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VTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYAECVQILQDWE HFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFSPARMKALRPEIGVETDRLIDDFIETGSGDLA AVAWRQPGIVFFKYLLGMPVDDVPLCVELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMI DVLLSAEIDGEKLAFADVVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIR FAGSIHGIPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHRCLG SNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKRVTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4979 | - | - | 100% (406) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4880 | - | 8e-48 | 30.66% (424) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4160 | - | 5e-44 | 31.99% (397) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 2e-36 | 29.36% (419) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_1768 | - | 0.0 | 88.59% (403) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 1e-38 | 30.25% (400) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-35 | 30.28% (317) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 4e-40 | 30.14% (365) | cytochrome P450 |
| M. marinum M | MMAR_4717 | cyp188A3 | 2e-47 | 32.54% (378) | cytochrome P450 188A3 Cyp188A3 |
| M. avium 104 | MAV_2213 | - | 2e-48 | 31.22% (378) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4803 | - | 3e-43 | 32.82% (323) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_3303 | - | 7e-61 | 34.06% (414) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 1e-41 | 29.25% (400) | cytochrome P450 108B4 Cyp108B4 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2289|M.bovis_AF2122/97 MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREA
MUL_3863|M.ulcerans_Agy99 ---------------MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQA
Rv3518c|M.tuberculosis_H37Rv -----------------MTEAPDVDLADGNFYASREAR--AAYRWMRANQ
MAB_1406c|M.abscessus_ATCC_199 ---------------MSVDVSHTVAPRYVPGTADNWTNPWPMYAALRDHD
MAV_2213|M.avium_104 ---------------------MTEAGGFVDQTVTGVAEPQPMYKALRESN
Mvan_4979|M.vanbaalenii_PYR-1 --------------MTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKS
Mflv_1768|M.gilvum_PYR-GCK --------------MSPTVEQHAENWDLRHADFNDPDFLYDVYTVMRGNS
MMAR_4717|M.marinum_M --------------MSVDDVVSDSDHQKNRYQFDRHSPEYRSQFKAITEE
MSMEG_4803|M.smegmatis_MC2_155 --------------MSIQDVTTDDDREKITYHFDRHTPEYRLQFEKITEE
TH_3303|M.thermoresistible__bu --------------MTTFDTRP-------TVDFDHHSPEYAQNSAAINAE
MLBr_02088|M.leprae_Br4923 -------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLID
Mb2289|M.bovis_AF2122/97 P--------ISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYP
MUL_3863|M.ulcerans_Agy99 P--------VALVDVPNYR------RFWAITRHADVMDIERDNTLFTNWP
Rv3518c|M.tuberculosis_H37Rv P--------VFRDRN----------GLAAASTYQAVIDAERQPELFS---
MAB_1406c|M.abscessus_ATCC_199 P--------VHHVVPEYTPD----QDYYVLTRHADVYEAARDWETFSSAR
MAV_2213|M.avium_104 P--------VFRSP-----------QAVVLSRLADIEMALKHTELFSSN-
Mvan_4979|M.vanbaalenii_PYR-1 P--------FARTDNPFLSATPA--GAWVAVRYAECVQILQDWEHFSSNP
Mflv_1768|M.gilvum_PYR-GCK P--------FARTDNPFLSATPS--GAWVAVRYAECVQILQDWEHFSSSP
MMAR_4717|M.marinum_M M--------HTTCP-MAWSDTYG--GHWVAAGSHEVFELARCP-AVSNDH
MSMEG_4803|M.smegmatis_MC2_155 M--------HSRCP-VAWTETYD--GHWVAAGSNEVFELARCP-VVSNHH
TH_3303|M.thermoresistible__bu L--------RAKCP-VAHTDAHG--GFWVISRYDDVVAAAKNDEVFASGY
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRL
. : :
Mb2289|M.bovis_AF2122/97 N----IT-----INDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKV
MUL_3863|M.ulcerans_Agy99 RP-VLAT-----VAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKA
Rv3518c|M.tuberculosis_H37Rv ------------NAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKR
MAB_1406c|M.abscessus_ATCC_199 GLTVTYG-----DLEKTGMGDNPPMVMQ--DPPTHTEFRKLVSRGFTPRQ
MAV_2213|M.avium_104 -------------MDAVDLGNVRPLIPLQIDPPEHAKYRRILDPLFTPRE
Mvan_4979|M.vanbaalenii_PYR-1 TPEGAEQ--------------LAGDLVITLDPPRQQKFRKVLNPYFSPAR
Mflv_1768|M.gilvum_PYR-GCK TPEGAEQ--------------LAGDLVITLDPPRQQKFRKVLNPYFSPAR
MMAR_4717|M.marinum_M DVNNQRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAA
MSMEG_4803|M.smegmatis_MC2_155 DISGETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAA
TH_3303|M.thermoresistible__bu TVNGVSP--LGVTIPPSP----VPMCPIEMDPPEYLPYRKLLNPFFSPGE
MLBr_02088|M.leprae_Br4923 KATLAQQ----AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKV
* * * :
Mb2289|M.bovis_AF2122/97 VARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIP
MUL_3863|M.ulcerans_Agy99 MRALKVRVDELAKNYVDAMMAAGP--ECDFVQQIAVNYPLYVIMSLLGLP
Rv3518c|M.tuberculosis_H37Rv VKDKEASIAALCDTLIDAVCERGE---CDFVRDLAAPLPMAVIGDMLGVR
MAB_1406c|M.abscessus_ATCC_199 VTAVEPKVREFVVQRLERLKERGE---GDIVVELFKPLPSMVVAHYLGVP
MAV_2213|M.avium_104 MARREPLVTELVNEMIDRFAARGE---CDFHAEFAVPLPCTVFLQLLGLP
Mvan_4979|M.vanbaalenii_PYR-1 MKALRPEIGVETDRLIDDFIETGS---GDLAAVAWRQPGIVFFKYLLGMP
Mflv_1768|M.gilvum_PYR-GCK MKALRHEIAAETDDLIDVFIESGS---GDLAEVAWRQPGIVFFKYLLGMP
MMAR_4717|M.marinum_M VKRWEPFIDEVTRACLDERIEQGS---IDFVDDLANIVPAVLTLAILGIP
MSMEG_4803|M.smegmatis_MC2_155 IKRWEPFVDEITRAAIDEHISSGR---IDFVEHLANVVPAVFTLAMMGIE
TH_3303|M.thermoresistible__bu SKKWEPRIAHWVDVCLDQVIEKGS---FDLVDDLANPVPSLFTCEFLGLP
MLBr_02088|M.leprae_Br4923 VQALEGDIAALVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVP
. : :. . *. . :*:
Mb2289|M.bovis_AF2122/97 KADHQRIFHWTNVILGFG-DPDLAT-----DFDEFMQVSADIGAYATALA
MUL_3863|M.ulcerans_Agy99 EADFPRMLKLTQELFGSD-DSEFKRG---STSEDQLPALLDMFGYFNAVT
Rv3518c|M.tuberculosis_H37Rv PEQRDMFLRWSDDLVTFL-SSHVSQ----EDFQITMDAFAAYNDFTRATI
MAB_1406c|M.abscessus_ATCC_199 EEDRTQFDAWTDGIVAAASGGAIDIE---AMQGEVAQTIGELMMYFTGLI
MAV_2213|M.avium_104 LEDLDRFLLWKDGVIRPAGDSGFDRR---HES--SAGVAQQIYEYFDKAI
Mvan_4979|M.vanbaalenii_PYR-1 VDDVPLCVELTDTALNGATE------------QDRMAAWGGLYQHLHDAV
Mflv_1768|M.gilvum_PYR-GCK VDDVPLCVELTDTALNGATE------------EARMGAWGGLYQHLHDAV
MMAR_4717|M.marinum_M LEKWNLYSEPVHAAVYTPEHS--------PDIQRVTEMHRQMGLDMVTNM
MSMEG_4803|M.smegmatis_MC2_155 LKKWNVYSEPTHASVYTPEHA--------PEREKINEQHREMGIDLINNM
TH_3303|M.thermoresistible__bu IEKWNDFASVQHEIIYTPPE----------EQEDILRRYMELCGEVFQLI
MLBr_02088|M.leprae_Br4923 YEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLV
. .
Mb2289|M.bovis_AF2122/97 EDRRVNHH-DDLTSSLVEAEVDGE--RLSSREIASFFILLVVAGNETTRN
MUL_3863|M.ulcerans_Agy99 TARRAHPT-ADLASAIANARIDGE--PLSDIDTVSYYLIVATAGHDTTSA
Rv3518c|M.tuberculosis_H37Rv AARRADPT-DDLVSVLVSSEVDGE--RLSDDELVMETLLILIGGDETTRH
MAB_1406c|M.abscessus_ATCC_199 ERRRAEPE-DDTVSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTG
MAV_2213|M.avium_104 DEHIAVPR-DDVLSAMIAADVGGQ--PLSREELLDICFLFLIAGLDTVTD
Mvan_4979|M.vanbaalenii_PYR-1 TARRGQPPRDDMIDVLLSAEIDGE--KLAFADVVSNAMLLVQAGLETTAS
Mflv_1768|M.gilvum_PYR-GCK TARTAEPPRDDMIDVLLSAEIDGE--KLAFGDVVSNAMLLVQAGLETTAS
MMAR_4717|M.marinum_M IEIRDNPR-PGLVNALVQMRIDGQ--PAPDLEILGNLGLVIGGGFDTTTA
MSMEG_4803|M.smegmatis_MC2_155 MEIRQNPR-PGLVNALLQLRIDGE--PAPDMEILGNLGLIIGGGFDTTTA
TH_3303|M.thermoresistible__bu TERRQNPTGEGLIDFLVTAEIDGE--PIPDDKVFSMVNLVIAGGFDTTTA
MLBr_02088|M.leprae_Br4923 KCRRGTPG-EDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVN
. . : ..: . . .* :*.
Mb2289|M.bovis_AF2122/97 AITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQ
MUL_3863|M.ulcerans_Agy99 TISGGLHALIEHPDQLARLQADP-ALMSLATEEMIRWVTPVKQFMRTASS
Rv3518c|M.tuberculosis_H37Rv TLSGGTEQLLRNRDQWDLLQRDP-SLLPGAIEEMLRWTAPVKNMCRVLTA
MAB_1406c|M.abscessus_ATCC_199 MLGGAIQLLHQNPAQRQKLIDDP-SLIPGAVEEFLRLTSPVQGLARTATR
MAV_2213|M.avium_104 SLDCFFVYLARHPQHRRQLVERP-DVLPGAVEELLRWETPVPGVARVATQ
Mvan_4979|M.vanbaalenii_PYR-1 AMSFAYHYLATNPAERDRLIDDPD-LLTRAVEEFIRFAGSIHGIPRTVAR
Mflv_1768|M.gilvum_PYR-GCK AMSFAYHYLATHPAERDRLIAEPD-LLARAVEEFIRFAGSIHGIPRTVAK
MMAR_4717|M.marinum_M LTAHALEWLSEHPDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSD
MSMEG_4803|M.smegmatis_MC2_155 LTAHALEWLGEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAE
TH_3303|M.thermoresistible__bu VTVSSLVYLAEHPEDRQRLIDNPD-LLPRAIEEFLRAFTPQQALARTVTK
MLBr_02088|M.leprae_Br4923 LIANAVLAMLRNPSQWKALSSNP-QRAPLVVEETLRYDPAIHLIGRVAAK
: . . ** :* . *. :
Mb2289|M.bovis_AF2122/97 DIELRGTKMAAGDKVSLWYCSANRDESKFA-DPWTFDLARNPNPHLGFGG
MUL_3863|M.ulcerans_Agy99 DTVVRGIPIAAGESVLLSYVSANRDEEVFD-QPFRFDIGREPNKHVAFGY
Rv3518c|M.tuberculosis_H37Rv DTEFHGTALCAGEKMMLLFESANFDEAVFC-EPEKFDVQRNPNSHLAFGF
MAB_1406c|M.abscessus_ATCC_199 DVIIGDTTIPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSH
MAV_2213|M.avium_104 DVEVGGCPISKGERVSPLLGAANTDPAEFP-DPETVDFTRSPNRHRAFGG
Mvan_4979|M.vanbaalenii_PYR-1 EVELSGCTFSPGESVIVNYAAANRDEQEFP-DAHRCILDRRDNRHLGFGA
Mflv_1768|M.gilvum_PYR-GCK EVELSGCTFSPGESVIVNYASANRDEEQFP-EADRCILDRRENRHLGFGA
MMAR_4717|M.marinum_M DVEFDGIHFKEGERLWISWAMANRDPQVFP-DPDELVLDRRGNRHFSFGI
MSMEG_4803|M.smegmatis_MC2_155 DAEVAGYKFKQYERLWLSWAMANRDPSVFD-KPNEVILDRKGNRHFSFGI
TH_3303|M.thermoresistible__bu PVTVAGVELQPGERVLLSWASANQDETAFE-RPEEIILDRFPNRHTTFGI
MLBr_02088|M.leprae_Br4923 DMTIGQTTLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLAFAV
. : ** * : . * *.
Mb2289|M.bovis_AF2122/97 GGAHFCLGANLARREIRVAFDELRRQMPDVVATEEP---ARLLSQFIHGI
MUL_3863|M.ulcerans_Agy99 G-VHFCMGAALARMEVASFFTELLPRLKSIELSGDP---QFTATTFVGGL
Rv3518c|M.tuberculosis_H37Rv G-THFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGL
MAB_1406c|M.abscessus_ATCC_199 G-NHHCLGAAAARMQSRIALEELLTRIPDFEVDLDG----VTWADGSYVR
MAV_2213|M.avium_104 G-PHRCLGSHLARMELRVALREFHRRIPDYEIKPGTQ---LTYTAALRSV
Mvan_4979|M.vanbaalenii_PYR-1 G-VHRCLGSNLARLEFQVGLERVLTRMPDFALSPTS-KAEFHGNSVTRGF
Mflv_1768|M.gilvum_PYR-GCK G-VHRCLGSNLARLEFQVGLERVLTRMPDFTLTAGA-EAKFHGNSVTRGF
MMAR_4717|M.marinum_M G-VHRCIGSNVARTVFKSMLSAVADRMPDYRCDPDG-AVHYETIGVIQGM
MSMEG_4803|M.smegmatis_MC2_155 G-VHRCVGSNVARTVFKSMLTAVLDRMPDYVCDPEG-TVHYDTIGVIQGM
TH_3303|M.thermoresistible__bu G-IHRCLGSHVARIELETMIRRVLDRMPDYHVDLAA-ARRYPSIGIINGW
MLBr_02088|M.leprae_Br4923 G-SHFCLGAALARLEATVTLSAISARFPQVQLAGEL---VYKPNVAMRGM
* * *:* ** . :: .
Mb2289|M.bovis_AF2122/97 KTLPVTWS---------------------------------------
MUL_3863|M.ulcerans_Agy99 KRLPVSYSLM-------------------------------------
Rv3518c|M.tuberculosis_H37Rv ESMPVVFTPSPPLG---------------------------------
MAB_1406c|M.abscessus_ATCC_199 RPLTVPIRVR-------------------------------------
MAV_2213|M.avium_104 ESLPLVFPVR-------------------------------------
Mvan_4979|M.vanbaalenii_PYR-1 RSVPVVFTPG--------------KRVTA------------------
Mflv_1768|M.gilvum_PYR-GCK RSVPVTFTPA--------------ARTR-------------------
MMAR_4717|M.marinum_M RKLPATFTPGRKAGAGLDETLAKLQRICDEQELARPVTERKQAAVID
MSMEG_4803|M.smegmatis_MC2_155 RNLPATFTPSRPLGPGLDETLEKLQRICNEEELARPITERKERAVID
TH_3303|M.thermoresistible__bu INAPATFTPG--------------QRLRDEK-LPGA-----------
MLBr_02088|M.leprae_Br4923 SALPVQV----------------------------------------
.