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VRVLHLGADTPKPSPHQPKTLLNSRNAPTRTLGAPHVFEGWSDLRVLSGVQGPYRQIAAAMAASLAGIAE LLDRRTAEELDAALHVRSVITAFDRTAVEVGAALALPSPKARELVRQADALHTRLPGLGALLAAGEVDYD TVAMVLDRTDLVHEDVMAQLEAALLERVRGWACFSRKQLRDEVDALVKEVDADAVKQRRTRAYDQRRVSV AAEADGMAVVRGTMSAEDGAALDTRLTAIAKKVCACDPRSLVQRRADAFKALTLGEPFGCMCGRNDCPDA LAATPAGSTPAAPPQQSLPMGRQVVLNVIASAETVTGLGNAAGYLLGYGVIDAELVRELARDATRRLVEA PRFEERQALTYRPSDALARFIRARDLTCRFPGCTVPATRCDIDHTTPFDHEDPAAGGWTVPWNLACYCRE HHRHKTFDTGWRDQQLVDGTIIWTAPTGHEYRTVPAGVGLFPGLGRARNSAERRRVAAARQRLHRHRDAS TYNRYRNQQARDEVRNRRWRNGFRGRYLLFKGEFAHNAPSRSPFGRFVNDPFEPESLPPDWHPPPQDRAD PDEPPPF
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1057 | - | - | 100% (567) | hypothetical protein Mflv_1057 |
M. gilvum PYR-GCK | Mflv_0946 | - | 0.0 | 98.35% (484) | hypothetical protein Mflv_0946 |
M. gilvum PYR-GCK | Mflv_3596 | - | 5e-69 | 36.54% (468) | hypothetical protein Mflv_3596 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0528 | - | 5e-74 | 38.75% (511) | 13E12 repeat family protein |
M. tuberculosis H37Rv | Rv0515 | - | 5e-74 | 38.75% (511) | 13E12 repeat family protein |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_4752 | - | 7e-67 | 37.42% (465) | hypothetical protein MAB_4752 |
M. marinum M | MMAR_1213 | - | 7e-75 | 38.20% (534) | 13e12 repeat-containing protein |
M. avium 104 | MAV_0536 | - | 1e-113 | 44.20% (543) | hypothetical protein MAV_0536 |
M. smegmatis MC2 155 | MSMEG_5026 | - | 2e-70 | 36.92% (493) | hypothetical protein MSMEG_5026 |
M. thermoresistible (build 8) | TH_0334 | - | 5e-53 | 37.02% (389) | HNH endonuclease |
M. ulcerans Agy99 | MUL_2679 | - | 4e-72 | 41.27% (424) | 13e12 repeat-containing protein |
M. vanbaalenii PYR-1 | Mvan_3778 | - | 7e-71 | 38.35% (485) | hypothetical protein Mvan_3778 |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_5026|M.smegmatis_MC2_155 ----------------------------MGAGILERMFDGTS-------- Mvan_3778|M.vanbaalenii_PYR-1 ------------------------------------MFAYAE-------- TH_0334|M.thermoresistible__bu ------------------------------------MFESLD-------- Mb0528|M.bovis_AF2122/97 ----------------------------MPSPEAIAHFDERFECHAPRTT Rv0515|M.tuberculosis_H37Rv ----------------------------MPSPEAIAHFDERFECHAPRTT MMAR_1213|M.marinum_M --------------------------MRAQALRPTVSVDQHMIEHVFDTD MUL_2679|M.ulcerans_Agy99 -------------------------------------MDQHIIEYVFDTD MAB_4752|M.abscessus_ATCC_1997 ------------------------------------MFDELG-------- Mflv_1057|M.gilvum_PYR-GCK MRVLHLGADTPKPSPHQPKTLLNSRNAPTRTLGAPHVFEGWSD------- MAV_0536|M.avium_104 ------------------------------------MFESSPD------- . MSMEG_5026|M.smegmatis_MC2_155 --DAGLIDAIAEAKRQENAATARRLFAIGELDT-R-RA-IDLAECNFWRT Mvan_3778|M.vanbaalenii_PYR-1 --PAELIDAMSSAARAESAAIARRLEAVAALFR-S-RK-CDYAEAGFLHT TH_0334|M.thermoresistible__bu --DGAVVDSIAAASREQSAACGREMLAIGELYA-R-RAPEDDTERANWAI Mb0528|M.bovis_AF2122/97 RVSAAFIDRICSATRAENRAAAAQLVALGELFA---YRWSRCGGREEWVM Rv0515|M.tuberculosis_H37Rv RVSAAFIDRICSATRAENRAAAAQLVALGELFA---YRWSRCGGREEWVM MMAR_1213|M.marinum_M --SSAPLTRITAAARAEARAAAERLAAIGDLFR---LRLSQHGNREDWVA MUL_2679|M.ulcerans_Agy99 --DSAPLTRITAAARAEARAAAERLAAIGDLFR---LRLSQHGNREDWVA MAB_4752|M.abscessus_ATCC_1997 --DVELIDLIASAQRAEAQACARKLDAIGVLVDRH-ADLGKPDERDHHAL Mflv_1057|M.gilvum_PYR-GCK --LRVLSGVQG-PYRQIAAAMAASLAGIAELLDRRTAEELDAALHVRSVI MAV_0536|M.avium_104 --PAALVAVIESTHREESMLVARRFAAVAALLRHR-VATADRPEPEYAEI . * . : .:. * MSMEG_5026|M.smegmatis_MC2_155 DPFEEVCAEVSAALRISRSRANWQVHLARVLRDRIPKVAAVFAQGDIDFR Mvan_3778|M.vanbaalenii_PYR-1 DVYEAVAAEVSAAQNISRSRAGYQVEMAVSLYTRLPKVAEAFARGDIDLR TH_0334|M.thermoresistible__bu DGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDFR Mb0528|M.bovis_AF2122/97 DTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYL Rv0515|M.tuberculosis_H37Rv DTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYL MMAR_1213|M.marinum_M DTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDFR MUL_2679|M.ulcerans_Agy99 DTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDFR MAB_4752|M.abscessus_ATCC_1997 DRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDFR Mflv_1057|M.gilvum_PYR-GCK TAFDRTAVEVGAALALPSPKARELVRQADALHTRLPGLGALLAAGEVDYD MAV_0536|M.avium_104 DGFEQTAAEVAAAMNLSAAAASYLVSYAETLDTRLPEVAALLAEGRTDWR . *:.** . . : * : *: . : * . MSMEG_5026|M.smegmatis_MC2_155 IVTKIATRT-ELVDPAAMPALDDVLARRCPNWMRLSEPKLEERIDQCILR Mvan_3778|M.vanbaalenii_PYR-1 MVQIVLART-KNVEDDVIGGLDKAIAPKLSRWMRLSKNDLRDRVDLWVAD TH_0334|M.thermoresistible__bu MVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVER Mb0528|M.bovis_AF2122/97 MFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVAR Rv0515|M.tuberculosis_H37Rv MFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVAR MMAR_1213|M.marinum_M LFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAK MUL_2679|M.ulcerans_Agy99 LFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAK MAB_4752|M.abscessus_ATCC_1997 TVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVLH Mflv_1057|M.gilvum_PYR-GCK TVAMVLDRTDLVH-EDVMAQLEAALLERVRGWACFSRKQLRDEVDALVKE MAV_0536|M.avium_104 TVRLIITRTSLVTDAELIAKLDRSLAARIGNWHGWSRQRIVNAVDAAVRT . : *: : :: : * : : :* : MSMEG_5026|M.smegmatis_MC2_155 LDPDGQRVTKRSE-DSRYFTVQPADTPG--MANAQGYLPAHDAAGFDKRL Mvan_3778|M.vanbaalenii_PYR-1 FDPAAVRVPPEAK-DNRYFDVTP-DVPG--MAFAGGLLNARDAAALDQRL TH_0334|M.thermoresistible__bu FDPTGVREPRSPG-EDRYVVVTP-AGQG--MVDVSARLTFEAGFAFXTRL Mb0528|M.bovis_AF2122/97 ADADAVRRRKEYQ-AQRQFWVGE-SQDG--VCQIGGSLLAVDAHALDARL Rv0515|M.tuberculosis_H37Rv ADADAVRRRKEYQ-AQRQFWVGE-SQDG--VCQIGGSLLAVDAHALDARL MMAR_1213|M.marinum_M FDRDAVRRSRRDA-ADRYVDCAP-LEPG--MALVNGQVFAATAEALARRL MUL_2679|M.ulcerans_Agy99 FDRDAVRRSRRDA-ADRYVDCAP-LEPG--MALVNRQVFSATAEALARRL MAB_4752|M.abscessus_ATCC_1997 FDQDAVRRNRSAT-DKRHLEIRP-LGNGEPVAEVWGTLQAVHAVALDKRL Mflv_1057|M.gilvum_PYR-GCK VDADAVKQRRTRAYDQRRVSVAA-EADG--MAVVRGTMSAEDGAALDTRL MAV_0536|M.avium_104 ADPDAARERRLAAEEDRHIGISA-AENG--MAEVHGSVAAAAATAFDRRL * . : .* . * : : . .: ** MSMEG_5026|M.smegmatis_MC2_155 DAIAATVCPNDPRTPDQRRADALGALGRYRDTLDCQCGREDCTAVAERD- Mvan_3778|M.vanbaalenii_PYR-1 EAIAATVCSNDPRSHNNLRADAAGALGRGESTLTCECGAEDCPAAVLRE- TH_0334|M.thermoresistible__bu DQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADT- Mb0528|M.bovis_AF2122/97 SALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPA- Rv0515|M.tuberculosis_H37Rv SALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPA- MMAR_1213|M.marinum_M DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQ- MUL_2679|M.ulcerans_Agy99 DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQ- MAB_4752|M.abscessus_ATCC_1997 DLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDCSG--RDT- Mflv_1057|M.gilvum_PYR-GCK TAIAKKVCACDPRSLVQRRADAFKALTLGE-PFGCMCGRNDCPDALAATP MAV_0536|M.avium_104 SQLAKQVCPADPRTLDQRRADALAALAEGR-RLPCACGQPDCPARTGNQN :* ** ***: : **** :: : * ** **. MSMEG_5026|M.smegmatis_MC2_155 --------------AVNNAMIHVLAEQSTLDG-GNEPG-YLPGFGMLPAH Mvan_3778|M.vanbaalenii_PYR-1 --------------SAAQVVIHILAEQATVDGDGDKAG-YLPGFGVLPAE TH_0334|M.thermoresistible__bu --------------AATRLVINVIAEQATVEGRSDNPG-YLPGYGAVPAS Mb0528|M.bovis_AF2122/97 --------------APP-VVIHLIAEAATINGTGSAPASQMNADGLITAE Rv0515|M.tuberculosis_H37Rv --------------APP-VVIHLIAEAATINGTGSAPASQMNADGLITAE MMAR_1213|M.marinum_M --------------QPSRVVIHVVAGRETVDGAGEAPG-VLPGDGIIPAE MUL_2679|M.ulcerans_Agy99 --------------QPSRVVIHVVAGCQTVDGAGEAPG-VLPGDGIIPAE MAB_4752|M.abscessus_ATCC_1997 --------------ADVPVVVNVVINQSTLAGSDDCPA-HVPGFGVLAAE Mflv_1057|M.gilvum_PYR-GCK AGSTPAAPPQQSLPMGRQVVLNVIASAETVTGLGNAAG-YLLGYGVIDAE MAV_0536|M.avium_104 ADDR----------TGARVVINVVASDRTVYADGAEPG-YLEGYGVIDAD ::::: *: . . .. : . * : * MSMEG_5026|M.smegmatis_MC2_155 MVREVAKTATTKPVTIPK--DKAQSGYRPNAELTEFIRWRDLTCRFPGCD Mvan_3778|M.vanbaalenii_PYR-1 EVRAAAKTAKLKPVRLPG--AEPEKGYRPSAGLKDFLQWRDLTCRFPGCD TH_0334|M.thermoresistible__bu ILRAKAATATLRPVALPQ--PCAEAGYRPSAALTRFIRCRDLTCRFPGCD Mb0528|M.bovis_AF2122/97 LVAELAKTATLVPLVHPGD-APPEPGYAPSKALADFVRCRDLTCRWPGCD Rv0515|M.tuberculosis_H37Rv LVAELAKTATLVPLVHPGD-APPEPGYAPSKALADFVRCRDLTCRWPGCD MMAR_1213|M.marinum_M IVRELAKSAKLQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCD MUL_2679|M.ulcerans_Agy99 IVRELAKSAKLQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCD MAB_4752|M.abscessus_ATCC_1997 SARAAVAGTPTRNLTDS-----RSTGYRPSAKLAAFVRSRDQLCRFPGCE Mflv_1057|M.gilvum_PYR-GCK LVRELARDATRRLVEAPRFEERQALTYRPSDALARFIRARDLTCRFPGCT MAV_0536|M.avium_104 QVRRLA-AAAHLLVANPATSPAAALRYQPSAALERAVRCRDLTCRFPGCS . : : . * *. * :: ** ** *** MSMEG_5026|M.smegmatis_MC2_155 APAMAADIDHTRPY-----PQG-PTHPSNTKLYCRTHHLIKTFYTGPNGW Mvan_3778|M.vanbaalenii_PYR-1 APVERCDVDHTTRW-----PFG-VTHASGLKHYCRTHHVIKTFLTGVYGW TH_0334|M.thermoresistible__bu APAAVCQIDHTIPY-----PAG-PTHPSNLKLLCVFHCRQAELR-----F Mb0528|M.bovis_AF2122/97 EPATNCDLDHTIPY-----AAGGPTHASNLKCYCRTHHLVKTFWG----W Rv0515|M.tuberculosis_H37Rv EPATNCDLDHTIPY-----AAGGPTHASNLKCYCRTHHLVKTFWG----W MMAR_1213|M.marinum_M RPATQCDVDHTIPY-----SDGGATHPSNLKCLCRKHHLLKTFWG----W MUL_2679|M.ulcerans_Agy99 RPATQCDVDHTIPY-----SDGGATHPSNLKCLCRKHHLLKTFWG----W MAB_4752|M.abscessus_ATCC_1997 AVADRADIDHTVPW-----ATGGPTTGANLKALCRKHHLLKTFGQ----W Mflv_1057|M.gilvum_PYR-GCK VPATRCDIDHTTPFDHEDPAAGGWTVPWNLACYCREHHRHKTFDT---GW MAV_0536|M.avium_104 RPAVICDLDHSVPFNHQNPVAGGWTVLENLKCLCRQHHRLKTFG----GW . .::**: : * * . * * : : MSMEG_5026|M.smegmatis_MC2_155 TDRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQQD--E Mvan_3778|M.vanbaalenii_PYR-1 RDEQRRDGTVVLTAPTGHVYTTEPLGGLLFPTLATPTAPL-PDVEVP--E TH_0334|M.thermoresistible__bu THDQHKHQSSCLPA-----YFQRPHG----PATRRP-------------- Mb0528|M.bovis_AF2122/97 RDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYD Rv0515|M.tuberculosis_H37Rv RDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYD MMAR_1213|M.marinum_M HDKQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPARKP-QD MUL_2679|M.ulcerans_Agy99 HDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPR----- MAB_4752|M.abscessus_ATCC_1997 TELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTRHH------------- Mflv_1057|M.gilvum_PYR-GCK RDQQLVDGTIIWTAPTGHEYRTVPAGVGLFPG-LGRARNSAERRRVAAAR MAV_0536|M.avium_104 RDRQLADGTVVWTSPTGRAYRTSPAGADLFAQPRGPARAAPTPNRRSRSK . * . : * * . . MSMEG_5026|M.smegmatis_MC2_155 PHPNRGVMMPKRRQ----------TREQDRADRINAERRERAELNAEQ-- Mvan_3778|M.vanbaalenii_PYR-1 DDPDKAAMMPRRR-----------TREQERRARIARERRQRIEINAER-- TH_0334|M.thermoresistible__bu ---------PSARG----------LREAVPRQGVDPRR-----VSGQ--- Mb0528|M.bovis_AF2122/97 HCDQRTAMMPKRRR----------TRAQDRAYRIATERRQNHAARQRAQV Rv0515|M.tuberculosis_H37Rv HCDQRTAMMPKRRR----------TRAQDRAYRIATERRQNHAARQRAQV MMAR_1213|M.marinum_M HCGNRDAMMPKRAR----------TRAQSSAARIAAERNHNMTSRQARRR MUL_2679|M.ulcerans_Agy99 --------------------------SEATGSLRKPRRDDAQTRPNSRPK MAB_4752|M.abscessus_ATCC_1997 ------------------------TRQQARDRRRRTERNLNREQR----- Mflv_1057|M.gilvum_PYR-GCK QRLHRHRDASTYN---------RYRNQQAR-DEVRNRRWRNGFRGRYLLF MAV_0536|M.avium_104 QRNGRIMRARKHNREQRPINEARIRLEQARQREIADRKFRNHMRDMLFLF .: MSMEG_5026|M.smegmatis_MC2_155 -------QRQRQAWLADNYEP-----------------------PPF Mvan_3778|M.vanbaalenii_PYR-1 -------ERQHQAWLAATYEP-----------------------PPF TH_0334|M.thermoresistible__bu ----------------------------------------------- Mb0528|M.bovis_AF2122/97 LTQTAAATDTHGPPPDHNDDP-----------------------PPF Rv0515|M.tuberculosis_H37Rv LTQTAAATDTHGPPPDHNDDP-----------------------PPF MMAR_1213|M.marinum_M RWEECYFGPRDASASDDEEPP-----------------------PF- MUL_2679|M.ulcerans_Agy99 ------LGRTHCDRTQPQHD--------------------------- MAB_4752|M.abscessus_ATCC_1997 ------LQREAALAALAAKDP-----------------------PPF Mflv_1057|M.gilvum_PYR-GCK KGEFAHNAPSRSPFGRFVNDPFEPESLPPDWHPPPQDRADPDEPPPF MAV_0536|M.avium_104 KG-----APSTSPFCAWVNDPREPEELPPDWVPDEPAYQPLPDDPPF