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VTDREEPQRHDQERPGGMFRQPTQPPQDWTPPTRPVPAPPPGYPPRPPWPDRPYPQADHPVPPQPSTYTE RIRPADLVPSRKPVPGHGWRLALLKATFGLVNVGPSPDERRAAALETAIRAPLRGHFKVGVMGKGGVGKT TVSACIGSLFAELRHEDRVVAVDADTAFGKLGSRVDPRARRSFWELTADQYLETFADIRNHLGSNAAGLF VLAGEASPARRRVLDAAIYREAMARLDRHFTITVVDCSSTMDSPVTEEVLRDLDALVVVSSPWVDGAAAA GQTLDWLAARGMTTLLQHTVVVLNDSDGHADKRTRKVLAQQFSGHGQLVVEVPFDGHLRPGGVIDGTAQM SRPARRKLVEVCAALAAFYPTQDDRSRERR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0776 | - | - | 100% (380) | hypothetical protein Mflv_0776 |
| M. gilvum PYR-GCK | Mflv_0765 | - | 4e-41 | 32.43% (370) | hypothetical protein Mflv_0765 |
| M. gilvum PYR-GCK | Mflv_0048 | - | 3e-39 | 31.08% (370) | hypothetical protein Mflv_0048 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3890 | - | 1e-103 | 52.13% (376) | hypothetical protein Mb3890 |
| M. tuberculosis H37Rv | Rv3860 | - | 1e-103 | 52.39% (376) | hypothetical protein Rv3860 |
| M. leprae Br4923 | MLBr_00798 | - | 9e-41 | 34.26% (324) | hypothetical protein MLBr_00798 |
| M. abscessus ATCC 19977 | MAB_0630 | - | 2e-49 | 33.60% (378) | hypothetical protein MAB_0630 |
| M. marinum M | MMAR_5436 | - | 1e-110 | 54.71% (382) | hypothetical protein MMAR_5436 |
| M. avium 104 | MAV_0163 | - | 1e-119 | 59.01% (383) | hypothetical protein MAV_0163 |
| M. smegmatis MC2 155 | MSMEG_0053 | - | 1e-141 | 63.75% (400) | hypothetical protein MSMEG_0053 |
| M. thermoresistible (build 8) | TH_0884 | - | 2e-44 | 35.47% (296) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1725 | secD | 8e-06 | 36.73% (98) | preprotein translocase subunit SecD |
| M. vanbaalenii PYR-1 | Mvan_0069 | - | 1e-158 | 73.08% (390) | hypothetical protein Mvan_0069 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0630|M.abscessus_ATCC_1997 MADTNDNAPDSPPPSGPWREPIADGLGGGDTKGSPFRRSKNSNQEFVPPS
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
Rv3860|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5436|M.marinum_M --------------------------------------------------
MAV_0163|M.avium_104 --------------------------------------------------
MLBr_00798|M.leprae_Br4923 -----------------------------------MTTFRERRTMFDAAV
MUL_1725|M.ulcerans_Agy99 -------------------------------------------------M
MAB_0630|M.abscessus_ATCC_1997 ADYFPQPTLKPPPPLPKAPKLSRRQRNHQRPMNPIWEPDPLSAYGMPQQQ
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
Rv3860|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5436|M.marinum_M --------------------------------------------------
MAV_0163|M.avium_104 --------------------------------------------------
MLBr_00798|M.leprae_Br4923 ASYQSGDKTSAGAAFARLTVENPDMSDSWLGRLACGDHNLDTLAGAHQHS
MUL_1725|M.ulcerans_Agy99 ASSSAPVHPARYLSVFLVLLIGVYLLVFLTGDKKAAPKLGIDLQGGTRVT
MAB_0630|M.abscessus_ATCC_1997 NQAPPAPPQGYGAPVQQPPQNYQPPPQNYYAPPQNYYGPPTDQPATPVAP
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK -----------------------------------------------MTD
Mvan_0069|M.vanbaalenii_PYR-1 ----------------------------------------------MVND
MSMEG_0053|M.smegmatis_MC2_155 -----------------------------------------------MAD
Mb3890|M.bovis_AF2122/97 -----------------------------------------------MYE
Rv3860|M.tuberculosis_H37Rv -----------------------------------------------MYE
MMAR_5436|M.marinum_M -----------------------------------------------MNE
MAV_0163|M.avium_104 -----------------------------------------------MNE
MLBr_00798|M.leprae_Br4923 EVLYSETRRVGLKDGDLRAEIAAPMYLTLTTWSRATIGLAYASALINAGR
MUL_1725|M.ulcerans_Agy99 LTARTPDGSAPSREALAQAQQIISARVNGLGVSGSEVVVDGDNLVITVPG
MAB_0630|M.abscessus_ATCC_1997 AEPAAPAVPPPAPATQLPAWPASAVVPEQPAPEAPAPARPAEQSPAPEGL
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK RE-----------------EPQ----------------------------
Mvan_0069|M.vanbaalenii_PYR-1 RD-----------------DPAT---------------------------
MSMEG_0053|M.smegmatis_MC2_155 PDDTLRRELGWTGPEEDDFEPDTGPTRPTLRPEPPSIPGRPPVSPTPPNP
Mb3890|M.bovis_AF2122/97 RD------------------------------------------------
Rv3860|M.tuberculosis_H37Rv RD------------------------------------------------
MMAR_5436|M.marinum_M RE------------------------------------------------
MAV_0163|M.avium_104 RD------------------------------------------------
MLBr_00798|M.leprae_Br4923 YDEASVALDDPVVTEDDDAALARQFVMATLFHQTRSWSNVLKVAEVPPQN
MUL_1725|M.ulcerans_Agy99 NDGNEARNLGQTARLYIRPVMNSMPAQP----------------------
MAB_0630|M.abscessus_ATCC_1997 DEAAQEQTPVEVPPPAPPAPVAPDPAPQVRADDASAMIPEGLTPWGGRAP
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK -----------RHDQERPGGMFR-------------------------QP
Mvan_0069|M.vanbaalenii_PYR-1 ------DQAAVTPEPPRPREMFR-------------------------QP
MSMEG_0053|M.smegmatis_MC2_155 VNPDAEDRVPADPDAERARTTFR-------------------------EP
Mb3890|M.bovis_AF2122/97 ------EFLRDRIRPHQPGT------------------------------
Rv3860|M.tuberculosis_H37Rv ------EFLRDRIRPHQPGT------------------------------
MMAR_5436|M.marinum_M ------EFLRDRVRPDQPSVPDASRSHQRSGMHRTATDAS-GPPVAPTHQ
MAV_0163|M.avium_104 ------EFLRDRLQPERPSAR-----------------------------
MLBr_00798|M.leprae_Br4923 SNTDDRNELTDAVAALASTAASN-------------------------LG
MUL_1725|M.ulcerans_Agy99 ------AAQEPQQEPQQPGGTAPAP-----------------------GG
MAB_0630|M.abscessus_ATCC_1997 QMPSAPTSPAPSWAPPPAGPPLAPAPPAAFSRADWSAPAAPPRAPYVPGQ
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0776|M.gilvum_PYR-GCK TQ--PPQDWT------PPTRPVPAPP------PGY-PPR--PPWPDRPYP
Mvan_0069|M.vanbaalenii_PYR-1 TRPLPPQPRR------PDGWEQQQPP------PGW-APQ--APPSAPPYP
MSMEG_0053|M.smegmatis_MC2_155 TQPSPPQQPSQPPPPPPPSALHPRPDPWEQRVPGWNAPQYGPPPGNQPWP
Mb3890|M.bovis_AF2122/97 PRGYSPRPPSGDRCPAPPPGRHAAAA------TPPGPPRLPSA-PLRPLP
Rv3860|M.tuberculosis_H37Rv PRGYSPRPPSGDRCPAPPPGRHAAAA------TPPGPPRLPSA-PLRPLP
MMAR_5436|M.marinum_M PRPAPPRPPTPQPSPVPPRGANPHPP------PPPAPPSVPAP-PPPPVA
MAV_0163|M.avium_104 PAPAPPPPPVASR-PAPPRPPTPAPT------PPTRPPAPPTFRPHPPAA
MLBr_00798|M.leprae_Br4923 QFQFALELTERVSTTNPQVAADVALNRAWCLRELGDDNAARAALTAAPVN
MUL_1725|M.ulcerans_Agy99 PAPNAGQPPESSAPASPQSGAPAAPQSGTPGRPGAQPRPYPQDPPPSPAP
MAB_0630|M.abscessus_ATCC_1997 TPFTAAR-PEAPVYRPVPQPQQPSRPQGPSHDQLGLIRSVKPLPKSGWRK
TH_0884|M.thermoresistible__bu ----------------------------VDLSTTALLGQRRPAPSRGWRR
Mflv_0776|M.gilvum_PYR-GCK ------------QADHP-VPPQP-STYTERIRPADLVPSRKPVPGHGWRL
Mvan_0069|M.vanbaalenii_PYR-1 PRP---------QADAPWTAPQP-TSYAEWIRPADLVPHRKVVPGSGWRL
MSMEG_0053|M.smegmatis_MC2_155 QAGGFGG----GPGQPPHVPPGPPQSYADRIRASDLVPPKRQPPSGGWRL
Mb3890|M.bovis_AF2122/97 DP---------AWPRQ--PEAPPPSTWAD--PALAPIRSRTRPGERGWRR
Rv3860|M.tuberculosis_H37Rv DP---------AWPRQ--PEAPPPSTWAD--PALAPIRSRTRPGERGWRR
MMAR_5436|M.marinum_M HPPNGHNSPPQAAPHEPMPEVPPPSLWAE--PTPARTPGEPPSTDHGWRH
MAV_0163|M.avium_104 AP----------------APAAPPTPRPQ--PSGAPQLP-----DRGWRR
MLBr_00798|M.leprae_Br4923 DIPTTHN-----TAEPASRPQPTTFRHPYDDGRDLLVARRRPAAGDGWRK
MUL_1725|M.ulcerans_Agy99 APSPAPTGSPAPPATGAQQPADLPPGEEPALPDPRKDLAERIAQEKKWRQ
**
MAB_0630|M.abscessus_ATCC_1997 ------AVHRLSGGAINPGESSEESHRSELIDRINLPVRGDYRIAVLSLK
TH_0884|M.thermoresistible__bu ------WLYRATFRTVNLGESPKVARHNELLNRVRHPLQDCYRIAVLSLK
Mflv_0776|M.gilvum_PYR-GCK ------ALLKATFGLVNVGPSPDERRAAALETAIRAPLRGHFKVGVMG-K
Mvan_0069|M.vanbaalenii_PYR-1 ------ALYKASFGLINLGPSPEDKRVAELEATIRTPLRGRFKIGVMG-K
MSMEG_0053|M.smegmatis_MC2_155 ------LVYRATFGLVNPGPSAEELRQAELEAKIRGVLRGHYKIGVMG-K
Mb3890|M.bovis_AF2122/97 ------MVRLVTFGLVGLGRSGMQRQEAQFEATIRTVLHGNHKVAVLG-K
Rv3860|M.tuberculosis_H37Rv ------MVRLVTFGLVGLGRSGMQRQEAQFEATIRTVLHGNHKVAVLG-K
MMAR_5436|M.marinum_M ------IIRVASFGLINPRPSAAQRDAAEFEAAIRAPLRGTHKVGVLG-K
MAV_0163|M.avium_104 ------ALRLATFGLIDLGPSPAQRREAQFEQAIQARLYGNYKVGVLG-K
MLBr_00798|M.leprae_Br4923 ------FVTKATLGRVNPEPSAKAEQTNELHRRICAPLADVHKVAFVSAK
MUL_1725|M.ulcerans_Agy99 STNQYIQMVALQFEATQCGKDDILAGNDDPKLPLVTCSTDHKTAYLLAPS
: . : . .:. .
MAB_0630|M.abscessus_ATCC_1997 GGVGKTTTTFSLGA------TFASLR-GDRVIAVDANPDFGTLAQRGPDE
TH_0884|M.thermoresistible__bu GGVGKTTITATLGS------TFGSAR-GDRVVAVDANPDRGTLSQKVPLQ
Mflv_0776|M.gilvum_PYR-GCK GGVGKTTVSACIGS------LFAELRHEDRVVAVDADTAFGKLGSRVDPR
Mvan_0069|M.vanbaalenii_PYR-1 GGVGKTTVSASIGS------VLAEIRQDDRVVAVDADTAFGKLGSRVDPR
MSMEG_0053|M.smegmatis_MC2_155 GGVGKTTVSATIGS------IFAHLRQDDRVVAIDADTSFGKLGSRVDPR
Mb3890|M.bovis_AF2122/97 GGVGKTSVAACVGS------ILAELRQQDRIVGIDADTAFGRLSSRIDPR
Rv3860|M.tuberculosis_H37Rv GGVGKTSVAACVGS------ILAELRQQDRIVGIDADTAFGRLSSRIDPR
MMAR_5436|M.marinum_M GGVGKTSVAASIGS------LLAELRQQDRIVAVDADTAFGRLSSRIDPT
MAV_0163|M.avium_104 GGVGKTSVAASVGS------LFAELRRQDHVVAIDADTAFGRLGSRIDPA
MLBr_00798|M.leprae_Br4923 GGVGKTTITVALGN------TMARLR-GDRVIAVDVDADLGDLSARFRER
MUL_1725|M.ulcerans_Agy99 IISGDQIQNATSGMDQRSIGYVVDLQFKSQAANTWADYTAAHIGTQTAFT
*. * . : .: .: . :. :
MAB_0630|M.abscessus_ATCC_1997 --------------------------------TRSTARDLLRDPD-IHRY
TH_0884|M.thermoresistible__bu --------------------------------TRATVRDLLRDADRIQTY
Mflv_0776|M.gilvum_PYR-GCK --------------------------------ARRSFWELTADQY-LETF
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------AQGSFWELAADRH-LEAF
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------AHGSYWELTSDKN-LETF
Mb3890|M.bovis_AF2122/97 --------------------------------AAGSFWELTTDTN-LRSF
Rv3860|M.tuberculosis_H37Rv --------------------------------AAGSFWELTTDTN-LRSF
MMAR_5436|M.marinum_M --------------------------------ARGSFWDLTADRN-LASF
MAV_0163|M.avium_104 --------------------------------STGSFWELTADQN-LRSF
MLBr_00798|M.leprae_Br4923 GG------------------------------PQTNIEHFVSARN-AKRY
MUL_1725|M.ulcerans_Agy99 LDSQVVSAPQILEAIPGGRTQISGGEPPFSASTARQLANVLKYGSLPLSF
. .. :
MAB_0630|M.abscessus_ATCC_1997 SDVRRHTSQSASRLEVLASERDPAASELFSEADYLAVMRILQRFYNIILT
TH_0884|M.thermoresistible__bu SDMRAYTSQSPSRLEVLASESDPAVSEAFSSDDYTRTLRVLERFYSLVLT
Mflv_0776|M.gilvum_PYR-GCK ADIRNHLGSNAAGLFVLAGEASPARRRVLDAAIYREAMARLDRHFTITVV
Mvan_0069|M.vanbaalenii_PYR-1 ADIRNHLGCNAAGLFVLAGEATPARRRVLDPAIYREATTRLDRHFTISVI
MSMEG_0053|M.smegmatis_MC2_155 ADVRSRVGNNSAGLFVLAGESTPARRRVLDAAIYREAVTRLDKHFSISVV
Mb3890|M.bovis_AF2122/97 TDITARLGRNSAGLYVLAGQPASGPRRALDPAIYREAALRLDHHFAISVI
Rv3860|M.tuberculosis_H37Rv TDITARLGRNSAGLYVLAGQPASGPRRVLDPAIYREAALRLDHHFAISVI
MMAR_5436|M.marinum_M ADVVARLGRNAAGLHVLPGEAAVGGRRLLDPAIYREAALRLDRHFTISII
MAV_0163|M.avium_104 DDVVARLGRNAAGLHVLGGEPASGPRRVLDPAIYREATRRLDRHFTISVI
MLBr_00798|M.leprae_Br4923 ADVRVHTVMNNDRLEMLGAQNDPRSTYRLGPDDYETAMKILENHCNVILL
MUL_1725|M.ulcerans_Agy99 ESSEAQTVSATLGLTSLRAGLIAGAIGLALVLLYSLLYYRVLGLLTALSL
. * * . * :
MAB_0630|M.abscessus_ATCC_1997 DCGTGLMHSAMAGVLGEANAIVLVT--SPAIDGARSALATLDWLDHHGYS
TH_0884|M.thermoresistible__bu DCGTGLIHSAMSAVLANADVLIVIS--SGSVDGARSAAATLDWLDAHGHQ
Mflv_0776|M.gilvum_PYR-GCK DCSSTMDSPVTEEVLRDLDALVVVS--SPWVDGAAAAGQTLDWLAARGMT
Mvan_0069|M.vanbaalenii_PYR-1 DCSSTMDSPVTQEVLRDLDALVVVS--SPWVDGAAAAGQTLDWLAARGLT
MSMEG_0053|M.smegmatis_MC2_155 DCSSTMDSPVTQEVLRDLDALIVVS--SPWVDGAATAGQTLDWLSANGMT
Mb3890|M.bovis_AF2122/97 DCGSSMEAAVTQEVLRDVDALIVVS--SPWADGASAAANTIEWLSDYGLT
Rv3860|M.tuberculosis_H37Rv DCGSSMEAAVTQEVLRDVDALIVVS--SPWADGASAAANTIEWLSDYGLT
MMAR_5436|M.marinum_M DCGSTMDAPLTQEVLRDLDALIVVS--SPWADGASAAAKTMEWLADRKLS
MAV_0163|M.avium_104 DCGSTMDAPLTQEVLRDLDALIVVS--SPWADGASAAARTLEWLADHGLT
MLBr_00798|M.leprae_Br4923 DCGTPVNGPLFNKIVSTVTGLVVVA--SDDVRGVEGALATLDWLDAHGYA
MUL_1725|M.ulcerans_Agy99 IASGAMVFAILVLLGRYINYTLDLAGIAGLIIGIGTTADSFVVFFERIKD
.. : . : : :: : * : :: :
MAB_0630|M.abscessus_ATCC_1997 HLVRQSVVAISSSRPGASSIDLEQLSRHFLTRARAVHIIPFDNHLS----
TH_0884|M.thermoresistible__bu DMVRNSIAVINAVRPRSGKVDLQKVVDHFSRRCRAVKMVPFDPHLE----
Mflv_0776|M.gilvum_PYR-GCK TLLQHTVVVLNDSDGHADKRTRKVLAQQFSGHGQLVVEVPFDGHLR----
Mvan_0069|M.vanbaalenii_PYR-1 DLLQRTVVVLNDSDGHADKRTRGILAQQFSGHGQLVIEVPFDGHLR----
MSMEG_0053|M.smegmatis_MC2_155 RLLQRTVVVLNDSDGHADKRTRSILLNQFAGQGQAVVEIPFDGHLR----
Mb3890|M.bovis_AF2122/97 GLLRRSIVVLNDSDGHADKRTKSLLAQEFIDHGQPVVEVPFDPHLR----
Rv3860|M.tuberculosis_H37Rv GLLRRSIVVLNDSDGHADKRTKSLLAQEFIDHGQPVVEVPFDPHLR----
MMAR_5436|M.marinum_M GLLRRSVVVLNDSDGHSDKRTRSVLAREFVDHGQQVVEVPFDPHLR----
MAV_0163|M.avium_104 TLLAHSLVVLNDSDGHADKRTRALLAREFIDHGRPVIEVPFDPHLR----
MLBr_00798|M.leprae_Br4923 RLLQHTVVVLNAIQKTKPFVDFGIVENQFRKRVPDFYPMPYDPHLA----
MUL_1725|M.ulcerans_Agy99 EIREGRSFRSAVPRGWARARKTIVSGNAVTFLAAAVLYFLAIGQVKGFAF
: . . . ::
MAB_0630|M.abscessus_ATCC_1997 ----------------EGSEIS-LDLMGKKTRMAFMELAGSVADGFYEGG
TH_0884|M.thermoresistible__bu ----------------EGAEID-LDQLKPQTRQALLELAAVVADGFPGAQ
Mflv_0776|M.gilvum_PYR-GCK ----------------PGGVIDGTAQMSRPARRKLVEVCAALAAFYPTQD
Mvan_0069|M.vanbaalenii_PYR-1 ----------------PGGVIDGTGEMSPSARRKFIEVVAALAAFFPASV
MSMEG_0053|M.smegmatis_MC2_155 ----------------PGGVVD-IQEMSPKVRRKFLEVAAALADHFPTSD
Mb3890|M.bovis_AF2122/97 ----------------PGGVIDMSHEMAPTTRLKILQVAATVTAYFASRP
Rv3860|M.tuberculosis_H37Rv ----------------PGGVIDMSHEMAPTTRLKILQVAATVTAYFASRP
MMAR_5436|M.marinum_M ----------------PGGVIDVSHELEPGTRLKFLQIAATITGHFAARS
MAV_0163|M.avium_104 ----------------PGGVIDVNGEMAPATRRKFLEVTATIAGYFARRP
MLBr_00798|M.leprae_Br4923 ----------------TGLAVEYTSLKR-KTRKALKELVGGVAQYYPVIR
MUL_1725|M.ulcerans_Agy99 TLGLTTILDIVVVFLVTWPLVYLASKSPRLAKPAYNGLGAVQQVARERRA
: .: : .
MAB_0630|M.abscessus_ATCC_1997 NTRQTSWG----------------
TH_0884|M.thermoresistible__bu QLQSPPF-----------------
Mflv_0776|M.gilvum_PYR-GCK DRSRERR-----------------
Mvan_0069|M.vanbaalenii_PYR-1 TRSG--------------------
MSMEG_0053|M.smegmatis_MC2_155 DHTRERS-----------------
Mb3890|M.bovis_AF2122/97 ADAHGSPPR---------------
Rv3860|M.tuberculosis_H37Rv ADAHGSPPR---------------
MMAR_5436|M.marinum_M AADDDPRPTENVASET--------
MAV_0163|M.avium_104 DRSADRHPPQH-------------
MLBr_00798|M.leprae_Br4923 AQQRDEDGLGTWIETIRQVEMTSR
MUL_1725|M.ulcerans_Agy99 SDSRTRSGIAKTGRE---------