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MAARGLLLNPNHFDPAWLDPESRRLLRALIDWFEQRGKARLLRDDLDGVWVADFLEFVKKERLFATFLTP SEFAEGDPNKRWDTARNAVLSEILGFYGLSYWYAEQVTILGLGPIWQSDNVKARERAAAQLEAGEVMAFG LSERAHGADIYNTDMLLTPASPGADDPVVFRASGEKYYIGNGNVAGMVSVFGRRTDVEGADGYVWFVADS RHPDYELIGNVVHGQMFVSNFALRDYPVYEEDILATGQDAFSAALNTVNVGKFNLCSGSIGMCEHAFYEA ITHANNRILYGNPVTDFPHVRATFVDAYARLIAMKLFSDRAIDYFRSAGPHDRRYLLFNPVTKSKVTSEG EKVVTLLWDVLAAKGFEKDTYFYQVTRLIGALPRLEGTVHVNVAQILKFMPNYMFNPAEYPPIGTRDDPA DDVFFWSQGPARGASKVRFADWAPVYERHAGIPNVGRFYEQVQAFKQLLTVSAPDADQQADLDFVLVVGH LFSLVVYGQLILEQAEITGLDRDVLDQIFDVAVRDFSAYAVALHGKPSSTAAQQDWALSAVRKPEPDSGR FDRVWEQVRGYDGVYTMRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0398 | - | - | 100% (579) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4601 | - | 1e-06 | 21.81% (243) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4558 | - | 3e-06 | 23.04% (191) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0236 | fadE4 | 0.0 | 56.08% (576) | acyl-CoA dehydrogenase FADE4 |
| M. tuberculosis H37Rv | Rv0231 | fadE4 | 0.0 | 56.08% (576) | acyl-CoA dehydrogenase FADE4 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3481 | - | 0.0 | 57.17% (572) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_0488 | fadE4 | 0.0 | 55.73% (576) | acyl-CoA dehydrogenase FadE4 |
| M. avium 104 | MAV_4939 | - | 0.0 | 55.73% (576) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4826 | - | 5e-07 | 25.15% (330) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 3e-06 | 22.84% (324) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_1151 | fadE4 | 0.0 | 55.73% (576) | acyl-CoA dehydrogenase FadE4 |
| M. vanbaalenii PYR-1 | Mvan_0281 | - | 0.0 | 86.15% (585) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0398|M.gilvum_PYR-GCK ------------MAARGLLLNPNHFDPAWLDPESRRLLRALIDWFEQRGK
Mvan_0281|M.vanbaalenii_PYR-1 ------------MPETPLLLDPNNFDPKRLDPESRRLLAALIDWFEQRGK
Mb0236|M.bovis_AF2122/97 -----------------MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGK
Rv0231|M.tuberculosis_H37Rv -----------------MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGK
MMAR_0488|M.marinum_M -----------------MLLNPNRLQRKYPDARSAEIMAATVDFFESRGK
MUL_1151|M.ulcerans_Agy99 -----------------MLLNPNRLQRKYPDARSAEIMAATVDFFESRGK
MAV_4939|M.avium_104 -----------------MLLNPNHLQRRYPDRRSAEIMAATVDFFESRGK
MAB_3481|M.abscessus_ATCC_1997 ------MSQDTNAAPKTELLHPTADDFAEFDGETRRLLKATVDWFEERGK
MSMEG_4826|M.smegmatis_MC2_155 -------------MAWDFETDPQYQEVLDWADEFVREKVEPLDLVWPHLQ
TH_3736|M.thermoresistible__bu MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
. . : .
Mflv_0398|M.gilvum_PYR-GCK ARLLRDDLDGVWVADFLEFVKKERLFATFLTPSEFAEGDPNKRWDTARNA
Mvan_0281|M.vanbaalenii_PYR-1 VRLLRDDLNAEWVTDFLDFVRRERLFATFLTPSEFANGDPNKRWDTSRNA
Mb0236|M.bovis_AF2122/97 ARLKHDDHERIWYSDFLDFVGRERIFASLLTPASYGADD--CRWDTYRIS
Rv0231|M.tuberculosis_H37Rv ARLKHDDHERIWYSDFLDFVGRERIFASLLTPASYGADD--CRWDTYRIS
MMAR_0488|M.marinum_M ARLKRDDHDRAWYSDFLNHIAEHRIFASLLTPSEYGADD--CRWDTYRIS
MUL_1151|M.ulcerans_Agy99 ARLKRDDHDRAWYSDFLNHIAEHRIFASLLTPSEYGADD--CRWDTYRIS
MAV_4939|M.avium_104 ARLKSDDHERVWYSDFLEHIGRERIFASLLTPTRYGSAD--CRWDTYRIS
MAB_3481|M.abscessus_ATCC_1997 TRLLQDYVDKVFYQDFLDFAGREKLFATFLTPAADGAGNTEKRWDTARVA
MSMEG_4826|M.smegmatis_MC2_155 FTPLN-EARRQVVDPLKEQVRRKGLWATHLGPELGGQGYG-----QLKLA
TH_3736|M.thermoresistible__bu PRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGGLGLD-----LAQDV
: : . ::. : . :
Mflv_0398|M.gilvum_PYR-GCK VLSEILGFYGLS-YWYAEQVTILGLGPIWQSDNVKARER--AAAQLEAGE
Mvan_0281|M.vanbaalenii_PYR-1 VLSEILGFYGLS-YWYAEQVTILGLGPIWQSGNVKAKER--AAEQLEAGG
Mb0236|M.bovis_AF2122/97 EFAEIMGFYGLS-YWYPFQVTALGLGPIWMSANEDAKRK--AAAGLEAGE
Rv0231|M.tuberculosis_H37Rv EFAEIMGFYGLS-YWYPFQVTALGLGPIWMSANEDAKRK--AAAGLEAGE
MMAR_0488|M.marinum_M EFAEIIGFYGLS-YWYPFQVTALGLGPIWMSDNEDAKRK--AAAQLEQGE
MUL_1151|M.ulcerans_Agy99 EFAEIIGFYGLS-YWYPFQVTALGLGPIWMSDNEDAKRK--AAAQLEQGE
MAV_4939|M.avium_104 GFAEILGFYGLN-YWYPFQVTALGLGPIWMSGNDEAKRK--AAGLLEAGE
MAB_3481|M.abscessus_ATCC_1997 KLSEILGFYGLN-YWYPWQVTVLGLGPVWQSANTDPRKR--AADLLDGGA
MSMEG_4826|M.smegmatis_MC2_155 LLNEILGRSQWAPIVFGCQAPDTGNAEIIAHYGTDEQKERYLRPLLEGEL
TH_3736|M.thermoresistible__bu ELAMELGYTSLA-LRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEV
: :* . . : . . :. .
Mflv_0398|M.gilvum_PYR-GCK VMAFGLSERAHGADIYNTDMLLTPASP-----------GADDPVVFRASG
Mvan_0281|M.vanbaalenii_PYR-1 VMAFGLSERDHGADIYNTDMLLTPAGDERSREEQTTADGDDDGVLFRASG
Mb0236|M.bovis_AF2122/97 VFAFGLSEQTHGADVYQTDMILTPS-DGG----------------WTANG
Rv0231|M.tuberculosis_H37Rv VFAFGLSEQTHGADVYQTDMILTPS-DGG----------------WTANG
MMAR_0488|M.marinum_M VFAFGLSEQAHGADVYQTDMILTPS-EHG----------------WTASG
MUL_1151|M.ulcerans_Agy99 VFAFGLSEQAHGADVYQTDMILTPS-EHG----------------WTASG
MAV_4939|M.avium_104 VFAFGLSEQTHGADVYQTDMNLTPAPGGG----------------WTAAG
MAB_3481|M.abscessus_ATCC_1997 VAAFGLSEQAHGADIYSSDLVLTPVDSSE-------------GGGYKASG
MSMEG_4826|M.smegmatis_MC2_155 FSSYSMTEPHAGADPTLFTTRAVRDGDD-----------------WVING
TH_3736|M.thermoresistible__bu VASFALTEPGAGSNPAGLRSRAVRDGSGAD-------------ADWIING
. ::.::* *:: . : *
Mflv_0398|M.gilvum_PYR-GCK EKYYIGNGNVAGMVSVFGRRT-DVEGADGYVWFVADSRHPDYEL-IGNV-
Mvan_0281|M.vanbaalenii_PYR-1 EKYYIGNGNVAGMVSVFARRT-DVEGADGYVWFVADSGHERYEL-IGNV-
Mb0236|M.bovis_AF2122/97 EKYYIGNANVARMVSTFGKIA-GTPESQEYVFFVADSQHERYDL-IKNV-
Rv0231|M.tuberculosis_H37Rv EKYYIGNANVARMVSTFGKIA-GTPESQEYVFFVADSQHERYDL-IKNV-
MMAR_0488|M.marinum_M EKYYIGNANVARMVSTFGKIE-DSSKEPEYVFFAADSQHDRYEL-KKNV-
MUL_1151|M.ulcerans_Agy99 EKYYIGNANVARMVSTFGKIE-DSSKEPEYVFFAADSQHDRYEL-KKNV-
MAV_4939|M.avium_104 QKYYIGNANVARMVSTFGKFA-GGATDSEYVFFAADSRHERYRL-IKNV-
MAB_3481|M.abscessus_ATCC_1997 RKYYIGNGNCARIVSVFGRVQ-GRDGLDQYVFFLADSEHPNYRV-IKNV-
MSMEG_4826|M.smegmatis_MC2_155 WKFFSSNAATASFLIVMVVTNPDVSAYQGMSMFLVPTDTPGVEI-VRNVG
TH_3736|M.thermoresistible__bu QKRFITNAPVADLFVVFARSRPADERGAGIAVFLVPADAPGVEVGAKDAK
* : *. * :. .: * . : : :.
Mflv_0398|M.gilvum_PYR-GCK -VHGQMFVSNFALRDYP---VYEEDILATG-QDAFSAALNTVNVGKFNLC
Mvan_0281|M.vanbaalenii_PYR-1 -VHGQMFVSNFALHDYP---VHEEDILATG-PDAFSAALNTVNVGKFNLC
Mb0236|M.bovis_AF2122/97 -VNSQNYVANYALRDYP---VTEADILHRG-AEAFHAALNTVNVCKYNLG
Rv0231|M.tuberculosis_H37Rv -VNSQNYVANYALRDYP---VTEADILHRG-AEAFHAALNTVNVCKYNLG
MMAR_0488|M.marinum_M -VNSQNYVANYALHDYP---VTEADLLHRG-MGAFHAALNTVNVCKYNLG
MUL_1151|M.ulcerans_Agy99 -VNSQNYVANYALHDYP---VTEADLLHRG-MGAFHAALNTVNVCKYNLG
MAV_4939|M.avium_104 -VNSQNYVGNFALSDYP---VTEADILHRG-PEAFHAALNTVNVCKYNLG
MAB_3481|M.abscessus_ATCC_1997 -VPSQMYVAEFELDEYP---VSEDDILHVG-ADAFSAALNTVNIGKFNLC
MSMEG_4826|M.smegmatis_MC2_155 LYGERDNEGSHALIHYDNVRVPAEALLGGE-GQAFVIAQTRLGGGRIHHA
TH_3736|M.thermoresistible__bu MGQEGAWTADVTFTDVR---VPASALVGGEEDIGYRAAMTSLARGRVHIA
.. : . * :: .: * . : : :
Mflv_0398|M.gilvum_PYR-GCK SGSIGMCEHAFYEAITHANNRILYGNPVTDFPHVRATFVDAYARLIAMKL
Mvan_0281|M.vanbaalenii_PYR-1 SGSIGMCEHAFYEAINHANNRILYGNPVTAFPHVRAGFVDAYTRLIAMKL
Mb0236|M.bovis_AF2122/97 WGAIGMCTHALYESVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKL
Rv0231|M.tuberculosis_H37Rv WGAIGMCTHALYESVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKL
MMAR_0488|M.marinum_M WGAVGMCTHAFYEAITHAANRHLYGTVVTDFSHVRRLLTDAYARLVAMRL
MUL_1151|M.ulcerans_Agy99 WGAVGMCTHAFYEAITHAANRHLYGTVVTDFSHVRRLLTDAYARLVAMRL
MAV_4939|M.avium_104 WGAVGMCTHAMYEAVTHASNRILYGTVVTDFSHVRRLLIDAYARLVAMRL
MAB_3481|M.abscessus_ATCC_1997 FGGIGLSTHAFYESITHAHNRILYGNPVTKFDHVRREFVDAYARLLAMKL
MSMEG_4826|M.smegmatis_MC2_155 MRTIGLARKALDMMCERALSRKTQGSRLSDKQFVQGYIADSYAQLLQFRL
TH_3736|M.thermoresistible__bu ALAVGTAQRALDESVAYAASATQGGTPIGQFQLVQAMLADQQTGVMAGRA
:* . :*: * . *. : *: : * . :: :
Mflv_0398|M.gilvum_PYR-GCK FSDRAIDYFRSAGPHDRRYLLFNPVTKSKVTSEGEKVVTLLWDVLAAKGF
Mvan_0281|M.vanbaalenii_PYR-1 FSDRAIDYFRSAGPDDRRYLLFNPVTKSKVTSEGEKVVTLLWDVLAAKGF
Mb0236|M.bovis_AF2122/97 VASRASDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGV
Rv0231|M.tuberculosis_H37Rv VASRASDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGV
MMAR_0488|M.marinum_M VASRASDYMRSASAEDRRYLLYSPLTKAKVTSEGERVIAALWDVIAAKGV
MUL_1151|M.ulcerans_Agy99 VASRASDYMRSASAEDRRYLLYSPLTKAKVTSEGERVIAALWDVIAAKGV
MAV_4939|M.avium_104 VATRACDYMRSASATDRRYLLYSPLTKAKITGEGERVITALWDVIAAKGV
MAB_3481|M.abscessus_ATCC_1997 FSERAVDYFRTASADDRRYLLFNPVTKMKATTEAEKVLALLADVMSAKAF
MSMEG_4826|M.smegmatis_MC2_155 MV-----------------------------------------LYTAWEI
TH_3736|M.thermoresistible__bu LVR-----------------------------------------DAARKW
. :*
Mflv_0398|M.gilvum_PYR-GCK EKDTYFYQVTRLIGALPRLEGTVHVNVAQILKFMPNYMFNP-AEYPPIGT
Mvan_0281|M.vanbaalenii_PYR-1 EKNTYFYQVTRLIGALPRLEGTVHVNVAQILKFMPNFMFNP-APYPEIGT
Mb0236|M.bovis_AF2122/97 EKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPR
Rv0231|M.tuberculosis_H37Rv EKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPR
MMAR_0488|M.marinum_M EKDTFFETVAREIGLLPRLEGTVHINIGLLAKFMPNFLFVPDAALPLIPR
MUL_1151|M.ulcerans_Agy99 EKDTFFETVAREIGLLPRLEGTVHINIGLLAKFMPNFLFAPDAALPLIPR
MAV_4939|M.avium_104 EKDTIFEAMTREIGLLPRLEGTVHINIGLLGKFMPNYLFAPSGELPVIGR
MAB_3481|M.abscessus_ATCC_1997 EAESYTTAARIDVAGLPKLEGTVAVNLALILKFMPAYLHDA-QDLPVPGV
MSMEG_4826|M.smegmatis_MC2_155 DKYNDYKLVRKDIAAVKVVMPTVLHDIAWRAMQVHGALGVT-NEMPFLG-
TH_3736|M.thermoresistible__bu VSGEDRRVAPSAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVER-----
. ::. :
Mflv_0398|M.gilvum_PYR-GCK RDDPADDVFFWSQGPARGASKVRFADWAPVYERHAGIPNVGRFYEQVQAF
Mvan_0281|M.vanbaalenii_PYR-1 RDDPADDVFFWSQGPARGASKVRFADWAPVYERNTGIPNVAVFYQQVQAF
Mb0236|M.bovis_AF2122/97 RDDAADDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVF
Rv0231|M.tuberculosis_H37Rv RDDAADDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVF
MMAR_0488|M.marinum_M RDDAADDTFLFNQGPTGGLGKVRFHDWRAPFDSYGHLPNVALLREQIDVL
MUL_1151|M.ulcerans_Agy99 RDDAADDTFLFNQGPTGGLGKVRFHDWRAPFGSYGHLPNVALLREQIDVL
MAV_4939|M.avium_104 RDDAADDEFLFAQGPTGGLGKVRFGDWRAPFDGFAHLPNVALLRAQIDVL
MAB_3481|M.abscessus_ATCC_1997 QLQPGDDEFLFDQGPASGLGKVRFHDWRKPFADNADIPNVAAFTQRAEAL
MSMEG_4826|M.smegmatis_MC2_155 -MVTGAAVMGLADGPTEVHKTTVAKQVLRDYQPTEDTWPTEWIPRKREAA
TH_3736|M.thermoresistible__bu -IYRDVRLLRLYEGTSEIQRLIIGGGLVKAAQRQTN--------------
: :*.:
Mflv_0398|M.gilvum_PYR-GCK KQLLTVSAPDADQQADLDFVLVVGHLFSLVVYGQLILEQAEITGLDRDVL
Mvan_0281|M.vanbaalenii_PYR-1 KDLLATAAPDADQQRDLDFVLVVGHLFTLVVYGQLILEQAELTGLESDLV
Mb0236|M.bovis_AF2122/97 AELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALI
Rv0231|M.tuberculosis_H37Rv AELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALI
MMAR_0488|M.marinum_M TEMLAGATPDASQQKDIDFAFGVGQIFALVPYAQLILEEAPLSGVDDALL
MUL_1151|M.ulcerans_Agy99 TEMLAGATPDASQQKDIDFAFGVGQIFALVPYAQLILEEAPLSGVDDALL
MAV_4939|M.avium_104 AEMLASATPDAVQQKDIDFAFAVGQLFATVPYAQLILEEATLSGVDDALI
MAB_3481|M.abscessus_ATCC_1997 ATLVANER-DAIKNAGLDLQLSIGELFTLVVYGGLILEQAQLRGTDSALI
MSMEG_4826|M.smegmatis_MC2_155 RAKLADYLENEVGNL-----------------------------------
TH_3736|M.thermoresistible__bu --------------------------------------------------
Mflv_0398|M.gilvum_PYR-GCK DQIFDVAVRDFSAYAVALHGKPSSTAAQQDWALSAVRKPEPDSGRFDRVW
Mvan_0281|M.vanbaalenii_PYR-1 DQIFDVQIRDFSAYAVALHGKPSSTLEQQEWALSAVRKPTVDAVRFDRVW
Mb0236|M.bovis_AF2122/97 DEIFGVLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIW
Rv0231|M.tuberculosis_H37Rv DEIFGVLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIW
MMAR_0488|M.marinum_M DEIFGLLVRDFNSYAVELNDKAATTDQQAQFAMRMIRRPAHDAARYDQVW
MUL_1151|M.ulcerans_Agy99 DEIFGLLVRDFNSYAVELNDKAATTDQQAQFAMRMIRRPAHDAARYDQVW
MAV_4939|M.avium_104 DEIFGVLVRDFNAYAVELSDKPATTEQQARFAMRMIRRPVHDPARYDQIW
MAB_3481|M.abscessus_ATCC_1997 DQIFEFLNRDFSVYAVDLLGKREATASQRQWAKAVISEPVFNSERFDEIW
MSMEG_4826|M.smegmatis_MC2_155 --------------------------------------------------
TH_3736|M.thermoresistible__bu --------------------------------------------------
Mflv_0398|M.gilvum_PYR-GCK -EQVRGYDGVYTMRP
Mvan_0281|M.vanbaalenii_PYR-1 -DQVRSYDGAYEMRP
Mb0236|M.bovis_AF2122/97 KDHVLALNGAYQMAP
Rv0231|M.tuberculosis_H37Rv KDHVLALNGAYQMAP
MMAR_0488|M.marinum_M KEHVLPLNGAYEMRP
MUL_1151|M.ulcerans_Agy99 KEHVLPLNGAYEMRP
MAV_4939|M.avium_104 KEQVLPLSGAYQMRP
MAB_3481|M.abscessus_ATCC_1997 -NRVEALSGAYEMRA
MSMEG_4826|M.smegmatis_MC2_155 ---------------
TH_3736|M.thermoresistible__bu ---------------