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MNGPSRSPWEESPISAFRFRHRLDSETFPKHGLPMMTSRKRGDVGGTPMAGIYGDVLGSASSMETRAHDL LDVLASRADSSASAICLWDPIQRCHVGVANREYPDQVMDHFNSWFVDNDPLFDAMRVHGLGALRWRDFPD YRRGYSVNNVFRPAGFDEGLSARLVTTDGTYVGTIHVNCDDARFPSDEDVAEINALRVQMADQLDFSVRP RMVSELIAPDAQAWAVDEAGRAHLLRLGDSFDSALDPVVVNEIAVAFRAPGFTVQPEVLRYHDGSSWLHV RRIATSSRYRGDSLCGVLLVTRTGLPMGITPRELDALTLAVCGLTNGQIAAQLFISARTAGHHLESASAK LGAPNRAACASHAVALGLLSAEVLRDLGVRHSVAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1688 | - | - | 100% (385) | response regulator receiver protein |
| M. gilvum PYR-GCK | Mflv_4288 | - | 1e-09 | 44.62% (65) | metal dependent phosphohydrolase |
| M. gilvum PYR-GCK | Mflv_5014 | - | 2e-06 | 41.54% (65) | two component LuxR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0914c | - | 2e-05 | 40.68% (59) | LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0890c | - | 3e-06 | 42.37% (59) | LuxR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 3e-05 | 40.32% (62) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 9e-06 | 46.55% (58) | putative regulatory protein |
| M. avium 104 | MAV_4201 | - | 9e-09 | 42.42% (66) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_1082 | - | 2e-08 | 42.86% (70) | putative response regulator |
| M. thermoresistible (build 8) | TH_3184 | - | 4e-06 | 41.54% (65) | PUTATIVE two component transcriptional regulator, LuxR family |
| M. ulcerans Agy99 | MUL_2876 | - | 3e-06 | 45.16% (62) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3766 | - | 3e-09 | 46.27% (67) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0914c|M.bovis_AF2122/97 MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAPITESG
Rv0890c|M.tuberculosis_H37Rv MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAPITESG
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3766|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4201|M.avium_104 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 IVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAAL
Rv0890c|M.tuberculosis_H37Rv IVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAAL
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3766|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4201|M.avium_104 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 VVELLGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASR
Rv0890c|M.tuberculosis_H37Rv VVELLGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASR
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3766|M.vanbaalenii_PYR-1 ----------------------------------MLTDTQIDLLSAARTA
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4201|M.avium_104 --------------------------------------------------
Mb0914c|M.bovis_AF2122/97 VQPGFTIANHNAAAVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDD
Rv0890c|M.tuberculosis_H37Rv VQPGFTIANHNAAAVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDD
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3766|M.vanbaalenii_PYR-1 HQRRDWAASYEAFELASRYAPLRTDDLEAFAFASWRLGHIKESSRAAERV
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4201|M.avium_104 ------MMLMAQAVLPTRAELLAALSVAIDLGLGQPAEHMLRAALIATRL
Mb0914c|M.bovis_AF2122/97 CFRLLAGGVRGAVQRQQTLRASIDWSHALLTETEQILFRRLAPFVGGFDL
Rv0890c|M.tuberculosis_H37Rv CFRLLAGGVRGAVQRQQTLRASIDWSHALLTETEQILFRRLAPFVGGFDL
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M --------------------------------------------------
MUL_2876|M.ulcerans_Agy99 --------------------------------------------MGFSPR
Mvan_3766|M.vanbaalenii_PYR-1 FAELTRTDPNAAAMKANELALAWLVRGDINIGQGWMSRARRLLAAAEESQ
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4201|M.avium_104 CDRLGLSRQQRDCVYYTTLVMWVGCHADSHEYARWFG-------------
Mb0914c|M.bovis_AF2122/97 AAVRAVAAGSDLDPFSVLDQLTLLVDKSLVVADDCQGRTRYRLLETVRRY
Rv0890c|M.tuberculosis_H37Rv AAVRAVAAGSDLDPFSVLDQLTLLVDKSLVVADDCQGRTRYRLLETVRRY
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M ----------MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYRE
MUL_2876|M.ulcerans_Agy99 RAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDATRHYRE
Mvan_3766|M.vanbaalenii_PYR-1 AHGYLIYLDAVVAAISQDLDALAGHVRSLRETSERLDVPAVTALGLIAAG
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK --------------------------MNGPSRSPWEESPISAFRFRHRLD
MAV_4201|M.avium_104 DDIAVRHDSYLVDWSGIPYLRFLASNVGRGQPLAHRLSVMATLFANARGH
Mb0914c|M.bovis_AF2122/97 ALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLVARAETEIDNL
Rv0890c|M.tuberculosis_H37Rv ALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLVARAETEIDNL
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu --------------------------------------------------
MMAR_2876|M.marinum_M AFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESLGDVHAVNALETLLDL
MUL_2876|M.ulcerans_Agy99 AFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESQGDVHAVNALETLLDL
Mvan_3766|M.vanbaalenii_PYR-1 IEAILHARTAEGYALIDEAILPLMADQVPIEWAGDIYCMVLHHCHKLADL
MSMEG_1082|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK SETFPKHGLPMMTSRKRGDVGGTPMAGIYGDVLGSASSMETRAHDLLDVL
MAV_4201|M.avium_104 ISRLIHSHCASAALLADRIGLGPNVQAALAYTFERYDGGGLPTGARGEDI
Mb0914c|M.bovis_AF2122/97 RAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRFH
Rv0890c|M.tuberculosis_H37Rv RAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRFH
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3184|M.thermoresistible__bu ------------------------------------------------ME
MMAR_2876|M.marinum_M SSLEREMIEDGAARRTLALLQVQEALS--KLRAVDDVAMIVDRAPRELVE
MUL_2876|M.ulcerans_Agy99 SSLEREMIEDGAARRTLALLQVQEALS--KLRAVDDVAMIVDRAPRELVE
Mvan_3766|M.vanbaalenii_PYR-1 PRMRSWTQSMEQWCGLSGSVPYGGVCDVHRLQVQVASTDLRG-LEDRLGT
MSMEG_1082|M.smegmatis_MC2_155 -----------------------------------------MTLMNEMRD
Mflv_1688|M.gilvum_PYR-GCK ASRADSSASAICLWDPIQRCHVG-------VANREYPDQVMDHFNSWFVD
MAV_4201|M.avium_104 PIQMRIAQLADMVEVHHRSYGVAGAVAMVGARRGGQFDPGIADVFLRDAD
Mb0914c|M.bovis_AF2122/97 RLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVGDP
Rv0890c|M.tuberculosis_H37Rv RLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVGDP
MAB_1522|M.abscessus_ATCC_1997 --MTDTEVGVLLVDDQELVRTGLRRILRR-KDGFAIVGECADGS------
TH_3184|M.thermoresistible__bu PVAAPSPVRIVLVDDHEMVIEGLKAMLAAFEDRVCVVGHAVGAE------
MMAR_2876|M.marinum_M SCGFDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAFAQSVAPLLD----
MUL_2876|M.ulcerans_Agy99 SCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFAQSVAPLLD----
Mvan_3766|M.vanbaalenii_PYR-1 ASRALVEVNAWAAAEGYYQLGEVRRLKGDLDGAATAFEQARALGLD----
MSMEG_1082|M.smegmatis_MC2_155 IASIAADMASTDTSVRVRGAIDFLRLEARCDTFLLAYKTPGAKGFN----
Mflv_1688|M.gilvum_PYR-GCK NDPLFDAMRVHGLGALRWRDFPDYRRGYSVNNVFRPAGFDEGLSAR----
MAV_4201|M.avium_104 AILAGPQTGDAWAAALREAPDRHRVDEQSLDAALVALGDFVDLKCPFTLG
Mb0914c|M.bovis_AF2122/97 AALVRALTACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWRGV
Rv0890c|M.tuberculosis_H37Rv AALVRALTACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWRGV
MAB_1522|M.abscessus_ATCC_1997 --------------------------EVAAAVSRARPDVVIMDLRMKQMS
TH_3184|M.thermoresistible__bu --------------------------RAVEVVAELDPDIVLCDVRMQNTS
MMAR_2876|M.marinum_M -----------------------HMLIETQMIRRHAPAIVRDARNDPRVN
MUL_2876|M.ulcerans_Agy99 -----------------------HMLIETQMIRRHAPAIVRDARNDPRVN
Mvan_3766|M.vanbaalenii_PYR-1 ----------------------PQPGEALLACRRGDNAAAWTSIRLALAG
MSMEG_1082|M.smegmatis_MC2_155 -------------------------LITSVGYSEPVARYLTSDIQAKPEF
Mflv_1688|M.gilvum_PYR-GCK -------------------------LVTTDGTYVGTIHVNCDDARFPSDE
MAV_4201|M.avium_104 ---------------------HSRAVARLAGQAARAAGLDADAVALTRRA
Mb0914c|M.bovis_AF2122/97 GTCISGDPNALRAAAEECRDLADTIGDRFVSRHCSLWLSLAQMWAGNLTE
Rv0890c|M.tuberculosis_H37Rv GTCISGDPNALRAAAEECRDLADTIGDRFVSRHCSLWLSLAQMWAGNLTE
MAB_1522|M.abscessus_ATCC_1997 G-------------------------------------------------
TH_3184|M.thermoresistible__bu G-------------------------------------------------
MMAR_2876|M.marinum_M R-------------------------------------------------
MUL_2876|M.ulcerans_Agy99 R-------------------------------------------------
Mvan_3766|M.vanbaalenii_PYR-1 GDRLAR------------------------------------------VR
MSMEG_1082|M.smegmatis_MC2_155 T-------------------------------------------------
Mflv_1688|M.gilvum_PYR-GCK D------------------------------------------------V
MAV_4201|M.avium_104 GHVHDLG-----------------------------------------RI
Mb0914c|M.bovis_AF2122/97 ALELSREITAEAEASNDVPTKVLGLYTQAQVLAYCGASAAHAIAGACIAA
Rv0890c|M.tuberculosis_H37Rv ALELSREITAEAEASNDVPTKVLGLYTQAQVLAYCGASAAHAIAGACIAA
MAB_1522|M.abscessus_ATCC_1997 -IEA-IRLLHAAQGP---PALALTTFDDDELLS-----------------
TH_3184|M.thermoresistible__bu -LDLCLTLREQAPHR---KVVMLSVYDDEQYLY-----------------
MMAR_2876|M.marinum_M -PIVDFSLTHSYVAAPVMPTGKVIGFLHADRLYSG---------------
MUL_2876|M.ulcerans_Agy99 -PIVDFSLTHSYVAAPVMPTGKMIGFLHADRLYSG---------------
Mvan_3766|M.vanbaalenii_PYR-1 LLRAAVEIALGRDALSEAENYCRELEADAKAFGTPG--------------
MSMEG_1082|M.smegmatis_MC2_155 ----KQFADQTRVWDWDDVPEFYDSYSGAEVLRPE---------------
Mflv_1688|M.gilvum_PYR-GCK AEINALRVQMADQLDFSVRPRMVSELIAPDAQAWA---------------
MAV_4201|M.avium_104 GVSNQIWSRPGPLSGSQFERVRLHPYLTVRILDQVPG-------------
Mb0914c|M.bovis_AF2122/97 ATELGGVYQGIGYAAMTYAALAAGDVTAALEASDAARPILRAQPDQVTMH
Rv0890c|M.tuberculosis_H37Rv ATELGGVYQGIGYAAMTYAALAAGDVTAALEASDAARPILRAQPDQVTMH
MAB_1522|M.abscessus_ATCC_1997 ------------------GALRAGAAGFILKDSPAEE-------------
TH_3184|M.thermoresistible__bu ------------------QALRVGASGYLLKSISSDE-------------
MMAR_2876|M.marinum_M -------RIVDEIDRDTVWAFAEGFGYAYERTVLLER-------------
MUL_2876|M.ulcerans_Agy99 -------RIVDEIDRDTVWAFAEGFGYAYERTVLLER-------------
Mvan_3766|M.vanbaalenii_PYR-1 -------FRAWAAHARGAVAVRRGDFGVALESLQSALR------------
MSMEG_1082|M.smegmatis_MC2_155 -------------------GFTNGFLMVLHDGAGDMVG------------
Mflv_1688|M.gilvum_PYR-GCK -----------------VDEAGRAHLLRLGDSFDSALDP-----------
MAV_4201|M.avium_104 -LRRLAEVAGNHHECLDGSGYPRGLAGSALGMPDRILAA-----------
.
Mb0914c|M.bovis_AF2122/97 QVLMAQLALAGGDAIAARQFANDAVDATNGWHRMVALTIRARVATARGEP
Rv0890c|M.tuberculosis_H37Rv QVLMAQLALAGGDAIAARQFANDAVDATNGWHRMVALTIRARVATARGEP
MAB_1522|M.abscessus_ATCC_1997 -------------------------------------LVRAVHAVARGEA
TH_3184|M.thermoresistible__bu -------------------------------------LVRQLEMVHRGQT
MMAR_2876|M.marinum_M --------------------------------------MRRQHAEVRSAL
MUL_2876|M.ulcerans_Agy99 --------------------------------------MRRQHAEVRSAL
Mvan_3766|M.vanbaalenii_PYR-1 ------------------------------------EYRVQQSRYETAEV
MSMEG_1082|M.smegmatis_MC2_155 ---------------------------------------MCQGNMERPDF
Mflv_1688|M.gilvum_PYR-GCK ------------------------------------VVVNEIAVAFRAPG
MAV_4201|M.avium_104 ----------------------------------AVCYQSGREPRPYREQ
Mb0914c|M.bovis_AF2122/97 ELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSHSEGVRLLGAA
Rv0890c|M.tuberculosis_H37Rv ELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSHSEGVRLLGAA
MAB_1522|M.abscessus_ATCC_1997 YLDPAVTSRVLN--------------------------------------
TH_3184|M.thermoresistible__bu ALDPGMAARAVDT-------------------------------------
MMAR_2876|M.marinum_M ASADEAARALQDA-------------------------------------
MUL_2876|M.ulcerans_Agy99 ASADEAARALQDA-------------------------------------
Mvan_3766|M.vanbaalenii_PYR-1 YEWMALAKRGLGDRE-----------------------------------
MSMEG_1082|M.smegmatis_MC2_155 TPRNRSTVEAVRP-------------------------------------
Mflv_1688|M.gilvum_PYR-GCK FTVQPEVLRYHDGSS-----------------------------------
MAV_4201|M.avium_104 LSEAEAARRLRGRVR-----------------------------------
.
Mb0914c|M.bovis_AF2122/97 AALRQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTDEA
Rv0890c|M.tuberculosis_H37Rv AALRQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTDEA
MAB_1522|M.abscessus_ATCC_1997 -----------------------------------------AYRRAPAAV
TH_3184|M.thermoresistible__bu -----------------------------------------AARLQRDEF
MMAR_2876|M.marinum_M -----------------------------------------DLDLRKIEP
MUL_2876|M.ulcerans_Agy99 -----------------------------------------DLDLRKIEP
Mvan_3766|M.vanbaalenii_PYR-1 ---------------------------------------GAVADAATADA
MSMEG_1082|M.smegmatis_MC2_155 -----------------------------------------LFTKYVTKL
Mflv_1688|M.gilvum_PYR-GCK --------------------------------------WLHVRRIATSSR
MAV_4201|M.avium_104 ----------------------------------------CGELDPVAAE
Mb0914c|M.bovis_AF2122/97 IAYAQRGRGERKRPARGWGSLTPTERDVVRLVSEGLSNKDIAKRLFVSPR
Rv0890c|M.tuberculosis_H37Rv IAYAQRGRGERKRPARGWGSLTPTERDVVRLVSEGLSNKDIAKRLFVSPR
MAB_1522|M.abscessus_ATCC_1997 SGDAQDK-------------LTARELDVLALIASGATNSEIAEQLVISEV
TH_3184|M.thermoresistible__bu WPGARHG-------------LTQRESEILSYVVNGLSNRGIAAKLVIGDE
MMAR_2876|M.marinum_M VERSPAARSLAEVQTRAMAMLTRREVEVLRLMAAGRTNQQIADELVISAG
MUL_2876|M.ulcerans_Agy99 VERSPAARSLAEVQTRVMAMLTRREVEVLRLMAAGRTNQQIADELVISAG
Mvan_3766|M.vanbaalenii_PYR-1 IYVQLGVEPAGICGAPTPGGLTRRELDVLTRIARGATNRQVAEQLHLSDK
MSMEG_1082|M.smegmatis_MC2_155 RTRARAR-------------LTPREQEILALLRSGLSNAEISDRLYLSPR
Mflv_1688|M.gilvum_PYR-GCK YRGDSLCGVLLVTRTGLPMGITPRELDALTLAVCGLTNGQIAAQLFISAR
MAV_4201|M.avium_104 AVLHAAGQPVGPRPNPRPDGLTPREIEVLGHVARGASNKEIAAALVISEK
:* * : : * :* :: * :.
Mb0914c|M.bovis_AF2122/97 TVQTHLTHVYAKLGLASRVQLVDEAARRGSPS---------------
Rv0890c|M.tuberculosis_H37Rv TVQTHLTHVYAKLGLPSRVQLVDEAARRGSPS---------------
MAB_1522|M.abscessus_ATCC_1997 TVKSHIGRIFVKLDLRDRAAAIVYAYDHGIVTPK-------------
TH_3184|M.thermoresistible__bu TVKSHLRSIYRKLGVSDRAAAVATALREGIYQ---------------
MMAR_2876|M.marinum_M TVKSHVKRVLRKLHATNRAEAASAYVRLASVPEVG------------
MUL_2876|M.ulcerans_Agy99 TVKSHVKRVLRKLHATNRAEAASAYVRLASVSEVG------------
Mvan_3766|M.vanbaalenii_PYR-1 TVSRHLANIYAKLGVSTRTAAANWAFQQGVLTDER------------
MSMEG_1082|M.smegmatis_MC2_155 TVSTHVERVLRKLGVANRVAAAVQATELELLDAGRDAVTPLP-----
Mflv_1688|M.gilvum_PYR-GCK TAGHHLESASAKLGAPNRAACASHAVALGLLSAEVLRDLGVRHSVAV
MAV_4201|M.avium_104 TARNHVERTYAKIGVSNRIGASMYALQHGLVPAAPPHS---------
*. *: *: *