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AANRSSWMDDDLDALRDLARTFCEKEVAPHSARFIEQHHVDRDLWTRAGDLGLLCMSIPEQYGGGGGTFA HEAVLIEEQARIGDSAWGAPLHSGIVAHYLLEYGTDEQKERFLPRLATGEMVGAIAMTEPGTGSDLQSVT TKASRVGDEYVVNGSKTFITNGAQADLIIVVAKTDPSAGANGISLVLVEGDRPGFRRGRVLDKVGQRGQD TSELYFEDVHIPVENLLGTTEGQGFIQLMQQLPQERLILALGAVTVLETALEFTVEYTKDRHAFGKPVFA FQNTKFKLAEVATDAHISRVFIDDCVARHLRGELDIPTVAMAKWWTTERAMVALDDCLQLHGGYGYMTEY PIGRMWADARVQKIYGGTNEIMKEIIARSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4601 | - | - | 100% (381) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2118 | - | 2e-98 | 47.18% (373) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4558 | - | 3e-91 | 47.11% (380) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2743c | fadE20 | 1e-108 | 53.12% (369) | acyl-CoA dehydrogenase FADE20 |
| M. tuberculosis H37Rv | Rv2724c | fadE20 | 1e-109 | 53.39% (369) | acyl-CoA dehydrogenase FADE20 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-61 | 34.49% (374) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2081 | - | 1e-166 | 72.18% (381) | acyl CoA dehydrogenase |
| M. marinum M | MMAR_3132 | - | 1e-164 | 71.39% (381) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_3616 | - | 1e-112 | 54.42% (373) | long-chain specific acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5197 | - | 9e-99 | 47.18% (373) | long-chain specific acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3180 | - | 1e-125 | 57.82% (377) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3367 | fadE20 | 1e-109 | 53.93% (369) | acyl-CoA dehydrogenase FadE20 |
| M. vanbaalenii PYR-1 | Mvan_2439 | - | 1e-110 | 52.85% (369) | long-chain-acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2081|M.abscessus_ATCC_1997 --------MSSPISPWMNAELLELRDLAAKFFSAELAPHANRFADQHHVD
MMAR_3132|M.marinum_M --------MTASISPWMSAELLELRDLAAKFFSTELAPHAQRFADQHQVD
Mflv_4601|M.gilvum_PYR-GCK --------MAANRSSWMDDDLDALRDLARTFCEKEVAPHSARFIEQHHVD
TH_3180|M.thermoresistible__bu -------MITKRMSPWFDDEVRALYDLAREFFEREVVAHVDTWDAQRHID
Mb2743c|M.bovis_AF2122/97 MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVD
Rv2724c|M.tuberculosis_H37Rv MGS-----ATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVD
MUL_3367|M.ulcerans_Agy99 MGS-----AIKYQRTLFEPEHDLFRESYRGFLERHVALYHDEWEKAKIVD
MAV_3616|M.avium_104 MSS-----AIKYQRTLFESEHELFRESYRAFLDRHVAPYHDEWEKAKIVD
Mvan_2439|M.vanbaalenii_PYR-1 MGASEAKPVIAYERTLFEPEHDMFRESFRAFLDRHVAPHHEEWEKNKLVD
MSMEG_5197|M.smegmatis_MC2_155 -----------MKRLIYNEEHEAFRQTVKEYIERELVPHSEKWEAERIVD
MLBr_00737|M.leprae_Br4923 --MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFP
: : . .:. : .
MAB_2081|M.abscessus_ATCC_1997 RELWNRAGELGLLCMSIPEEYGGGGG-TFAHEAVVLEEQARIGDSSWGAG
MMAR_3132|M.marinum_M RELWHKAGELGLLCMSIPEEYGGGGG-TFAHEAVVLEEQARVGDSSWGAG
Mflv_4601|M.gilvum_PYR-GCK RDLWTRAGDLGLLCMSIPEQYGGGGG-TFAHEAVLIEEQARIGDSAWGAP
TH_3180|M.thermoresistible__bu RQVWLEAGKLGLLLCSVPEEYGGGGG-TFAHDVAVFDAQGYSGDLSLGIA
Mb2743c|M.bovis_AF2122/97 RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
Rv2724c|M.tuberculosis_H37Rv RGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFG
MUL_3367|M.ulcerans_Agy99 RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFG
MAV_3616|M.avium_104 RGVWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETTRGRYSGIGFG
Mvan_2439|M.vanbaalenii_PYR-1 RDVWLEAGKQGFLGMAVPEEYGGGGVDDFRYNTIVTEEVTAGRYTGLGFS
MSMEG_5197|M.smegmatis_MC2_155 RSAYTAAGKYGLIGFNMPEEFGGGGSDDFRFNAIIDEEIAKSGVHGPALS
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYG-GQGADSVAACIVIEEVARVDASASLIP
. . *: :**::* * : : .
MAB_2081|M.abscessus_ATCC_1997 LHSGIVAHYILQYATEELRAQWLPKMASGEMIGAIAMTEPGTGSDLQSVK
MMAR_3132|M.marinum_M LHSGIVAHYILQYAAEELRRQWLPKMASGEMIGAIAMTEPGTGSDLQSVK
Mflv_4601|M.gilvum_PYR-GCK LHSGIVAHYLLEYGTDEQKERFLPRLATGEMVGAIAMTEPGTGSDLQSVT
TH_3180|M.thermoresistible__bu VHSGIVPHYIVKYGSEEQKRQWLPPMATGEVLSAIGMTEPGAGSDLKAIR
Mb2743c|M.bovis_AF2122/97 LHNDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGIT
Rv2724c|M.tuberculosis_H37Rv LHNDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGIT
MUL_3367|M.ulcerans_Agy99 LHNEIVAPYLLALATEEQKQRRLPKFCTGEFITAIAMTEPGTGSDLQGIK
MAV_3616|M.avium_104 LHNDIVAPYLLALATEEQKQRWLPKFCTGELITAIAMTEPGTGSDLQGIK
Mvan_2439|M.vanbaalenii_PYR-1 LHNDVAAPYLIRLATEEQKQRWLPKFCSGEIISAIAMTEPGTGSDLQGIK
MSMEG_5197|M.smegmatis_MC2_155 LHNDVVGPYFKELANDEQRRRWLPGITSGELIIAIAMTEPGAGSDLAGIR
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
. : : . :* : : :* : : : .::* :*** .:
MAB_2081|M.abscessus_ATCC_1997 TKALLDGDEYVITGSKTFITNGQQADLIIVVAKTDPSQGAAGISLIVVEA
MMAR_3132|M.marinum_M TKAILDGDEYVITGAKTFITNGQQADLIIVVAKTDPSQGAAGISLIVAEA
Mflv_4601|M.gilvum_PYR-GCK TKASRVGDEYVVNGSKTFITNGAQADLIIVVAKTDPSAGANGISLVLVEG
TH_3180|M.thermoresistible__bu TTAVRDGDEYIVNGSKTFITNGGSADMILLAVKTDPKAGARGISLLIVDL
Mb2743c|M.bovis_AF2122/97 TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
Rv2724c|M.tuberculosis_H37Rv TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
MUL_3367|M.ulcerans_Agy99 TRAVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVER
MAV_3616|M.avium_104 TRAVKQGDHYVLNGSKTFITNGINSDLVIVVAQTDPDKGAQGFSLLVVER
Mvan_2439|M.vanbaalenii_PYR-1 TRAVRDGDHYVLNGAKTFITNGIHSDLVIVVAQTDPDKGALGFSLLVVER
MSMEG_5197|M.smegmatis_MC2_155 TSAVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVER
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
* * **.:::.* * :*:.* . : . ***. * *:* .:..
MAB_2081|M.abscessus_ATCC_1997 -DRAGFRRGKVLDKIGQRGQDTSELFFDEVRVPRSHLLGQAEGQGFIQLM
MMAR_3132|M.marinum_M -DRPGFRRGKVLDKIGQRGQDTSELFFDDVRVPRSHLLGETEGQGFIQLM
Mflv_4601|M.gilvum_PYR-GCK -DRPGFRRGRVLDKVGQRGQDTSELYFEDVHIPVENLLGTTEGQGFIQLM
TH_3180|M.thermoresistible__bu RDCDGYQVTRVLDKVGQHGADTAELSFTDVRVPVANLLGAEEGKGFGQMI
Mb2743c|M.bovis_AF2122/97 -GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQ-EGMGFIYLM
Rv2724c|M.tuberculosis_H37Rv -GMAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQ-EGMGFIYLM
MUL_3367|M.ulcerans_Agy99 -GMEGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQ-EGMGFIYLM
MAV_3616|M.avium_104 -GMEGFERGRHLDKIGLDAQDTAELSFTDVHVPAENLLGQ-EGMGFIYLM
Mvan_2439|M.vanbaalenii_PYR-1 -GMAGFERGRKLDKIGLDAQDTAELSFTDVKVPVENLLGE-EGQGFIYLM
MSMEG_5197|M.smegmatis_MC2_155 -GMEGFTRGRKLDKMGLHSQDTSELHFENVRVPHANLLGK-EGRGFYHLM
MLBr_00737|M.leprae_Br4923 -DDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGE-PGTGFKTAL
. *: .*:* . *:** * . :* .::* * ** :
MAB_2081|M.abscessus_ATCC_1997 TQLPQERLIVAVGAVAAMELALEQTLKYTREREAFGRPVFGFQNTKFTLA
MMAR_3132|M.marinum_M TQLPQERLIVAVGAVAAMELAVEQTLKYTREREAFGRPVFGFQNTKFILA
Mflv_4601|M.gilvum_PYR-GCK QQLPQERLILALGAVTVLETALEFTVEYTKDRHAFGKPVFAFQNTKFKLA
TH_3180|M.thermoresistible__bu DQLAQERLAVAAQAMGGMERAVDDTVAYTKSREAFGQSIFDFQNTAFELA
Mb2743c|M.bovis_AF2122/97 QNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLA
Rv2724c|M.tuberculosis_H37Rv QNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLA
MUL_3367|M.ulcerans_Agy99 QNLPQERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLA
MAV_3616|M.avium_104 QNLPQERISIAVMAAAAMEQVLEQTLEYTKERKAFGKSIGSFQNSRFVLA
Mvan_2439|M.vanbaalenii_PYR-1 QNLPQERISIAIMAAAAMEAVLDVTLQYTKERKAFGRPIGSQQNSRFLLA
MSMEG_5197|M.smegmatis_MC2_155 TNLPSERLSIAISAIAGARAVFDETLQYCKDRKAFGQPIGSFQHNRFLLA
MLBr_00737|M.leprae_Br4923 ATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLA
* * :. * . ..: :: * :.*. **..: * * **
MAB_2081|M.abscessus_ATCC_1997 EAATETRIARVFLDYCIDLHLAGQLDV-QTVAMAKWWTTERAMKVLDDCM
MMAR_3132|M.marinum_M EAATETRIARVFLDYCIDLHLAGQLDV-QTVAMAKWWTTERAMKVLDDCL
Mflv_4601|M.gilvum_PYR-GCK EVATDAHISRVFIDDCVARHLRGELDI-PTVAMAKWWTTERAMVALDDCL
TH_3180|M.thermoresistible__bu ECATIARTCRAFFDQCVEAHLRGELDG-TDAAMAKYWLTDRQCEVVDRCV
Mb2743c|M.bovis_AF2122/97 ELATEATVVRIMVDEFIKLHLAGKLTA-EQAAMAKWYATEKQVYLNDRCL
Rv2724c|M.tuberculosis_H37Rv ELATEATVVRIMVDEFIKLHLAGKLTA-EQAAMAKWYATEKQVYLNDRCL
MUL_3367|M.ulcerans_Agy99 ELATEATMVRIMVDESIELHLDGKLTA-EQAAMAKWYSTEKQVSLNDRCL
MAV_3616|M.avium_104 ELATEATVVRMMVDEFVRLHLDHKLTA-EQAAMAKWYSTEKQVHLIDRCL
Mvan_2439|M.vanbaalenii_PYR-1 ELSTEATVVRMMVDEFIKLHLQDKLTV-EQAAMAKWYSTEKQVHLIDRCL
MSMEG_5197|M.smegmatis_MC2_155 EMETELEVTENYIDRCLQGVVDGELTA-VEAAKAKWWATETAKKIVDNCV
MLBr_00737|M.leprae_Br4923 DMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAV
: . . : * :* : :: .:
MAB_2081|M.abscessus_ATCC_1997 QLHGGYGYMTEYPISRLWVDQRVQKIYAGTNEVMKEIISRSL--
MMAR_3132|M.marinum_M QLHGGYGYMTEYPISRLWVDQRVQKIYAGTNEVMKEIISRSL--
Mflv_4601|M.gilvum_PYR-GCK QLHGGYGYMTEYPIGRMWADARVQKIYGGTNEIMKEIIARSL--
TH_3180|M.thermoresistible__bu QLHGGYGYMREYLIARMYEDARVQRIYAGANEVMKQIIARSL--
Mb2743c|M.bovis_AF2122/97 QLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Rv2724c|M.tuberculosis_H37Rv QLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
MUL_3367|M.ulcerans_Agy99 QLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MAV_3616|M.avium_104 QLHGGYGYMREYPVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
Mvan_2439|M.vanbaalenii_PYR-1 QLHGGYGYMREYDVARAYLDARVQTIYGGTTEIMKEIIGRSLGV
MSMEG_5197|M.smegmatis_MC2_155 QLHGGYGYMMEYRVARAYVDGRIQTIFGGTTEIMKEIIGRDLGV
MLBr_00737|M.leprae_Br4923 QLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
**.** ** :: : * * :: *: *:.:: : ::.* *