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SRDSADAVVIGAGHNGLVAAAMLADAGWDVLVLEAQPEPGGAVKSAELVPGYTSDLFSAFYPLSVASPAL RALNLEDHGLRWTHAPAVVGHPRSAADDDAPMIYRDIDRTAAELDRHHSGDGRRWCDLFEQWLKIKDGLI SSLFTPFPPVSGLMQLLRKLGTAEALRLAQQLVMPAGIMAEHLFDGEAARLLLLGNAMHADVPIDGVGSA VMGYLLIMMAQDGGWPVPVGGAGQLTAALVNRARSAGARIECDRRVDGIDVRGGRAVGVRVSDGTTVRVR RAVIADTSAPRLYRDLLPEHAVPAAVRRSFDRFVWDTPVLKINYALDAPVPWRSKNLNDAGTVHVGADHD GLVRWMADLNTRTLPQQPFMLFGQMTTADPTRSPAGTESAWAYTHLPRGMADDASADRLSEIVDHVLEEH APGFGDRVIGRVVQRPSDLEGADANLHTGAVNGGTSQLYQQLIFRPVPGFGTAETPVANVFLGSAGAHPG GGVHGVCGRNAAKAALANNGVLGWPRRKLSKAVLSLVTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5400 | - | - | 100% (530) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2377 | - | 2e-52 | 30.43% (516) | P49 protein |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 2e-35 | 29.56% (548) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1467 | - | 1e-61 | 34.06% (505) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4235 | - | 4e-49 | 30.27% (512) | hypothetical protein Mflv_4235 |
| M. tuberculosis H37Rv | Rv1432 | - | 2e-61 | 34.06% (505) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4734 | - | 1e-63 | 32.93% (501) | dehydrogenase |
| M. marinum M | MMAR_1580 | - | 1e-63 | 32.42% (509) | dehydrogenase |
| M. avium 104 | MAV_3342 | - | 9e-64 | 34.37% (515) | dehydrogenase |
| M. thermoresistible (build 8) | TH_4571 | - | 3e-59 | 32.73% (501) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_1826 | - | 9e-62 | 33.86% (508) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2127 | - | 1e-49 | 30.66% (512) | hypothetical protein Mvan_2127 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1580|M.marinum_M --------------------MKGASQTAIVVGGGPNGLAAAITLAKAGLQ
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
MAB_4734|M.abscessus_ATCC_1997 ------------------------MSTAVIVGGGPNGLTAAILLAQQGVH
Mb1467|M.bovis_AF2122/97 ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
Rv1432|M.tuberculosis_H37Rv ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
MUL_1826|M.ulcerans_Agy99 ------------------------MTKAVVVGAGPNGLAAAIQLARHGVE
MAV_3342|M.avium_104 ----------------------------MVVGAGPNGLAAAIQLARRGVE
Mflv_4235|M.gilvum_PYR-GCK -------------------MGSNGQVELTVVGSGPNGLAAAVICARAGVS
Mvan_2127|M.vanbaalenii_PYR-1 -------------------MGSNVQVELTVVGSGPNGLAAAVICARAGLS
MSMEG_5400|M.smegmatis_MC2_155 --------------------MSRDSADAVVIGAGHNGLVAAAMLADAGWD
::*.* ***.** * *
MMAR_1580|M.marinum_M VTVLEAAEEVGGGARSS-EAIVLGLVHDHCSAIHPMAVGSEFLTGLDLDR
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSF-EAIVPGLLHDHCSAIHPMAVGSPFINEFGLDR
MAB_4734|M.abscessus_ATCC_1997 VTVLEAADSVGGGVRSG-AATGPGLIHDYCSAIHPMAVGSPVLAGLDLEK
Mb1467|M.bovis_AF2122/97 VQVLEARDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWAAIDLQR
Rv1432|M.tuberculosis_H37Rv VQVLEARDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWAAIDLQR
MUL_1826|M.ulcerans_Agy99 VQVLEAHDTIGGGARSG-ELTVPGVIHDHCSAFHPLGVGSPFWNEIDLQS
MAV_3342|M.avium_104 VQVLEAGETPGGGARSS-ELTVPGVIHDLCSATHPFGVGSPFWKEIDLPS
Mflv_4235|M.gilvum_PYR-GCK VRVVEAQPTAGGGARTLPDPEFSGVSHDICSAVHPLALASPFFAAFDLRA
Mvan_2127|M.vanbaalenii_PYR-1 VRVVEAQPTPGGGARTLPDPEFSGVSHDICSAVHPLALASPFFAEFDLQA
MSMEG_5400|M.smegmatis_MC2_155 VLVLEAQPEPGGAVKSA--ELVPGYTSDLFSAFYPLSVASPALRALNLED
* *:** **..:: * * ** :*:.:.* :.*
MMAR_1580|M.marinum_M HGLSWLLPDIDCVHP--LDDGSAGVLHRSVGQTADGLGA----DGRRWRA
TH_4571|M.thermoresistible__bu HGLRWRWPDIDCVHP--LDDGTAGVLRRSVDHTAAGLGP----DGRVWRA
MAB_4734|M.abscessus_ATCC_1997 HGLQWLWPEVDCAHP--LDDGSCGVLYRDVAATANGLGR----DGRRWRA
Mb1467|M.bovis_AF2122/97 YGLTWKWPDVDCAHP--LDDGTAGVLYRSIEATAAGLGP----DGKRWQR
Rv1432|M.tuberculosis_H37Rv YGLTWKWPDVDCAHP--LDDGTAGVLYRSIEATAAGLGP----DGKRWQR
MUL_1826|M.ulcerans_Agy99 YGLTWNWPEVDCAHP--LDDGTAGVLHQSIERTAAGMGP----DGKRWRC
MAV_3342|M.avium_104 YGLVWKWPQIDCAHP--LDDGSAGVLYRSIEQTTAGMGP----DATRWRR
Mflv_4235|M.gilvum_PYR-GCK RGVTLEVPEVSYGNP--LPGRRAAIGYLDIDRTCAELE-----DGEPWRR
Mvan_2127|M.vanbaalenii_PYR-1 RGVTLAVPEVSYGNP--LPGRPAAVGYRDIERTCAELD-----DGASWRR
MSMEG_5400|M.smegmatis_MC2_155 HGLRWTHAPAVVGHPRSAADDDAPMIYRDIDRTAAELDRHHSGDGRRWCD
*: . :* . . : .: * : *. *
MMAR_1580|M.marinum_M LFDWTSQRFDMLAEDIMGPLLSIP--------GHPITLARFGVPTVLPA-
TH_4571|M.thermoresistible__bu LFGRPVDRFDAVNDAVMGPLLRVP--------KHPLTLARFGAPTVLPA-
MAB_4734|M.abscessus_ATCC_1997 LFERPARNFDLLTADIMGPLLRIP--------RHPLALTRFGVPTVLPA-
Mb1467|M.bovis_AF2122/97 AVGDLAAGFDELAEDLLRPVLNMP--------RHPIRLARFGPRAALPA-
Rv1432|M.tuberculosis_H37Rv AVGDLAAGFDELAEDLLRPVLNMP--------RHPIRLARFGPRAALPA-
MUL_1826|M.ulcerans_Agy99 AVGDLAAGFDELAGDLLRPVLGVP--------RHPLRPAAFGPRAALPA-
MAV_3342|M.avium_104 AVGDLAAGFDQLASDLMRPVLRVP--------HHPVRLARFGPRALLPA-
Mflv_4235|M.gilvum_PYR-GCK LLGPLAADCDGVVGLLLGDKRSIP--------PSIPAALRVAPRLLAQG-
Mvan_2127|M.vanbaalenii_PYR-1 LLGPLADDCDGVVGLLLGDKRSIP--------PSIPAAVRVAPRLLAQG-
MSMEG_5400|M.smegmatis_MC2_155 LFEQWLKIKDGLISSLFTPFPPVSGLMQLLRKLGTAEALRLAQQLVMPAG
. * : :: :. .. .
MMAR_1580|M.marinum_M SVLARLFRTDQGRALFGGVAAHAFRPLHYPMTSAIGLGIITAGHRHGWPV
TH_4571|M.thermoresistible__bu SALARVFRTPAARALWGGVAAHAFRPLHLPMTSAIGVGIITAGHRHGWAV
MAB_4734|M.abscessus_ATCC_1997 AATAQLFRTRQARALFGGIAAHAFRPLHYPMTSAIGLGIITAGHRHGWPV
Mb1467|M.bovis_AF2122/97 TAMARRFHTERARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPV
Rv1432|M.tuberculosis_H37Rv TAMARRFHTERARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPV
MUL_1826|M.ulcerans_Agy99 TMMARWFRTEQARALFGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPV
MAV_3342|M.avium_104 TVLARWFHTEQARALFGGAAAHIYTRLDRPLTASLGLLFLASGHRYGWPV
Mflv_4235|M.gilvum_PYR-GCK TPAWGTLLGEDARALFTGVAAHTISRMPSLVASGAGLMLSTLAHAVGWPI
Mvan_2127|M.vanbaalenii_PYR-1 SPAWGTLAGEDARALFTGVAAHTISRMPSLVSAGAGLMLATLGHTVGWPV
MSMEG_5400|M.smegmatis_MC2_155 IMAEHLFDGEAARLLLLGNAMHADVPIDGVGSAVMGYLLIMMAQDGGWPV
: .* * * * * : :: * : .: **.:
MMAR_1580|M.marinum_M AAGGSQSITNALVATLDELGGKIETG---------------VRVQTASQL
TH_4571|M.thermoresistible__bu AEGGSRAITDAMAARLRELGGTIETG---------------VRVRDIADL
MAB_4734|M.abscessus_ATCC_1997 AAGGSQSITDALSSLLAQFGGRIETG---------------VHVTSFTQL
Mb1467|M.bovis_AF2122/97 ARGGSGSITKALAAALDAYGGTVATG---------------VTVTSRRDI
Rv1432|M.tuberculosis_H37Rv ARGGSGSITKALAAALDAYGGTVATG---------------VTVTSRRDI
MUL_1826|M.ulcerans_Agy99 AQGGSGSITAALGAALDALGGVVATG---------------ITVTSRRDI
MAV_3342|M.avium_104 AEGGSGSIIHALVAALRAHGGDVATG---------------VTVSDRRDI
Mflv_4235|M.gilvum_PYR-GCK PVGGSQAIPDALIADLRAHGGELVVG---------------EEVST----
Mvan_2127|M.vanbaalenii_PYR-1 PSGGSQAIPDALLADLQAHGGELVLG---------------EEVTS----
MSMEG_5400|M.smegmatis_MC2_155 PVGGAGQLTAALVNRARSAGARIECDRRVDGIDVRGGRAVGVRVSDGTTV
. **: : *: *. : . *
MMAR_1580|M.marinum_M PPADVTMFDLAPDAVAGILG--DRMPGRIARAYNKFRRGPGAFKVDFAIE
TH_4571|M.thermoresistible__bu PPTTITVFDLAPEAVAEILG--DRLPPRVARAYRAFRRGPGAFKVDFAVE
MAB_4734|M.abscessus_ATCC_1997 PTADVTLFDLSPTQVADILR--DHLPTSVARGLSRFRYGPGAFKVDFAIE
Mb1467|M.bovis_AF2122/97 PDADIVMLDLSPAAVLGIYG--DVMPTRINRSYRRYRAGSSAFKVDFAIE
Rv1432|M.tuberculosis_H37Rv PDADIVMLDLSPAAVLGIYG--DVMPTRINRSYRRYRAGSSAFKVDFAIE
MUL_1826|M.ulcerans_Agy99 PDADIVMLDLSPANVLTLYG--DEMPARIKRSYRRYREGSSAFKVDFAIE
MAV_3342|M.avium_104 PDADIVMLDLTPAAALRLYG--ELMPARIARSYRRYRQGSSAFKVDFAVE
Mflv_4235|M.gilvum_PYR-GCK PPSGVVLYDTAPTALLDIYG--DRLPSRYARTLRRYRYGPGVAKVDFVLS
Mvan_2127|M.vanbaalenii_PYR-1 PPSGVVLYDTAPTALLRIYG--DRLPPGYAKTLRRYRYGPGVAKVDFVLS
MSMEG_5400|M.smegmatis_MC2_155 RVRRAVIADTSAPRLYRDLLPEHAVPAAVRRSFDRFVWDTPVLKINYALD
.: * :. . :* : : .. . *:::.:.
MMAR_1580|M.marinum_M GAVPWTNPQARRAGTVHLGGPYAELAAAEREVHAGRMPQRPFVLVGQQYL
TH_4571|M.thermoresistible__bu GGVPWCNPDAHRAGTVHVGGTFEEIAATERDVNAGRMPERPFVLVAQQYV
MAB_4734|M.abscessus_ATCC_1997 DGVPWTNPDAGRAGTVHLGGTFAEVASTERAVHAGRMPERPFVLVGQQYL
Mb1467|M.bovis_AF2122/97 GDVGWTNPDCRRAGTVHLGGTFAEIADTERQRAQGTMVQRPFVLVGQQYL
Rv1432|M.tuberculosis_H37Rv GDVGWTNPDCRRAGTVHLGGTFAEIADTERQRAQGTMVQRPFVLVGQQYL
MUL_1826|M.ulcerans_Agy99 GDIPWTNPDCRRAGTVHLGGTFAEIADTERQRAQGRMVQRPFVLIGQQYL
MAV_3342|M.avium_104 GDIPWTNPHCARAGSVHLGGSFAEIADTERQRAQGKLAPRPFVLVGQQYL
Mflv_4235|M.gilvum_PYR-GCK GEIPWRDKRLASAPTLHMGGDRATMALAEKDIAEGRHAQWPMVLASLPHL
Mvan_2127|M.vanbaalenii_PYR-1 GEIPWRDPRLANAPTLHLGGDRATMARAEKDVAAGRHAEWPMVLASLPHL
MSMEG_5400|M.smegmatis_MC2_155 APVPWRSKNLNDAGTVHVGADHDGLVRWMADLNTRTLPQQPFMLFGQMTT
: * . * ::*:*. :. *::* .
MMAR_1580|M.marinum_M ADPERS-VGNIHPLWTYAHVPNGYTGDATAA-----IIAQIERFAPGFRE
TH_4571|M.thermoresistible__bu ADPGRS-VGDIHPVWSYAHVPHGYPGDATEA-----VVAQIERFAPGFRD
MAB_4734|M.abscessus_ATCC_1997 ADPGRS-NGNIHPLWTYAHVPHGFTGDATQA-----LIDQIERFAPGFRD
Mb1467|M.bovis_AF2122/97 ADPSRS-VGNINPIWAYAHVPFGYTGDATAA-----VIDQIERFAPGFRD
Rv1432|M.tuberculosis_H37Rv ADPSRS-VGNINPIWAYAHVPFGYTGDATAA-----VIDQIERFAPGFRD
MUL_1826|M.ulcerans_Agy99 ADPSRS-AGNINPIWAYAHVPFGYAGDATAA-----VIDQIERFAPGFRD
MAV_3342|M.avium_104 ADPSRS-AGGINPIWAYAHVPFGYTGDATAL-----VVDQIERFAPGFRD
Mflv_4235|M.gilvum_PYR-GCK ADPGRIDAAGRRPLWTYAHVPAGSTVDMAET-----ITGVFERFAPGFRD
Mvan_2127|M.vanbaalenii_PYR-1 ADPGRVDPQGRRPLWTYAHVPAGSTVDMAEA-----VTEVIERFAPGFRD
MSMEG_5400|M.smegmatis_MC2_155 ADPTRS-PAGTESAWAYTHLPRGMADDASADRLSEIVDHVLEEHAPGFGD
*** * . .. *:*:*:* * . * : : :*..**** :
MMAR_1580|M.marinum_M HIVGQTVRSTTEMSRYNPNYVGGDIMTGA-KDIRQLTFGPRVTLSPYRTG
TH_4571|M.thermoresistible__bu RIVGYRTESAEGMARFNANFTGGDILTGA-KDIRQLTFGPRITLSPYATG
MAB_4734|M.abscessus_ATCC_1997 RIVATAVRSTTDMTVYNPNYVGGDIVTGA-KDIRQLVFGPRTTAHPYRLG
Mb1467|M.bovis_AF2122/97 RIVATVSTSTTELQTYNRNFIGGDIIGGA-NDRLQVIFRPRVAVDPYAIG
Rv1432|M.tuberculosis_H37Rv RIVATVSTSTTELQTYNRNFIGGDIIGGA-NDRLQVIFRPRVAVDPYAIG
MUL_1826|M.ulcerans_Agy99 RITATVSKSTAELQAYNRNFIGGDIIGGA-NDGLQVIFRPRIALDPYAIG
MAV_3342|M.avium_104 RVVATVSRGTADLAAYNANYIGGDILGGA-NDGLQVILRPRVSVSPYATG
Mflv_4235|M.gilvum_PYR-GCK LVVGVRSVPAARLADHNANLVGGDIGVGG-NNMFSALTGPALRWNPWATP
Mvan_2127|M.vanbaalenii_PYR-1 VVVGVRSVPAARLSAHNANLVGGDIGVGG-NNMVSALTGPALRWNPWSTP
MSMEG_5400|M.smegmatis_MC2_155 RVIGRVVQRPSDLEGADANLHTGAVNGGTSQLYQQLIFRPVPGFGTAETP
: . . : : * * : * : . * .
MMAR_1580|M.marinum_M VPGTYICSAATPPGPGAHGMCGANAAKLALA---ELK-------------
TH_4571|M.thermoresistible__bu APGYYICSAATPPGPGAHGMCGYHAAQTALR---ELAR------------
MAB_4734|M.abscessus_ATCC_1997 IPGMYICSAATPPGPGAHGMCGAHAAAEALR---HLRASI----------
Mb1467|M.bovis_AF2122/97 VPGVYLCSQSAPPGAGIHGLCGYHAAESALR---WLRKRR----------
Rv1432|M.tuberculosis_H37Rv VPGVYLCSQSAPPGAGIHGLCGYHAAESALR---WLRKRR----------
MUL_1826|M.ulcerans_Agy99 VPGVYLCSQSAPPGAGIHGLCGYHAAESALQ---GLRKRR----------
MAV_3342|M.avium_104 VPGVYLCSQSTPPGPGIHGLCGYHAAEAALG---WLRRRGG---------
Mflv_4235|M.gilvum_PYR-GCK IPRTYLCSSATPPGGGVHGMAGYYAARTVLRREFGIREMPPLAP------
Mvan_2127|M.vanbaalenii_PYR-1 IPKAYLCSSATPPGGGVHGMAGFYAARTVLRREFGIRELPPLAP------
MSMEG_5400|M.smegmatis_MC2_155 VANVFLGSAGAHPGGGVHGVCGRNAAKAALANNGVLGWPRRKLSKAVLSL
. :: * .: ** * **:.* ** .* :
MMAR_1580|M.marinum_M ---
TH_4571|M.thermoresistible__bu ---
MAB_4734|M.abscessus_ATCC_1997 ---
Mb1467|M.bovis_AF2122/97 ---
Rv1432|M.tuberculosis_H37Rv ---
MUL_1826|M.ulcerans_Agy99 ---
MAV_3342|M.avium_104 ---
Mflv_4235|M.gilvum_PYR-GCK ---
Mvan_2127|M.vanbaalenii_PYR-1 ---
MSMEG_5400|M.smegmatis_MC2_155 VTR