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VSIQDVTTDDDREKITYHFDRHTPEYRLQFEKITEEMHSRCPVAWTETYDGHWVAAGSNEVFELARCPVV SNHHDISGETPFQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWEPFVDEITRAAID EHISSGRIDFVEHLANVVPAVFTLAMMGIELKKWNVYSEPTHASVYTPEHAPEREKINEQHREMGIDLIN NMMEIRQNPRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWLGEHPDERERLSR ERDTLLNPATEEFLRFFTPAPGDGRTFAEDAEVAGYKFKQYERLWLSWAMANRDPSVFDKPNEVILDRKG NRHFSFGIGVHRCVGSNVARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPSRPLG PGLDETLEKLQRICNEEELARPITERKERAVID
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4803 | - | - | 100% (453) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2257 | - | 4e-34 | 24.70% (413) | cytochrome P450-terp |
| M. smegmatis MC2 155 | MSMEG_2558 | - | 1e-33 | 28.86% (350) | NikQ protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 7e-30 | 30.32% (310) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_2498 | - | 0.0 | 91.35% (451) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 8e-30 | 30.32% (310) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-23 | 24.21% (318) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 5e-31 | 27.19% (320) | cytochrome P450 |
| M. marinum M | MMAR_4717 | cyp188A3 | 0.0 | 72.47% (454) | cytochrome P450 188A3 Cyp188A3 |
| M. avium 104 | MAV_0940 | - | 0.0 | 75.33% (454) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_2693 | - | 0.0 | 88.94% (452) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0317 | cyp188A3 | 1e-177 | 71.07% (394) | cytochrome P450 188A3 Cyp188A3 |
| M. vanbaalenii PYR-1 | Mvan_4160 | - | 0.0 | 87.28% (456) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1813c|M.bovis_AF2122/97 -------------------------------MTTPGEDHAGSFYLPRLEY
Rv1785c|M.tuberculosis_H37Rv -------------------------------MTTPGEDHAGSFYLPRLEY
Mflv_2498|M.gilvum_PYR-GCK MTNYTEIAASKESRLLSVDDVVDGTADDSRRKNTYYFDRHTPEYRLQFDK
Mvan_4160|M.vanbaalenii_PYR-1 ---------------MSVDDVVSGTADDSRKQNRYYFDRHTPEYRLQFEK
MSMEG_4803|M.smegmatis_MC2_155 ---------------MSIQDVTT---DDDREKITYHFDRHTPEYRLQFEK
TH_2693|M.thermoresistible__bu ---------------LSVDDIIT---DAERKKHRYHFDRHTPEYRLQFEK
MMAR_4717|M.marinum_M ---------------MSVDDVVS---DSDHQKNRYQFDRHSPEYRSQFKA
MUL_0317|M.ulcerans_Agy99 ---------------MSVDDVVS---DSDHHQNRYQFDRHSPEYRSQFKA
MAV_0940|M.avium_104 ---------------MSVDDGVN---DSDRKKNRYHFDRHSPDYRSRFKA
MAB_3825|M.abscessus_ATCC_1997 -------------------MATALSEIEEAGRVLADPAAYADELRLHAAM
MLBr_02088|M.leprae_Br4923 -------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLID
:
Mb1813c|M.bovis_AF2122/97 STLPMAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKV----
Rv1785c|M.tuberculosis_H37Rv STLPMAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKV----
Mflv_2498|M.gilvum_PYR-GCK ITEEMHAKCPMAWSETYNGHWVAADSKHVFELARCPAVSNHHDISG----
Mvan_4160|M.vanbaalenii_PYR-1 ITEEMQTKCPMAWSDTYGGHWVAADSKHVFELARCPVVSNHHDISG----
MSMEG_4803|M.smegmatis_MC2_155 ITEEMHSRCPVAWTETYDGHWVAAGSNEVFELARCPVVSNHHDISG----
TH_2693|M.thermoresistible__bu ITEEMHAKCPMAWTDTYGGHWVAADSKHVFELARCPVVSNHHDITG----
MMAR_4717|M.marinum_M ITEEMHTTCPMAWSDTYGGHWVAAGSHEVFELARCPAVSNDHDVNN----
MUL_0317|M.ulcerans_Agy99 ITEEMHTTCPMAWSDTYGGHWVAAGSHEVFELARCPAVSNDHDVNN----
MAV_0940|M.avium_104 ITEEMHAKCPMAWTDTYGGHWVAAGSHEVFELARCPAVSNDHDING----
MAB_3825|M.abscessus_ATCC_1997 TLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL----
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRL
.
Mb1813c|M.bovis_AF2122/97 FSS--RKALQPPGNPLPVVP---LAFDPPEHTRYRRILQPYFSPAALSKA
Rv1785c|M.tuberculosis_H37Rv FSS--RKALQPPGNPLPVVP---LAFDPPEHTRYRRILQPYFSPAALSKA
Mflv_2498|M.gilvum_PYR-GCK ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
Mvan_4160|M.vanbaalenii_PYR-1 ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
MSMEG_4803|M.smegmatis_MC2_155 ETP-FQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRW
TH_2693|M.thermoresistible__bu ETP-FQGITIPKASRATVVRGGILEMDEPEHSIYRGALNPYLSPAAIKRW
MMAR_4717|M.marinum_M QRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MUL_0317|M.ulcerans_Agy99 QRRGYKGISIPTASRINGVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MAV_0940|M.avium_104 ERRGYKGISIPTASRVSAVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRW
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
: : :* *.* * : * .:
Mb1813c|M.bovis_AF2122/97 LPSLRRHTVAMIDAIAGRG-ECEAMADLANLFPFQLFLVLYGLPLEDRDR
Rv1785c|M.tuberculosis_H37Rv LPSLRRHTVAMIDAIAGRG-ECEAMADLANLFPFQLFLVLYGLPLEDRDR
Mflv_2498|M.gilvum_PYR-GCK EPFIDEITRAALDEHIESG-RIDFVDHLANVVPAVFTLAMMGIELKKWNV
Mvan_4160|M.vanbaalenii_PYR-1 EPFIHEITRAALDEHIESG-RIDFVDHLANVVPAVFTLAMMGIKLDKWNV
MSMEG_4803|M.smegmatis_MC2_155 EPFVDEITRAAIDEHISSG-RIDFVEHLANVVPAVFTLAMMGIELKKWNV
TH_2693|M.thermoresistible__bu EPFVHEITRAAIDEKIESG-EIDFVEDLANVVPAVFTLAMMGIELKKWKV
MMAR_4717|M.marinum_M EPFIDEVTRACLDERIEQG-SIDFVDDLANIVPAVLTLAILGIPLEKWNL
MUL_0317|M.ulcerans_Agy99 EPFIDEVTRACLDERIEQG-SIDFVDDLANIVPAVLTLAILGIPLEKWNL
MAV_0940|M.avium_104 EPFIDEVTRAALDEKIEEG-SIDFVDDLANIVPAVLTLAMLGIPLKKWKM
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
. :: * : .:* .. . : *: ..
Mb1813c|M.bovis_AF2122/97 LIGWKDAVIAMSD--------RPHPTEADVAAARELLEYLTAMVAERRRN
Rv1785c|M.tuberculosis_H37Rv LIGWKDAVIAMSD--------RPHPTEADVAAARELLEYLTAMVAERRRN
Mflv_2498|M.gilvum_PYR-GCK YSEPTHASVYTPE--------HAPEREKINEQHREMGIDLINNMMEIREN
Mvan_4160|M.vanbaalenii_PYR-1 YSEPTHASVYTPE--------HAPEREKINEQHRAMGLDLITNMMEIREN
MSMEG_4803|M.smegmatis_MC2_155 YSEPTHASVYTPE--------HAPEREKINEQHREMGIDLINNMMEIRQN
TH_2693|M.thermoresistible__bu YSEPTHASVYTPE--------HAPEREKVNEMHREMGIDLINNMMEIREN
MMAR_4717|M.marinum_M YSEPVHAAVYTPE--------HSPDIQRVTEMHRQMGLDMVTNMIEIRDN
MUL_0317|M.ulcerans_Agy99 YSEPVHAAVYTPE--------HSPDIQRVTEMHRQMGLDMVTNMIEIRDN
MAV_0940|M.avium_104 YSEPVHAAVYTPE--------HSPDIERVTAMHREMGLDMVNNMLEIREN
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDSEF----QRGTTPEEQLMALLDFFGYFSGLTASRRQH
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
. : : : : *
Mb1813c|M.bovis_AF2122/97 PGP---DVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLEL
Rv1785c|M.tuberculosis_H37Rv PGP---DVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLEL
Mflv_2498|M.gilvum_PYR-GCK PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
Mvan_4160|M.vanbaalenii_PYR-1 PRPGLVNALLQLRIDGEPAPDIEILGNLGLIIGGGFDTTTALTAHALEWL
MSMEG_4803|M.smegmatis_MC2_155 PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
TH_2693|M.thermoresistible__bu PRPGLVNALLQLRIDGEPAPDMEILGNLGLIIGGGFDTTTALTAHALEWL
MMAR_4717|M.marinum_M PRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWL
MUL_0317|M.ulcerans_Agy99 PRPGLVNALVQMRIDGQPAPDLEILGNLGLVIGGGFDTTTALTAHALEWL
MAV_0940|M.avium_104 PRPGIVNALLQMRIDGEPAPDLEILGNLGLVIGGGFDTTTALTAHSLEWL
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
* . : : . : .: : . :: .* :*. . .: :
Mb1813c|M.bovis_AF2122/97 ARRPQLR-AMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMTL
Rv1785c|M.tuberculosis_H37Rv ARRPQLR-AMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVGGMTL
Mflv_2498|M.gilvum_PYR-GCK GEHPDERERLSRERATLLAPATEEFLRFFTPAPGDGRTFSEDVEVAGQRF
Mvan_4160|M.vanbaalenii_PYR-1 GEHPDQRQRLSSERATLLDPATEEFLRFFTPAPGDGRTFADDVEVEGQRF
MSMEG_4803|M.smegmatis_MC2_155 GEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDAEVAGYKF
TH_2693|M.thermoresistible__bu GEHPDERERLSRERDTLLNPATEEFLRFFTPAPGDGRTFAEDVEVLGTQF
MMAR_4717|M.marinum_M SEHPDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDVEFDGIHF
MUL_0317|M.ulcerans_Agy99 SEHHDERERLWRNRDTLIDSATEEFLRYFTPAPGDGRTFSDDLEFFGIHF
MAV_0940|M.avium_104 SEHPEQRQLLSDERKTLLDPATEEFLRYFTPAPGDGRTFSEDFELDGTVF
MAB_3825|M.abscessus_ATCC_1997 LEHPDQLARLREN-PGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPI
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
.. . : : :* :* .. *. : . :
Mb1813c|M.bovis_AF2122/97 PAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHL
Rv1785c|M.tuberculosis_H37Rv PAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHL
Mflv_2498|M.gilvum_PYR-GCK KQYERLWLSWAMANRDPAVFDEPNKVVLDRKGNRHFSFGIGVHRCVGSNV
Mvan_4160|M.vanbaalenii_PYR-1 KKFERLWLSWAMANRDASVFDRPNEVVLDRKGNRHFSFGIGVHRCVGSNV
MSMEG_4803|M.smegmatis_MC2_155 KQYERLWLSWAMANRDPSVFDKPNEVILDRKGNRHFSFGIGVHRCVGSNV
TH_2693|M.thermoresistible__bu KKYERLWLSWAMANRDPAVFERPNEIILDRKGNRHFSFGIGVHRCVGSNV
MMAR_4717|M.marinum_M KEGERLWISWAMANRDPQVFPDPDELVLDRRGNRHFSFGIGVHRCIGSNV
MUL_0317|M.ulcerans_Agy99 KEGERLWISWAMANREPQVFPDPDELVLDRRGNRHFSFGIGVHRCVGSNV
MAV_0940|M.avium_104 KEGERLWISWAMANRDPAVFHDPDEVILDRKGNRHFSFGLGIHRCIGSNV
MAB_3825|M.abscessus_ATCC_1997 TEGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAAL
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAAL
. : : . **: . . :* .*. * * *:*: :
Mb1813c|M.bovis_AF2122/97 ARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS----
Rv1785c|M.tuberculosis_H37Rv ARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS----
Mflv_2498|M.gilvum_PYR-GCK ARTVFKSMLTAVLDRMPDYVCDPEGTVHYDSIGVIQGMRNLPATFTPGKP
Mvan_4160|M.vanbaalenii_PYR-1 ARTLFKSMVTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPGKR
MSMEG_4803|M.smegmatis_MC2_155 ARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPSRP
TH_2693|M.thermoresistible__bu ARTVFKSMLTAVLDRMPDYVCDPEGTMHYDTIGVIQGMRHLPAKFTPGKP
MMAR_4717|M.marinum_M ARTVFKSMLSAVADRMPDYRCDPDGAVHYETIGVIQGMRKLPATFTPGRK
MUL_0317|M.ulcerans_Agy99 ARTVFKSMLSAVADRMPDYRCDPDGRSTTRPSASSRACASCPQRSPRAAR
MAV_0940|M.avium_104 ARTVFKSMLIAVLDRMPDYRCDPEGTVHYETIGVIQGMRKLPATFTPGRR
MAB_3825|M.abscessus_ATCC_1997 ARMEVNSFFSALLPRLESIEVDGN--IERTSTIFVGGIKHLPIRYTLR--
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELVYKPN--VAMRGMSALPVQV-----
** . . :: . : . *
Mb1813c|M.bovis_AF2122/97 --------------------------------------------------
Rv1785c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2498|M.gilvum_PYR-GCK LGPGLDETIEKLQRICNEQELAR-------------------PITERKEA
Mvan_4160|M.vanbaalenii_PYR-1 LGPGLDETLEKLQRICDEQELAR-------------------PITERKEA
MSMEG_4803|M.smegmatis_MC2_155 LGPGLDETLEKLQRICNEEELAR-------------------PITERKER
TH_2693|M.thermoresistible__bu LGPKLDETLDRLQQICDEQELAR-------------------PITERKEP
MMAR_4717|M.marinum_M AGAGLDETLAKLQRICDEQELAR-------------------PVTERKQA
MUL_0317|M.ulcerans_Agy99 SAR----AWTRLSRSCNASATNRNSRGPSPSANKPRSSTDAPPASRHKIA
MAV_0940|M.avium_104 IGAGLDETLEKLQRICDEQELAR-------------------PITERKEA
MAB_3825|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Mb1813c|M.bovis_AF2122/97 -----
Rv1785c|M.tuberculosis_H37Rv -----
Mflv_2498|M.gilvum_PYR-GCK AVID-
Mvan_4160|M.vanbaalenii_PYR-1 AVID-
MSMEG_4803|M.smegmatis_MC2_155 AVID-
TH_2693|M.thermoresistible__bu AVITW
MMAR_4717|M.marinum_M AVID-
MUL_0317|M.ulcerans_Agy99 SGSGR
MAV_0940|M.avium_104 AVID-
MAB_3825|M.abscessus_ATCC_1997 -----
MLBr_02088|M.leprae_Br4923 -----