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PETPLLLDPNNFDPKRLDPESRRLLAALIDWFEQRGKVRLLRDDLNAEWVTDFLDFVRRERLFATFLTPS EFANGDPNKRWDTSRNAVLSEILGFYGLSYWYAEQVTILGLGPIWQSGNVKAKERAAEQLEAGGVMAFGL SERDHGADIYNTDMLLTPAGDERSREEQTTADGDDDGVLFRASGEKYYIGNGNVAGMVSVFARRTDVEGA DGYVWFVADSGHERYELIGNVVHGQMFVSNFALHDYPVHEEDILATGPDAFSAALNTVNVGKFNLCSGSI GMCEHAFYEAINHANNRILYGNPVTAFPHVRAGFVDAYTRLIAMKLFSDRAIDYFRSAGPDDRRYLLFNP VTKSKVTSEGEKVVTLLWDVLAAKGFEKNTYFYQVTRLIGALPRLEGTVHVNVAQILKFMPNFMFNPAPY PEIGTRDDPADDVFFWSQGPARGASKVRFADWAPVYERNTGIPNVAVFYQQVQAFKDLLATAAPDADQQR DLDFVLVVGHLFTLVVYGQLILEQAELTGLESDLVDQIFDVQIRDFSAYAVALHGKPSSTLEQQEWALSA VRKPTVDAVRFDRVWDQVRSYDGAYEMRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0281 | - | - | 100% (590) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4587 | - | 1e-05 | 22.46% (276) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1719 | - | 1e-05 | 21.79% (335) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0236 | fadE4 | 1e-180 | 55.03% (587) | acyl-CoA dehydrogenase FADE4 |
| M. gilvum PYR-GCK | Mflv_0398 | - | 0.0 | 86.15% (585) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0231 | fadE4 | 1e-180 | 55.03% (587) | acyl-CoA dehydrogenase FADE4 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-06 | 24.17% (240) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3481 | - | 0.0 | 55.75% (583) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_0488 | fadE4 | 1e-178 | 54.17% (587) | acyl-CoA dehydrogenase FadE4 |
| M. avium 104 | MAV_4939 | - | 1e-179 | 53.83% (587) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1821 | - | 2e-07 | 23.28% (335) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 7e-07 | 24.74% (291) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_1151 | fadE4 | 1e-178 | 54.17% (587) | acyl-CoA dehydrogenase FadE4 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0281|M.vanbaalenii_PYR-1 -----------MPETPLLLDPNNFDPKRLDPESRRLLAALIDWFEQRGKV
Mflv_0398|M.gilvum_PYR-GCK -----------MAARGLLLNPNHFDPAWLDPESRRLLRALIDWFEQRGKA
MAB_3481|M.abscessus_ATCC_1997 -----MSQDTNAAPKTELLHPTADDFAEFDGETRRLLKATVDWFEERGKT
Mb0236|M.bovis_AF2122/97 ----------------MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKA
Rv0231|M.tuberculosis_H37Rv ----------------MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKA
MAV_4939|M.avium_104 ----------------MLLNPNHLQRRYPDRRSAEIMAATVDFFESRGKA
MMAR_0488|M.marinum_M ----------------MLLNPNRLQRKYPDARSAEIMAATVDFFESRGKA
MUL_1151|M.ulcerans_Agy99 ----------------MLLNPNRLQRKYPDARSAEIMAATVDFFESRGKA
MLBr_00737|M.leprae_Br4923 ---------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA
MSMEG_1821|M.smegmatis_MC2_155 ---------------MAAWGGNPSFDLFQLPEEHQELRAAIRALAEKEIA
TH_3736|M.thermoresistible__bu MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
. . . : : .
Mvan_0281|M.vanbaalenii_PYR-1 RLLRDDLNAEWVTDFLDFVRRERLFATFLTPSEFANGDPNKRWDTSRNAV
Mflv_0398|M.gilvum_PYR-GCK RLLRDDLDGVWVADFLEFVKKERLFATFLTPSEFAEGDPNKRWDTARNAV
MAB_3481|M.abscessus_ATCC_1997 RLLQDYVDKVFYQDFLDFAGREKLFATFLTPAADGAGNTEKRWDTARVAK
Mb0236|M.bovis_AF2122/97 RLKHDDHERIWYSDFLDFVGRERIFASLLTPASYGADD--CRWDTYRISE
Rv0231|M.tuberculosis_H37Rv RLKHDDHERIWYSDFLDFVGRERIFASLLTPASYGADD--CRWDTYRISE
MAV_4939|M.avium_104 RLKSDDHERVWYSDFLEHIGRERIFASLLTPTRYGSAD--CRWDTYRISG
MMAR_0488|M.marinum_M RLKRDDHDRAWYSDFLNHIAEHRIFASLLTPSEYGADD--CRWDTYRISE
MUL_1151|M.ulcerans_Agy99 RLKRDDHDRAWYSDFLNHIAEHRIFASLLTPSEYGADD--CRWDTYRISE
MLBr_00737|M.leprae_Br4923 PHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQG----ADSVAACI
MSMEG_1821|M.smegmatis_MC2_155 PHAADVDENARFPQEALDALNASGFNAVHVPEEYGGQG----ADSVAACI
TH_3736|M.thermoresistible__bu PRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGGLG----LDLAQDVE
: : : . : * . . *
Mvan_0281|M.vanbaalenii_PYR-1 LSEILGFYGLSYWYAEQVT--ILGLGPIWQSGNVKAKERAAEQLEAGGVM
Mflv_0398|M.gilvum_PYR-GCK LSEILGFYGLSYWYAEQVT--ILGLGPIWQSDNVKARERAAAQLEAGEVM
MAB_3481|M.abscessus_ATCC_1997 LSEILGFYGLNYWYPWQVT--VLGLGPVWQSANTDPRKRAADLLDGGAVA
Mb0236|M.bovis_AF2122/97 FAEIMGFYGLSYWYPFQVT--ALGLGPIWMSANEDAKRKAAAGLEAGEVF
Rv0231|M.tuberculosis_H37Rv FAEIMGFYGLSYWYPFQVT--ALGLGPIWMSANEDAKRKAAAGLEAGEVF
MAV_4939|M.avium_104 FAEILGFYGLNYWYPFQVT--ALGLGPIWMSGNDEAKRKAAGLLEAGEVF
MMAR_0488|M.marinum_M FAEIIGFYGLSYWYPFQVT--ALGLGPIWMSDNEDAKRKAAAQLEQGEVF
MUL_1151|M.ulcerans_Agy99 FAEIIGFYGLSYWYPFQVT--ALGLGPIWMSDNEDAKRKAAAQLEQGEVF
MLBr_00737|M.leprae_Br4923 VIEEVARVDASASLIPAVN-KLGTMGLILRGSEELKKQVLPSLAAEGAMA
MSMEG_1821|M.smegmatis_MC2_155 VIEEVARVDASASLIPAVN-KLGTMGLILRGSDELKKQVLPQLASGAAMA
TH_3736|M.thermoresistible__bu LAMELGYTSLALRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEVVA
. :. . .. : . : . :
Mvan_0281|M.vanbaalenii_PYR-1 AFGLSERDHGADIYNTDMLLTPAGDERSREEQTTADGDDDGVLFRASGEK
Mflv_0398|M.gilvum_PYR-GCK AFGLSERAHGADIYNTDMLLTPASP-----------GADDPVVFRASGEK
MAB_3481|M.abscessus_ATCC_1997 AFGLSEQAHGADIYSSDLVLTPVDS-------------SEGGGYKASGRK
Mb0236|M.bovis_AF2122/97 AFGLSEQTHGADVYQTDMILTPS-----------------DGGWTANGEK
Rv0231|M.tuberculosis_H37Rv AFGLSEQTHGADVYQTDMILTPS-----------------DGGWTANGEK
MAV_4939|M.avium_104 AFGLSEQTHGADVYQTDMNLTPAP----------------GGGWTAAGQK
MMAR_0488|M.marinum_M AFGLSEQAHGADVYQTDMILTPS-----------------EHGWTASGEK
MUL_1151|M.ulcerans_Agy99 AFGLSEQAHGADVYQTDMILTPS-----------------EHGWTASGEK
MLBr_00737|M.leprae_Br4923 SYALSEREAGSDAASMRTRAKADGD-----------------DWILNGFK
MSMEG_1821|M.smegmatis_MC2_155 SYALSEREAGSDAASMRTRARADGD-----------------DWVLNGTK
TH_3736|M.thermoresistible__bu SFALTEPGAGSNPAGLRSRAVRDGSG-------------ADADWIINGQK
::.*:* *:: : * *
Mvan_0281|M.vanbaalenii_PYR-1 YYIGNGNVAGMVSVFARRTD-VEGADGYVWFVADSGHERYELIGN---VV
Mflv_0398|M.gilvum_PYR-GCK YYIGNGNVAGMVSVFGRRTD-VEGADGYVWFVADSRHPDYELIGN---VV
MAB_3481|M.abscessus_ATCC_1997 YYIGNGNCARIVSVFGRVQG-RDGLDQYVFFLADSEHPNYRVIKN---VV
Mb0236|M.bovis_AF2122/97 YYIGNANVARMVSTFGKIAG-TPESQEYVFFVADSQHERYDLIKN---VV
Rv0231|M.tuberculosis_H37Rv YYIGNANVARMVSTFGKIAG-TPESQEYVFFVADSQHERYDLIKN---VV
MAV_4939|M.avium_104 YYIGNANVARMVSTFGKFAG-GATDSEYVFFAADSRHERYRLIKN---VV
MMAR_0488|M.marinum_M YYIGNANVARMVSTFGKIED-SSKEPEYVFFAADSQHDRYELKKN---VV
MUL_1151|M.ulcerans_Agy99 YYIGNANVARMVSTFGKIED-SSKEPEYVFFAADSQHDRYELKKN---VV
MLBr_00737|M.leprae_Br4923 CWITNGGKSTWYTVMAVTDP-DKGANGISAFIVHKDDEGFSIGPKEKKLG
MSMEG_1821|M.smegmatis_MC2_155 CWITNGGKSSWYTVMAVTDP-DKGANGISAFMVHQDDEGFSVGPKERKLG
TH_3736|M.thermoresistible__bu RFITNAPVADLFVVFARSRPADERGAGIAVFLVPADAPGVEVGAKDAKMG
:* *. : .:. * . : : :
Mvan_0281|M.vanbaalenii_PYR-1 HGQMFVSNFALHDYPVHEEDILA-TGPDAFSAALNTVNVGKFNLCSGSIG
Mflv_0398|M.gilvum_PYR-GCK HGQMFVSNFALRDYPVYEEDILA-TGQDAFSAALNTVNVGKFNLCSGSIG
MAB_3481|M.abscessus_ATCC_1997 PSQMYVAEFELDEYPVSEDDILH-VGADAFSAALNTVNIGKFNLCFGGIG
Mb0236|M.bovis_AF2122/97 NSQNYVANYALRDYPVTEADILH-RGAEAFHAALNTVNVCKYNLGWGAIG
Rv0231|M.tuberculosis_H37Rv NSQNYVANYALRDYPVTEADILH-RGAEAFHAALNTVNVCKYNLGWGAIG
MAV_4939|M.avium_104 NSQNYVGNFALSDYPVTEADILH-RGPEAFHAALNTVNVCKYNLGWGAVG
MMAR_0488|M.marinum_M NSQNYVANYALHDYPVTEADLLH-RGMGAFHAALNTVNVCKYNLGWGAVG
MUL_1151|M.ulcerans_Agy99 NSQNYVANYALHDYPVTEADLLH-RGMGAFHAALNTVNVCKYNLGWGAVG
MLBr_00737|M.leprae_Br4923 IKGSPTTELYFDKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVG
MSMEG_1821|M.smegmatis_MC2_155 IKGSPTTELYFENCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVG
TH_3736|M.thermoresistible__bu QEGAWTADVTFTDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAALAVG
. : : . : :: .: :*: :: : : .:*
Mvan_0281|M.vanbaalenii_PYR-1 MCEHAFYEAINHANNRILYGNPVTAFPHVRAGFVDAYTRLIAMKLFSDRA
Mflv_0398|M.gilvum_PYR-GCK MCEHAFYEAITHANNRILYGNPVTDFPHVRATFVDAYARLIAMKLFSDRA
MAB_3481|M.abscessus_ATCC_1997 LSTHAFYESITHAHNRILYGNPVTKFDHVRREFVDAYARLLAMKLFSERA
Mb0236|M.bovis_AF2122/97 MCTHALYESVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKLVASRA
Rv0231|M.tuberculosis_H37Rv MCTHALYESVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKLVASRA
MAV_4939|M.avium_104 MCTHAMYEAVTHASNRILYGTVVTDFSHVRRLLIDAYARLVAMRLVATRA
MMAR_0488|M.marinum_M MCTHAFYEAITHAANRHLYGTVVTDFSHVRRLLTDAYARLVAMRLVASRA
MUL_1151|M.ulcerans_Agy99 MCTHAFYEAITHAANRHLYGTVVTDFSHVRRLLTDAYARLVAMRLVASRA
MLBr_00737|M.leprae_Br4923 IAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAA
MSMEG_1821|M.smegmatis_MC2_155 IAQGALDAAIAYTKDRKQFGTSISDFQAVQFMLADMAMKVESARLMVYHA
TH_3736|M.thermoresistible__bu TAQRALDESVAYAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDA
. *: :: :: . * : * :: : * : : : . *
Mvan_0281|M.vanbaalenii_PYR-1 IDYFRSAGPDDRRYLLFNPVTKSKVTSEGEKVVTLLWDVLAAKGFEKNTY
Mflv_0398|M.gilvum_PYR-GCK IDYFRSAGPHDRRYLLFNPVTKSKVTSEGEKVVTLLWDVLAAKGFEKDTY
MAB_3481|M.abscessus_ATCC_1997 VDYFRTASADDRRYLLFNPVTKMKATTEAEKVLALLADVMSAKAFEAESY
Mb0236|M.bovis_AF2122/97 SDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGVEKDTF
Rv0231|M.tuberculosis_H37Rv SDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGVEKDTF
MAV_4939|M.avium_104 CDYMRSASATDRRYLLYSPLTKAKITGEGERVITALWDVIAAKGVEKDTI
MMAR_0488|M.marinum_M SDYMRSASAEDRRYLLYSPLTKAKVTSEGERVIAALWDVIAAKGVEKDTF
MUL_1151|M.ulcerans_Agy99 SDYMRSASAEDRRYLLYSPLTKAKVTSEGERVIAALWDVIAAKGVEKDTF
MLBr_00737|M.leprae_Br4923 AARAE---RGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFP
MSMEG_1821|M.smegmatis_MC2_155 AARAE---RGEKNLGFISAASKCLASDIAMEVTTDAVQLFGGAGYTQDFP
TH_3736|M.thermoresistible__bu ARKWV---SGE-DRRVAPSAAKLFCTEMAGQVADLAVQIHGGTGYMREVP
: . . :* : . .* :: .. . :
Mvan_0281|M.vanbaalenii_PYR-1 FYQVTRLIGALPRLEGTVHVNVAQILKFMPNFMFNP-APYPEIGTRDDPA
Mflv_0398|M.gilvum_PYR-GCK FYQVTRLIGALPRLEGTVHVNVAQILKFMPNYMFNP-AEYPPIGTRDDPA
MAB_3481|M.abscessus_ATCC_1997 TTAARIDVAGLPKLEGTVAVNLALILKFMPAYLHDA-QDLPVPGVQLQPG
Mb0236|M.bovis_AF2122/97 FETVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAA
Rv0231|M.tuberculosis_H37Rv FETVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAA
MAV_4939|M.avium_104 FEAMTREIGLLPRLEGTVHINIGLLGKFMPNYLFAPSGELPVIGRRDDAA
MMAR_0488|M.marinum_M FETVAREIGLLPRLEGTVHINIGLLAKFMPNFLFVPDAALPLIPRRDDAA
MUL_1151|M.ulcerans_Agy99 FETVAREIGLLPRLEGTVHINIGLLAKFMPNFLFAPDAALPLIPRRDDAA
MLBr_00737|M.leprae_Br4923 VERFMRDAKITQIYEGTNQIQRVVMSRALLR-------------------
MSMEG_1821|M.smegmatis_MC2_155 VERMMRDAKITQIYEGTNQIQRVVMSRALLR-------------------
TH_3736|M.thermoresistible__bu VERIYRDVRLLRLYEGTSEIQRLIIGGGLVKAAQRQTN------------
*** :: : :
Mvan_0281|M.vanbaalenii_PYR-1 DDVFFWSQGPARGASKVRFADWAPVYERNTGIPNVAVFYQQVQAFKDLLA
Mflv_0398|M.gilvum_PYR-GCK DDVFFWSQGPARGASKVRFADWAPVYERHAGIPNVGRFYEQVQAFKQLLT
MAB_3481|M.abscessus_ATCC_1997 DDEFLFDQGPASGLGKVRFHDWRKPFADNADIPNVAAFTQRAEALATLVA
Mb0236|M.bovis_AF2122/97 DDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLA
Rv0231|M.tuberculosis_H37Rv DDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLA
MAV_4939|M.avium_104 DDEFLFAQGPTGGLGKVRFGDWRAPFDGFAHLPNVALLRAQIDVLAEMLA
MMAR_0488|M.marinum_M DDTFLFNQGPTGGLGKVRFHDWRAPFDSYGHLPNVALLREQIDVLTEMLA
MUL_1151|M.ulcerans_Agy99 DDTFLFNQGPTGGLGKVRFHDWRAPFGSYGHLPNVALLREQIDVLTEMLA
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MSMEG_1821|M.smegmatis_MC2_155 --------------------------------------------------
TH_3736|M.thermoresistible__bu --------------------------------------------------
Mvan_0281|M.vanbaalenii_PYR-1 TAAPDADQQRDLDFVLVVGHLFTLVVYGQLILEQAELTGLESDLVDQIFD
Mflv_0398|M.gilvum_PYR-GCK VSAPDADQQADLDFVLVVGHLFSLVVYGQLILEQAEITGLDRDVLDQIFD
MAB_3481|M.abscessus_ATCC_1997 NER-DAIKNAGLDLQLSIGELFTLVVYGGLILEQAQLRGTDSALIDQIFE
Mb0236|M.bovis_AF2122/97 SATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFG
Rv0231|M.tuberculosis_H37Rv SATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFG
MAV_4939|M.avium_104 SATPDAVQQKDIDFAFAVGQLFATVPYAQLILEEATLSGVDDALIDEIFG
MMAR_0488|M.marinum_M GATPDASQQKDIDFAFGVGQIFALVPYAQLILEEAPLSGVDDALLDEIFG
MUL_1151|M.ulcerans_Agy99 GATPDASQQKDIDFAFGVGQIFALVPYAQLILEEAPLSGVDDALLDEIFG
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MSMEG_1821|M.smegmatis_MC2_155 --------------------------------------------------
TH_3736|M.thermoresistible__bu --------------------------------------------------
Mvan_0281|M.vanbaalenii_PYR-1 VQIRDFSAYAVALHGKPSSTLEQQEWALSAVRKPTVDAVRFDRVW-DQVR
Mflv_0398|M.gilvum_PYR-GCK VAVRDFSAYAVALHGKPSSTAAQQDWALSAVRKPEPDSGRFDRVW-EQVR
MAB_3481|M.abscessus_ATCC_1997 FLNRDFSVYAVDLLGKREATASQRQWAKAVISEPVFNSERFDEIW-NRVE
Mb0236|M.bovis_AF2122/97 VLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVL
Rv0231|M.tuberculosis_H37Rv VLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVL
MAV_4939|M.avium_104 VLVRDFNAYAVELSDKPATTEQQARFAMRMIRRPVHDPARYDQIWKEQVL
MMAR_0488|M.marinum_M LLVRDFNSYAVELNDKAATTDQQAQFAMRMIRRPAHDAARYDQVWKEHVL
MUL_1151|M.ulcerans_Agy99 LLVRDFNSYAVELNDKAATTDQQAQFAMRMIRRPAHDAARYDQVWKEHVL
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MSMEG_1821|M.smegmatis_MC2_155 --------------------------------------------------
TH_3736|M.thermoresistible__bu --------------------------------------------------
Mvan_0281|M.vanbaalenii_PYR-1 SYDGAYEMRP
Mflv_0398|M.gilvum_PYR-GCK GYDGVYTMRP
MAB_3481|M.abscessus_ATCC_1997 ALSGAYEMRA
Mb0236|M.bovis_AF2122/97 ALNGAYQMAP
Rv0231|M.tuberculosis_H37Rv ALNGAYQMAP
MAV_4939|M.avium_104 PLSGAYQMRP
MMAR_0488|M.marinum_M PLNGAYEMRP
MUL_1151|M.ulcerans_Agy99 PLNGAYEMRP
MLBr_00737|M.leprae_Br4923 ----------
MSMEG_1821|M.smegmatis_MC2_155 ----------
TH_3736|M.thermoresistible__bu ----------