAEAAISK
MUL_2892|M.ulcerans_Agy99           RARGLDSDPRIRDRLAWCYSRTQIMRYRGYCSLTWALNGVLPGAEAAISK
MAB_0597|M.abscessus_ATCC_1997      KSNGAADDPAIRERLAQAYVGMRTMRAYALATMDEERPG-----QDNVSK
Mflv_1794|M.gilvum_PYR-GCK          -ESAPVDDPIVADRLAGFETELAALRGMCRRMVEH---GPSGPADPSVVK
Mvan_4956|M.vanbaalenii_PYR-1       -QSAPVDDPIVADRLAGFETEITGLRGLCRQIVER---GATGPADASVVK
MSMEG_5619|M.smegmatis_MC2_155      -ACSPVDDPVVADRLAQFEIELTGLRGLCRDLVERSETGEAGPADASIVK
TH_3515|M.thermoresistible__bu      -AQSPVDDPVVADRLAQFEVELTALRGMCRDLVLDAEAGAVGPADASIVK
MAV_2619|M.avium_104                GRRPAIADDDIARRLARARASVASLRALTYTNICEAMKTETPGPRGSIVK
MLBr_00737|M.leprae_Br4923          KDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLG-
                                           :                ::      :              :  

Mb1969c|M.bovis_AF2122/97           VIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMD
Rv1934c|M.tuberculosis_H37Rv        VIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMD
MMAR_2862|M.marinum_M               VIWSEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMD
MUL_2892|M.ulcerans_Agy99           VIWSEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWMD
MAB_0597|M.abscessus_ATCC_1997      LLWANWHRDLGELAMEIIGTSTLLTN------------AGEMDE---WQR
Mflv_1794|M.gilvum_PYR-GCK          LYYSELLQRLTDFGAEIGGLPAHTVLTKP---------MSSGWESGSWVL
Mvan_4956|M.vanbaalenii_PYR-1       LYYSELLQRLTDFAVEIGGPEAHTVLAKP---------MSSGWESGSWVL
MSMEG_5619|M.smegmatis_MC2_155      LYYSELLQRMTDFGAQIAGLPAHTVLTKP---------ASSGWESGAWML
TH_3515|M.thermoresistible__bu      LYYSELLQRMTDFGAEVAGLPAHTQLAKP---------VSSGWESGSWVL
MAV_2619|M.avium_104                LMYAELAKEIGRLAMDVVGP-----ASVR---------YSSRWDVDGWVG
MLBr_00737|M.leprae_Br4923          FISAASKCFASDIAMEVTTDAVQLFGGAG---------YTSDFPVERFMR
                                    .  :        :. ::                              :  

Mb1969c|M.bovis_AF2122/97           ELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv        ELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
MMAR_2862|M.marinum_M               ELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH
MUL_2892|M.ulcerans_Agy99           ELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH
MAB_0597|M.abscessus_ATCC_1997      LFLFSRADTIYGGSNEIQRNIISERVLGLPREAR-----
Mflv_1794|M.gilvum_PYR-GCK          DFVGSWEWTIPGGASEIQRTIIGERGLGLPREPSAL---
Mvan_4956|M.vanbaalenii_PYR-1       DFVGSWEWTIPGGASEIQRTIIAERGLGLPREPGAA---
MSMEG_5619|M.smegmatis_MC2_155      DFIGSWEWTIPGGASEIQRTIIGERGLGLPREPSAV---
TH_3515|M.thermoresistible__bu      DFIGSWEWTIPGGSSEIQRTIIAERGLGLPREPSVA---
MAV_2619|M.avium_104                YYYYSFSQAIGGGTSEIQRNIVGERVLGLPR--------
MLBr_00737|M.leprae_Br4923          D---AKITQIYEGTNQIQRVVMSRALLR-----------
                                        :    *  *:.:*** ::..  *

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_1794	-	-	100% (384)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_1481	-	6e-62	38.44% (398)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_2287	-	3e-58	38.62% (391)	acyl-CoA dehydrogenase domain-containing protein