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SKRWFVTGGTPGGFGVAFAEAALEAGDRVVITSRRPHELAAWADGYDDRVLVVPLELTDAAQVQRVVQAA EEHFGGIDVLVNNAGRGWYGSIEGMDESSLRAMFELNFFAVLSVTRAVLPGMRARGSGWIVNVSSVAGLV AAPGFGYYSATKFAIEAVTDALRDEVSTHGISVLAVEPGAFRTNAYAGFANKPVAETIPSYHDMLEEVRA AFVEMDGVQPGDPRRGARAVIAAMAQDPPPRRLVLGNSGYDAVIDALEQSLGDIRANETLSRSADFPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0930 | - | - | 100% (279) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0295 | - | 5e-35 | 36.76% (253) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_5243 | - | 2e-23 | 36.10% (205) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1277c | - | 8e-23 | 30.87% (230) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv1245c | - | 8e-23 | 30.87% (230) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-18 | 28.72% (188) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3405 | - | 3e-27 | 39.58% (192) | short chain dehydrogenase |
| M. marinum M | MMAR_1614 | - | 2e-47 | 43.21% (243) | short chain dehydrogenase |
| M. avium 104 | MAV_3827 | - | 1e-55 | 43.27% (275) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2808 | - | 6e-51 | 41.45% (275) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3670 | - | 5e-42 | 39.36% (249) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 1e-47 | 43.21% (243) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3508 | - | 1e-108 | 68.48% (276) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0930|M.gilvum_PYR-GCK ------MSKRWFVTGGTPGGFGVAFAEAALEAGDRVVITSRR---PHELA
Mvan_3508|M.vanbaalenii_PYR-1 -------MRTWFITGGTPGGFGMAFADAALDAGDRVALTVRR---PEELD
MMAR_1614|M.marinum_M -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARS---VGGVA
MUL_3423|M.ulcerans_Agy99 -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARS---VGGVA
MAV_3827|M.avium_104 -------MARWLITGCSTG-LGREIAGAALQAGHRVVVTARR---ADAVR
MSMEG_2808|M.smegmatis_MC2_155 -------MAVWLITGASRG-LGSAIARAALAEGHTVVAGARN---VPAAA
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRG-FGREWAIAALDRGDRVAATARD---VSTLD
Mb1277c|M.bovis_AF2122/97 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKVAISDVDTDGLADTE
Rv1245c|M.tuberculosis_H37Rv --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKVAISDVDTDGLADTE
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKLAISDVDGEGLAQTE
MAB_3405|M.abscessus_ATCC_1997 --MDKITGKNIAITGAARG-IGYATATALLRRGARVVIGDRD-VEALGSA
:** * :* * * .
Mflv_0930|M.gilvum_PYR-GCK AWADGYDDRVLVVPLELTDAAQVQRVVQAAEEHFGGIDVLVNNAGRGWYG
Mvan_3508|M.vanbaalenii_PYR-1 GWAREHGDRVLVVPLDVTDPEQVRVAVKATEERFGGIDVLVNNAGRAWAG
MMAR_1614|M.marinum_M DLVQRSPERVLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAGYGYRA
MUL_3423|M.ulcerans_Agy99 DLAQRSPERVLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAGYGYRA
MAV_3827|M.avium_104 GFAEEFGELALPVALDVTDRDQIAAAVAAADAAFGGIDVLVNNAGHGYLS
MSMEG_2808|M.smegmatis_MC2_155 AELPHS-DALTVIDLDVTNSAQVSAVADATAKRHGGIDVLVNNAGYSVLG
TH_3670|M.thermoresistible__bu DLRDRFGDAVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFG
Mb1277c|M.bovis_AF2122/97 HRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTG
Rv1245c|M.tuberculosis_H37Rv HRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTG
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTG
MAB_3405|M.abscessus_ATCC_1997 VEGLKEEGNVDAHPLDVTDPASFKRFLEAASAG-GPIDVLVNNAGVMPIG
*::*: . * :: : **** .
Mflv_0930|M.gilvum_PYR-GCK SIEGMDESSLRAMFELNFFAVLSVTRAVLPGMRARGSGWIVNVSSVAGLV
Mvan_3508|M.vanbaalenii_PYR-1 TVEGMDESELRAMFELNFFAVLSVLRAALPGMRARRGGWIVNVSSVAGLR
MMAR_1614|M.marinum_M AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
MUL_3423|M.ulcerans_Agy99 AVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVAL
MAV_3827|M.avium_104 AVEEGEDAEVRKLFDVNYFGAVDMIKAVLPGMRARGCGHIVNISSMTGLV
MSMEG_2808|M.smegmatis_MC2_155 AVEELTDTETRDMFEVNVFGLHRMTRAVLPHMRARGRGRILNIGSVGGFA
TH_3670|M.thermoresistible__bu FVEELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGGVS
Mb1277c|M.bovis_AF2122/97 DIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLF
Rv1245c|M.tuberculosis_H37Rv DIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLF
MLBr_01094|M.leprae_Br4923 DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLF
MAB_3405|M.abscessus_ATCC_1997 PFLSTSDRAIRSMLEVNLYGVINGCQLALPEMVARRRGQVVNIASVAGLM
. . :: . :. : ** : * ::::.*:
Mflv_0930|M.gilvum_PYR-GCK AAPGFGYYSATKFAIEAVTDALRDEVSTHG--ISVLAVEPGAFRTNAYAG
Mvan_3508|M.vanbaalenii_PYR-1 GVTGFGHYSATKFAVEAITGVLRDEVAPWG--INVMAVEPAAFRTRAYSG
MMAR_1614|M.marinum_M TPVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRTDFAG-
MUL_3423|M.ulcerans_Agy99 TPVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRTDFAG-
MAV_3827|M.avium_104 ANPPNAYYSSTKFALEAVTEALAAEVRPLG--IKVTAIEPGAFRTDWAT-
MSMEG_2808|M.smegmatis_MC2_155 AVASSGLYGATKFAVEAITEALALELRGSG--VSATVIEPGAFRTDFLSP
TH_3670|M.thermoresistible__bu AFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYATDWGG-
Mb1277c|M.bovis_AF2122/97 SAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKTAIAR-
Rv1245c|M.tuberculosis_H37Rv SAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKTAIAR-
MLBr_01094|M.leprae_Br4923 SVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAIAR-
MAB_3405|M.abscessus_ATCC_1997 AVPGMAVYNASKFGVVGLSRALSDEFAPQG--VQVSAVLPTFTNTELIAG
. * ::* .: ..: * *. * : . : * *
Mflv_0930|M.gilvum_PYR-GCK FANKPVAETIPSYHDMLEEVRAAFVEMDGVQPGDPRRGARAVIAAMAQDP
Mvan_3508|M.vanbaalenii_PYR-1 FADEPLREPVSEYRALLQGVREAMIAQDGMQPGDPRRGARAVLAAMAQDP
MMAR_1614|M.marinum_M RSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESPA
MUL_3423|M.ulcerans_Agy99 RSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESPA
MAV_3827|M.avium_104 RSMKESGTPIADYTDVAA-RKDLIKQFADHLPGDPRKVAEAVLMVTGLDE
MSMEG_2808|M.smegmatis_MC2_155 RSVRFAATEIDAYADTAGAARTAFAALDGHQPGDPDKAAAAILAVAAADP
TH_3670|M.thermoresistible__bu -SSARRSATMPEYAESRAEADRVR-SQRVARPGDPKASAAALLKVVDAEK
Mb1277c|M.bovis_AF2122/97 ---------NATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNK
Rv1245c|M.tuberculosis_H37Rv ---------NATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNK
MLBr_01094|M.leprae_Br4923 ---------NATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKKK
MAB_3405|M.abscessus_ATCC_1997 --TDSTGAQKPVEPEDIAAAVVRIIEKPRVQVTVPKPLGAVTTIVNSLPT
* .
Mflv_0930|M.gilvum_PYR-GCK PPRRLVLGNSGYDAVIDALEQSLGDIRANETLSRSADFPT----------
Mvan_3508|M.vanbaalenii_PYR-1 PPHRLVLGGDGFDAVKAELEAALAELHENETLSRGADFPH----------
MMAR_1614|M.marinum_M PPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----------
MUL_3423|M.ulcerans_Agy99 PPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----------
MAV_3827|M.avium_104 PPLRLLLGRDVLKAMRDKIAAMSASIDEWEAVTKDVNFPGA---------
MSMEG_2808|M.smegmatis_MC2_155 APLRVQLGRDCVARVERKLLDVCQELGRWRAIAESTDFSTSPAESTSGTR
TH_3670|M.thermoresistible__bu PPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG------------
Mb1277c|M.bovis_AF2122/97 --ARVLVGVDAKVLDLVVRLTG-SGYQRIFPIITGRLIPRPR--------
Rv1245c|M.tuberculosis_H37Rv --ARVLVGVDAKVLDLVVRLTG-SGYQRIFPIITGRLIPRPR--------
MLBr_01094|M.leprae_Br4923 --ARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR--------
MAB_3405|M.abscessus_ATCC_1997 GVRRFMSKKTGTDRVFLDFDTSARTAYENRAGSSLGVTKPDGE-------
.
Mflv_0930|M.gilvum_PYR-GCK -----
Mvan_3508|M.vanbaalenii_PYR-1 -----
MMAR_1614|M.marinum_M -----
MUL_3423|M.ulcerans_Agy99 -----
MAV_3827|M.avium_104 -----
MSMEG_2808|M.smegmatis_MC2_155 TVGAA
TH_3670|M.thermoresistible__bu -----
Mb1277c|M.bovis_AF2122/97 -----
Rv1245c|M.tuberculosis_H37Rv -----
MLBr_01094|M.leprae_Br4923 -----
MAB_3405|M.abscessus_ATCC_1997 -----