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TEAGGFVDQTVTGVAEPQPMYKALRESNPVFRSPQAVVLSRLADIEMALKHTELFSSNMDAVDLGNVRPL IPLQIDPPEHAKYRRILDPLFTPREMARREPLVTELVNEMIDRFAARGECDFHAEFAVPLPCTVFLQLLG LPLEDLDRFLLWKDGVIRPAGDSGFDRRHESSAGVAQQIYEYFDKAIDEHIAVPRDDVLSAMIAADVGGQ PLSREELLDICFLFLIAGLDTVTDSLDCFFVYLARHPQHRRQLVERPDVLPGAVEELLRWETPVPGVARV ATQDVEVGGCPISKGERVSPLLGAANTDPAEFPDPETVDFTRSPNRHRAFGGGPHRCLGSHLARMELRVA LREFHRRIPDYEIKPGTQLTYTAALRSVESLPLVFPVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2213 | - | - | 100% (389) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_1950 | - | 3e-75 | 42.03% (345) | putative cytochrome P450 126 |
| M. avium 104 | MAV_1953 | - | 3e-71 | 39.57% (374) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1813c | cyp143 | 6e-64 | 38.15% (367) | cytochrome P450 143 |
| M. gilvum PYR-GCK | Mflv_1764 | - | 4e-64 | 37.23% (368) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1785c | cyp143 | 7e-64 | 38.15% (367) | cytochrome P450 143 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-45 | 30.23% (387) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 7e-57 | 36.01% (411) | cytochrome P450 |
| M. marinum M | MMAR_0274 | cyp271A1 | 2e-77 | 40.63% (379) | cytochrome P450 271A1 Cyp271A1 |
| M. smegmatis MC2 155 | MSMEG_5038 | - | 1e-50 | 34.69% (369) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_2649 | - | 1e-55 | 35.96% (381) | PUTATIVE cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_3091 | cyp143A4 | 1e-63 | 37.81% (365) | cytochrome P450 143A4 Cyp143A4 |
| M. vanbaalenii PYR-1 | Mvan_4983 | - | 5e-66 | 37.67% (369) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
TH_2649|M.thermoresistible__bu ----------VLTTVPLHSPDFYAGN-----------------------P
MAB_1406c|M.abscessus_ATCC_199 --MSVDVSHTVAPRYVPGTADNWTNP------------------------
MSMEG_5038|M.smegmatis_MC2_155 --MGADLSHPAVA-FELANADTWADP------------------------
MAV_2213|M.avium_104 ----MTEAG---GFVD------QTVTG-----------------------
MMAR_0274|M.marinum_M ----MEGNE---RFVPRLAPLTLAVKS-----------------------
Mb1813c|M.bovis_AF2122/97 ----MTTPGEDHAGSFYLPRLEYSTLP-----------------------
Rv1785c|M.tuberculosis_H37Rv ----MTTPGEDHAGSFYLPRLEYSTLP-----------------------
MUL_3091|M.ulcerans_Agy99 ----MSTPGEGSASSFYLPRLEYSTLP-----------------------
Mflv_1764|M.gilvum_PYR-GCK ----MTAT----AAPLGLPQVLYGDLP-----------------------
Mvan_4983|M.vanbaalenii_PYR-1 ----MSA----------LPHVLYGDLP-----------------------
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG---MPLTVFSSFSDCDEALRHPLSASDRLKATL
TH_2649|M.thermoresistible__bu YPAYRELRATTPVVYN-----DVTNFWALLKYEDIR--YVSSHPQLFSST
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
MSMEG_5038|M.smegmatis_MC2_155 WDMYTALRDHDPVHHVVPPERPHHDYFVLSRHADIWAAARDHETYSSAQG
MAV_2213|M.avium_104 --VAEPQPMYKALRESNPVFRSPQ-AVVLSRLADIEMALKHTELFSSNMD
MMAR_0274|M.marinum_M --LANPQFIYNAKAQGVRAERTEAGVVTLYRRDDLMRISRHPAVLGPGGR
Mb1813c|M.bovis_AF2122/97 --MAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKA
Rv1785c|M.tuberculosis_H37Rv --MAVDRGVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKA
MUL_3091|M.ulcerans_Agy99 --LSADRAVGWNTLRDAGPVVFMNGHYYLTRREDVLAALRNPKIFSSR-I
Mflv_1764|M.gilvum_PYR-GCK --MSRDRGHGWATLRDLGPVLYGDGWFYLTRREDVLAALRNPEVFSSRIA
Mvan_4983|M.vanbaalenii_PYR-1 --MAADRGAGWATLREFGPVAYGDGWYYLTRRDDVLAALRNPEVFSSRIA
: :
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
TH_2649|M.thermoresistible__bu KGITIPDPDQPEPVQEGNLIFTDPPRHRQLRKLINTAFTRRQVALLEPKV
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTGMGDNPPMVMQDPPTHTEFRKLVSRGFTPRQVTAVEPKV
MSMEG_5038|M.smegmatis_MC2_155 LTVNYGELELIGLADNPPFVMQDPPTHTEFRKLVSRGFTPRQVEAVEPQV
MAV_2213|M.avium_104 AVDLGNVRPLIP-------LQIDPPEHAKYRRILDPLFTPREMARREPLV
MMAR_0274|M.marinum_M GGNFGNDNPLIP-------LEIDGEEHKKWRRLLDPLFAPKQMARLEAAV
Mb1813c|M.bovis_AF2122/97 LQPPGNPLPVVP-------LAFDPPEHTRYRRILQPYFSPAALSKALPSL
Rv1785c|M.tuberculosis_H37Rv LQPPGNPLPVVP-------LAFDPPEHTRYRRILQPYFSPAALSKALPSL
MUL_3091|M.ulcerans_Agy99 LQPPGNPLPVVP-------LAFDPPEHTRYRKALQPYFSPHALGKSRPVL
Mflv_1764|M.gilvum_PYR-GCK YDDMISPVPLVP-------LGFDPPEHTRYRHILHPFFSPQTLAALLPSL
Mvan_4983|M.vanbaalenii_PYR-1 YDDMISPVPLVP-------LGFDPPEHTRYRRILHPFFSPQALGVLLPSL
: * * . *: : *: : :
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
TH_2649|M.thermoresistible__bu REIVYGIFEGVAPGSEQEFAESFAAPLPTRMIAELLGASPEDWERFRRWS
MAB_1406c|M.abscessus_ATCC_199 REFVVQRLERLKERGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFDAWT
MSMEG_5038|M.smegmatis_MC2_155 REFVVERLERLRAEGGGDIVAELFKPLPSMVVAHYLGVPEADRAQFDGWT
MAV_2213|M.avium_104 TELVNEMIDRFAARGECDFHAEFAVPLPCTVFLQLLGLPLEDLDRFLLWK
MMAR_0274|M.marinum_M RNRAAQLVDGFASQTSAELYQAYCAPLPCFTFLELLGAPLEDIEFFTAFK
Mb1813c|M.bovis_AF2122/97 RRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWK
Rv1785c|M.tuberculosis_H37Rv RRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWK
MUL_3091|M.ulcerans_Agy99 ERHAAEMIAGFAGRGECDAMAEFARLYPFQVFLDLYGLPLQDRDRVIAWK
Mflv_1764|M.gilvum_PYR-GCK QAQVADIVEEIARRDRCEVMAELATPYPSQVFLTLFGLPLQDRERLIAWK
Mvan_4983|M.vanbaalenii_PYR-1 QAQAADIVETIAQRDACEVMAELATPYPSQVFLTLFGLPLQDRERLIAWK
. . : . . * . * . .
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDL
TH_2649|M.thermoresistible__bu DACTGTAD---------PEIELDAMEAIGELYEYFQQLIAARRTEPRDDM
MAB_1406c|M.abscessus_ATCC_199 DGIVAAAS---GGAIDIEAMQGEVAQTIGELMMYFTGLIERRRAEPEDDT
MSMEG_5038|M.smegmatis_MC2_155 EAIVAANS---EAGSALGAGDAVMSMTG-----YFAELIERRRREPGDDT
MAV_2213|M.avium_104 DGVIRPAG-----DSGFDRRHESSAGVAQQIYEYFDKAIDEHIAVPR--D
MMAR_0274|M.marinum_M NGVLHPQG-----ET-REEIQANQAAAGAMLLEYFTRLVARQRAEGAQGE
Mb1813c|M.bovis_AF2122/97 DAVIAMSD-----RPHPTEADVAAAR---ELLEYLTAMVAERRRNPGP--
Rv1785c|M.tuberculosis_H37Rv DAVIAMSD-----RPHPTEADVAAAR---ELLEYLTAMVAERRRNPGP--
MUL_3091|M.ulcerans_Agy99 DAIIG--D-----KLYLTREELEVGQL--ELLEYLNNAIQQRRQNPGS--
Mflv_1764|M.gilvum_PYR-GCK DAIIAFSL-----TTDPSSVDLKPAV---ELYTYLSEAVAAQRDDPRE--
Mvan_4983|M.vanbaalenii_PYR-1 DAIIAFSL-----TNDPTSVDLTPAV---ELYGYLTEAVARQREKPRE--
*: : :
MLBr_02088|M.leprae_Br4923 ISRLIELD--ESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRN
TH_2649|M.thermoresistible__bu MSVLAQAE--VDGARLSDEDLLNFAFLLLVAGNETTRNLIALGTLALIEH
MAB_1406c|M.abscessus_ATCC_199 VSHLVAAGVGADGDISGTLQILGFAFTMVTGGNDTTTGMLGGAIQLLHQN
MSMEG_5038|M.smegmatis_MC2_155 ISHLVAA--GADDEAVDVLSILAFTFTMVTGGNDTTTGMLGGAVQLLQQH
MAV_2213|M.avium_104 DVLSAMIAADVGGQPLSREELLDICFLFLIAGLDTVTDSLDCFFVYLARH
MMAR_0274|M.marinum_M EVLAVLLRSRIDGQPLTDAELFNIIHLLIFAGLDTVTASMSCILAWLGQH
Mb1813c|M.bovis_AF2122/97 ---DVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARR
Rv1785c|M.tuberculosis_H37Rv ---DVLSQVQIGEDPLSEIEVLGLSHLLILAGLDTVTAAVGFSLLELARR
MUL_3091|M.ulcerans_Agy99 ---DMLSQVMTGPGEFTDLELLGMSHLLILAGLDTVTAAIGFSLLELARR
Mflv_1764|M.gilvum_PYR-GCK ---GVLSHLLHGDDPLTDNEAVGLSLVFVLAGLDTVTSAIGATMLELARR
Mvan_4983|M.vanbaalenii_PYR-1 ---GILSHLLHGDEQLTDNEAVGLSLVFVLAGLDTVTSTIGATMLELARR
. . . :: .* :*. : : ..
MLBr_02088|M.leprae_Br4923 PSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIG-QTTLTEG
TH_2649|M.thermoresistible__bu PDQCRKLIENPTLIPGAVEEMLRYTSPVTHMARQATEDVEIR-GRHIRKG
MAB_1406c|M.abscessus_ATCC_199 PAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIG-DTTIPAG
MSMEG_5038|M.smegmatis_MC2_155 PDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATRDVTIG-DTTIPAG
MAV_2213|M.avium_104 PQHRRQLVERPDVLPGAVEELLRWETPVPGVARVATQDVEVG-GCPISKG
MMAR_0274|M.marinum_M PHERRRLVEDTARIPAAIEELMRYESPAPSGIRYATADIDLGDGLTIRAG
Mb1813c|M.bovis_AF2122/97 PQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVG-GMTLPAG
Rv1785c|M.tuberculosis_H37Rv PQLRAMLRDNPKQIRVFIEEIVRLEPSAPVAPRVTTEPVTVG-GMTLPAG
MUL_3091|M.ulcerans_Agy99 PQLRTQLRDNPKEIRVFIEEIVRLEPSAPVAPRITTDFVNVG-GMTLPPG
Mflv_1764|M.gilvum_PYR-GCK PELRGALREDPEGIAVFVEEMIRLEPAAPIVGRVTTRPVTVA-GVTLPAG
Mvan_4983|M.vanbaalenii_PYR-1 PELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREVTVA-GVTLPKG
* * . ::* :* .. * :: : : : *
MLBr_02088|M.leprae_Br4923 DTMVLLLAAANRDPAVY-SRPDEFDPDRPSSRHLAFAVGSHFCLGAALAR
TH_2649|M.thermoresistible__bu DTVVMLYGSANRDEEIFGDDAEDFRIDRQPNPHIAFGCGEHSCIGAQLAR
MAB_1406c|M.abscessus_ATCC_199 RRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHGNHHCLGAAAAR
MSMEG_5038|M.smegmatis_MC2_155 RKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSHGAHFCLGAAAAR
MAV_2213|M.avium_104 ERVSPLLGAANTD-PAEFPDPETVDFTRSPNRHRAFGGGPHRCLGSHLAR
MMAR_0274|M.marinum_M EAIHVSWAAANVD-PTAHPDPLHVDFDRARFHHLAFGSGIHRCLGSHLAR
Mb1813c|M.bovis_AF2122/97 SPVRLCMAAVNRD-GSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHLAR
Rv1785c|M.tuberculosis_H37Rv SPVRLCMAAVNRD-GSDAMSTDELVMDGKVHRHWGFGGGPHRCLGSHLAR
MUL_3091|M.ulcerans_Agy99 SQVRLCMAAVNRD-GSDAMSTNELVMDGKVHRHWGFGGGPHRCLGSHLAR
Mflv_1764|M.gilvum_PYR-GCK SEVRLCLGAINRD-GTDEHSGDDLVLDGKLHKHWGFGGGPHRCLGSHLAR
Mvan_4983|M.vanbaalenii_PYR-1 AEVRLCLGAINRD-GADEHSGDDFVLDGKLHKHWGFGGGPHRCLGSHLAR
.: * * . *. * * *:*: **
MLBr_02088|M.leprae_Br4923 LEATVTLSAISARFPQVQLAG-ELVYKPN-VAMRGMSALPVQV-------
TH_2649|M.thermoresistible__bu LEACVFFEVLLGRFPDLELVG-TVDRMRA-TMVPGVKRMPVRLGAGR---
MAB_1406c|M.abscessus_ATCC_199 MQSRIALEELLTRIPDFEVDLDGVTWADG-SYVRRPLTVPIRVR------
MSMEG_5038|M.smegmatis_MC2_155 MQSRVALTELLTRCPDFTVDLDAVVWAGG-SYVRRPLSVPFRAGA-----
MAV_2213|M.avium_104 MELRVALREFHRRIPDYEIKPGTQLTYTAALRSVESLPLVFPVR------
MMAR_0274|M.marinum_M LELRVALEEFLARIPDYAVDTAGLVYDNVSVRTVQQLRITFNANTPSPVD
Mb1813c|M.bovis_AF2122/97 LELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS------
Rv1785c|M.tuberculosis_H37Rv LELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS------
MUL_3091|M.ulcerans_Agy99 IELTVIVAEWLKQLPDFELAPDYSPEIAFPSKTFALKSLPLRWA------
Mflv_1764|M.gilvum_PYR-GCK MELKLVVSEWLSRIPDFDLEPGYVPEITWPSATCTLTGLPLRILR-----
Mvan_4983|M.vanbaalenii_PYR-1 MELRLVVTEWLSRIPDFELAPGYVPEITWPSATCTLPTLPLILTRKTP--
:: : . : *: : : .
MLBr_02088|M.leprae_Br4923 ---------------------------
TH_2649|M.thermoresistible__bu ---------------------------
MAB_1406c|M.abscessus_ATCC_199 ---------------------------
MSMEG_5038|M.smegmatis_MC2_155 ---------------------------
MAV_2213|M.avium_104 ---------------------------
MMAR_0274|M.marinum_M PSQRHAFMAPLTGQRDSVLERNGHEHR
Mb1813c|M.bovis_AF2122/97 ---------------------------
Rv1785c|M.tuberculosis_H37Rv ---------------------------
MUL_3091|M.ulcerans_Agy99 ---------------------------
Mflv_1764|M.gilvum_PYR-GCK ---------------------------
Mvan_4983|M.vanbaalenii_PYR-1 ---------------------------