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MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHDDHERIWYSDFLDFVGRERIFASLLTPASYGA DDCRWDTYRISEFAEIMGFYGLSYWYPFQVTALGLGPIWMSANEDAKRKAAAGLEAGEVFAFGLSEQTHG ADVYQTDMILTPSDGGWTANGEKYYIGNANVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKNVVN SQNYVANYALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYESVTHAANRHLYGTV VTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAA KGVEKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAADDAFLFAQGPTG GLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLIL EEARLSGVDEALIDEIFGVLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLAL NGAYQMAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0231 | fadE4 | - | 100% (568) | PROBABLE ACYL-CoA DEHYDROGENASE FADE4 |
| M. tuberculosis H37Rv | Rv0400c | fadE7 | 2e-07 | 22.22% (198) | acyl-CoA dehydrogenase FADE7 |
| M. tuberculosis H37Rv | Rv0672 | fadE8 | 8e-05 | 23.04% (217) | acyl-CoA dehydrogenase FADE8 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0236 | fadE4 | 0.0 | 100.00% (568) | acyl-CoA dehydrogenase FADE4 |
| M. gilvum PYR-GCK | Mflv_0398 | - | 0.0 | 56.08% (576) | acyl-CoA dehydrogenase domain-containing protein |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-06 | 20.34% (290) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3481 | - | 1e-166 | 52.77% (559) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_0488 | fadE4 | 0.0 | 84.51% (568) | acyl-CoA dehydrogenase FadE4 |
| M. avium 104 | MAV_4939 | - | 0.0 | 84.36% (569) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1821 | - | 8e-09 | 21.03% (290) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4603 | - | 1e-12 | 23.29% (322) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_1151 | fadE4 | 0.0 | 84.51% (568) | acyl-CoA dehydrogenase FadE4 |
| M. vanbaalenii PYR-1 | Mvan_0281 | - | 1e-180 | 55.03% (587) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0398|M.gilvum_PYR-GCK ------MAARGLLLNPNHFDPAWLDPESRRLLRALIDWFEQRGKARLLRD
Mvan_0281|M.vanbaalenii_PYR-1 ------MPETPLLLDPNNFDPKRLDPESRRLLAALIDWFEQRGKVRLLRD
MAB_3481|M.abscessus_ATCC_1997 MSQDTNAAPKTELLHPTADDFAEFDGETRRLLKATVDWFEERGKTRLLQD
Rv0231|M.tuberculosis_H37Rv -----------MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHD
Mb0236|M.bovis_AF2122/97 -----------MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHD
MAV_4939|M.avium_104 -----------MLLNPNHLQRRYPDRRSAEIMAATVDFFESRGKARLKSD
MMAR_0488|M.marinum_M -----------MLLNPNRLQRKYPDARSAEIMAATVDFFESRGKARLKRD
MUL_1151|M.ulcerans_Agy99 -----------MLLNPNRLQRKYPDARSAEIMAATVDFFESRGKARLKRD
MLBr_00737|M.leprae_Br4923 ---------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADV
MSMEG_1821|M.smegmatis_MC2_155 ---------MAAWGGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADV
TH_4603|M.thermoresistible__bu ----------------MAVDRLLPSQEAAELIELTREIADKVLDPIVDRH
. .: :.
Mflv_0398|M.gilvum_PYR-GCK DLDGVWVADFLEFVKKERLFATFLTPSEFAEGDPNKRWDTARNAVLSEIL
Mvan_0281|M.vanbaalenii_PYR-1 DLNAEWVTDFLDFVRRERLFATFLTPSEFANGDPNKRWDTSRNAVLSEIL
MAB_3481|M.abscessus_ATCC_1997 YVDKVFYQDFLDFAGREKLFATFLTPAADGAGNTEKRWDTARVAKLSEIL
Rv0231|M.tuberculosis_H37Rv DHERIWYSDFLDFVGRERIFASLLTPASYGADD--CRWDTYRISEFAEIM
Mb0236|M.bovis_AF2122/97 DHERIWYSDFLDFVGRERIFASLLTPASYGADD--CRWDTYRISEFAEIM
MAV_4939|M.avium_104 DHERVWYSDFLEHIGRERIFASLLTPTRYGSAD--CRWDTYRISGFAEIL
MMAR_0488|M.marinum_M DHDRAWYSDFLNHIAEHRIFASLLTPSEYGADD--CRWDTYRISEFAEII
MUL_1151|M.ulcerans_Agy99 DHDRAWYSDFLNHIAEHRIFASLLTPSEYGADD--CRWDTYRISEFAEII
MLBr_00737|M.leprae_Br4923 DQRARFPEEALAALN-ASGFNAIHVPEEYGGQG----ADSVAACIVIEEV
MSMEG_1821|M.smegmatis_MC2_155 DENARFPQEALDALN-ASGFNAVHVPEEYGGQG----ADSVAACIVIEEV
TH_4603|M.thermoresistible__bu EKDETYPEGVFEQLG-AAGLLSLPQPEEWGGGG----QPYEVYLQVLEEI
: : : :. * . . . * :
Mflv_0398|M.gilvum_PYR-GCK GFYGLSYWYAEQVTILGLGPIWQSDNVKARERAAAQLEAG-EVMAFGLSE
Mvan_0281|M.vanbaalenii_PYR-1 GFYGLSYWYAEQVTILGLGPIWQSGNVKAKERAAEQLEAG-GVMAFGLSE
MAB_3481|M.abscessus_ATCC_1997 GFYGLNYWYPWQVTVLGLGPVWQSANTDPRKRAADLLDGG-AVAAFGLSE
Rv0231|M.tuberculosis_H37Rv GFYGLSYWYPFQVTALGLGPIWMSANEDAKRKAAAGLEAG-EVFAFGLSE
Mb0236|M.bovis_AF2122/97 GFYGLSYWYPFQVTALGLGPIWMSANEDAKRKAAAGLEAG-EVFAFGLSE
MAV_4939|M.avium_104 GFYGLNYWYPFQVTALGLGPIWMSGNDEAKRKAAGLLEAG-EVFAFGLSE
MMAR_0488|M.marinum_M GFYGLSYWYPFQVTALGLGPIWMSDNEDAKRKAAAQLEQG-EVFAFGLSE
MUL_1151|M.ulcerans_Agy99 GFYGLSYWYPFQVTALGLGPIWMSDNEDAKRKAAAQLEQG-EVFAFGLSE
MLBr_00737|M.leprae_Br4923 ARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSE
MSMEG_1821|M.smegmatis_MC2_155 ARVDASASLIPAVNKLGTMGLILRGSDELKKQVLPQLASGAAMASYALSE
TH_4603|M.thermoresistible__bu AARWASVAVAVSVHSLSSHPLLVFGTEEQKKRWLPGMLSGEQIGAYSLSE
. . * *. : . . :.: : : ::.***
Mflv_0398|M.gilvum_PYR-GCK RAHGADIYNTDMLLTPASP-----------GADDPVVFRASGEKYYIGNG
Mvan_0281|M.vanbaalenii_PYR-1 RDHGADIYNTDMLLTPAGDERSREEQTTADGDDDGVLFRASGEKYYIGNG
MAB_3481|M.abscessus_ATCC_1997 QAHGADIYSSDLVLTPVDS-------------SEGGGYKASGRKYYIGNG
Rv0231|M.tuberculosis_H37Rv QTHGADVYQTDMILTPS-----------------DGGWTANGEKYYIGNA
Mb0236|M.bovis_AF2122/97 QTHGADVYQTDMILTPS-----------------DGGWTANGEKYYIGNA
MAV_4939|M.avium_104 QTHGADVYQTDMNLTPAP----------------GGGWTAAGQKYYIGNA
MMAR_0488|M.marinum_M QAHGADVYQTDMILTPS-----------------EHGWTASGEKYYIGNA
MUL_1151|M.ulcerans_Agy99 QAHGADVYQTDMILTPS-----------------EHGWTASGEKYYIGNA
MLBr_00737|M.leprae_Br4923 REAGSDAASMRTRAKAD-----------------GDDWILNGFKCWITNG
MSMEG_1821|M.smegmatis_MC2_155 REAGSDAASMRTRARAD-----------------GDDWVLNGTKCWITNG
TH_4603|M.thermoresistible__bu PQAGSDAAALRCAATPT-----------------DGGYVINGSKSWITHG
*:* . : * * :* :.
Mflv_0398|M.gilvum_PYR-GCK NVAGMVSVFGRRTDVEGADGYVWFVADSRHPDYELIGN---VVHGQMFVS
Mvan_0281|M.vanbaalenii_PYR-1 NVAGMVSVFARRTDVEGADGYVWFVADSGHERYELIGN---VVHGQMFVS
MAB_3481|M.abscessus_ATCC_1997 NCARIVSVFGRVQGRDGLDQYVFFLADSEHPNYRVIKN---VVPSQMYVA
Rv0231|M.tuberculosis_H37Rv NVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKN---VVNSQNYVA
Mb0236|M.bovis_AF2122/97 NVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKN---VVNSQNYVA
MAV_4939|M.avium_104 NVARMVSTFGKFAGGATDSEYVFFAADSRHERYRLIKN---VVNSQNYVG
MMAR_0488|M.marinum_M NVARMVSTFGKIEDSSKEPEYVFFAADSQHDRYELKKN---VVNSQNYVA
MUL_1151|M.ulcerans_Agy99 NVARMVSTFGKIEDSSKEPEYVFFAADSQHDRYELKKN---VVNSQNYVA
MLBr_00737|M.leprae_Br4923 GKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTT
MSMEG_1821|M.smegmatis_MC2_155 GKSSWYTVMAVTDPDKGANGISAFMVHQDDEGFSVGPKERKLGIKGSPTT
TH_4603|M.thermoresistible__bu GKADFYTLFARTG--EGSRGVSCFLVPADQPGLSFGKPEEKMGLHAVPTT
. : : :. * . . . : .
Mflv_0398|M.gilvum_PYR-GCK NFALRDYPVYEEDILATGQDAFSAALNTVNVGKFNLCSGSIGMCEHAFYE
Mvan_0281|M.vanbaalenii_PYR-1 NFALHDYPVHEEDILATGPDAFSAALNTVNVGKFNLCSGSIGMCEHAFYE
MAB_3481|M.abscessus_ATCC_1997 EFELDEYPVSEDDILHVGADAFSAALNTVNIGKFNLCFGGIGLSTHAFYE
Rv0231|M.tuberculosis_H37Rv NYALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYE
Mb0236|M.bovis_AF2122/97 NYALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYE
MAV_4939|M.avium_104 NFALSDYPVTEADILHRGPEAFHAALNTVNVCKYNLGWGAVGMCTHAMYE
MMAR_0488|M.marinum_M NYALHDYPVTEADLLHRGMGAFHAALNTVNVCKYNLGWGAVGMCTHAFYE
MUL_1151|M.ulcerans_Agy99 NYALHDYPVTEADLLHRGMGAFHAALNTVNVCKYNLGWGAVGMCTHAFYE
MLBr_00737|M.leprae_Br4923 ELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDA
MSMEG_1821|M.smegmatis_MC2_155 ELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDA
TH_4603|M.thermoresistible__bu SAFYDNARIDADRRIGEEGQGLQIAFSALDSGRLGIAAVATGLAQAALDE
. . : : .: *: ::: : : . *:. *:
Mflv_0398|M.gilvum_PYR-GCK AITHANNRILYGNPVTDFPHVRATFVDAYARLIAMKLFSDRAIDYFRSAG
Mvan_0281|M.vanbaalenii_PYR-1 AINHANNRILYGNPVTAFPHVRAGFVDAYTRLIAMKLFSDRAIDYFRSAG
MAB_3481|M.abscessus_ATCC_1997 SITHAHNRILYGNPVTKFDHVRREFVDAYARLLAMKLFSERAVDYFRTAS
Rv0231|M.tuberculosis_H37Rv SVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSAS
Mb0236|M.bovis_AF2122/97 SVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSAS
MAV_4939|M.avium_104 AVTHASNRILYGTVVTDFSHVRRLLIDAYARLVAMRLVATRACDYMRSAS
MMAR_0488|M.marinum_M AITHAANRHLYGTVVTDFSHVRRLLTDAYARLVAMRLVASRASDYMRSAS
MUL_1151|M.ulcerans_Agy99 AITHAANRHLYGTVVTDFSHVRRLLTDAYARLVAMRLVASRASDYMRSAS
MLBr_00737|M.leprae_Br4923 AIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA---RAE
MSMEG_1821|M.smegmatis_MC2_155 AIAYTKDRKQFGTSISDFQAVQFMLADMAMKVESARLMVYHAAA---RAE
TH_4603|M.thermoresistible__bu AVAYANERTAFGRKIIDHQGLGFLLADMAAAVATARATYLDAAR---RRD
:: :: :* :* : . : : * : : : *
Mflv_0398|M.gilvum_PYR-GCK PHDRRYLLFNPVTKSKVTSEGEKVVTLLWDVLAAKGFEKDTYFYQVTRLI
Mvan_0281|M.vanbaalenii_PYR-1 PDDRRYLLFNPVTKSKVTSEGEKVVTLLWDVLAAKGFEKNTYFYQVTRLI
MAB_3481|M.abscessus_ATCC_1997 ADDRRYLLFNPVTKMKATTEAEKVLALLADVMSAKAFEAESYTTAARIDV
Rv0231|M.tuberculosis_H37Rv AADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGVEKDTFFETVAREI
Mb0236|M.bovis_AF2122/97 AADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGVEKDTFFETVAREI
MAV_4939|M.avium_104 ATDRRYLLYSPLTKAKITGEGERVITALWDVIAAKGVEKDTIFEAMTREI
MMAR_0488|M.marinum_M AEDRRYLLYSPLTKAKVTSEGERVIAALWDVIAAKGVEKDTFFETVAREI
MUL_1151|M.ulcerans_Agy99 AEDRRYLLYSPLTKAKVTSEGERVIAALWDVIAAKGVEKDTFFETVAREI
MLBr_00737|M.leprae_Br4923 RGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDA
MSMEG_1821|M.smegmatis_MC2_155 RGEKNLGFISAASKCLASDIAMEVTTDAVQLFGGAGYTQDFPVERMMRDA
TH_4603|M.thermoresistible__bu QGRP-YSQQASIAKLTATDAAMKVTTDAVQVFGGVGYTRDYRVERYMREA
. :* : . .* : :::.. . :
Mflv_0398|M.gilvum_PYR-GCK GALPRLEGTVHVNVAQILKFMPNYMFNP-AEYPPIGTRDDPADDVFFWSQ
Mvan_0281|M.vanbaalenii_PYR-1 GALPRLEGTVHVNVAQILKFMPNFMFNP-APYPEIGTRDDPADDVFFWSQ
MAB_3481|M.abscessus_ATCC_1997 AGLPKLEGTVAVNLALILKFMPAYLHDA-QDLPVPGVQLQPGDDEFLFDQ
Rv0231|M.tuberculosis_H37Rv GLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAADDAFLFAQ
Mb0236|M.bovis_AF2122/97 GLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAADDAFLFAQ
MAV_4939|M.avium_104 GLLPRLEGTVHINIGLLGKFMPNYLFAPSGELPVIGRRDDAADDEFLFAQ
MMAR_0488|M.marinum_M GLLPRLEGTVHINIGLLAKFMPNFLFVPDAALPLIPRRDDAADDTFLFNQ
MUL_1151|M.ulcerans_Agy99 GLLPRLEGTVHINIGLLAKFMPNFLFAPDAALPLIPRRDDAADDTFLFNQ
MLBr_00737|M.leprae_Br4923 KITQIYEGTNQIQRVVMSRALLR---------------------------
MSMEG_1821|M.smegmatis_MC2_155 KITQIYEGTNQIQRVVMSRALLR---------------------------
TH_4603|M.thermoresistible__bu KIMQIFEGTNQIQRLVIARGLTR---------------------------
*** :: : : :
Mflv_0398|M.gilvum_PYR-GCK GPARGASKVRFADWAPVYERHAGIPNVGRFYEQVQAFKQLLTVSAPDADQ
Mvan_0281|M.vanbaalenii_PYR-1 GPARGASKVRFADWAPVYERNTGIPNVAVFYQQVQAFKDLLATAAPDADQ
MAB_3481|M.abscessus_ATCC_1997 GPASGLGKVRFHDWRKPFADNADIPNVAAFTQRAEALATLVANER-DAIK
Rv0231|M.tuberculosis_H37Rv GPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLASATPDAAQ
Mb0236|M.bovis_AF2122/97 GPTGGLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLASATPDAAQ
MAV_4939|M.avium_104 GPTGGLGKVRFGDWRAPFDGFAHLPNVALLRAQIDVLAEMLASATPDAVQ
MMAR_0488|M.marinum_M GPTGGLGKVRFHDWRAPFDSYGHLPNVALLREQIDVLTEMLAGATPDASQ
MUL_1151|M.ulcerans_Agy99 GPTGGLGKVRFHDWRAPFGSYGHLPNVALLREQIDVLTEMLAGATPDASQ
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MSMEG_1821|M.smegmatis_MC2_155 --------------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mflv_0398|M.gilvum_PYR-GCK QADLDFVLVVGHLFSLVVYGQLILEQAEITGLDRDVLDQIFDVAVRDFSA
Mvan_0281|M.vanbaalenii_PYR-1 QRDLDFVLVVGHLFTLVVYGQLILEQAELTGLESDLVDQIFDVQIRDFSA
MAB_3481|M.abscessus_ATCC_1997 NAGLDLQLSIGELFTLVVYGGLILEQAQLRGTDSALIDQIFEFLNRDFSV
Rv0231|M.tuberculosis_H37Rv QKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFGVLVRDFNT
Mb0236|M.bovis_AF2122/97 QKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFGVLVRDFNT
MAV_4939|M.avium_104 QKDIDFAFAVGQLFATVPYAQLILEEATLSGVDDALIDEIFGVLVRDFNA
MMAR_0488|M.marinum_M QKDIDFAFGVGQIFALVPYAQLILEEAPLSGVDDALLDEIFGLLVRDFNS
MUL_1151|M.ulcerans_Agy99 QKDIDFAFGVGQIFALVPYAQLILEEAPLSGVDDALLDEIFGLLVRDFNS
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MSMEG_1821|M.smegmatis_MC2_155 --------------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mflv_0398|M.gilvum_PYR-GCK YAVALHGKPSSTAAQQDWALSAVRKPEPDSGRFDRVW-EQVRGYDGVYTM
Mvan_0281|M.vanbaalenii_PYR-1 YAVALHGKPSSTLEQQEWALSAVRKPTVDAVRFDRVW-DQVRSYDGAYEM
MAB_3481|M.abscessus_ATCC_1997 YAVDLLGKREATASQRQWAKAVISEPVFNSERFDEIW-NRVEALSGAYEM
Rv0231|M.tuberculosis_H37Rv HAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLALNGAYQM
Mb0236|M.bovis_AF2122/97 HAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLALNGAYQM
MAV_4939|M.avium_104 YAVELSDKPATTEQQARFAMRMIRRPVHDPARYDQIWKEQVLPLSGAYQM
MMAR_0488|M.marinum_M YAVELNDKAATTDQQAQFAMRMIRRPAHDAARYDQVWKEHVLPLNGAYEM
MUL_1151|M.ulcerans_Agy99 YAVELNDKAATTDQQAQFAMRMIRRPAHDAARYDQVWKEHVLPLNGAYEM
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MSMEG_1821|M.smegmatis_MC2_155 --------------------------------------------------
TH_4603|M.thermoresistible__bu --------------------------------------------------
Mflv_0398|M.gilvum_PYR-GCK RP
Mvan_0281|M.vanbaalenii_PYR-1 RP
MAB_3481|M.abscessus_ATCC_1997 RA
Rv0231|M.tuberculosis_H37Rv AP
Mb0236|M.bovis_AF2122/97 AP
MAV_4939|M.avium_104 RP
MMAR_0488|M.marinum_M RP
MUL_1151|M.ulcerans_Agy99 RP
MLBr_00737|M.leprae_Br4923 --
MSMEG_1821|M.smegmatis_MC2_155 --
TH_4603|M.thermoresistible__bu --