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ITAFDRTAVEVGAALALPSPKARELVRQADALHTRLPGLGALLAAGEVDYDTVAMVLDRTDLVHEDVMAQ LEAALLERVRGWACFSRKQLRDAVDALVKEVDADAVKQRRTRAYDQRRVSVAAEADGMAVVRGTMSAEDG AALDTRLTAIAKKVCACDPRSLVQRRADAFKALTLGEPFGCMCGRNDCPDALAATPVASTPVGSTPAAPP RQSLPMGRQVVLNVIASAETVTGLGNAAGYLLGYGVIDAELVRELARDATRRLVEAPRFEERQALTYRPS DALARFIRARDLTCRFPGCTVPATRCDIDHTTPFDHEDPAAGGWTVPWNLACYCREHHRHKTFDTGWRDQ QLVDGTIIWTAPTGHEYRTVPAGVGLFPGLGRARNSAERRRVAAARQRLHRHRDASTYNRYRNQQARDEV RNRRWRNGFRGRYLLFKGEFAHNAPSRSPFGRFVNDPFEPESLPPDWHPPPQDRADPDEPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0946 | - | - | 100% (484) | hypothetical protein Mflv_0946 |
| M. gilvum PYR-GCK | Mflv_1057 | - | 0.0 | 98.35% (484) | hypothetical protein Mflv_1057 |
| M. gilvum PYR-GCK | Mflv_3596 | - | 5e-67 | 37.05% (440) | hypothetical protein Mflv_3596 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 2e-72 | 38.81% (487) | 13E12 repeat family protein |
| M. tuberculosis H37Rv | Rv0515 | - | 2e-72 | 38.81% (487) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-64 | 39.27% (410) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 1e-72 | 39.08% (476) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_0536 | - | 1e-111 | 46.15% (494) | hypothetical protein MAV_0536 |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 4e-66 | 37.10% (442) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 6e-48 | 38.55% (332) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 2e-69 | 42.86% (378) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3778 | - | 3e-68 | 39.59% (442) | hypothetical protein Mvan_3778 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5026|M.smegmatis_MC2_155 -MGAGILERMFDG---------------TSDAGLIDAIAEAKRQENAATA
Mvan_3778|M.vanbaalenii_PYR-1 ---------MFAY---------------AEPAELIDAMSSAARAESAAIA
TH_0334|M.thermoresistible__bu ---------MFES---------------LDDGAVVDSIAAASREQSAACG
MAB_4752|M.abscessus_ATCC_1997 ---------MFDE---------------LGDVELIDLIASAQRAEAQACA
Mb0528|M.bovis_AF2122/97 -MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAAA
Rv0515|M.tuberculosis_H37Rv -MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAAA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAA
MUL_2679|M.ulcerans_Agy99 -MDQHIIEYVFDT----------------DDSAPLTRITAAARAEARAAA
Mflv_0946|M.gilvum_PYR-GCK --------------------------------------------------
MAV_0536|M.avium_104 ---------MFES--------------SPDPAALVAVIESTHREESMLVA
MSMEG_5026|M.smegmatis_MC2_155 RRLFAIGELDTRRA--IDLAECNFWRTDPFEEVCAEVSAALRISRSRANW
Mvan_3778|M.vanbaalenii_PYR-1 RRLEAVAALFRSRK--CDYAEAGFLHTDVYEAVAAEVSAAQNISRSRAGY
TH_0334|M.thermoresistible__bu REMLAIGELYARRAP-EDDTERANWAIDGHANVVAEISAALNISRGRAAG
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASS
Mb0528|M.bovis_AF2122/97 AQLVALGELFAYRWS--RCGGREEWVMDTMAAVAAEVAAALRISQGLAAS
Rv0515|M.tuberculosis_H37Rv AQLVALGELFAYRWS--RCGGREEWVMDTMAAVAAEVAAALRISQGLAAS
MMAR_5187|M.marinum_M AQLIEIGQLFAYRLS--RCSETEDWAVDTMEAVAAEVAAGLRISQGLAAS
MUL_2679|M.ulcerans_Agy99 ERLAAIGDLFRLRLS--QHGNREDWVADTCDAVAAEVAAALNTSVAMGHS
Mflv_0946|M.gilvum_PYR-GCK -------------------------MITAFDRTAVEVGAALALPSPKARE
MAV_0536|M.avium_104 RRFAAVAALLRHRVATADRPEPEYAEIDGFEQTAAEVAAAMNLSAAAASY
. *:.*. . .
MSMEG_5026|M.smegmatis_MC2_155 QVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALDD
Mvan_3778|M.vanbaalenii_PYR-1 QVEMAVSLYTRLPKVAEAFARGDIDLRMVQIVLART-KNVEDDVIGGLDK
TH_0334|M.thermoresistible__bu RLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDA
MAB_4752|M.abscessus_ATCC_1997 QMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDA
Mb0528|M.bovis_AF2122/97 RLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDA
Rv0515|M.tuberculosis_H37Rv RLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDA
MMAR_5187|M.marinum_M RLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVDA
MUL_2679|M.ulcerans_Agy99 NLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDA
Mflv_0946|M.gilvum_PYR-GCK LVRQADALHTRLPGLGALLAAGEVDYDTVAMVLDRTDLVH-EDVMAQLEA
MAV_0536|M.avium_104 LVSYAETLDTRLPEVAALLAEGRTDWRTVRLIITRTSLVTDAELIAKLDR
: * : *: . : * . . : *: : ::
MSMEG_5026|M.smegmatis_MC2_155 VLARRCPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSE-DSRYFTVQP
Mvan_3778|M.vanbaalenii_PYR-1 AIAPKLSRWMRLSKNDLRDRVDLWVADFDPAAVRVPPEAK-DNRYFDVTP
TH_0334|M.thermoresistible__bu ALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPG-EDRYVVVTP
MAB_4752|M.abscessus_ATCC_1997 AIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSAT-DKRHLEIRP
Mb0528|M.bovis_AF2122/97 QLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQ-AQRQFWVGE
Rv0515|M.tuberculosis_H37Rv QLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQ-AQRQFWVGE
MMAR_5187|M.marinum_M LVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERH-ADREIWIGQ
MUL_2679|M.ulcerans_Agy99 RLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDA-ADRYVDCAP
Mflv_0946|M.gilvum_PYR-GCK ALLERVRGWACFSRKQLRDAVDALVKEVDADAVKQRRTRAYDQRRVSVAA
MAV_0536|M.avium_104 SLAARIGNWHGWSRQRIVNAVDAAVRTADPDAARERRLAAEEDRHIGISA
: * : : :* : * . : .* .
MSMEG_5026|M.smegmatis_MC2_155 A-DTPGMANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALG
Mvan_3778|M.vanbaalenii_PYR-1 --DVPGMAFAGGLLNARDAAALDQRLEAIAATVCSNDPRSHNNLRADAAG
TH_0334|M.thermoresistible__bu --AGQGMVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMA
MAB_4752|M.abscessus_ATCC_1997 LGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVG
Mb0528|M.bovis_AF2122/97 --SQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALG
Rv0515|M.tuberculosis_H37Rv --SQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALG
MMAR_5187|M.marinum_M --DADGISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADALG
MUL_2679|M.ulcerans_Agy99 --LEPGMALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRADALG
Mflv_0946|M.gilvum_PYR-GCK --EADGMAVVRGTMSAEDGAALDTRLTAIAKKVCACDPRSLVQRRADAFK
MAV_0536|M.avium_104 --AENGMAEVHGSVAAAAATAFDRRLSQLAKQVCPADPRTLDQRRADALA
: : . .: ** :* ** ***: : ****
MSMEG_5026|M.smegmatis_MC2_155 ALGRYRDTLDCQCGREDCTAVA-----------ERDAVNN---------A
Mvan_3778|M.vanbaalenii_PYR-1 ALGRGESTLTCECGAEDCPAAV-----------LRESAAQ---------V
TH_0334|M.thermoresistible__bu AMSEGQNRLVCGCGSEDCPADP-----------ADTAATR---------L
MAB_4752|M.abscessus_ATCC_1997 ALTQGLNRMRCACGHPDCSGR-------------DTADVP---------V
Mb0528|M.bovis_AF2122/97 ALAGGADRLGCGCGRADCAAGK-----------RPAAPP----------V
Rv0515|M.tuberculosis_H37Rv ALAGGADRLGCGCGRADCAAGK-----------RPAAPP----------V
MMAR_5187|M.marinum_M VLAAGGDRLGCRCGLPDCAAGA-----------RPAAQP----------V
MUL_2679|M.ulcerans_Agy99 TLAAGQDRLICDCGRTDCPAAG-----------APQQPSR---------V
Mflv_0946|M.gilvum_PYR-GCK ALTLGE-PFGCMCGRNDCPDALAATPVASTPVGSTPAAPPRQSLPMGRQV
MAV_0536|M.avium_104 ALAEGR-RLPCACGQPDCP----------ARTGNQNADDR-----TGARV
.: : * ** **.
MSMEG_5026|M.smegmatis_MC2_155 MIHVLAEQSTLDG-GNEPG-YLPGFGMLPAHMVREVAKTATTKPVTIP--
Mvan_3778|M.vanbaalenii_PYR-1 VIHILAEQATVDGDGDKAG-YLPGFGVLPAEEVRAAAKTAKLKPVRLP--
TH_0334|M.thermoresistible__bu VINVIAEQATVEGRSDNPG-YLPGYGAVPASILRAKAATATLRPVALP--
MAB_4752|M.abscessus_ATCC_1997 VVNVVINQSTLAGSDDCPA-HVPGFGVLAAESARAAVAGTPTRNLTDS--
Mb0528|M.bovis_AF2122/97 VIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPG-
Rv0515|M.tuberculosis_H37Rv VIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPG-
MMAR_5187|M.marinum_M VIHVIAERATLDGDGGAPAWEVGADGLVTPELVAELAKSAKLVPLRHPG-
MUL_2679|M.ulcerans_Agy99 VIHVVAGCQTVDGAGEAPG-VLPGDGIIPAEIVRELAKSAKLQPMSTP--
Mflv_0946|M.gilvum_PYR-GCK VLNVIASAETVTGLGNAAG-YLLGYGVIDAELVRELARDATRRLVEAPRF
MAV_0536|M.avium_104 VINVVASDRTVYADGAEPG-YLEGYGVIDADQVRRLA-AAAHLLVANPAT
::::: *: . . .. : . * : . . : : .
MSMEG_5026|M.smegmatis_MC2_155 KDKAQSGYRPNAELTEFIRWRDLTCRFPGCDAPAMAADIDHTRPY-----
Mvan_3778|M.vanbaalenii_PYR-1 GAEPEKGYRPSAGLKDFLQWRDLTCRFPGCDAPVERCDVDHTTRW-----
TH_0334|M.thermoresistible__bu QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPY-----
MAB_4752|M.abscessus_ATCC_1997 RS---TGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPW-----
Mb0528|M.bovis_AF2122/97 DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPY-----
Rv0515|M.tuberculosis_H37Rv DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPY-----
MMAR_5187|M.marinum_M DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIPY-----
MUL_2679|M.ulcerans_Agy99 -ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPY-----
Mflv_0946|M.gilvum_PYR-GCK EERQALTYRPSDALARFIRARDLTCRFPGCTVPATRCDIDHTTPFDHEDP
MAV_0536|M.avium_104 SPAAALRYQPSAALERAVRCRDLTCRFPGCSRPAVICDLDHSVPFNHQNP
* *. * :: ** ** *** . .::**: :
MSMEG_5026|M.smegmatis_MC2_155 PQG-PTHPSNTKLYCRTHHLIKTFYTGPNGWTDRQLPDGTIEFTAPTGHI
Mvan_3778|M.vanbaalenii_PYR-1 PFG-VTHASGLKHYCRTHHVIKTFLTGVYGWRDEQRRDGTVVLTAPTGHV
TH_0334|M.thermoresistible__bu PAG-PTHPSNLKLLCVFHCRQAELR-----FTHDQHKHQSSCLPA-----
MAB_4752|M.abscessus_ATCC_1997 ATGGPTTGANLKALCRKHHLLKTFG----QWTELQEPDGTVIWKSPTGHR
Mb0528|M.bovis_AF2122/97 AAGGPTHASNLKCYCRTHHLVKTFWG----WRDQQLPDGTLILTSPSGHT
Rv0515|M.tuberculosis_H37Rv AAGGPTHASNLKCYCRTHHLVKTFWG----WRDQQLPDGTLILTSPSGHT
MMAR_5187|M.marinum_M AQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTSPAGHT
MUL_2679|M.ulcerans_Agy99 SDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQLPDATVIWSLPDGQT
Mflv_0946|M.gilvum_PYR-GCK AAGGWTVPWNLACYCREHHRHKTFDT---GWRDQQLVDGTIIWTAPTGHE
MAV_0536|M.avium_104 VAGGWTVLENLKCLCRQHHRLKTFG----GWRDRQLADGTVVWTSPTGRA
* * . * * : : . * . :
MSMEG_5026|M.smegmatis_MC2_155 YTTEPQGAALFPVLGTPTGELNLPPQQDEPHP--NRGVMMPKRRQ-----
Mvan_3778|M.vanbaalenii_PYR-1 YTTEPLGGLLFPTLATPTAPL-PDVEVPEDDP--DKAAMMPRRR------
TH_0334|M.thermoresistible__bu YFQRPHG----PATRRP-----------------------PSARG-----
MAB_4752|M.abscessus_ATCC_1997 YATTPVSWFLFPALTRH-----------------------HTRQQ-----
Mb0528|M.bovis_AF2122/97 YVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRR-----
Rv0515|M.tuberculosis_H37Rv YVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRR-----
MMAR_5187|M.marinum_M YVTTPGSALLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMPRRQR-----
MUL_2679|M.ulcerans_Agy99 YVTTPGSAWLLP-------GLFAPSPELPPPPRSEATGSLRKPRR-----
Mflv_0946|M.gilvum_PYR-GCK YRTVPAGVGLFPG-LGRARNSAERRRVAAARQRLHRHRDASTYN------
MAV_0536|M.avium_104 YRTSPAGADLFAQPRGPARAAPTPNRRSRSKQRNGRIMRARKHNREQRPI
* * . . .
MSMEG_5026|M.smegmatis_MC2_155 ----TREQDRADRINAERRERAELN-------------AEQQRQRQAWLA
Mvan_3778|M.vanbaalenii_PYR-1 ----TREQERRARIARERRQRIEIN-------------AERERQHQAWLA
TH_0334|M.thermoresistible__bu ----LREAVPRQGVDPRR-----VS-------------GQ----------
MAB_4752|M.abscessus_ATCC_1997 ----ARDRRRRTERNLNR----EQR-------------LQREAALAALAA
Mb0528|M.bovis_AF2122/97 ----TRAQDRAYRIATERRQNHAAR-------------QRAQVLTQTAAA
Rv0515|M.tuberculosis_H37Rv ----TRAQDRAYRIATERRQNHAAR-------------QRAQVLTQTAAA
MMAR_5187|M.marinum_M ----TRAQDRARRVATERRQNHHAR-------------S-TQPGGQPRSA
MUL_2679|M.ulcerans_Agy99 ----DDAQTRPNSRPKLGR-----------------------------TH
Mflv_0946|M.gilvum_PYR-GCK ---RYRNQQAR-DEVRNRRWRNGFRGRYLLFKGEFAHNAPSRSPFGRFVN
MAV_0536|M.avium_104 NEARIRLEQARQREIADRKFRNHMRDMLFLFKG-----APSTSPFCAWVN
MSMEG_5026|M.smegmatis_MC2_155 DNYEPPPF--------------------
Mvan_3778|M.vanbaalenii_PYR-1 ATYEPPPF--------------------
TH_0334|M.thermoresistible__bu ----------------------------
MAB_4752|M.abscessus_ATCC_1997 K--DPPPF--------------------
Mb0528|M.bovis_AF2122/97 TDTHGPPPDHNDDPPPF-----------
Rv0515|M.tuberculosis_H37Rv TDTHGPPPDHNDDPPPF-----------
MMAR_5187|M.marinum_M APPTPPQSEPQSHPPPF-----------
MUL_2679|M.ulcerans_Agy99 CDRTQPQHD-------------------
Mflv_0946|M.gilvum_PYR-GCK DPFEPESLPPDWHPPPQDRADPDEPPPF
MAV_0536|M.avium_104 DPREPEELPPDWVPDEPAYQPLPDDPPF