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SPTVEQHAENWDLRHADFNDPDFLYDVYTVMRGNSPFARTDNPFLSATPSGAWVAVRYAECVQILQDWEH FSSSPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFSPARMKALRHEIAAETDDLIDVFIESGSGDLAE VAWRQPGIVFFKYLLGMPVDDVPLCVELTDTALNGATEEARMGAWGGLYQHLHDAVTARTAEPPRDDMID VLLSAEIDGEKLAFGDVVSNAMLLVQAGLETTASAMSFAYHYLATHPAERDRLIAEPDLLARAVEEFIRF AGSIHGIPRTVAKEVELSGCTFSPGESVIVNYASANRDEEQFPEADRCILDRRENRHLGFGAGVHRCLGS NLARLEFQVGLERVLTRMPDFTLTAGAEAKFHGNSVTRGFRSVPVTFTPAARTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1768 | - | - | 100% (405) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2498 | - | 1e-43 | 33.96% (321) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_0425 | - | 2e-42 | 31.27% (403) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 5e-35 | 30.79% (367) | cytochrome P450 124 CYP124 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 2e-39 | 29.43% (401) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-35 | 32.19% (320) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 2e-36 | 29.78% (366) | cytochrome P450 |
| M. marinum M | MMAR_4833 | cyp123B1 | 4e-48 | 33.00% (400) | cytochrome P450 123B1 Cyp123B1 |
| M. avium 104 | MAV_2213 | - | 4e-48 | 30.34% (379) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4803 | - | 1e-42 | 30.90% (411) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_3303 | - | 8e-60 | 34.41% (401) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 4e-43 | 29.75% (400) | cytochrome P450 108B4 Cyp108B4 |
| M. vanbaalenii PYR-1 | Mvan_4979 | - | 0.0 | 88.59% (403) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MMAR_4833|M.marinum_M -------------------------MWQETLMSTVQLRYDPFDPEIQDDP
MAB_1406c|M.abscessus_ATCC_199 --------------------------MSVDVSHTVAPRYVPGTADNWTNP
MAV_2213|M.avium_104 --------------------------------MTEAGGFVDQTVTGVAEP
Mb2289|M.bovis_AF2122/97 -MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRRE
Rv3518c|M.tuberculosis_H37Rv ------------------------------MTEAPDVDLADGNFYASREA
MUL_3863|M.ulcerans_Agy99 --------------------------MSAPTMDEAALLADPLAYTDETRL
Mflv_1768|M.gilvum_PYR-GCK -------------------------MSPTVEQHAENWDLRHADFNDPDFL
Mvan_4979|M.vanbaalenii_PYR-1 -------------------------MTRTPERHAENWDLRHPDFNDNDFL
MSMEG_4803|M.smegmatis_MC2_155 --------------------MSIQDVTTDDDREKITYHFDRHTPEYRLQF
TH_3303|M.thermoresistible__bu -------------------------MTTFDTRP--TVDFDHHSPEYAQNS
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMP------LTVFSSFSDCDEALRHPLSASDRLK
MMAR_4833|M.marinum_M YPVYRQLRDDAPVYHATDTN-----TWVLSRHADVISALLDHHSYSS---
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSAR-
MAV_2213|M.avium_104 QPMYKALRESNPVFRSP-------QAVVLSRLADIEMALKHTELFSSN--
Mb2289|M.bovis_AF2122/97 APISFWPTIELPGFVAGNG------HWALTKYDDVFYASRHPDIFSSYP-
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFRDRNG------LAAASTYQAVIDAERQPELFSNAG-
MUL_3863|M.ulcerans_Agy99 HAALTRLRAQAPVALVDVPN--YRRFWAITRHADVMDIERDNTLFTNWP-
Mflv_1768|M.gilvum_PYR-GCK YDVYTVMRGNSPFARTDNPFL----SATPSGAWVAVRYAECVQILQDWEH
Mvan_4979|M.vanbaalenii_PYR-1 YDVYAVMRAKSPFARTDNPFL----SATPAGAWVAVRYAECVQILQDWEH
MSMEG_4803|M.smegmatis_MC2_155 EKITEEMHSRCPVAWTETYDG----HWVAAGSNEVFELARCP-VVSNHHD
TH_3303|M.thermoresistible__bu AAINAELRAKCPVAHTDAHGG----FWVISRYDDVVAAAKNDEVFASGYT
* . : .
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRP---FYASSFMFLDPPDHTRLRKLVSKAFAPKVVQ
MMAR_4833|M.marinum_M -VDGVFPTPPGSTFRE---SLLPMMILMDPPRHDQLRALVSKAFTPRRIA
MAB_1406c|M.abscessus_ATCC_199 GLTVTYGDLEKTGMGD---NPPMVMQ--DPPTHTEFRKLVSRGFTPRQVT
MAV_2213|M.avium_104 --------MDAVDLGN---VRPLIPLQIDPPEHAKYRRILDPLFTPREMA
Mb2289|M.bovis_AF2122/97 ----NITINDQTPELA---EYFGSMIVLDDPRHQRLRSIVSRAFTPKVVA
Rv3518c|M.tuberculosis_H37Rv ----GIRPDQP---------ALPMMIDMDDPAHLLRRKLVNAGFTRKRVK
MUL_3863|M.ulcerans_Agy99 -RPVLATVAGDELQAA---AGVRTLIHLDDPQHRVARAIGADWFRPKAMR
Mflv_1768|M.gilvum_PYR-GCK FSSSPTPEGAEQLAGD-------LVITLDPPRQQKFRKVLNPYFSPARMK
Mvan_4979|M.vanbaalenii_PYR-1 FSSNPTPEGAEQLAGD-------LVITLDPPRQQKFRKVLNPYFSPARMK
MSMEG_4803|M.smegmatis_MC2_155 ISGETPFQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIK
TH_3303|M.thermoresistible__bu VNGVSPLG-VTIPPSP----VPMCPIEMDPPEYLPYRKLLNPFFSPGESK
* * * :
MLBr_02088|M.leprae_Br4923 ALEGDIAALVDSLLD-KGAAA--GQFDVIADLAFPLAVAVICRLLGVPYE
MMAR_4833|M.marinum_M ALTSAIEDLADHLTGGLIQEA--GSADFVADFAAVLPAMVIADLLGVPRE
MAB_1406c|M.abscessus_ATCC_199 AVEPKVREFVVQRLE-RLKER--GEGDIVVELFKPLPSMVVAHYLGVPEE
MAV_2213|M.avium_104 RREPLVTELVNEMID-RFAAR--GECDFHAEFAVPLPCTVFLQLLGLPLE
Mb2289|M.bovis_AF2122/97 RIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKA
Rv3518c|M.tuberculosis_H37Rv DKEASIAALCDTLIDAVCERG---ECDFVRDLAAPLPMAVIGDMLGVRPE
MUL_3863|M.ulcerans_Agy99 ALKVRVDELAKNYVDAMMAAG--PECDFVQQIAVNYPLYVIMSLLGLPEA
Mflv_1768|M.gilvum_PYR-GCK ALRHEIAAETDDLIDVFIESG---SGDLAEVAWRQPGIVFFKYLLGMPVD
Mvan_4979|M.vanbaalenii_PYR-1 ALRPEIGVETDRLIDDFIETG---SGDLAAVAWRQPGIVFFKYLLGMPVD
MSMEG_4803|M.smegmatis_MC2_155 RWEPFVDEITRAAIDEHISSG---RIDFVEHLANVVPAVFTLAMMGIELK
TH_3303|M.thermoresistible__bu KWEPRIAHWVDVCLDQVIEKG---SFDLVDDLANPVPSLFTCEFLGLPIE
: *. . :*:
MLBr_02088|M.leprae_Br4923 DAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKC
MMAR_4833|M.marinum_M DRTQFRQWSNALVQ--------SNPTHGETGEALAAAAAIYGYFTDFLAD
MAB_1406c|M.abscessus_ATCC_199 DRTQFDAWTDGIVAAAS---GGAIDIEAMQGEVAQTIGELMMYFTGLIER
MAV_2213|M.avium_104 DLDRFLLWKDGVIRPAG---DSGFDRRHES--SAGVAQQIYEYFDKAIDE
Mb2289|M.bovis_AF2122/97 DHQRIFHWTNVILGFGD-----PDLAT-DFDEFMQVSADIGAYATALAED
Rv3518c|M.tuberculosis_H37Rv QRDMFLRWSDDLVTFLS-----SHVSQEDFQITMDAFAAYNDFTRATIAA
MUL_3863|M.ulcerans_Agy99 DFPRMLKLTQELFGSDD----SEFKRGSTSEDQLPALLDMFGYFNAVTTA
Mflv_1768|M.gilvum_PYR-GCK DVPLCVELTDTALNGAT-----------EEARMGAWGGLYQHLHDAVTAR
Mvan_4979|M.vanbaalenii_PYR-1 DVPLCVELTDTALNGAT-----------EQDRMAAWGGLYQHLHDAVTAR
MSMEG_4803|M.smegmatis_MC2_155 KWNVYSEPTHASVYTPEH-------APEREKINEQHREMGIDLINNMMEI
TH_3303|M.thermoresistible__bu KWNDFASVQHEIIYTPP---------EEQEDILRRYMELCGEVFQLITER
. .
MLBr_02088|M.leprae_Br4923 RRGTPGEDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVNLIA
MMAR_4833|M.marinum_M RRRQPRDDLMSALVCAEIDGK--HLSDDELLGFCLLLLIAGHETTSNLLA
MAB_1406c|M.abscessus_ATCC_199 RRAEPEDDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTGMLG
MAV_2213|M.avium_104 HIAVPRDDVLSAMIAADVGGQ--PLSREELLDICFLFLIAGLDTVTDSLD
Mb2289|M.bovis_AF2122/97 RRVNHHDDLTSSLVEAEVDGE--RLSSREIASFFILLVVAGNETTRNAIT
Rv3518c|M.tuberculosis_H37Rv RRADPTDDLVSVLVSSEVDGE--RLSDDELVMETLLILIGGDETTRHTLS
MUL_3863|M.ulcerans_Agy99 RRAHPTADLASAIANARIDGE--PLSDIDTVSYYLIVATAGHDTTSATIS
Mflv_1768|M.gilvum_PYR-GCK TAEPPRDDMIDVLLSAEIDGE--KLAFGDVVSNAMLLVQAGLETTASAMS
Mvan_4979|M.vanbaalenii_PYR-1 RGQPPRDDMIDVLLSAEIDGE--KLAFADVVSNAMLLVQAGLETTASAMS
MSMEG_4803|M.smegmatis_MC2_155 RQNPR-PGLVNALLQLRIDGE--PAPDMEILGNLGLIIGGGFDTTTALTA
TH_3303|M.thermoresistible__bu RQNPTGEGLIDFLVTAEIDGE--PIPDDKVFSMVNLVIAGGFDTTTAVTV
. . : ... . . .* :*.
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMT
MMAR_4833|M.marinum_M NAAVVLADYRDTRRQLAGDES-LLGAAVEELLRYDSPAQGLSRTLTRDVT
MAB_1406c|M.abscessus_ATCC_199 GAIQLLHQNPAQRQKLIDDPS-LIPGAVEEFLRLTSPVQGLARTATRDVI
MAV_2213|M.avium_104 CFFVYLARHPQHRRQLVERPD-VLPGAVEELLRWETPVPGVARVATQDVE
Mb2289|M.bovis_AF2122/97 HGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIE
Rv3518c|M.tuberculosis_H37Rv GGTEQLLRNRDQWDLLQRDPS-LLPGAIEEMLRWTAPVKNMCRVLTADTE
MUL_3863|M.ulcerans_Agy99 GGLHALIEHPDQLARLQADPA-LMSLATEEMIRWVTPVKQFMRTASSDTV
Mflv_1768|M.gilvum_PYR-GCK FAYHYLATHPAERDRLIAEPD-LLARAVEEFIRFAGSIHGIPRTVAKEVE
Mvan_4979|M.vanbaalenii_PYR-1 FAYHYLATNPAERDRLIDDPD-LLTRAVEEFIRFAGSIHGIPRTVAREVE
MSMEG_4803|M.smegmatis_MC2_155 HALEWLGEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDAE
TH_3303|M.thermoresistible__bu SSLVYLAEHPEDRQRLIDNPD-LLPRAIEEFLRAFTPQQALARTVTKPVT
: . ** :* . *. :
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLAFAVG-S
MMAR_4833|M.marinum_M VHGVRMSAGESVLLLFGSANRDERVFA-DPDVFDIGRKPEHQVAFGRG-I
MAB_1406c|M.abscessus_ATCC_199 IGDTTIPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHG-N
MAV_2213|M.avium_104 VGGCPISKGERVSPLLGAANTDPAEFP-DPETVDFTRSPNRHRAFGGG-P
Mb2289|M.bovis_AF2122/97 LRGTKMAAGDKVSLWYCSANRDESKFA-DPWTFDLARNPNPHLGFGGGGA
Rv3518c|M.tuberculosis_H37Rv FHGTALCAGEKMMLLFESANFDEAVFC-EPEKFDVQRNPNSHLAFGFG-T
MUL_3863|M.ulcerans_Agy99 VRGIPIAAGESVLLSYVSANRDEEVFD-QPFRFDIGREPNKHVAFGYG-V
Mflv_1768|M.gilvum_PYR-GCK LSGCTFSPGESVIVNYASANRDEEQFP-EADRCILDRRENRHLGFGAG-V
Mvan_4979|M.vanbaalenii_PYR-1 LSGCTFSPGESVIVNYAAANRDEQEFP-DAHRCILDRRDNRHLGFGAG-V
MSMEG_4803|M.smegmatis_MC2_155 VAGYKFKQYERLWLSWAMANRDPSVFD-KPNEVILDRKGNRHFSFGIG-V
TH_3303|M.thermoresistible__bu VAGVELQPGERVLLSWASANQDETAFE-RPEEIILDRFPNRHTTFGIG-I
. : ** * : . * *. *
MLBr_02088|M.leprae_Br4923 HFCLGAALARLEATVTLSAISARFPQVQLAGEL--VYKPN-VAMRGMSAL
MMAR_4833|M.marinum_M HFCLGASLARMEARIALRALLARVPNWEVDLER--AQRLRSGPIRGYLSL
MAB_1406c|M.abscessus_ATCC_199 HHCLGAAAARMQSRIALEELLTRIPDFEVDLDG--VTWADGSYVRRPLTV
MAV_2213|M.avium_104 HRCLGSHLARMELRVALREFHRRIPDYEIKPGTQ-LTYTAALRSVESLPL
Mb2289|M.bovis_AF2122/97 HFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLS---QFIHGIKTL
Rv3518c|M.tuberculosis_H37Rv HFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESM
MUL_3863|M.ulcerans_Agy99 HFCMGAALARMEVASFFTELLPRLKSIELSGDP---QFTATTFVGGLKRL
Mflv_1768|M.gilvum_PYR-GCK HRCLGSNLARLEFQVGLERVLTRMPDFTLTAGA-EAKFHGNSVTRGFRSV
Mvan_4979|M.vanbaalenii_PYR-1 HRCLGSNLARLEFQVGLERVLTRMPDFALSPTS-KAEFHGNSVTRGFRSV
MSMEG_4803|M.smegmatis_MC2_155 HRCVGSNVARTVFKSMLTAVLDRMPDYVCDPEG-TVHYDTIGVIQGMRNL
TH_3303|M.thermoresistible__bu HRCLGSHVARIELETMIRRVLDRMPDYHVDLAA-ARRYPSIGIINGWINA
* *:* ** . :. .
MLBr_02088|M.leprae_Br4923 PVQV----------------------------------------
MMAR_4833|M.marinum_M PISWSAN-------------------------------------
MAB_1406c|M.abscessus_ATCC_199 PIRVR---------------------------------------
MAV_2213|M.avium_104 VFPVR---------------------------------------
Mb2289|M.bovis_AF2122/97 PVTWS---------------------------------------
Rv3518c|M.tuberculosis_H37Rv PVVFTPSPPLG---------------------------------
MUL_3863|M.ulcerans_Agy99 PVSYSLM-------------------------------------
Mflv_1768|M.gilvum_PYR-GCK PVTFTPAARTR---------------------------------
Mvan_4979|M.vanbaalenii_PYR-1 PVVFTPGKRVTA--------------------------------
MSMEG_4803|M.smegmatis_MC2_155 PATFTPSRPLGPGLDETLEKLQRICNEEELARPITERKERAVID
TH_3303|M.thermoresistible__bu PATFTPGQRLR---DEKLPGA-----------------------