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HPGVDTIRFERVFDSFLAAVANVRTPGDGVRACARLENAACSARLGHMADMLAAAYASAGSDNREQWRCD NWSAVCAQIGAAHAVTSGVVSGLLMDAVTLRERLPKVAAVFAEGLIAYRLVHLICTRTMLVKDAEALRAL DSELADMLRTWGARSKDQTQSDIDALVLLHDPDAVRRSESGNRGNYVEVASDNATGNAYVTATVTATDGE AFDQRLDALARTVCARDPRDLDQRRAAAVGAMSFGWDRLPCLCEHDDCDAAAKPAAGGVVIHVVARREAL GLDVDSGAGPTDSEGPRDGEPPREPKPAPQPPRDLTAQRRALVGKNPPLLPRPWYSYTLTGLIGALKDGQ GELCAVGPATILGGAVIPAPVAAQAAMHATITTLIHPGQAPPEPRYRPSRKLADFVRCRDQTCRFPGCTR PSTLTDIDHTIPYPYGPTCASNLACLCREHHLLKTFWPGWSNVQFPDGTIVWRDPDGNTATTYPGSRLLF PELCGPTAEFDVTRTPPPKHTAGLTMPKRPITRAAARRQRIDDERRKPMHGHPGTPEYR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2756 | - | - | 100% (550) | HNH nuclease |
| M. gilvum PYR-GCK | Mflv_0314 | - | e-120 | 45.37% (529) | hypothetical protein Mflv_0314 |
| M. gilvum PYR-GCK | Mflv_0179 | - | 1e-96 | 40.73% (523) | hypothetical protein Mflv_0179 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-95 | 41.72% (513) | hypothetical protein Mb3805 |
| M. tuberculosis H37Rv | Rv3776 | - | 8e-96 | 41.72% (513) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-34 | 37.20% (250) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 2e-76 | 37.09% (523) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 1e-69 | 36.29% (507) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_0144 | - | 9e-93 | 36.54% (583) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 1e-51 | 36.32% (424) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 1e-40 | 47.72% (197) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0426 | - | 1e-120 | 47.69% (520) | hypothetical protein Mvan_0426 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5187|M.marinum_M ----------------MFESMGVAAGVDHPCDALAERRQLRTPTAESARW
MAV_4456|M.avium_104 ----------------------MCEDATAWFDELMER-CYPSATPESAAL
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------MFDELGDVEL
Mb3805|M.bovis_AF2122/97 ------------------------------MFEISLSDPVELRDADDAAL
Rv3776|M.tuberculosis_H37Rv ------------------------------MFEISLSDPVELRDADDAAL
Mflv_2756|M.gilvum_PYR-GCK ---------MHPGVDTI---------RFERVFDSFLAAVANVRTP-----
Mvan_0426|M.vanbaalenii_PYR-1 ------------------------------MFEGLVESAVRSRG------
MSMEG_0144|M.smegmatis_MC2_155 MSWGYPQTRVHPQIAVLRCRGGFTVGRFERMYEGLLVQIAEFSALSDLEL
TH_0334|M.thermoresistible__bu ----------------------------------------MFESLDDGAV
MMAR_5187|M.marinum_M VQRIGAAARAENRAAAAQLIEIGQLFAYR--LSRCSETEDWAVDTMEAVA
MAV_4456|M.avium_104 VQRIGVFARVENRAAAEQLAAIGELFAYR--LSRCSECEDWAVDTEAAVS
MUL_1813|M.ulcerans_Agy99 MERAREASRREAAAAAERLDVVGALFVLR--CRESGDRAEWATDTWEAVG
MAB_4752|M.abscessus_ATCC_1997 IDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHALDRWDRVA
Mb3805|M.bovis_AF2122/97 LAAIEDCARAEVAAGARRLSAIAELTSRRTGN---DQRADWACDGWDCAA
Rv3776|M.tuberculosis_H37Rv LAAIEDCARAEVAAGARRLSAIAELTSRRTGN---DQRADWACDGWDCAA
Mflv_2756|M.gilvum_PYR-GCK GDGVRACARLENAACSARLGHMADMLAAAYASAGSDNREQWRCDNWSAVC
Mvan_0426|M.vanbaalenii_PYR-1 AAAIGAWARMENAAAARRLFAMADLLEAKLADKDSAERDQWCLDNWDAVS
MSMEG_0144|M.smegmatis_MC2_155 EGQARGWAQAEASASAHKHAAMAELFIRATSTPSADERRWWFVDPDAAVG
TH_0334|M.thermoresistible__bu VDSIAAASREQSAACGREMLAIGELYARR-APEDDTERANWAIDGHANVV
: : * . . :. : : * .
MMAR_5187|M.marinum_M AEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVF
MAV_4456|M.avium_104 AEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDFRLFATIVY
MUL_1813|M.ulcerans_Agy99 AQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAEDIDYRAFQTIVF
MAB_4752|M.abscessus_ATCC_1997 SEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIIN
Mb3805|M.bovis_AF2122/97 AEVAAALTVSHRKASGQMHLSLTL-NRLPQVAALFLAGQLSARLVSIIAW
Rv3776|M.tuberculosis_H37Rv AEVAAALTVSHRKASGQMHLSLTL-NRLPQVAALFLAGQLSARLVSIIAW
Mflv_2756|M.gilvum_PYR-GCK AQIGAAHAVTSGVVSGLLMDAVTLRERLPKVAAVFAEGLIAYRLVHLICT
Mvan_0426|M.vanbaalenii_PYR-1 AEVAAAQNVSPGVASNELLDAWAMRERLPRVAEVFATGAISYRLARTVVK
MSMEG_0144|M.smegmatis_MC2_155 AQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSEMIVRNICW
TH_0334|M.thermoresistible__bu AEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVN
:::.* . : .** . * : :
MMAR_5187|M.marinum_M RTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVARADADAVR
MAV_4456|M.avium_104 RTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVAKADADAVR
MUL_1813|M.ulcerans_Agy99 RTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVADVDRDVVR
MAB_4752|M.abscessus_ATCC_1997 RTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVLHFDQDAVR
Mb3805|M.bovis_AF2122/97 RTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALR
Rv3776|M.tuberculosis_H37Rv RTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALR
Mflv_2756|M.gilvum_PYR-GCK RTMLVKDAEALRALDSELADMLRTWGARSKDQTQSDIDALVLLHDPDAVR
Mvan_0426|M.vanbaalenii_PYR-1 RTRLIADRDARAKVDVEIAAQLTAWGSLSVAKQEAEIDDWVDRFDPSAVV
MSMEG_0144|M.smegmatis_MC2_155 STALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLILKHDPGSFR
TH_0334|M.thermoresistible__bu RSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVR
: : : :* :. : :* : * .
MMAR_5187|M.marinum_M RRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLSALAATVCA
MAV_4456|M.avium_104 RTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLDALAATVCE
MUL_1813|M.ulcerans_Agy99 RVAEAADGRFVDVDVIADGSGLAALAGSVLATAGRAFDRRLDELANTVCA
MAB_4752|M.abscessus_ATCC_1997 RNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCP
Mb3805|M.bovis_AF2122/97 RTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCD
Rv3776|M.tuberculosis_H37Rv RTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCD
Mflv_2756|M.gilvum_PYR-GCK RSESGNRGNYVEVA-SDNATGNAYVTATVTATDGEAFDQRLDALARTVCA
Mvan_0426|M.vanbaalenii_PYR-1 RAEGSSRSRHVDVIPAKNGSGVCYVEAVLHSHDGEALDRRLEELARSVCD
MSMEG_0144|M.smegmatis_MC2_155 RGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARIAELIEGVCP
TH_0334|M.thermoresistible__bu EPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCR
. . . : : : . : . *: : **
MMAR_5187|M.marinum_M QDPRSREQRRADALGVLAAGGDRLGCRCGLPDCAA--GARPAAQPVVIHV
MAV_4456|M.avium_104 HDPRTGEQRRADALGALAAGADRLGCRCGRADCAA--GTRPAAGPVVIHL
MUL_1813|M.ulcerans_Agy99 ADPRTREQRRADAVGALVAGSDRLACGCTSADCTA--AARSAPSKVVIHV
MAB_4752|M.abscessus_ATCC_1997 ADPRSKTQRRADAVGALTQGLNRMRCACGHPDCSG--RD-TADVPVVVNV
Mb3805|M.bovis_AF2122/97 DDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHV
Rv3776|M.tuberculosis_H37Rv DDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHV
Mflv_2756|M.gilvum_PYR-GCK RDPRDLDQRRAAAVGAMSFGWDRLPCLCEHDDCDA-AAK-PAAGGVVIHV
Mvan_0426|M.vanbaalenii_PYR-1 RDPRTKDQLRSDAIGAMAAKADRLMCLCGIDDCEA-AQR-TPS-AVVVHV
MSMEG_0144|M.smegmatis_MC2_155 DDPRTLNELRHDALGAILDHTT-LACECEDPDCVR-GREQSPRGHLVVHV
TH_0334|M.thermoresistible__bu DDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPA-DPADTAATRLVINV
*** : * *:..: : * * ** :*:::
MMAR_5187|M.marinum_M IAERATLDGDGG--------------------------------------
MAV_4456|M.avium_104 IAERASVEGTGG--------------------------------------
MUL_1813|M.ulcerans_Agy99 VADQSTVDGTGH--------------------------------------
MAB_4752|M.abscessus_ATCC_1997 VINQSTLAGSDD--------------------------------------
Mb3805|M.bovis_AF2122/97 VADAAALGAAP----------DPRLSGPEPALAPEAPAT-----------
Rv3776|M.tuberculosis_H37Rv VADAAALGAAP----------DPRLSGPEPALAPEAPAT-----------
Mflv_2756|M.gilvum_PYR-GCK VARREALGLDVDSGAGPTDSEGPRDGEPPREPKPAPQPPRDLTAQRRALV
Mvan_0426|M.vanbaalenii_PYR-1 IAHEDSLTDDTPFAG---HGERPPDAAVEPDVHPGEDPDEKAGQDAAEAH
MSMEG_0144|M.smegmatis_MC2_155 IAREDTVTAAQHAATTTNTPDDAPADTPAADTEPAEPAEPAEPAEPAEPA
TH_0334|M.thermoresistible__bu IAEQATVEGRSD--------------------------------------
: ::
MMAR_5187|M.marinum_M --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3805|M.bovis_AF2122/97 --------------PAVKP-------------------------------
Rv3776|M.tuberculosis_H37Rv --------------PAVKP-------------------------------
Mflv_2756|M.gilvum_PYR-GCK G-----------KNPPLLPRPWYSYTLTGLIGALK---------------
Mvan_0426|M.vanbaalenii_PYR-1 D-----------LQPDGEPRQEPGSGRGKDLLAPP---------------
MSMEG_0144|M.smegmatis_MC2_155 EPAEPAEPVEPVDDPDIAPAASATETATDTTASPTGTDCDPESVSVTEFT
TH_0334|M.thermoresistible__bu --------------------------------------------------
MMAR_5187|M.marinum_M ---------------------APAWEVGADGLVTPELVAELAKSAKLVPL
MAV_4456|M.avium_104 ---------------------GPAVEVGAEGLLPAQLVAELAASARLMPL
MUL_1813|M.ulcerans_Agy99 ---------------------TPAVLLGAEGLIPASLIAELAKVATLRPL
MAB_4752|M.abscessus_ATCC_1997 ---------------------CPAHVPGFG-----VLAAESARAAVAGTP
Mb3805|M.bovis_AF2122/97 ---------------------PAALISGGGVVPAPLLAELIRGGAALSRV
Rv3776|M.tuberculosis_H37Rv ---------------------PAALISGGGVVPAPLLAELIRGGAALSRM
Mflv_2756|M.gilvum_PYR-GCK ------------DGQGELCAVGPATILGGAVIPAP-VAAQAAMHATITTL
Mvan_0426|M.vanbaalenii_PYR-1 ------------PATG-PAKTKPAMILGGGMLPAPLLAATVAHTATIKRL
MSMEG_0144|M.smegmatis_MC2_155 DNSSDTPSAFLDPDEHPLDRVPPAVLFGGGVLPAY-ALAEIINNATIRPL
TH_0334|M.thermoresistible__bu ---------------------NPGYLPGYGAVPASILRAKAAT-ATLRPV
.. * *
MMAR_5187|M.marinum_M RHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIPYA
MAV_4456|M.avium_104 VHPADAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLDHTIPYA
MUL_1813|M.ulcerans_Agy99 MRPSGRP-ESGYAPSAGLAEFVRCRDLTCRARGCDQPAVCCDLDHTVAYG
MAB_4752|M.abscessus_ATCC_1997 TRNLTDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPWA
Mb3805|M.bovis_AF2122/97 RHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYP
Rv3776|M.tuberculosis_H37Rv RHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYP
Mflv_2756|M.gilvum_PYR-GCK IHPGQAPPEPRYRPSRKLADFVRCRDQTCRFPGCTRPSTLTDIDHTIPYP
Mvan_0426|M.vanbaalenii_PYR-1 VHPGQSPPEPRYTPSQKLADFVRCRDMTCRFPGCDVPADRCDLDHTIAYP
MSMEG_0144|M.smegmatis_MC2_155 KHPGDTAPEDRYIPSRALADYVRCRDLTCRFPGCDKPADRCDLDHTVPYP
TH_0334|M.thermoresistible__bu ALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPYP
. * ** *: ::* ** ** ** : ::***:.:
MMAR_5187|M.marinum_M QGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTSPAGHTY
MAV_4456|M.avium_104 EGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLILTSPAGRTY
MUL_1813|M.ulcerans_Agy99 DGGHTHASNLKCLCRKHHLLKTFWG----WRDLQLPDGTVIWLLPDGHTY
MAB_4752|M.abscessus_ATCC_1997 TGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKSPTGHRY
Mb3805|M.bovis_AF2122/97 LG-PTHPSNLKCLCRKHHLLKTFWT---GWRDVQLPDGTIIWTAPNGHTY
Rv3776|M.tuberculosis_H37Rv LG-PTHPSNLKCLCRKHHLLKTFWT---GWRDVQLPDGTIIWTAPNGHTY
Mflv_2756|M.gilvum_PYR-GCK YG-PTCASNLACLCREHHLLKTFWP---GWSNVQFPDGTIVWRDPDGNTA
Mvan_0426|M.vanbaalenii_PYR-1 AG-PTQASNLKALCRKHHLLKTFW----GWRDAQDCDGTVVWTSPGGQVF
MSMEG_0144|M.smegmatis_MC2_155 AG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQHPDGTIVWTSPSGRQY
TH_0334|M.thermoresistible__bu AG-PTHPSNLKLLCVFHCRQ----------AELRFTHDQHKHQSSCLPAY
* * :** * * : : . .
MMAR_5187|M.marinum_M VTTPGS--ALLFPSLCHSTGGLPAAEADPP----------SDHCD-----
MAV_4456|M.avium_104 VTTPGS--ALLFPSLCVPTG-EPARPVAAG----------SQPCG-----
MUL_1813|M.ulcerans_Agy99 VTTPGS--ALLFPNLCVPTGELPPIVGTAGKPPRWPSGEDADPCPNPRTK
MAB_4752|M.abscessus_ATCC_1997 ATTPVS--WFLFPALT----------------------------------
Mb3805|M.bovis_AF2122/97 TTHPDS--RIFLPSWHTTTAALPPAP--SPPAIG----------------
Rv3776|M.tuberculosis_H37Rv TTHPDS--RIFLPSWHTTTAALPPAP--SPPAIG----------------
Mflv_2756|M.gilvum_PYR-GCK TTYPGS--RLLFPELCGPTAEFDVT---RTPPPK----------------
Mvan_0426|M.vanbaalenii_PYR-1 TTHPGS--RLLFPALCRPTAPVVVSSADLAPAPG----------------
MSMEG_0144|M.smegmatis_MC2_155 TTVPGSHRRLSITELAAPTGALDLPATPIPTADP----------------
TH_0334|M.thermoresistible__bu FQRPHG------PATRRPPS------------------------------
* . .
MMAR_5187|M.marinum_M ------QRSAMMP-----RRQRTR-------AQDRARRVATERRQNHHAR
MAV_4456|M.avium_104 ------ERTAMMP-----TRRRTR-------GQNRAARVAAERRANRAAR
MUL_1813|M.ulcerans_Agy99 PGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAAALLAATSLGT
MAB_4752|M.abscessus_ATCC_1997 -------------------RHHTR-------QQARDRRRRTERNLNREQR
Mb3805|M.bovis_AF2122/97 -----PTHTLLMP-----RRRRTR-------AAELAHRIKRERAHVTQRN
Rv3776|M.tuberculosis_H37Rv -----PTHTLLMP-----RRRRTR-------AAELAHRIKRERAHVTQRN
Mflv_2756|M.gilvum_PYR-GCK -----HTAGLTMP-----KRPITR-------AAARRQRIDDERRKP----
Mvan_0426|M.vanbaalenii_PYR-1 -----RPSGLGMP-----RRKQTR-------AQARARRIAEQRRENE---
MSMEG_0144|M.smegmatis_MC2_155 -----DLRGVKMP-----KRRRTR-------AQNTARTIAAERKLN----
TH_0334|M.thermoresistible__bu -------------------ARGLR--------EAVPRQGVDPRRVSGQ--
*
MMAR_5187|M.marinum_M STQPGGQPRSAAPPTPPQSEPQS-----------HPPPF-----------
MAV_4456|M.avium_104 LARATRPAPAASQSWPAGHGPDA-----------DPPPF-----------
MUL_1813|M.ulcerans_Agy99 CQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARPRACVAG--------
MAB_4752|M.abscessus_ATCC_1997 LQREAALAALAAK---------------------DPPPF-----------
Mb3805|M.bovis_AF2122/97 KPPPSGGDTAVAEGF-------------------EPPDGVSRLSLSRRVH
Rv3776|M.tuberculosis_H37Rv KPPPSGGDTAVAEGF-------------------EPPDGVSRLSLSRRVH
Mflv_2756|M.gilvum_PYR-GCK ----------MHGHP-------------------GTPEYR----------
Mvan_0426|M.vanbaalenii_PYR-1 -------ALLKTVQD-------------------DAPPF-----------
MSMEG_0144|M.smegmatis_MC2_155 -------DDLVAEHN-------------------KPPPF-----------
TH_0334|M.thermoresistible__bu --------------------------------------------------