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FAYAEPAELIDAMSSAARAESAAIARRLEAVAALFRSRKCDYAEAGFLHTDVYEAVAAEVSAAQNISRSR AGYQVEMAVSLYTRLPKVAEAFARGDIDLRMVQIVLARTKNVEDDVIGGLDKAIAPKLSRWMRLSKNDLR DRVDLWVADFDPAAVRVPPEAKDNRYFDVTPDVPGMAFAGGLLNARDAAALDQRLEAIAATVCSNDPRSH NNLRADAAGALGRGESTLTCECGAEDCPAAVLRESAAQVVIHILAEQATVDGDGDKAGYLPGFGVLPAEE VRAAAKTAKLKPVRLPGAEPEKGYRPSAGLKDFLQWRDLTCRFPGCDAPVERCDVDHTTRWPFGVTHASG LKHYCRTHHVIKTFLTGVYGWRDEQRRDGTVVLTAPTGHVYTTEPLGGLLFPTLATPTAPLPDVEVPEDD PDKAAMMPRRRTREQERRARIARERRQRIEINAERERQHQAWLAATYEPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3778 | - | - | 100% (473) | hypothetical protein Mvan_3778 |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 1e-79 | 37.45% (502) | hypothetical protein Mvan_0728 |
| M. vanbaalenii PYR-1 | Mvan_0426 | - | 2e-61 | 34.69% (516) | hypothetical protein Mvan_0426 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 4e-95 | 45.72% (479) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_3596 | - | 0.0 | 73.71% (464) | hypothetical protein Mflv_3596 |
| M. tuberculosis H37Rv | Rv0515 | - | 4e-95 | 45.72% (479) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 8e-79 | 40.21% (485) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 6e-95 | 45.80% (452) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 1e-88 | 41.15% (486) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 1e-142 | 54.62% (476) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-86 | 45.98% (361) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 1e-83 | 40.33% (481) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3778|M.vanbaalenii_PYR-1 ---------MFAYAEP---------------AELIDAMSSAARAESAAIA
Mflv_3596|M.gilvum_PYR-GCK ----------------------------------MDAMTSAARCESRAAA
MSMEG_5026|M.smegmatis_MC2_155 -MGAGILERMFDGTSD---------------AGLIDAIAEAKRQENAATA
TH_0334|M.thermoresistible__bu ---------MFESLDD---------------GAVVDSIAAASREQSAACG
Mb0528|M.bovis_AF2122/97 -MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAAA
Rv0515|M.tuberculosis_H37Rv -MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAAA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAA
MAV_4456|M.avium_104 --MCEDATAWFDELMERCYPS-----ATPESAALVQRIGVFARVENRAAA
MUL_1813|M.ulcerans_Agy99 ----------------------------------MERAREASRREAAAAA
MAB_4752|M.abscessus_ATCC_1997 ---------MFDELGD---------------VELIDLIASAQRAEAQACA
:: * : * .
Mvan_3778|M.vanbaalenii_PYR-1 RRLEAVAALFRSRK---CDYAEAGFLHTDVYEAVAAEVSAAQNISRSRAG
Mflv_3596|M.gilvum_PYR-GCK ERLAAVASLYRVRK---SMYVEAGLWRTDVFEAVAAEVSAAQNISRWRAG
MSMEG_5026|M.smegmatis_MC2_155 RRLFAIGELDTRRA---IDLAECNFWRTDPFEEVCAEVSAALRISRSRAN
TH_0334|M.thermoresistible__bu REMLAIGELYARRAP--EDDTERANWAIDGHANVVAEISAALNISRGRAA
Mb0528|M.bovis_AF2122/97 AQLVALGELFAYR---WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAA
Rv0515|M.tuberculosis_H37Rv AQLVALGELFAYR---WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAA
MMAR_5187|M.marinum_M AQLIEIGQLFAYR---LSRCSETEDWAVDTMEAVAAEVAAGLRISQGLAA
MAV_4456|M.avium_104 EQLAAIGELFAYR---LSRCSECEDWAVDTEAAVSAEVAAQLRIGQGLAA
MUL_1813|M.ulcerans_Agy99 ERLDVVGALFVLR---CRESGDRAEWATDTWEAVGAQVAAALRTSVAMGS
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHA-DLGKPDERDHHALDRWDRVASEVAAAQGITHALAS
.: :. * : * * ::::* .
Mvan_3778|M.vanbaalenii_PYR-1 YQVEMAVSLYTRLPKVAEAFARGDIDLRMVQIVLART-KNVEDDVIGGLD
Mflv_3596|M.gilvum_PYR-GCK SQVRMAVSLYERLPQVAEVFYRGDIDQRMVQLTLSRT-ETVDDAIIAELD
MSMEG_5026|M.smegmatis_MC2_155 WQVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALD
TH_0334|M.thermoresistible__bu GRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLD
Mb0528|M.bovis_AF2122/97 SRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVD
Rv0515|M.tuberculosis_H37Rv SRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVD
MMAR_5187|M.marinum_M SRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVD
MAV_4456|M.avium_104 AKVRYARAMRERLPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVD
MUL_1813|M.ulcerans_Agy99 SYLRYAMAMRNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVD
MAB_4752|M.abscessus_ATCC_1997 SQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVD
:. * : *: .. * ::. . *: : : :*
Mvan_3778|M.vanbaalenii_PYR-1 KAIAPKLSRWMRLSKNDLRDRVDLWVADFDPAAVRVPPEAKDNRYFDVTP
Mflv_3596|M.gilvum_PYR-GCK AALARRIVKWMRFSKDKLRDRLDQWVAKFDPAGVRVPPAAKDNRYFDVTP
MSMEG_5026|M.smegmatis_MC2_155 DVLARRCPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQP
TH_0334|M.thermoresistible__bu AALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTP
Mb0528|M.bovis_AF2122/97 AQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE
Rv0515|M.tuberculosis_H37Rv AQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE
MMAR_5187|M.marinum_M ALVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIGQ
MAV_4456|M.avium_104 AELAATAARWPSMTRARLAARVDAVVAKADADAVRRTEKQAASRHVWIAE
MUL_1813|M.ulcerans_Agy99 AQLAALLARCPAVTRGRLSVAVDQVVADVDRDVVRRVAEAADGRFVDVDV
MAB_4752|M.abscessus_ATCC_1997 AAIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRP
:. . : : :* : * * * . :
Mvan_3778|M.vanbaalenii_PYR-1 -DVPG--MAFAGGLLNARDAAALDQRLEAIAATVCSNDPRSHNNLRADAA
Mflv_3596|M.gilvum_PYR-GCK -DVPG--MAFAGGVLTARDAAALDQRLEAMADTVCANDPRTWNQRRADAA
MSMEG_5026|M.smegmatis_MC2_155 ADTPG--MANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADAL
TH_0334|M.thermoresistible__bu -AGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAM
Mb0528|M.bovis_AF2122/97 -SQDG--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADAL
Rv0515|M.tuberculosis_H37Rv -SQDG--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADAL
MMAR_5187|M.marinum_M -DADG--ISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADAL
MAV_4456|M.avium_104 -MGEG--LSHLEGTVSSPDAHALDKRLDALAATVCEHDPRTGEQRRADAL
MUL_1813|M.ulcerans_Agy99 -IADGSGLAALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAV
MAB_4752|M.abscessus_ATCC_1997 -LGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAV
* : . : . .: **. :* *** ***: : ****
Mvan_3778|M.vanbaalenii_PYR-1 GALGRGESTLTCECGAEDCPAAVLRESAAQVVIHILAEQATVDGDGDKAG
Mflv_3596|M.gilvum_PYR-GCK GALGRGEATLACQCGGDDCPAVALRESAAKVVIHILAEQATVEGRSDDPG
MSMEG_5026|M.smegmatis_MC2_155 GALGRYRDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLDG-GNEPG
TH_0334|M.thermoresistible__bu AAMSEGQNRLVCGCGSEDCPADPADTAATRLVINVIAEQATVEGRSDNPG
Mb0528|M.bovis_AF2122/97 GALAGGADRLGCGCGRADCAAG-KRPAAPPVVIHLIAEAATINGTGSAPA
Rv0515|M.tuberculosis_H37Rv GALAGGADRLGCGCGRADCAAG-KRPAAPPVVIHLIAEAATINGTGSAPA
MMAR_5187|M.marinum_M GVLAAGGDRLGCRCGLPDCAAG-ARPAAQPVVIHVIAERATLDGDGGAPA
MAV_4456|M.avium_104 GALAAGADRLGCRCGRADCAAG-TRPAAGPVVIHLIAERASVEGTGGGPA
MUL_1813|M.ulcerans_Agy99 GALVAGSDRLACGCTSADCTAA-ARSAPSKVVIHVVADQSTVDGTGHTPA
MAB_4752|M.abscessus_ATCC_1997 GALTQGLNRMRCACGHPDCSG--RDTADVPVVVNVVINQSTLAGSDDCPA
..: : * * **.. : ::::: : ::: * . ..
Mvan_3778|M.vanbaalenii_PYR-1 YLPGFG-VLPAEEVRAAAKTAKLKPVRLPGAEP-EKGYRPSAGLKDFLQW
Mflv_3596|M.gilvum_PYR-GCK YLSGFG-VLPAEEVRAAARTAKLVPVSQPGTEP-ETGYKPSAKLRDYLRW
MSMEG_5026|M.smegmatis_MC2_155 YLPGFG-MLPAHMVREVAKTATTKPVTIPKDKA-QSGYRPNAELTEFIRW
TH_0334|M.thermoresistible__bu YLPGYG-AVPASILRAKAATATLRPVALPQPCA-EAGYRPSAALTRFIRC
Mb0528|M.bovis_AF2122/97 SQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRC
Rv0515|M.tuberculosis_H37Rv SQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRC
MMAR_5187|M.marinum_M WEVGADGLVTPELVAELAKSAKLVPLRHPGDVPPEPGYVPSKALADFVRC
MAV_4456|M.avium_104 VEVGAEGLLPAQLVAELAASARLMPLVHPADAPPENRYTPSAALADFVRC
MUL_1813|M.ulcerans_Agy99 VLLGAEGLIPASLIAELAKVATLRPLMRPSGRP-ESGYAPSAGLAEFVRC
MAB_4752|M.abscessus_ATCC_1997 HVPGFG-----VLAAESARAAVAGTPTRNLTDSRSTGYRPSAKLAAFVRS
. * * . . . * *. * :::
Mvan_3778|M.vanbaalenii_PYR-1 RDLTCRFPGCDAPVERCDVDHTTRWPFG-VTHASGLKHYCRTHHVIKTFL
Mflv_3596|M.gilvum_PYR-GCK RDLTCRFPGCDAPVEGCDVDHTTPWPFG-VTHASGTKHYCRTHHLIKTFY
MSMEG_5026|M.smegmatis_MC2_155 RDLTCRFPGCDAPAMAADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFY
TH_0334|M.thermoresistible__bu RDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELR
Mb0528|M.bovis_AF2122/97 RDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFW
Rv0515|M.tuberculosis_H37Rv RDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFW
MMAR_5187|M.marinum_M RDLTCRWPGCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFW
MAV_4456|M.avium_104 RDLTCRWPGCDRPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFW
MUL_1813|M.ulcerans_Agy99 RDLTCRARGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFW
MAB_4752|M.abscessus_ATCC_1997 RDQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFG
** ** **: . .::*** : * * :. * * * :
Mvan_3778|M.vanbaalenii_PYR-1 TGVYGWRDEQRRDGTVVLTAPTGHVYTTEPLGGLLFPTLATPTAPLPDVE
Mflv_3596|M.gilvum_PYR-GCK GGPSGWRDAQSPDGTVVVIAPTGHVYSTEAHGAGLFPKLAEPTAPLPPPT
MSMEG_5026|M.smegmatis_MC2_155 TGPNGWTDRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPP
TH_0334|M.thermoresistible__bu -----FTHDQHKHQSSCLPA-----YFQRPHG-----------------P
Mb0528|M.bovis_AF2122/97 G----WRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPE
Rv0515|M.tuberculosis_H37Rv G----WRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPE
MMAR_5187|M.marinum_M G----WHDQQLPDGTLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAE
MAV_4456|M.avium_104 G----WREQQLPDATLILTSPAGRTYVTTPGSALLFPSLCVPTG-EPARP
MUL_1813|M.ulcerans_Agy99 G----WRDLQLPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIV
MAB_4752|M.abscessus_ATCC_1997 Q----WTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALT----------
: . * . : * . .
Mvan_3778|M.vanbaalenii_PYR-1 VPEDD------------------------PDKAAMMP-----RR-RTR--
Mflv_3596|M.gilvum_PYR-GCK STQEP------------------------SDKSAMMP-----RRKRTR--
MSMEG_5026|M.smegmatis_MC2_155 QQDEPH-----------------------PNRGVMMP-----KRRQTR--
TH_0334|M.thermoresistible__bu ATRRP-------------------------------P-----SARGLR--
Mb0528|M.bovis_AF2122/97 ADPP----------YDHCD-----------QRTAMMP-----KRRRTR--
Rv0515|M.tuberculosis_H37Rv ADPP----------YDHCD-----------QRTAMMP-----KRRRTR--
MMAR_5187|M.marinum_M ADPP----------SDHCD-----------QRSAMMP-----RRQRTR--
MAV_4456|M.avium_104 VAAG----------SQPCG-----------ERTAMMP-----TRRRTR--
MUL_1813|M.ulcerans_Agy99 GTAGKPPRWPSGEDADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRP
MAB_4752|M.abscessus_ATCC_1997 -------------------------------------------RHHTR--
*
Mvan_3778|M.vanbaalenii_PYR-1 -----EQERRARIARERRQR-------IEINAERERQHQAWLAATYE---
Mflv_3596|M.gilvum_PYR-GCK -----EQDRRARIERERRQR-------IELDAEEERQRQAWLAETYE---
MSMEG_5026|M.smegmatis_MC2_155 -----EQDRADRINAERRER-------AELNAEQQRQRQAWLADNYE---
TH_0334|M.thermoresistible__bu -----EAVPRQGVDPRR------------VSGQ-----------------
Mb0528|M.bovis_AF2122/97 -----AQDRAYRIATERRQN-----HAARQRAQVLTQTAAATDTHGP---
Rv0515|M.tuberculosis_H37Rv -----AQDRAYRIATERRQN-----HAARQRAQVLTQTAAATDTHGP---
MMAR_5187|M.marinum_M -----AQDRARRVATERRQN-----HHARS-TQPGGQPRSAAPPTPP---
MAV_4456|M.avium_104 -----GQNRAARVAAERRAN-----RAARL-ARATRPAPAASQSWPA---
MUL_1813|M.ulcerans_Agy99 VRHPGAGNRSRRAAALLAATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTR
MAB_4752|M.abscessus_ATCC_1997 -----QQARDRRRRTERNLN-----REQRLQREAALAALAAK--------
Mvan_3778|M.vanbaalenii_PYR-1 ---------PPPF---
Mflv_3596|M.gilvum_PYR-GCK ---------PPPF---
MSMEG_5026|M.smegmatis_MC2_155 ---------PPPF---
TH_0334|M.thermoresistible__bu ----------------
Mb0528|M.bovis_AF2122/97 --PPDHNDDPPPF---
Rv0515|M.tuberculosis_H37Rv --PPDHNDDPPPF---
MMAR_5187|M.marinum_M --QSEPQSHPPPF---
MAV_4456|M.avium_104 --GHGPDADPPPF---
MUL_1813|M.ulcerans_Agy99 MGESSMSARPRACVAG
MAB_4752|M.abscessus_ATCC_1997 --------DPPPF---