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ADPDDTLRRELGWTGPEEDDFEPDTGPTRPTLRPEPPSIPGRPPVSPTPPNPVNPDAEDRVPADPDAERA RTTFREPTQPSPPQQPSQPPPPPPPSALHPRPDPWEQRVPGWNAPQYGPPPGNQPWPQAGGFGGGPGQPP HVPPGPPQSYADRIRASDLVPPKRQPPSGGWRLLVYRATFGLVNPGPSAEELRQAELEAKIRGVLRGHYK IGVMGKGGVGKTTVSATIGSIFAHLRQDDRVVAIDADTSFGKLGSRVDPRAHGSYWELTSDKNLETFADV RSRVGNNSAGLFVLAGESTPARRRVLDAAIYREAVTRLDKHFSISVVDCSSTMDSPVTQEVLRDLDALIV VSSPWVDGAATAGQTLDWLSANGMTRLLQRTVVVLNDSDGHADKRTRSILLNQFAGQGQAVVEIPFDGHL RPGGVVDIQEMSPKVRRKFLEVAAALADHFPTSDDHTRERS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0053 | - | - | 100% (462) | hypothetical protein MSMEG_0053 |
| M. smegmatis MC2 155 | MSMEG_0975 | - | 4e-52 | 32.94% (428) | hypothetical protein MSMEG_0975 |
| M. smegmatis MC2 155 | MSMEG_0067 | - | 4e-45 | 29.37% (463) | hypothetical protein MSMEG_0067 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3890 | - | 1e-107 | 48.97% (435) | hypothetical protein Mb3890 |
| M. gilvum PYR-GCK | Mflv_0776 | - | 1e-141 | 63.75% (400) | hypothetical protein Mflv_0776 |
| M. tuberculosis H37Rv | Rv3860 | - | 1e-108 | 49.20% (435) | hypothetical protein Rv3860 |
| M. leprae Br4923 | MLBr_00048 | - | 5e-52 | 29.98% (477) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_0630 | - | 1e-57 | 31.19% (497) | hypothetical protein MAB_0630 |
| M. marinum M | MMAR_5436 | - | 1e-114 | 49.34% (456) | hypothetical protein MMAR_5436 |
| M. avium 104 | MAV_0163 | - | 1e-112 | 53.61% (388) | hypothetical protein MAV_0163 |
| M. thermoresistible (build 8) | TH_0884 | - | 2e-49 | 36.95% (295) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4057 | mce4F | 8e-08 | 33.85% (130) | MCE-family protein Mce4F |
| M. vanbaalenii PYR-1 | Mvan_0069 | - | 1e-142 | 64.86% (407) | hypothetical protein Mvan_0069 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0630|M.abscessus_ATCC_1997 MADTNDNAPDSPPPSGPWREPIADGLGGGDTKGSPFRRSKNSNQEFVPPS
TH_0884|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 ---------------------------MAADYDKLFRLDDGAYASPDQAA
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
Rv3860|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5436|M.marinum_M --------------------------------------------------
MAV_0163|M.avium_104 --------------------------------------------------
MUL_4057|M.ulcerans_Agy99 ------------------------------MIDKLTKIQLSIFAIITVLT
MAB_0630|M.abscessus_ATCC_1997 ADYFPQPTLKPPPPLPKAPKLSRRQRNHQRPMNPIWEPDPLSAYGMPQQQ
TH_0884|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 EQLFDDAPLYPPPIIPTCTTTPNGEVASP----------------MPDWS
Mflv_0776|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0053|M.smegmatis_MC2_155 --------------------------------------------------
Mb3890|M.bovis_AF2122/97 --------------------------------------------------
Rv3860|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5436|M.marinum_M --------------------------------------------------
MAV_0163|M.avium_104 --------------------------------------------------
MUL_4057|M.ulcerans_Agy99 LTVMGIFYLRLPATFGIGTYEVSADFVAGGGLYKNANVTYRGVAVGRVES
MAB_0630|M.abscessus_ATCC_1997 NQAPPAPPQGYGAPVQQPPQNYQPPPQNYYAPPQNYYGPPTDQPATPVAP
TH_0884|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 EQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAPPRSPAAS
Mflv_0776|M.gilvum_PYR-GCK -------------------MTDRE-----------------EPQ------
Mvan_0069|M.vanbaalenii_PYR-1 ------------------MVNDRD-----------------DPAT-----
MSMEG_0053|M.smegmatis_MC2_155 -------------------MADPDDTLRRELGWTGPEEDDFEPDTGPTRP
Mb3890|M.bovis_AF2122/97 -------------------MYERD--------------------------
Rv3860|M.tuberculosis_H37Rv -------------------MYERD--------------------------
MMAR_5436|M.marinum_M -------------------MNERE--------------------------
MAV_0163|M.avium_104 -------------------MNERD--------------------------
MUL_4057|M.ulcerans_Agy99 VGLNPNGVTAQMRLNSGTAIPSNVTATVKSMSAIG---------------
MAB_0630|M.abscessus_ATCC_1997 AEPAAPAVPPPAPATQLPAWPASAVVPEQPAPEAPAPARPAEQSPAPEGL
TH_0884|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 LMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATPMPMTP--
Mflv_0776|M.gilvum_PYR-GCK ---------------------------------RHDQERPGGMFR-----
Mvan_0069|M.vanbaalenii_PYR-1 ----------------------------DQAAVTPEPPRPREMFR-----
MSMEG_0053|M.smegmatis_MC2_155 TLRPEPPSIPGRPPVSPTPPNPVNPDAEDRVPADPDAERARTTFR-----
Mb3890|M.bovis_AF2122/97 ----------------------------EFLRDRIRPHQPGT--------
Rv3860|M.tuberculosis_H37Rv ----------------------------EFLRDRIRPHQPGT--------
MMAR_5436|M.marinum_M ----------------------------EFLRDRVRPDQPSVPDASRSHQ
MAV_0163|M.avium_104 ----------------------------EFLRDRLQPERPSAR-------
MUL_4057|M.ulcerans_Agy99 ----------------------------EQYIDLVPPDDPSAGRLHDG--
MAB_0630|M.abscessus_ATCC_1997 DEAAQEQTPVEVPPPAPPAPVAPDPAPQVRADDASAMIPEGLTPWGGRAP
TH_0884|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 -IDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRPSANQ
Mflv_0776|M.gilvum_PYR-GCK -------------------QPTQ--PPQDWT------PPTRPVPAPP---
Mvan_0069|M.vanbaalenii_PYR-1 -------------------QPTRPLPPQPRR------PDGWEQQQPP---
MSMEG_0053|M.smegmatis_MC2_155 -------------------EPTQPSPPQQPSQPPPPPPPSALHPRPDPWE
Mb3890|M.bovis_AF2122/97 ---------------------PRGYSPRPPSGDRCPAPPPGRHAAAA---
Rv3860|M.tuberculosis_H37Rv ---------------------PRGYSPRPPSGDRCPAPPPGRHAAAA---
MMAR_5436|M.marinum_M RSGMHRTATDASGPPVAPTHQPRPAPPRPPTPQPSPVPPRGANPHPP---
MAV_0163|M.avium_104 ---------------------PAPAPPPPPVASR-PAPPRPPTPAPT---
MUL_4057|M.ulcerans_Agy99 ----------------SRIERNNTRIGQDVADLLHQAETLVNSLGDTRLR
MAB_0630|M.abscessus_ATCC_1997 QMPSAPTSPAPSWAPPPAGPPLAPAPPAAFSRADWSAPAAPPRAPYVPGQ
TH_0884|M.thermoresistible__bu --------------------------------------------------
MLBr_00048|M.leprae_Br4923 HSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAEPAPT
Mflv_0776|M.gilvum_PYR-GCK ----------PGY-PPR--PPWPDRPYP----------------------
Mvan_0069|M.vanbaalenii_PYR-1 ----------PGW-APQ--APPSAPPYPPRP-------------------
MSMEG_0053|M.smegmatis_MC2_155 QR-------VPGWNAPQYGPPPGNQPWPQAGGFGG---------------
Mb3890|M.bovis_AF2122/97 ----------TPPGPPRLPSA-PLRPLPDP--------------------
Rv3860|M.tuberculosis_H37Rv ----------TPPGPPRLPSA-PLRPLPDP--------------------
MMAR_5436|M.marinum_M ----------PPPAPPSVPAP-PPPPVAHPPNGHNSP-------------
MAV_0163|M.avium_104 ----------PPTRPPAPPTFRPHPPAAAP--------------------
MUL_4057|M.ulcerans_Agy99 EVLHEAFVATNGSGPELARLVESARLLVDEAN------------------
MAB_0630|M.abscessus_ATCC_1997 TPFTAARPEAPVYRPVPQPQQPSRPQGPSHDQLGLIRSVKPLPKSGWRKA
TH_0884|M.thermoresistible__bu ---------------------------VDLSTTALLGQRRPAPSRGWRRW
MLBr_00048|M.leprae_Br4923 QHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKRGWRHW
Mflv_0776|M.gilvum_PYR-GCK -----------QADHP-VPPQP-STYTERIRPADLVPSRKPVPGHGWRLA
Mvan_0069|M.vanbaalenii_PYR-1 -----------QADAPWTAPQP-TSYAEWIRPADLVPHRKVVPGSGWRLA
MSMEG_0053|M.smegmatis_MC2_155 ----------GPGQPPHVPPGPPQSYADRIRASDLVPPKRQPPSGGWRLL
Mb3890|M.bovis_AF2122/97 ----------AWPRQ--PEAPPPSTWAD--PALAPIRSRTRPGERGWRRM
Rv3860|M.tuberculosis_H37Rv ----------AWPRQ--PEAPPPSTWAD--PALAPIRSRTRPGERGWRRM
MMAR_5436|M.marinum_M --------PQAAPHEPMPEVPPPSLWAE--PTPARTPGEPPSTDHGWRHI
MAV_0163|M.avium_104 -----------------APAAPPTPRPQ--PSGAPQLP-----DRGWRRA
MUL_4057|M.ulcerans_Agy99 ----------ADYPQVSQLIDQAGPFLQAQVRAGGDIKSLADGLARFTAE
:
MAB_0630|M.abscessus_ATCC_1997 VHRLSGGAINPGESS------EESHRSELIDRINLPVRGDYRIAVLSLKG
TH_0884|M.thermoresistible__bu LYRATFRTVNLGESP------KVARHNELLNRVRHPLQDCYRIAVLSLKG
MLBr_00048|M.leprae_Br4923 VHTVTR--INLGLSP------DERYELDLRTRVRRPPRGSYQIGILGLKG
Mflv_0776|M.gilvum_PYR-GCK LLKATFGLVNVGPSP------DERRAAALETAIRAPLRGHFKVGVMG-KG
Mvan_0069|M.vanbaalenii_PYR-1 LYKASFGLINLGPSP------EDKRVAELEATIRTPLRGRFKIGVMG-KG
MSMEG_0053|M.smegmatis_MC2_155 VYRATFGLVNPGPSA------EELRQAELEAKIRGVLRGHYKIGVMG-KG
Mb3890|M.bovis_AF2122/97 VRLVTFGLVGLGRSG------MQRQEAQFEATIRTVLHGNHKVAVLG-KG
Rv3860|M.tuberculosis_H37Rv VRLVTFGLVGLGRSG------MQRQEAQFEATIRTVLHGNHKVAVLG-KG
MMAR_5436|M.marinum_M IRVASFGLINPRPSA------AQRDAAEFEAAIRAPLRGTHKVGVLG-KG
MAV_0163|M.avium_104 LRLATFGLIDLGPSP------AQRREAQFEQAIQARLYGNYKVGVLG-KG
MUL_4057|M.ulcerans_Agy99 LRQADPGLRNTLATAPDAIDEANTAFSGIRPSFPALAANLANLGRVGVIY
: . : : . . .:. :.
MAB_0630|M.abscessus_ATCC_1997 GVGKTTTTFSLGATFASLR-GDRVIAVDANPDFGTLAQRGPDE-------
TH_0884|M.thermoresistible__bu GVGKTTITATLGSTFGSAR-GDRVVAVDANPDRGTLSQKVPLQ-------
MLBr_00048|M.leprae_Br4923 GAGKTTVTVTLGSMFARVR-NDRILVVDADTSCGNLADRAGRF-------
Mflv_0776|M.gilvum_PYR-GCK GVGKTTVSACIGSLFAELRHEDRVVAVDADTAFGKLGSRVDPR-------
Mvan_0069|M.vanbaalenii_PYR-1 GVGKTTVSASIGSVLAEIRQDDRVVAVDADTAFGKLGSRVDPR-------
MSMEG_0053|M.smegmatis_MC2_155 GVGKTTVSATIGSIFAHLRQDDRVVAIDADTSFGKLGSRVDPR-------
Mb3890|M.bovis_AF2122/97 GVGKTSVAACVGSILAELRQQDRIVGIDADTAFGRLSSRIDPR-------
Rv3860|M.tuberculosis_H37Rv GVGKTSVAACVGSILAELRQQDRIVGIDADTAFGRLSSRIDPR-------
MMAR_5436|M.marinum_M GVGKTSVAASIGSLLAELRQQDRIVAVDADTAFGRLSSRIDPT-------
MAV_0163|M.avium_104 GVGKTSVAASVGSLFAELRRQDHVVAIDADTAFGRLGSRIDPA-------
MUL_4057|M.ulcerans_Agy99 NKSIEQLLVVFPALFAAITTAAGGVPQDEGAKLDFKVDLNDPPPCNVGFL
. . . : :. : * .. . .
MAB_0630|M.abscessus_ATCC_1997 --------TRSTARDLLRDPD-IHRYSDVRRHTSQSASRLEVLASERDPA
TH_0884|M.thermoresistible__bu --------TRATVRDLLRDADRIQTYSDMRAYTSQSPSRLEVLASESDPA
MLBr_00048|M.leprae_Br4923 --------SEANIADLLADKD-VKSYNDIRTHTSVNAVNLEVLPAAEYST
Mflv_0776|M.gilvum_PYR-GCK --------ARRSFWELTADQY-LETFADIRNHLGSNAAGLFVLAGEASPA
Mvan_0069|M.vanbaalenii_PYR-1 --------AQGSFWELAADRH-LEAFADIRNHLGCNAAGLFVLAGEATPA
MSMEG_0053|M.smegmatis_MC2_155 --------AHGSYWELTSDKN-LETFADVRSRVGNNSAGLFVLAGESTPA
Mb3890|M.bovis_AF2122/97 --------AAGSFWELTTDTN-LRSFTDITARLGRNSAGLYVLAGQPASG
Rv3860|M.tuberculosis_H37Rv --------AAGSFWELTTDTN-LRSFTDITARLGRNSAGLYVLAGQPASG
MMAR_5436|M.marinum_M --------ARGSFWDLTADRN-LASFADVVARLGRNAAGLHVLPGEAAVG
MAV_0163|M.avium_104 --------STGSFWELTADQN-LRSFDDVVARLGRNAAGLHVLGGEPASG
MUL_4057|M.ulcerans_Agy99 PPPLIRSPADETLRELPPDMYCKVAQNDATTVRGARNYPCQEFPGKRAPT
: . :* * * . : .
MAB_0630|M.abscessus_ATCC_1997 ASELFSEADYLAVMRILQR----FYNIILTDCGTGLMHSAMAGVLGEAN-
TH_0884|M.thermoresistible__bu VSEAFSSDDYTRTLRVLER----FYSLVLTDCGTGLIHSAMSAVLANAD-
MLBr_00048|M.leprae_Br4923 AQHALSGEDWNFAAATVSK----YYNVMLADCGVGLFDPVTRGVLSTAS-
Mflv_0776|M.gilvum_PYR-GCK RRRVLDAAIYREAMARLDR----HFTITVVDCSSTMDSPVTEEVLRDLD-
Mvan_0069|M.vanbaalenii_PYR-1 RRRVLDPAIYREATTRLDR----HFTISVIDCSSTMDSPVTQEVLRDLD-
MSMEG_0053|M.smegmatis_MC2_155 RRRVLDAAIYREAVTRLDK----HFSISVVDCSSTMDSPVTQEVLRDLD-
Mb3890|M.bovis_AF2122/97 PRRALDPAIYREAALRLDH----HFAISVIDCGSSMEAAVTQEVLRDVD-
Rv3860|M.tuberculosis_H37Rv PRRVLDPAIYREAALRLDH----HFAISVIDCGSSMEAAVTQEVLRDVD-
MMAR_5436|M.marinum_M GRRLLDPAIYREAALRLDR----HFTISIIDCGSTMDAPLTQEVLRDLD-
MAV_0163|M.avium_104 PRRVLDPAIYREATRRLDR----HFTISVIDCGSTMDAPLTQEVLRDLD-
MUL_4057|M.ulcerans_Agy99 IQLCRDPKGYFPVGRNPWRGPPVPYDTPVTDGLNVLPPNKFPYIPPDSDP
. : . : : : * : : .
MAB_0630|M.abscessus_ATCC_1997 ----AIVLVTSPAIDGARSALATLDWLDHHGYSHLVRQSVVAISSSRPGA
TH_0884|M.thermoresistible__bu ----VLIVISSGSVDGARSAAATLDWLDAHGHQDMVRNSIAVINAVRPRS
MLBr_00048|M.leprae_Br4923 ----GVVIVTSTSVDAARQAAIALDWLRHNGYQDLLSRACVVINHVMPKE
Mflv_0776|M.gilvum_PYR-GCK ----ALVVVSSPWVDGAAAAGQTLDWLAARGMTTLLQHTVVVLNDSDGHA
Mvan_0069|M.vanbaalenii_PYR-1 ----ALVVVSSPWVDGAAAAGQTLDWLAARGLTDLLQRTVVVLNDSDGHA
MSMEG_0053|M.smegmatis_MC2_155 ----ALIVVSSPWVDGAATAGQTLDWLSANGMTRLLQRTVVVLNDSDGHA
Mb3890|M.bovis_AF2122/97 ----ALIVVSSPWADGASAAANTIEWLSDYGLTGLLRRSIVVLNDSDGHA
Rv3860|M.tuberculosis_H37Rv ----ALIVVSSPWADGASAAANTIEWLSDYGLTGLLRRSIVVLNDSDGHA
MMAR_5436|M.marinum_M ----ALIVVSSPWADGASAAAKTMEWLADRKLSGLLRRSVVVLNDSDGHS
MAV_0163|M.avium_104 ----ALIVVSSPWADGASAAARTLEWLADHGLTTLLAHSLVVLNDSDGHA
MUL_4057|M.ulcerans_Agy99 DPGTPIVGPPPPGVIPGPPPAPNQPAQPAPPPNDNGPPPPFTSWMPPDYP
:: .. . . . .
MAB_0630|M.abscessus_ATCC_1997 SSIDLEQLSRHFLTRAR--AVHIIPFDNHLSEGSEIS-LDLMGKKTRMAF
TH_0884|M.thermoresistible__bu GKVDLQKVVDHFSRRCR--AVKMVPFDPHLEEGAEID-LDQLKPQTRQAL
MLBr_00048|M.leprae_Br4923 PNIASKDLVQQFEQQIQPGRVVVLPWDKHIAAGTEIR-LDRLDPLYRRRI
Mflv_0776|M.gilvum_PYR-GCK DKRTRKVLAQQFSGHGQ--LVVEVPFDGHLRPGGVIDGTAQMSRPARRKL
Mvan_0069|M.vanbaalenii_PYR-1 DKRTRGILAQQFSGHGQ--LVIEVPFDGHLRPGGVIDGTGEMSPSARRKF
MSMEG_0053|M.smegmatis_MC2_155 DKRTRSILLNQFAGQGQ--AVVEIPFDGHLRPGGVVD-IQEMSPKVRRKF
Mb3890|M.bovis_AF2122/97 DKRTKSLLAQEFIDHGQ--PVVEVPFDPHLRPGGVIDMSHEMAPTTRLKI
Rv3860|M.tuberculosis_H37Rv DKRTKSLLAQEFIDHGQ--PVVEVPFDPHLRPGGVIDMSHEMAPTTRLKI
MMAR_5436|M.marinum_M DKRTRSVLAREFVDHGQ--QVVEVPFDPHLRPGGVIDVSHELEPGTRLKF
MAV_0163|M.avium_104 DKRTRALLAREFIDHGR--PVIEVPFDPHLRPGGVIDVNGEMAPATRRKF
MUL_4057|M.ulcerans_Agy99 PQAPQIPYPKTLPPPPPPVGVGPEPGPQPQASGPAYTTYDPLTGVFKDPA
. : * * * : :
MAB_0630|M.abscessus_ATCC_1997 MELAGSVADGFYEGGNTRQTSWG--------
TH_0884|M.thermoresistible__bu LELAAVVADGFPGAQQLQSPPF---------
MLBr_00048|M.leprae_Br4923 LELAAALSDDFERAGRH--------------
Mflv_0776|M.gilvum_PYR-GCK VEVCAALAAFYPTQDDRSRERR---------
Mvan_0069|M.vanbaalenii_PYR-1 IEVVAALAAFFPASVTRSG------------
MSMEG_0053|M.smegmatis_MC2_155 LEVAAALADHFPTSDDHTRERS---------
Mb3890|M.bovis_AF2122/97 LQVAATVTAYFASRPADAHGSPPR-------
Rv3860|M.tuberculosis_H37Rv LQVAATVTAYFASRPADAHGSPPR-------
MMAR_5436|M.marinum_M LQIAATITGHFAARSAADDDPRPTENVASET
MAV_0163|M.avium_104 LEVTATIAGYFARRPDRSADRHPPQH-----
MUL_4057|M.ulcerans_Agy99 GGAGIFVGGISGASSAENWVDLMLAPRTM--
: