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FESSPDPAALVAVIESTHREESMLVARRFAAVAALLRHRVATADRPEPEYAEIDGFEQTAAEVAAAMNLS AAAASYLVSYAETLDTRLPEVAALLAEGRTDWRTVRLIITRTSLVTDAELIAKLDRSLAARIGNWHGWSR QRIVNAVDAAVRTADPDAARERRLAAEEDRHIGISAAENGMAEVHGSVAAAAATAFDRRLSQLAKQVCPA DPRTLDQRRADALAALAEGRRLPCACGQPDCPARTGNQNADDRTGARVVINVVASDRTVYADGAEPGYLE GYGVIDADQVRRLAAAAHLLVANPATSPAAALRYQPSAALERAVRCRDLTCRFPGCSRPAVICDLDHSVP FNHQNPVAGGWTVLENLKCLCRQHHRLKTFGGWRDRQLADGTVVWTSPTGRAYRTSPAGADLFAQPRGPA RAAPTPNRRSRSKQRNGRIMRARKHNREQRPINEARIRLEQARQREIADRKFRNHMRDMLFLFKGAPSTS PFCAWVNDPREPEELPPDWVPDEPAYQPLPDDPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0536 | - | - | 100% (526) | hypothetical protein MAV_0536 |
| M. avium 104 | MAV_3457 | - | 4e-85 | 43.07% (469) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 2e-81 | 39.96% (468) | 13e12 repeat-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 3e-74 | 37.93% (464) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_1057 | - | 1e-113 | 44.20% (543) | hypothetical protein Mflv_1057 |
| M. tuberculosis H37Rv | Rv0515 | - | 3e-74 | 37.93% (464) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 6e-80 | 40.56% (461) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_1213 | - | 3e-84 | 41.49% (470) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 1e-76 | 39.79% (485) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 1e-69 | 39.95% (418) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 2e-82 | 41.19% (454) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3778 | - | 9e-79 | 40.50% (479) | hypothetical protein Mvan_3778 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5026|M.smegmatis_MC2_155 ----------------------------MGAGILERMFDGTS--------
Mvan_3778|M.vanbaalenii_PYR-1 ------------------------------------MFAYAE--------
TH_0334|M.thermoresistible__bu ------------------------------------MFESLD--------
Mb0528|M.bovis_AF2122/97 ----------------------------MPSPEAIAHFDERFECHAPRTT
Rv0515|M.tuberculosis_H37Rv ----------------------------MPSPEAIAHFDERFECHAPRTT
MMAR_1213|M.marinum_M --------------------------MRAQALRPTVSVDQHMIEHVFDTD
MUL_2679|M.ulcerans_Agy99 -------------------------------------MDQHIIEYVFDTD
MAB_4752|M.abscessus_ATCC_1997 ------------------------------------MFDELG--------
MAV_0536|M.avium_104 ------------------------------------MFESSPD-------
Mflv_1057|M.gilvum_PYR-GCK MRVLHLGADTPKPSPHQPKTLLNSRNAPTRTLGAPHVFEGWSD-------
.
MSMEG_5026|M.smegmatis_MC2_155 --DAGLIDAIAEAKRQENAATARRLFAIGELDT-R-RA-IDLAECNFWRT
Mvan_3778|M.vanbaalenii_PYR-1 --PAELIDAMSSAARAESAAIARRLEAVAALFR-S-RK-CDYAEAGFLHT
TH_0334|M.thermoresistible__bu --DGAVVDSIAAASREQSAACGREMLAIGELYA-R-RAPEDDTERANWAI
Mb0528|M.bovis_AF2122/97 RVSAAFIDRICSATRAENRAAAAQLVALGELFA---YRWSRCGGREEWVM
Rv0515|M.tuberculosis_H37Rv RVSAAFIDRICSATRAENRAAAAQLVALGELFA---YRWSRCGGREEWVM
MMAR_1213|M.marinum_M --SSAPLTRITAAARAEARAAAERLAAIGDLFR---LRLSQHGNREDWVA
MUL_2679|M.ulcerans_Agy99 --DSAPLTRITAAARAEARAAAERLAAIGDLFR---LRLSQHGNREDWVA
MAB_4752|M.abscessus_ATCC_1997 --DVELIDLIASAQRAEAQACARKLDAIGVLVDRH-ADLGKPDERDHHAL
MAV_0536|M.avium_104 --PAALVAVIESTHREESMLVARRFAAVAALLRHR-VATADRPEPEYAEI
Mflv_1057|M.gilvum_PYR-GCK --LRVLSGVQG-PYRQIAAAMAASLAGIAELLDRRTAEELDAALHVRSVI
. * . : .:. *
MSMEG_5026|M.smegmatis_MC2_155 DPFEEVCAEVSAALRISRSRANWQVHLARVLRDRIPKVAAVFAQGDIDFR
Mvan_3778|M.vanbaalenii_PYR-1 DVYEAVAAEVSAAQNISRSRAGYQVEMAVSLYTRLPKVAEAFARGDIDLR
TH_0334|M.thermoresistible__bu DGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDFR
Mb0528|M.bovis_AF2122/97 DTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYL
Rv0515|M.tuberculosis_H37Rv DTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYL
MMAR_1213|M.marinum_M DTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDFR
MUL_2679|M.ulcerans_Agy99 DTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDFR
MAB_4752|M.abscessus_ATCC_1997 DRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDFR
MAV_0536|M.avium_104 DGFEQTAAEVAAAMNLSAAAASYLVSYAETLDTRLPEVAALLAEGRTDWR
Mflv_1057|M.gilvum_PYR-GCK TAFDRTAVEVGAALALPSPKARELVRQADALHTRLPGLGALLAAGEVDYD
. *:.** . . : * : *: . : * .
MSMEG_5026|M.smegmatis_MC2_155 IVTKIATRT-ELVDPAAMPALDDVLARRCPNWMRLSEPKLEERIDQCILR
Mvan_3778|M.vanbaalenii_PYR-1 MVQIVLART-KNVEDDVIGGLDKAIAPKLSRWMRLSKNDLRDRVDLWVAD
TH_0334|M.thermoresistible__bu MVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVER
Mb0528|M.bovis_AF2122/97 MFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVAR
Rv0515|M.tuberculosis_H37Rv MFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVAR
MMAR_1213|M.marinum_M LFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAK
MUL_2679|M.ulcerans_Agy99 LFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAK
MAB_4752|M.abscessus_ATCC_1997 TVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVLH
MAV_0536|M.avium_104 TVRLIITRTSLVTDAELIAKLDRSLAARIGNWHGWSRQRIVNAVDAAVRT
Mflv_1057|M.gilvum_PYR-GCK TVAMVLDRTDLVH-EDVMAQLEAALLERVRGWACFSRKQLRDEVDALVKE
. : *: : :: : * : : :* :
MSMEG_5026|M.smegmatis_MC2_155 LDPDGQRVTKRSE-DSRYFTVQPADTPG--MANAQGYLPAHDAAGFDKRL
Mvan_3778|M.vanbaalenii_PYR-1 FDPAAVRVPPEAK-DNRYFDVTP-DVPG--MAFAGGLLNARDAAALDQRL
TH_0334|M.thermoresistible__bu FDPTGVREPRSPG-EDRYVVVTP-AGQG--MVDVSARLTFEAGFAFXTRL
Mb0528|M.bovis_AF2122/97 ADADAVRRRKEYQ-AQRQFWVGE-SQDG--VCQIGGSLLAVDAHALDARL
Rv0515|M.tuberculosis_H37Rv ADADAVRRRKEYQ-AQRQFWVGE-SQDG--VCQIGGSLLAVDAHALDARL
MMAR_1213|M.marinum_M FDRDAVRRSRRDA-ADRYVDCAP-LEPG--MALVNGQVFAATAEALARRL
MUL_2679|M.ulcerans_Agy99 FDRDAVRRSRRDA-ADRYVDCAP-LEPG--MALVNRQVFSATAEALARRL
MAB_4752|M.abscessus_ATCC_1997 FDQDAVRRNRSAT-DKRHLEIRP-LGNGEPVAEVWGTLQAVHAVALDKRL
MAV_0536|M.avium_104 ADPDAARERRLAAEEDRHIGISA-AENG--MAEVHGSVAAAAATAFDRRL
Mflv_1057|M.gilvum_PYR-GCK VDADAVKQRRTRAYDQRRVSVAA-EADG--MAVVRGTMSAEDGAALDTRL
* . : .* . * : : . .: **
MSMEG_5026|M.smegmatis_MC2_155 DAIAATVCPNDPRTPDQRRADALGALGRYRDTLDCQCGREDCTAVAERD-
Mvan_3778|M.vanbaalenii_PYR-1 EAIAATVCSNDPRSHNNLRADAAGALGRGESTLTCECGAEDCPAAVLRE-
TH_0334|M.thermoresistible__bu DQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADT-
Mb0528|M.bovis_AF2122/97 SALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPA-
Rv0515|M.tuberculosis_H37Rv SALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPA-
MMAR_1213|M.marinum_M DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQ-
MUL_2679|M.ulcerans_Agy99 DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQ-
MAB_4752|M.abscessus_ATCC_1997 DLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDCSG--RDT-
MAV_0536|M.avium_104 SQLAKQVCPADPRTLDQRRADALAALAEGR-RLPCACGQPDCPARTGNQN
Mflv_1057|M.gilvum_PYR-GCK TAIAKKVCACDPRSLVQRRADAFKALTLGE-PFGCMCGRNDCPDALAATP
:* ** ***: : **** :: : * ** **.
MSMEG_5026|M.smegmatis_MC2_155 --------------AVNNAMIHVLAEQSTLDG-GNEPG-YLPGFGMLPAH
Mvan_3778|M.vanbaalenii_PYR-1 --------------SAAQVVIHILAEQATVDGDGDKAG-YLPGFGVLPAE
TH_0334|M.thermoresistible__bu --------------AATRLVINVIAEQATVEGRSDNPG-YLPGYGAVPAS
Mb0528|M.bovis_AF2122/97 --------------APP-VVIHLIAEAATINGTGSAPASQMNADGLITAE
Rv0515|M.tuberculosis_H37Rv --------------APP-VVIHLIAEAATINGTGSAPASQMNADGLITAE
MMAR_1213|M.marinum_M --------------QPSRVVIHVVAGRETVDGAGEAPG-VLPGDGIIPAE
MUL_2679|M.ulcerans_Agy99 --------------QPSRVVIHVVAGCQTVDGAGEAPG-VLPGDGIIPAE
MAB_4752|M.abscessus_ATCC_1997 --------------ADVPVVVNVVINQSTLAGSDDCPA-HVPGFGVLAAE
MAV_0536|M.avium_104 ADDR----------TGARVVINVVASDRTVYADGAEPG-YLEGYGVIDAD
Mflv_1057|M.gilvum_PYR-GCK AGSTPAAPPQQSLPMGRQVVLNVIASAETVTGLGNAAG-YLLGYGVIDAE
::::: *: . . .. : . * : *
MSMEG_5026|M.smegmatis_MC2_155 MVREVAKTATTKPVTIPK--DKAQSGYRPNAELTEFIRWRDLTCRFPGCD
Mvan_3778|M.vanbaalenii_PYR-1 EVRAAAKTAKLKPVRLPG--AEPEKGYRPSAGLKDFLQWRDLTCRFPGCD
TH_0334|M.thermoresistible__bu ILRAKAATATLRPVALPQ--PCAEAGYRPSAALTRFIRCRDLTCRFPGCD
Mb0528|M.bovis_AF2122/97 LVAELAKTATLVPLVHPGD-APPEPGYAPSKALADFVRCRDLTCRWPGCD
Rv0515|M.tuberculosis_H37Rv LVAELAKTATLVPLVHPGD-APPEPGYAPSKALADFVRCRDLTCRWPGCD
MMAR_1213|M.marinum_M IVRELAKSAKLQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCD
MUL_2679|M.ulcerans_Agy99 IVRELAKSAKLQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCD
MAB_4752|M.abscessus_ATCC_1997 SARAAVAGTPTRNLTDS-----RSTGYRPSAKLAAFVRSRDQLCRFPGCE
MAV_0536|M.avium_104 QVRRLA-AAAHLLVANPATSPAAALRYQPSAALERAVRCRDLTCRFPGCS
Mflv_1057|M.gilvum_PYR-GCK LVRELARDATRRLVEAPRFEERQALTYRPSDALARFIRARDLTCRFPGCT
. : : . * *. * :: ** ** ***
MSMEG_5026|M.smegmatis_MC2_155 APAMAADIDHTRPY-----PQG-PTHPSNTKLYCRTHHLIKTFYTGPNGW
Mvan_3778|M.vanbaalenii_PYR-1 APVERCDVDHTTRW-----PFG-VTHASGLKHYCRTHHVIKTFLTGVYGW
TH_0334|M.thermoresistible__bu APAAVCQIDHTIPY-----PAG-PTHPSNLKLLCVFHCRQAELR-----F
Mb0528|M.bovis_AF2122/97 EPATNCDLDHTIPY-----AAGGPTHASNLKCYCRTHHLVKTFWG----W
Rv0515|M.tuberculosis_H37Rv EPATNCDLDHTIPY-----AAGGPTHASNLKCYCRTHHLVKTFWG----W
MMAR_1213|M.marinum_M RPATQCDVDHTIPY-----SDGGATHPSNLKCLCRKHHLLKTFWG----W
MUL_2679|M.ulcerans_Agy99 RPATQCDVDHTIPY-----SDGGATHPSNLKCLCRKHHLLKTFWG----W
MAB_4752|M.abscessus_ATCC_1997 AVADRADIDHTVPW-----ATGGPTTGANLKALCRKHHLLKTFGQ----W
MAV_0536|M.avium_104 RPAVICDLDHSVPFNHQNPVAGGWTVLENLKCLCRQHHRLKTFG----GW
Mflv_1057|M.gilvum_PYR-GCK VPATRCDIDHTTPFDHEDPAAGGWTVPWNLACYCREHHRHKTFDT---GW
. .::**: : * * . * * : :
MSMEG_5026|M.smegmatis_MC2_155 TDRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQQD--E
Mvan_3778|M.vanbaalenii_PYR-1 RDEQRRDGTVVLTAPTGHVYTTEPLGGLLFPTLATPTAPL-PDVEVP--E
TH_0334|M.thermoresistible__bu THDQHKHQSSCLPA-----YFQRPHG----PATRRP--------------
Mb0528|M.bovis_AF2122/97 RDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYD
Rv0515|M.tuberculosis_H37Rv RDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYD
MMAR_1213|M.marinum_M HDKQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPARKP-QD
MUL_2679|M.ulcerans_Agy99 HDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPR-----
MAB_4752|M.abscessus_ATCC_1997 TELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTRHH-------------
MAV_0536|M.avium_104 RDRQLADGTVVWTSPTGRAYRTSPAGADLFAQPRGPARAAPTPNRRSRSK
Mflv_1057|M.gilvum_PYR-GCK RDQQLVDGTIIWTAPTGHEYRTVPAGVGLFPG-LGRARNSAERRRVAAAR
. * . : * * . .
MSMEG_5026|M.smegmatis_MC2_155 PHPNRGVMMPKRRQ----------TREQDRADRINAERRERAELNAEQ--
Mvan_3778|M.vanbaalenii_PYR-1 DDPDKAAMMPRRR-----------TREQERRARIARERRQRIEINAER--
TH_0334|M.thermoresistible__bu ---------PSARG----------LREAVPRQGVDPRR-----VSGQ---
Mb0528|M.bovis_AF2122/97 HCDQRTAMMPKRRR----------TRAQDRAYRIATERRQNHAARQRAQV
Rv0515|M.tuberculosis_H37Rv HCDQRTAMMPKRRR----------TRAQDRAYRIATERRQNHAARQRAQV
MMAR_1213|M.marinum_M HCGNRDAMMPKRAR----------TRAQSSAARIAAERNHNMTSRQARRR
MUL_2679|M.ulcerans_Agy99 --------------------------SEATGSLRKPRRDDAQTRPNSRPK
MAB_4752|M.abscessus_ATCC_1997 ------------------------TRQQARDRRRRTERNLNREQR-----
MAV_0536|M.avium_104 QRNGRIMRARKHNREQRPINEARIRLEQARQREIADRKFRNHMRDMLFLF
Mflv_1057|M.gilvum_PYR-GCK QRLHRHRDASTYN---------RYRNQQAR-DEVRNRRWRNGFRGRYLLF
.:
MSMEG_5026|M.smegmatis_MC2_155 -------QRQRQAWLADNYEP-----------------------PPF
Mvan_3778|M.vanbaalenii_PYR-1 -------ERQHQAWLAATYEP-----------------------PPF
TH_0334|M.thermoresistible__bu -----------------------------------------------
Mb0528|M.bovis_AF2122/97 LTQTAAATDTHGPPPDHNDDP-----------------------PPF
Rv0515|M.tuberculosis_H37Rv LTQTAAATDTHGPPPDHNDDP-----------------------PPF
MMAR_1213|M.marinum_M RWEECYFGPRDASASDDEEPP-----------------------PF-
MUL_2679|M.ulcerans_Agy99 ------LGRTHCDRTQPQHD---------------------------
MAB_4752|M.abscessus_ATCC_1997 ------LQREAALAALAAKDP-----------------------PPF
MAV_0536|M.avium_104 KG-----APSTSPFCAWVNDPREPEELPPDWVPDEPAYQPLPDDPPF
Mflv_1057|M.gilvum_PYR-GCK KGEFAHNAPSRSPFGRFVNDPFEPESLPPDWHPPPQDRADPDEPPPF