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MSHGDYDVLVIGAGLAGLRCAALLASSGRSVAVWESGDAVGGRVRTDVVDGFRCDRGFQVLNPAYPELRR AIDVPALRLHPFLAGVAIRDTDRARHWVHPLRAPRRLPGMLTGGGLRPRDVVALMRWAAPALRPATLTEG RDDVSVADALDRSGVDGLARRVVDKFLAGVVLDDQGSTSNAFTLLLARMFALGVPGLPAEGMQALPRLMS APIADRITLNHRVDRIVRDGRGWAVSAGGDTVRASHVVVATDPQTAETLTGAPAPPMKGVVTDWWATEDT IPGSRLLWVDGRPTPPGPLVNTAIVSAVAPGYAPAGHHLIAASALIGGDGEAPPESVTRTHAADILRVTG AQGWSLVTRHVVPEALPVQPPPLRVRRPVRTPDGLWLCGDHRDTASIQGALVSGRRVADAIDRCDRRSDT AHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0339 | - | - | 100% (423) | amine oxidase |
| M. gilvum PYR-GCK | Mflv_4501 | - | 4e-08 | 28.07% (285) | amine oxidase |
| M. gilvum PYR-GCK | Mflv_1230 | - | 7e-08 | 22.55% (306) | amine oxidase (flavin-containing) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 4e-11 | 26.42% (299) | flavin-containing monoamine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 4e-11 | 26.42% (299) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 3e-09 | 28.45% (239) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_4321 | - | 6e-09 | 26.48% (287) | putrescine oxidase |
| M. marinum M | MMAR_3362 | aofH_1 | 3e-13 | 28.57% (280) | flavin-containing monoamine oxidase AofH_1 |
| M. avium 104 | MAV_4062 | - | 2e-11 | 25.11% (470) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_5400 | - | 4e-07 | 28.67% (286) | dehydrogenase |
| M. thermoresistible (build 8) | TH_2567 | - | 3e-08 | 26.07% (280) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1281 | aofH_1 | 2e-13 | 28.57% (280) | flavin-containing monoamine oxidase AofH_1 |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | 3e-12 | 25.62% (281) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 ------------MTNPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLV
Rv3170|M.tuberculosis_H37Rv ------------MTNPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLV
MAV_4062|M.avium_104 ------------MSGPPRIVDVVVVGAGFAGLAAARELNRQG---HDVVV
MMAR_3362|M.marinum_M ------------MAE----VDVCVVGAGFAGLTAALRLKQAG---HSVAL
MUL_1281|M.ulcerans_Agy99 ------------MAE----VDVCVVGAGFAGLTAALRLKQAG---HSVAL
Mvan_1178|M.vanbaalenii_PYR-1 ------------MVD----LDYCVVGAGFAGLTAALRLKQAG---HSVTL
MAB_4321|M.abscessus_ATCC_1997 MTEFAVPT--TTHSGPAVERDVVVIGAGISGLMTARRLVQAG---HSVAV
Mflv_0339|M.gilvum_PYR-GCK -------MSHG-------DYDVLVIGAGLAGLRCAALLASSG---RSVAV
MLBr_01044|M.leprae_Br4923 ----------------MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITL
TH_2567|M.thermoresistible__bu -------------MTTEQEFDAIVIGAGAGGLFTAARLAHQG---FRTVV
MSMEG_5400|M.smegmatis_MC2_155 --------------MSRDSADAVVIGAGHNGLVAAAMLADAG---WDVLV
. *:*.* ** * * :
Mb3195|M.bovis_AF2122/97 FEGRDRVGGRSLTG-RVAGVPADMGGSFIGPTQDAVLALATELGIPTTPT
Rv3170|M.tuberculosis_H37Rv FEGRDRVGGRSLTG-RVAGVPADMGGSFIGPTQDAVLALATELGIPTTPT
MAV_4062|M.avium_104 FEGRDRVGGRSFTG-SVAGLPADLGGTFVGPTQDAVLALAAELEVPTTPT
MMAR_3362|M.marinum_M LEARDRVGGRTFTVVREDGSWIDKGGAWIGPTQHRIYALMKEFGVAAFKQ
MUL_1281|M.ulcerans_Agy99 LEARDRVGGRTFTVVREDGSWIDKGGAWIGPTQHRIYALMKEFGVAAFKQ
Mvan_1178|M.vanbaalenii_PYR-1 LEARDRIGGRTFTVNRDDGTWIDRGGAWIGPGQDRIDALMEEFGIPSYKQ
MAB_4321|M.abscessus_ATCC_1997 LEARDRVGGRTWSQ-IMDGEFFEIGGQWISSDQDALKDLLAELGKKTFRR
Mflv_0339|M.gilvum_PYR-GCK WESGDAVGGRVRTD-VVDGFRCDRGFQVLNP---AYPELRRAIDVPALRL
MLBr_01044|M.leprae_Br4923 FDPGDRLGG-VLRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQR
TH_2567|M.thermoresistible__bu VERLDKVGGRASTD-DIDGFKVNNG-AIVIETGGITQQTCEEVGAPFDIR
MSMEG_5400|M.smegmatis_MC2_155 LEAQPEPGGAVKSAELVPGYTSDLFSAFYPLSVASPALRALNLEDHGLRW
: ** * : .
Mb3195|M.bovis_AF2122/97 HRDGRNVIQWR-GSARSYRGTIP-KLSLTGLIDIGRLR---------WQF
Rv3170|M.tuberculosis_H37Rv HRDGRNVIQWR-GSARSYRGTIP-KLSLTGLIDIGRLR---------WQF
MAV_4062|M.avium_104 HHEGKNLIHWR-GWTHAYHGTIP-KLSLTGLLDIGRLR---------WQF
MMAR_3362|M.marinum_M YTDGEAMMVVD-GKQYRYQGTIPRTLSPLASMNLGTAM---------FEI
MUL_1281|M.ulcerans_Agy99 YTDGEAMMVVD-GKQYRYQGTIPRTLSPLASMNLGTAM---------FEI
Mvan_1178|M.vanbaalenii_PYR-1 YVDGDAMMFID-GKTYRYHGTIPMSMSPFAVANLGVVF---------LEL
MAB_4321|M.abscessus_ATCC_1997 YREGNSVYIGQDGERREFTGDFP--VPEATLQQVNQLI---------HAL
Mflv_0339|M.gilvum_PYR-GCK HPFLAGVAIRDTDRARHWVHPLRAPRRLPGMLTGGGLR---------PRD
MLBr_01044|M.leprae_Br4923 ATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLVDD--------ATV
TH_2567|M.thermoresistible__bu EPKPPILYRIGGKNVDVTGGGWG--------FLLGKLT---------RQG
MSMEG_5400|M.smegmatis_MC2_155 THAPAVVGHPRSAADDDAPMIYRDIDRTAAELDRHHSGDGRRWCDLFEQW
Mb3195|M.bovis_AF2122/97 ERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRV-
Rv3170|M.tuberculosis_H37Rv ERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRV-
MAV_4062|M.avium_104 DRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRATASSHALLAMVARV-
MMAR_3362|M.marinum_M SQMCKTIPLEAPWEAKRAAKWDRMTLAQWLRNNVKSKAAHDLLETAIAG-
MUL_1281|M.ulcerans_Agy99 SQMCKTIPLEAPWEAKRAAKWDRMTLAQWLRNNVKSKAAHDLLETAIAG-
Mvan_1178|M.vanbaalenii_PYR-1 TRMCKSIPPEAPWTAPKAHKWDQVTWAKWLDGNTLSTPARQLLESAVSG-
MAB_4321|M.abscessus_ATCC_1997 DSLAAEIDAATPWQHPRAAELDAIPFATWLASNSDDKEARRIVGHYIAAG
Mflv_0339|M.gilvum_PYR-GCK VVALMRWAAPALRPATLTEGRDDVSVADALDRSGVDGLARRVVDKFLAGV
MLBr_01044|M.leprae_Br4923 ARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVARLVDPLLGGVYAGSA
TH_2567|M.thermoresistible__bu AKLVKGIGAAR---NDSGLPEDEISTAEWVAKYTKNEGVHGIFRNMCAS-
MSMEG_5400|M.smegmatis_MC2_155 LKIKDGLISSLFTPFPPVSGLMQLLRKLGTAEALRLAQQLVMPAGIMAEH
: :
Mb3195|M.bovis_AF2122/97 TWGCEPDDVSMLHAARYVRA-------AGGLDRLLDVKNGAQQDRVPGGT
Rv3170|M.tuberculosis_H37Rv TWGCEPDDVSMLHAARYVRA-------AGGLDRLLDVKNGAQQDRVPGGT
MAV_4062|M.avium_104 TWGCEPDEVSMLHAARYAHA-------AGGLDRLLDVEDGAQQDRFPGGT
MMAR_3362|M.marinum_M CYTSDASEVSMLFVLYQMAS-------GGGPGFVLGSKGAAQDARPIGGM
MUL_1281|M.ulcerans_Agy99 CYTSDASEVSMLFVLYQMAS-------GGGPGFVLGSKGAAQDARPIGGM
Mvan_1178|M.vanbaalenii_PYR-1 LYTSAASELSLLFCLYQMAA-------AGGPSFVLGVKDAAEDARPVGGM
MAB_4321|M.abscessus_ATCC_1997 MFTKPSHSFSVLQAMLMIAS-------AGKFEHLID-EGILLDERVVGGM
Mflv_0339|M.gilvum_PYR-GCK VLDDQGSTSNAFTLLLARMF-------ALG-----------VPGLPAEGM
MLBr_01044|M.leprae_Br4923 ATIGLRAGAPSVAAALDCGA-------TSLMEAVRQGLPPVAAGPVFGAL
TH_2567|M.thermoresistible__bu VFAVGSEDLPARVFLTYFTR-------KSAFKR---------FGFHPEGT
MSMEG_5400|M.smegmatis_MC2_155 LFDGEAARLLLLGNAMHADVPIDGVGSAVMGYLLIMMAQDGGWPVPVGGA
.
Mb3195|M.bovis_AF2122/97 QQIAQAAAAQLG---ARVLLNAAVRRIDRHGAG------VTVTSDQGQAE
Rv3170|M.tuberculosis_H37Rv QQIAQAAAAQLG---ARVLLNAAVRRIDRHGAG------VTVTSDQGQAE
MAV_4062|M.avium_104 QQIAAAAAAELG---ARVVLGAPVRRIERHGAG------VTVRTDLGDTE
MMAR_3362|M.marinum_M GAVYGPMAAELG---DAIHLSQPVRSITQDSGG------VTVQAEGLTVR
MUL_1281|M.ulcerans_Agy99 GAVYGPMAAELG---DAIHLSQPVRSITQDSGG------VTVQAEGLTVR
Mvan_1178|M.vanbaalenii_PYR-1 GAIHRAVAAELG---DVVQLSQPVRSIAQDAEG------VTVRSEDRVVR
MAB_4321|M.abscessus_ATCC_1997 QSVSQQIADELGP--DVVHLSTRVRHLAWSDAGDGLPSIVSAVSDRVTVR
Mflv_0339|M.gilvum_PYR-GCK QALPRLMSAPIA---DRITLNHRVDRIVRDGRG------WAVSAGGDTVR
MLBr_01044|M.leprae_Br4923 DGGYQVLIDELVRRSRLQWVAATVVGLDRGTCG-----WTLVDDTGACWS
TH_2567|M.thermoresistible__bu IGLWRGLAGAVERHGGQVWLSTPATKILTDGTAVQG-VVVERDGRQLTLT
MSMEG_5400|M.smegmatis_MC2_155 GQLTAALVNRARSAGARIECDRRVDGIDVRGGRAVG--VRVSDGTTVRVR
. :
Mb3195|M.bovis_AF2122/97 AGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQ-GRLSKAYAAYSTPF
Rv3170|M.tuberculosis_H37Rv AGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQ-GRLSKAYAAYSTPF
MAV_4062|M.avium_104 AGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQ-GRLSKAYAAYSTPF
MMAR_3362|M.marinum_M ANRTIVAVPLAIASQIVYEPMLPTDRSFLHQRMPS-GAVVKISAVYDEPF
MUL_1281|M.ulcerans_Agy99 ANRTIVAVPLAIASQIVYEPMLPTDRSFLHQRMPS-GAVVKISAVYDEPF
Mvan_1178|M.vanbaalenii_PYR-1 ARRAIVTVPIAIASHILYEPMLPVDRSFLHQRMPS-GAVFKIAMVFDEPF
MAB_4321|M.abscessus_ATCC_1997 ARFAVLAIPPNLYSTIDYQPPLPRIQQVSHQHQSM-GLVIKAQAVYETPF
Mflv_0339|M.gilvum_PYR-GCK ASHVVVATDPQTAETLTGAPAPPMKGVVTDWWATE-DTIPGSRLLWVD--
MLBr_01044|M.leprae_Br4923 ADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSAS-SAVVALSVPRDTTF
TH_2567|M.thermoresistible__bu APVVVSDVGPAATVTLLGEENVPADYRKMVKKGDRPTSMISVNFASRERL
MSMEG_5400|M.smegmatis_MC2_155 RAVIADTSAPRLYRDLLPEHAVPAAVRRSFDRFVWDTPVLKINYALDAPV
: :
Mb3195|M.bovis_AF2122/97 WRASGYSGQALSDEA--------PVFITFDVSPHADGPGILMGFVD----
Rv3170|M.tuberculosis_H37Rv WRASGYSGQALSDEA--------PVFITFDVSPHADGPGILMGFVD----
MAV_4062|M.avium_104 WRADGFSGQALSDEG--------PVFITFDVSPHPDGPGILMGFVD----
MMAR_3362|M.marinum_M WRADGLCGQSAAPTS--------LATLTIDASPNSGTPGVLCVVIEGPV-
MUL_1281|M.ulcerans_Agy99 WRADGLCGQSAAPTS--------LATLTIDASPNSGTPGVLCVVIEGPV-
Mvan_1178|M.vanbaalenii_PYR-1 WRADGLSGQSFAPGS--------AANLTIDSCTDTGSPGILTAITEGLE-
MAB_4321|M.abscessus_ATCC_1997 WRAHGLSGTGFASRE--------RICEVYDNTVADHPHGTLVGFVAGEQ-
Mflv_0339|M.gilvum_PYR-GCK -------GRPTPPGP--------LVNTAIVSAVAPGYAPAGHHLIA----
MLBr_01044|M.leprae_Br4923 PQNSGVLVASGERLR--------AKAVTLSSRKWGLQGDTQLVRLS----
TH_2567|M.thermoresistible__bu VDVPGMLSFAKSRRL--------AYIANFTDTCPEMAPEGWNLYVG----
MSMEG_5400|M.smegmatis_MC2_155 PWRSKNLNDAGTVHVGADHDGLVRWMADLNTRTLPQQPFMLFGQMTTADP
Mb3195|M.bovis_AF2122/97 ---------ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWG-
Rv3170|M.tuberculosis_H37Rv ---------ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWG-
MAV_4062|M.avium_104 ---------ARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWG-
MMAR_3362|M.marinum_M ---------ARQYERLDDDGRRQAVLAALVERFGAKAAKPIDYFEQNWS-
MUL_1281|M.ulcerans_Agy99 ---------ARQYERLDDDGRRQAVLAALVERFGAKAAKPIDYFEQNWS-
Mvan_1178|M.vanbaalenii_PYR-1 ---------ARELCKLSDADRRKAVLAAVAERFGDKALSPLDYIEHNWT-
MAB_4321|M.abscessus_ATCC_1997 ---------AEETWALPDDQRRGAILESFAAYFGDEAKRPLAVYLSDWG-
Mflv_0339|M.gilvum_PYR-GCK -------------ASALIGGDGEAPPESVTRTHAADILRVTGAQGWSLV-
MLBr_01044|M.leprae_Br4923 ---------------FGKFGDQVASTASDDELLAWAVSDLAAVFDVTVD-
TH_2567|M.thermoresistible__bu -------------TAVPKPSIGDFDQAAETELLLQDLRDNIDDFDNRAR-
MSMEG_5400|M.smegmatis_MC2_155 TRSPAGTESAWAYTHLPRGMADDASADRLSEIVDHVLEEHAPGFGDRVIG
Mb3195|M.bovis_AF2122/97 --------TEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWASTETADE
Rv3170|M.tuberculosis_H37Rv --------TEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWASTETADE
MAV_4062|M.avium_104 --------AEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHWAGTETADE
MMAR_3362|M.marinum_M --------RERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHWAGTETSAK
MUL_1281|M.ulcerans_Agy99 --------RERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHWAGTEISAK
Mvan_1178|M.vanbaalenii_PYR-1 --------VERYSGGGMIAHTPPGVLTEYGPALRRPCGRIHWAGTESSAL
MAB_4321|M.abscessus_ATCC_1997 --------TEEFTRGAYGASWSIGGLSRWGHLQNRPVGPIFFASSDIQGI
Mflv_0339|M.gilvum_PYR-GCK --------TRHVVPEALPVQPPP---LRVRRPVRTPDG--LWLCGDHRDT
MLBr_01044|M.leprae_Br4923 --------PVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHM
TH_2567|M.thermoresistible__bu --------ILNIAITR-DDWPPQRAVAGFDLPHDTPFANLWNVGDGVKEY
MSMEG_5400|M.smegmatis_MC2_155 RVVQRPSDLEGADANLHTGAVNGGTSQLYQQLIFRPVPGFGTAETPVANV
Mb3195|M.bovis_AF2122/97 WTGYFDGAVRSGQRAAAEVAALL--------------------------
Rv3170|M.tuberculosis_H37Rv WTGYFDGAVRSGQRAAAEVAALL--------------------------
MAV_4062|M.avium_104 WTGFLDGAIRSGRRAAAEVTALL--------------------------
MMAR_3362|M.marinum_M MCGWIDGAIRSGERAASEVMANQTMTMASDS------------------
MUL_1281|M.ulcerans_Agy99 MCGWIDGAIRSGERAASEVMANQTMTMASDS------------------
Mvan_1178|M.vanbaalenii_PYR-1 MYGFIDGAVRSGERAAAEVVEHEAMATS---------------------
MAB_4321|M.abscessus_ATCC_1997 GYMHVDGGVRIGTDTANRINSALLAPVNS--------------------
Mflv_0339|M.gilvum_PYR-GCK AS--IQGALVSGRRVADAIDRCDRRSDTAHA------------------
MLBr_01044|M.leprae_Br4923 DGIGVPACISAAGRAIEALQAEVAR------------------------
TH_2567|M.thermoresistible__bu ANGGTTACAETAKLVVDKILASHRPAASR--------------------
MSMEG_5400|M.smegmatis_MC2_155 FLGSAGAHPGGGVHGVCGRNAAKAALANNGVLGWPRRKLSKAVLSLVTR
. .