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THPENLDDFRATVRDWCAAHVPKDWRAAQTGVSDDEFAAFQKAWFAELHSAGYAVPHWPAEWGGGMSVPQ QIVLYSELAAHDAPRLVLAFVGIHHAASTLLAAGTDAQRNRHLPAILDGEIWVQGFSEPEAGSDLASLRT TARAEGDTFVVNGQKLWASGAMYADWCLLLARTDPNAPKRHGISYFMMDMKTPGVDVRPIRNAVGDSHFC EIFLNDVVIPSANLVGPVNKGWQVAQATLGAERGMTMLELAERLGNAGFRWLVDACSPVDDPVVADRLAQ FEIELTGLRGLCRDLVERSETGEAGPADASIVKLYYSELLQRMTDFGAQIAGLPAHTVLTKPASSGWESG AWMLDFIGSWEWTIPGGASEIQRTIIGERGLGLPREPSAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5619 | - | - | 100% (391) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6012 | - | 2e-57 | 35.18% (398) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4805 | - | 5e-55 | 36.75% (400) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1969c | fadE17 | 1e-66 | 38.98% (413) | acyl-CoA dehydrogenase FADE17 |
| M. gilvum PYR-GCK | Mflv_1794 | - | 0.0 | 80.52% (385) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1934c | fadE17 | 1e-66 | 38.98% (413) | acyl-CoA dehydrogenase FADE17 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-22 | 25.94% (347) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 8e-58 | 35.40% (387) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_2862 | fadE17 | 3e-62 | 38.61% (404) | acyl-CoA dehydrogenase FadE17 |
| M. avium 104 | MAV_1909 | - | 2e-70 | 42.28% (395) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3515 | - | 0.0 | 85.38% (383) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2892 | fadE17 | 3e-60 | 39.38% (386) | acyl-CoA dehydrogenase FadE17 |
| M. vanbaalenii PYR-1 | Mvan_4956 | - | 0.0 | 78.73% (395) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5619|M.smegmatis_MC2_155 ---MTHPEN----------LDDFRATVRDWCAAHVPKDWRAAQTG---VS
TH_3515|M.thermoresistible__bu ---MTG-------------LDEFRDEVRTWCAEHIPKDWRAAQTN---VS
Mflv_1794|M.gilvum_PYR-GCK ---MSELET-------------FRAEVRDWCREHVPADWRAAQSG---VG
Mvan_4956|M.vanbaalenii_PYR-1 --MTAESEDQRDNPTDSQSQAQFRQQVRAWCRDHIPADWRDTQTG---VG
MAV_1909|M.avium_104 ---MDLDFTP--------DQLEFRDRVRTWLDEHKPTEARPRD-------
Mb1969c|M.bovis_AF2122/97 ---MDVSYPPEAEAFRDR--------IREFVAEHLPPGWPGPGAL--PPH
Rv1934c|M.tuberculosis_H37Rv ---MDVSYPPEAEAFRDR--------IREFVAEHLPPGWPGPGAL--PPH
MMAR_2862|M.marinum_M ---MDVAYPPEAEEFRER--------VRAFLDEHLPCGWSGPGAL--AVQ
MUL_2892|M.ulcerans_Agy99 ------------------------------MDEHLPCGWSGPGAL--AVQ
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MLBr_00737|M.leprae_Br4923 -MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQR-----
.
MSMEG_5619|M.smegmatis_MC2_155 DDEFAAFQKAWFAELHSAGYAVPHWPAEWGG-GMSVPQQIVLYSELAAHD
TH_3515|M.thermoresistible__bu DDDFVAFQQAWFAELHRAGYAVPHWPAEWGG-GMPVDRQIVLYSELAAHD
Mflv_1794|M.gilvum_PYR-GCK EEEFVRFQKAWFAELHSAGYAVPHWPAQWGG-GLPVDKQVVLYQELAAHD
Mvan_4956|M.vanbaalenii_PYR-1 DEEFVRFQKAWFAELHSAGYAVPHWPAEWGG-GLPVDRQVVLYQELAAHD
MAV_1909|M.avium_104 DAGIREYDLAWQRTQWEGGWAGIAWPKEYGGQGLTLMQQLIWYEEYAARG
Mb1969c|M.bovis_AF2122/97 EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
Rv1934c|M.tuberculosis_H37Rv EREEFARH--WRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAG
MMAR_2862|M.marinum_M DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MUL_2892|M.ulcerans_Agy99 DRKAFAAR--WRQLLVAAGLIAVSWPKEYGGGGYSPVEQVVLAEEFARAG
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MLBr_00737|M.leprae_Br4923 ----ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
.* * : ** * : .* *
MSMEG_5619|M.smegmatis_MC2_155 AP-RLVLAFVGIHHAASTLLAAGTDAQRNRHLPAILDGE-IWVQGFSEPE
TH_3515|M.thermoresistible__bu AP-RLVLAFVGIHHAASTLLVAGTDEQRRRHLPAILDGE-IWVQGFSEPE
Mflv_1794|M.gilvum_PYR-GCK AP-RLVLAFVGIHHAASTLLVAGTEEQRRRHLPAILDGE-IWVQGFSEPE
Mvan_4956|M.vanbaalenii_PYR-1 AP-RLVLAFVGIHHAASTLLVAGTDEQRRRHLPAILDGE-IWVQGFSEPE
MAV_1909|M.avium_104 FP-GIDACFVGNSHAGPTLITRATDEQKSFHLPKILRGEVIWCQGFSEPE
Mb1969c|M.bovis_AF2122/97 APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
Rv1934c|M.tuberculosis_H37Rv APERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPE
MMAR_2862|M.marinum_M APEREENDLFGVDLLGNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MUL_2892|M.ulcerans_Agy99 APEREENDLFGVDLLCNTLIALGTEAQKRHFLPRILTGDDRWCQGFSEPE
MAB_0597|M.abscessus_ATCC_1997 APHKVNH--LGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPG
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
. *: .: : ** : . **
MSMEG_5619|M.smegmatis_MC2_155 AGSDLASLRTTARAEGDTFVVNGQKLWASGAMYADWCLLLARTDPNAPKR
TH_3515|M.thermoresistible__bu AGSDLASLRTTARRDGDRFIVNGQKLWASGAKHADWCLLLARTDPDAPKR
Mflv_1794|M.gilvum_PYR-GCK AGSDLAALRTSARRVGDEFIVNGQKLWASGGMHADWCLLLARTDPDAPKR
Mvan_4956|M.vanbaalenii_PYR-1 AGSDLAALRTTARRAGDEFVVNGQKLWASGGMHADWCLLLARTDPDAPKR
MAV_1909|M.avium_104 AGSDLAALRTKAVIDGDHLVVSGQKLWTSFATVADYQELLVRTDNTGSKH
Mb1969c|M.bovis_AF2122/97 AGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
Rv1934c|M.tuberculosis_H37Rv AGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKH
MMAR_2862|M.marinum_M AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MUL_2892|M.ulcerans_Agy99 AGSDLASVRTRAVLDGDQWVINGQKIWTSAGSTANWIFVLARTDPVAPKH
MAB_0597|M.abscessus_ATCC_1997 AGSDLANVSTSAVLDGGDWVINGQKVWTSLALQSQWCFVVARTEPGSSRH
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN
**** * : * . *. ::.* * * : . : : ::. *: .
MSMEG_5619|M.smegmatis_MC2_155 ------HGISYFMMDMKTPGVDVRPIRNAVGD--SHFCEIFLNDVVIPSA
TH_3515|M.thermoresistible__bu ------HGISYFLLDMTTPGVEVRPIRNAIGD--SHFCEIFLNDVVIPET
Mflv_1794|M.gilvum_PYR-GCK ------KGISYFLLDMTSPGVDVRPIRNAIGD--SHFCEIFLDDVRIPAT
Mvan_4956|M.vanbaalenii_PYR-1 PGARKSAGISYFLMDMTTPGVDVRPIRNAIGD--SHFCEIFLDDVRIPAA
MAV_1909|M.avium_104 ------KGITWVICDMNTPGIDIRPIETIEGG--SEFCEVFYDDVRIPLS
Mb1969c|M.bovis_AF2122/97 ------RGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAG
Rv1934c|M.tuberculosis_H37Rv ------RGLSFLLVPMDQPGVVVRPIVNAAGH--SSFSEVFLTDARTSAG
MMAR_2862|M.marinum_M ------QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVA
MUL_2892|M.ulcerans_Agy99 ------QGLSLLLVPMDQPAVVVRPIVNAAGH--SLFNEVFFADARTGVA
MAB_0597|M.abscessus_ATCC_1997 ------KGLSYLLVPLDQPGVEIRPIIQLTGT--SEFNEVFFDNARTSAD
MLBr_00737|M.leprae_Br4923 -------GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGD
*:: .: .. : * * * *:: .
MSMEG_5619|M.smegmatis_MC2_155 NLVGPVNKGWQVAQATLGAERGMTMLELAERLGNAGFRWLVDACSPVDD-
TH_3515|M.thermoresistible__bu NLVGRENQGWQVAQATLGAERGLTMLELAERLGTAGFRWLV-AQSPVDD-
Mflv_1794|M.gilvum_PYR-GCK NLIGAENAGWQVAQETLGAERGMTMLELAERLGNAGFRWLV-ESAPVDD-
Mvan_4956|M.vanbaalenii_PYR-1 NLIGAENNGWQVAQATLGAERGLTMLELAERLGNAGFRWLV-QSAPVDD-
MAV_1909|M.avium_104 NVVGDVGEGWSVAMATLSFERGTAFTANQVRLAKIVEDLIDYARDHVGPD
Mb1969c|M.bovis_AF2122/97 NVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHT
Rv1934c|M.tuberculosis_H37Rv NVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHT
MMAR_2862|M.marinum_M NVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARARGLDS
MUL_2892|M.ulcerans_Agy99 NVVGEVGSGWTAAMSLLGFERGAQATTGAIDFARDLSRLCDLARARGLDS
MAB_0597|M.abscessus_ATCC_1997 LVVGEPGDGWRVAMGTLTFERGVSTLGNQITYARELSRLAELAKSNGAAD
MLBr_00737|M.leprae_Br4923 RIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFG
::* . *: .* * *
MSMEG_5619|M.smegmatis_MC2_155 ---PVVAD-----RLAQFEIELTGLRGLCRDLVERSETGEA-GPADASIV
TH_3515|M.thermoresistible__bu ---PVVAD-----RLAQFEVELTALRGMCRDLVLDAEAGAV-GPADASIV
Mflv_1794|M.gilvum_PYR-GCK ---PIVAD-----RLAGFETELAALRGMCRRMVEH---GPS-GPADPSVV
Mvan_4956|M.vanbaalenii_PYR-1 ---PIVAD-----RLAGFETEITGLRGLCRQIVER---GAT-GPADASVV
MAV_1909|M.avium_104 GRRPAIADDEFARRLARARASVASLRALTYTNICEAMKTET-PGPRGSIV
Mb1969c|M.bovis_AF2122/97 D--PRVRD-----GLAWCYARVQIMRYRGYRDLTLALTGRP-PGAEAAIT
Rv1934c|M.tuberculosis_H37Rv D--PRVRD-----GLAWCYARVQIMRYRGYRDLTLALTGRP-PGAEAAIT
MMAR_2862|M.marinum_M D--PRIRD-----RLAWCYSRTQIMRYRGYRSLTWALNGLL-PGAEAAIS
MUL_2892|M.ulcerans_Agy99 D--PRIRD-----RLAWCYSRTQIMRYRGYCSLTWALNGVL-PGAEAAIS
MAB_0597|M.abscessus_ATCC_1997 D--PAIRE-----RLAQAYVGMRTMRAYALATMDEERPG------QDNVS
MLBr_00737|M.leprae_Br4923 ESISTFQS--IQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAAS
. . . ** *
MSMEG_5619|M.smegmatis_MC2_155 KLYYSELLQRMTDFGAQIAGLPAHTVLTKP---------ASSGWESGAWM
TH_3515|M.thermoresistible__bu KLYYSELLQRMTDFGAEVAGLPAHTQLAKP---------VSSGWESGSWV
Mflv_1794|M.gilvum_PYR-GCK KLYYSELLQRLTDFGAEIGGLPAHTVLTKP---------MSSGWESGSWV
Mvan_4956|M.vanbaalenii_PYR-1 KLYYSELLQRLTDFAVEIGGPEAHTVLAKP---------MSSGWESGSWV
MAV_1909|M.avium_104 KLMYAELTKEIGKLAMDILGP-----ASIR---------HSSRWDADGWA
Mb1969c|M.bovis_AF2122/97 KVIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWM
Rv1934c|M.tuberculosis_H37Rv KVIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWM
MMAR_2862|M.marinum_M KVIWSEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWM
MUL_2892|M.ulcerans_Agy99 KVIWSEYFQRYTELAVEILGLDALCPSGPGNGEARVVPQAGTANSPACWM
MAB_0597|M.abscessus_ATCC_1997 KLLWANWHRDLGELAMEIIGTSTLLTN------------AGEMDE---WQ
MLBr_00737|M.leprae_Br4923 KCFASDIAMEVTTDAVQLFGG-------------------AGYTSDFPVE
* :: . :: * . .
MSMEG_5619|M.smegmatis_MC2_155 LDFIGSWEWTIPGGASEIQRTIIGERGLGLPREPSAV---
TH_3515|M.thermoresistible__bu LDFIGSWEWTIPGGSSEIQRTIIAERGLGLPREPSVA---
Mflv_1794|M.gilvum_PYR-GCK LDFVGSWEWTIPGGASEIQRTIIGERGLGLPREPSAL---
Mvan_4956|M.vanbaalenii_PYR-1 LDFVGSWEWTIPGGASEIQRTIIAERGLGLPREPGAA---
MAV_1909|M.avium_104 GYYYYGFSQAIGGGTSEIQRNIVGERVLGLPR--------
Mb1969c|M.bovis_AF2122/97 DELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Rv1934c|M.tuberculosis_H37Rv DELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
MMAR_2862|M.marinum_M DELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH
MUL_2892|M.ulcerans_Agy99 DELLYARAATIYAGSSQIQRNVIGEQLLGLPKEPRREAVH
MAB_0597|M.abscessus_ATCC_1997 RLFLFSRADTIYGGSNEIQRNIISERVLGLPREAR-----
MLBr_00737|M.leprae_Br4923 RFMRDAKITQIYEGTNQIQRVVMSRALLR-----------
. * *:.:*** ::.. *